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1. Full Text Role of Thiol Reactivity for Targeting Mutant p53
by Zhang, Qiang and Bergman, Jan and Wiman, Klas G and Bykov, Vladimir J.N and Bykov, Vladimir J N
Cell chemical biology, ISSN 2451-9456, 10/2018, Volume 25, Issue 10, pp. 1219 - 1230
mutant p53 | anticancer drug | p53 refolding | cell death | reactive oxygen species | thiol reactivity | thermostabilization | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology
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2. Pharmacological Activation of p53 in Cancer Cells
by Athar, Mohammad and Elmets, Craig A and Kopelovich, Levy
Current pharmaceutical design, ISSN 1381-6128, 2011, Volume 17, Issue 6, pp. 631 - 639
MDM2 | Mutant p53 refolding | Restoration of tumor suppressor functions | Cancer therapeutics | p53 | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Neoplasms - metabolism | Humans | Tumor Suppressor Protein p53 - metabolism | Molecular Targeted Therapy | Tumor Suppressor Protein p53 - genetics | Neoplasms - drug therapy | Antineoplastic Agents - metabolism | Genes, p53 | Animals | Neoplasms - genetics | Tumor Suppressor Protein p53 - agonists | Antineoplastic Agents - pharmacology | Mutation | Antineoplastic Agents - classification | Neoplasms - pathology
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3. Full Text Refolding mutant p53: a simple way to resolve a complex problem?
by Zeimet, Alain G
Drug discovery today, ISSN 1359-6446, 2003, Volume 8, Issue 14, pp. 620 - 620
refolding | Bcl | mutant | cellular proteins | p53 | Cellular proteins | Cancer biology | Pharmaceutical Science | Refolding | Mutant | Cell biology | Biochemistry | Molecular Medicine | Drug Discovery | P53 | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Neoplasms - therapy | Antineoplastic Agents - therapeutic use | Extracellular Matrix Proteins - genetics | Humans | Index Medicus
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4. Full Text A Peptide That Binds and Stabilizes p53 Core Domain: Chaperone Strategy for Rescue of Oncogenic Mutants
by Assaf Friedler and Lars O. Hansson and Dmitry B. Veprintsev and Stefan M. V. Freund and Thomas M. Rippin and Penka V. Nikolova and Mark R. Proctor and Stefan Rüdiger and Alan R. Fersht
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 1/2002, Volume 99, Issue 2, pp. 937 - 942
Molecules | Chemical equilibrium | Biological Sciences | Anisotropy | Protein refolding | DNA | Fluorescence | Standard deviation | Color semiotics | Genetic mutation | Binding sites | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Binding, Competitive | Protein Structure, Tertiary | Amino Acid Sequence | Peptide Fragments - metabolism | Molecular Chaperones - metabolism | Drug Stability | Humans | Tumor Suppressor Protein p53 - metabolism | Models, Molecular | Molecular Sequence Data | Binding Sites - genetics | DNA - metabolism | Oligopeptides - metabolism | Protein Folding | Tumor Suppressor Protein p53 - genetics | DNA - genetics | Peptide Fragments - chemistry | Base Sequence | Protein Binding | Tumor Suppressor Protein p53 - chemistry | Mutation | In Vitro Techniques | Peptide Fragments - genetics | Physiological aspects | Genetic aspects | Research | Carrier proteins | Cytochemistry | Cancer | Proteins | Peptides | Tumors | CDB3 protein | Index Medicus
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5. Full Text Mutant p53 as a therapeutic target for the treatment of triple-negative breast cancer: Preclinical investigation with the anti-p53 drug, PK11007
by Synnott, Naoise C and Bauer, Matthias R and Madden, Stephen and Murray, Alyson and Klinger, Rut and O'Donovan, Norma and O'Connor, Darran and Gallagher, William M and Crown, John and Fersht, Alan R and Duffy, Michael J
Cancer letters, ISSN 0304-3835, 02/2018, Volume 414, pp. 99 - 106
mutant p53 | breast cancer | triple-negative breast cancer | APR-246 | 2-sulfonylpyrimidine PK11007 | PRIMA-1MET | Life Sciences & Biomedicine | Oncology | Science & Technology | Care and treatment | Analysis | Therapeutics | Breast cancer | Tumor proteins | Health aspects | Investigations | Homeopathy | Materia medica and therapeutics | Index Medicus
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6. Full Text Drug discovery and mutant p53
by Maslon, Magda M and Hupp, Ted R
Trends in cell biology, ISSN 0962-8924, 2010, Volume 20, Issue 9, pp. 542 - 555
Pathology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Neoplasms - genetics | Signal Transduction | Humans | Tumor Suppressor Protein p53 - metabolism | Tumor Suppressor Protein p53 - chemistry | Mutation | Proto-Oncogene Proteins c-mdm2 - chemistry | Drug Discovery | Proto-Oncogene Proteins c-mdm2 - metabolism | Tumor Suppressor Protein p53 - genetics | Tumor proteins | Analysis | Index Medicus
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7. Full Text Targeting of mutant P53 and the cellular redox balance by APR-246 as a strategy for efficient cancer therapy
by Bykov, Vladimir J.N and Zhang, Qiang and Zhang, Meiqiongzi and Ceder, Sophia and Abrahmsen, Lars and Wiman, Klas G
Frontiers in oncology, ISSN 2234-943X, 2016, Volume 6, pp. 21 - 21
Mutant p53 | Cancer therapy | Redox balance | Clinical trial | APR-246 | Thioredoxin reductase | Apoptosis | Glutathione | Life Sciences & Biomedicine | Oncology | Science & Technology | Care and treatment | Gene mutations | Observations | Methods | Cancer | Medicin och hälsovetenskap | cancer therapy | mutant p53 | Clinical Trial | thioredoxin reductase
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8. Full Text Treating p53 mutant aggregation-associated cancer
by Kanapathipillai, Mathumai
Cancers, ISSN 2072-6694, 06/2018, Volume 10, Issue 6, p. 154
Aggregation | Drugs | Inhibition | P53 mutant | Cancer | Life Sciences & Biomedicine | Oncology | Science & Technology | Cell proliferation | Proteins | Cell growth | p53 Protein | Tumor suppressor genes | Mutation | Protein interaction | DNA repair | Apoptosis | inhibition | aggregation | cancer | p53 mutant | drugs
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9. Full Text Molecular chaperone HspB2 inhibited pancreatic cancer cell proliferation via activating p53 downstream gene RPRM, BAI1, and TSAP6
by Yu, Ze and Wang, Hao and Fang, Yilin and Lu, Liangliang and Li, Minghao and Yan, Bingru and Nie, Yuzhe and Teng, Chunbo
Journal of cellular biochemistry, ISSN 0730-2312, 03/2020, Volume 121, Issue 3, pp. 2318 - 2329
Panc‐1mm | HspB2 | TSAP6 | BAI‐1 | p53 | RPRM | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Cell proliferation | p53 Protein | Heat shock proteins | Control systems | Chaperones | Gene expression | Substrates | Mutants | Proteins | Angiogenesis | Cell growth | Protein folding | Pancreatic cancer | Quality control | Inhibition | Binding sites | Deoxyribonucleic acid--DNA | Apoptosis | Cancer | Heat shock | Index Medicus
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10. Full Text Probing the Roles of Calcium-Binding Sites during the Folding of Human Peptidylarginine Deiminase 4
by Liu, Yi-Liang and Lee, Chien-Yun and Huang, Yu-Ni and Chen, Hui-Yi and Liu, Guang-Yaw and Hung, Hui-Chih
Scientific reports, ISSN 2045-2322, 05/2017, Volume 7, Issue 1, pp. 2429 - 14
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Calcium-Binding Proteins - chemistry | Calcium-Binding Proteins - metabolism | Gene Expression | Protein-Arginine Deiminases - genetics | Protein-Arginine Deiminases - chemistry | Calcium - metabolism | Protein Unfolding | Humans | Protein Refolding | Models, Molecular | Calcium - chemistry | Protein-Arginine Deiminases - metabolism | Protein Folding | Thermodynamics | Models, Biological | Protein Binding | Protein Conformation | Mutation | Binding Sites | Calcium-Binding Proteins - genetics | Enzymes | Calcium | Protein-arginine deiminase | Calcium-binding protein | Denaturation | Ions | Monomers | Binding sites | Conformation | Index Medicus
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11. Full Text Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: Definition of mutant states for rescue in cancer therapy
by Bullock, Alex N and Henckel, Julia and Fersht, Alan R
Oncogene, ISSN 0950-9232, 03/2000, Volume 19, Issue 10, pp. 1245 - 1256
Activity | Tumour suppressor | Stability | Denaturation | Protein | Biochemistry & Molecular Biology | Oncology | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Cell physiology | Molecular and cellular biology | Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes | Temperature | Models, Chemical | Humans | Transcriptional Activation | Models, Molecular | Recombinant Proteins - chemistry | Spectrometry, Fluorescence | Protein Folding | Thermodynamics | Genes, p53 | Peptide Fragments - chemistry | Protein Denaturation | Tumor Suppressor Protein p53 - chemistry | Mutation | Peptide Fragments - genetics | Apoptosis | Databases, Factual | Protein folding | Physiological aspects | Tumor suppressor genes | Genetic aspects | Research | DNA-ligand interactions | Cancer | Index Medicus
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12. Full Text Targeting of Mutant p53 and the Cellular Redox Balance by APR-246 as a Strategy for Efficient Cancer Therapy
by Bykov, Vladimir J N and Zhang, Qiang and Zhang, Meiqiongzi and Ceder, Sophia and Abrahmsen, Lars and Wiman, Klas G
Frontiers in oncology, ISSN 2234-943X, 2016, Volume 6, p. 21
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13. Full Text Strong synergy with APR-246 and DNA-damaging drugs in primary cancer cells from patients with TP53 mutant High-Grade Serous ovarian cancer
by Fransson, Åsa and Glaessgen, Daria and Alfredsson, Jessica and Wiman, Klas G and Bajalica-Lagercrantz, Svetlana and Mohell, Nina
Journal of ovarian research, ISSN 1757-2215, 05/2016, Volume 9, Issue 1, pp. 27 - 27
High-Grade Serous (HGS) cancer | p53 reactivation | DNA-damaging drugs | Primary cancer cells</