X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
mutasynthesis (104) 104
biosynthesis (60) 60
index medicus (58) 58
antibiotics (34) 34
natural-products (31) 31
chemistry, medicinal (26) 26
biochemistry & molecular biology (25) 25
derivatives (23) 23
mutation (22) 22
natural products (22) 22
chemistry, multidisciplinary (21) 21
polyketides (21) 21
antitumor agents (18) 18
combinatorial biosynthesis (16) 16
humans (16) 16
streptomyces (16) 16
streptomyces - metabolism (16) 16
anti-bacterial agents - chemistry (15) 15
gene-cluster (15) 15
semisynthesis (15) 15
anti-bacterial agents - biosynthesis (14) 14
chemistry, organic (14) 14
polyketide synthase (14) 14
analogs (13) 13
analysis (13) 13
chemistry (12) 12
precursor-directed biosynthesis (12) 12
streptomyces - genetics (12) 12
biotechnology & applied microbiology (11) 11
chemical-synthesis (11) 11
identification (11) 11
biosynthese (10) 10
enzymes (10) 10
generation (10) 10
metabolic engineering (10) 10
molecular structure (10) 10
structural diversity (10) 10
geldanamycin (9) 9
polyketide (9) 9
polyketide synthases - metabolism (9) 9
antitumor agent ansamitocin (8) 8
biological products - chemistry (8) 8
cancer (8) 8
cell line, tumor (8) 8
heterologous expression (8) 8
metabolites (8) 8
microbiology (8) 8
nachwachsender rohstoff (8) 8
physiological aspects (8) 8
streptomyces - enzymology (8) 8
structure-activity relationship (8) 8
3-amino-5-hydroxybenzoic acid (7) 7
animals (7) 7
antineoplastic agents - chemistry (7) 7
antineoplastic agents - pharmacology (7) 7
benzoquinones - chemistry (7) 7
biocatalysis (7) 7
biological products - metabolism (7) 7
biotechnology (7) 7
magnetic resonance spectroscopy (7) 7
pharmacology & pharmacy (7) 7
starter unit (7) 7
synthase (7) 7
actinosynnema-pretiosum (6) 6
anti-bacterial agents - chemical synthesis (6) 6
antibiotika (6) 6
bioengineering (6) 6
cell proliferation - drug effects (6) 6
fermentation (6) 6
gene (6) 6
genetic engineering (6) 6
hsp90 (6) 6
inhibitor (6) 6
inhibitors (6) 6
lactams, macrocyclic - chemistry (6) 6
metabolic engineering - methods (6) 6
microbial sensitivity tests (6) 6
streptomyces - chemistry (6) 6
synthetic biology (6) 6
amino acid sequence (5) 5
ansamitocins (5) 5
anti-bacterial agents - pharmacology (5) 5
antineoplastic agents - metabolism (5) 5
bacteria (5) 5
bacterial proteins - genetics (5) 5
bacterial proteins - metabolism (5) 5
biosynthetic pathways (5) 5
chemical properties (5) 5
complex (5) 5
enzyme (5) 5
gen (5) 5
genes (5) 5
glycopeptide antibiotics (5) 5
macrolides - chemistry (5) 5
macrolides - metabolism (5) 5
maytansine - analogs & derivatives (5) 5
maytansine - chemistry (5) 5
mechanism (5) 5
models, molecular (5) 5
molecular conformation (5) 5
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Angewandte Chemie International Edition, ISSN 1433-7851, 03/2017, Volume 56, Issue 14, pp. 4066 - 4066
The conversion of the counterintuitive biosynthetic intermediate pseudomonic acid B into pseudomonic acid A, which corresponds to the formal loss of a hydroxy... 
mutasynthesis | structure determination | polyketides | antibiotics | biosynthesis | Mupirocin | Complementation | Biosynthesis | Antibiotics | Workers | Intermediates
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2013, Volume 341, Issue 6150, pp. 1089 - 1094
Journal Article
Natural Product Reports, ISSN 0265-0568, 8/2012, Volume 29, Issue 8, pp. 87 - 889
Journal Article
Organic Letters, ISSN 1523-7060, 07/2013, Volume 15, Issue 14, pp. 3774 - 3777
A strategy for introducing structural diversity into polyketides by exploiting the promiscuity of an in-line methyltransferase domain in a multidomain... 
SYNTHASE | ANALOG | BIOSYNTHESIS | ENZYMES | DNA | MACHINERY | CHEMISTRY, ORGANIC | MUTASYNTHESIS | LOGIC | BIOCATALYSIS | Protein Structure, Tertiary | Amino Acid Sequence | Methyltransferases - chemistry | Pargyline - analogs & derivatives | Polyketide Synthases - chemistry | Pyrones - chemistry | Pargyline - chemistry | Furans - chemistry | Polyketides - chemistry
Journal Article
Beilstein journal of organic chemistry, ISSN 1860-5397, 2019, Volume 15, Issue 1, pp. 2922 - 2929
The argyrins are secondary metabolites from myxobacteria with antibiotic activity against . Studying their structure–activity relationship is hampered by the... 
antibiotic | ELUCIDATION | NRPS | BIOSYNTHESIS | PROTEASOME | CHEMISTRY, ORGANIC | mutasynthesis | BACTERIAL PROTEIN-SYNTHESIS | INHIBITOR | argyrin | peptide synthesis | IMMUNOSUPPRESSIVE CYCLIC-PEPTIDES | Pathogens | Incorporation | Peptides | Biosynthesis | Intermediates | Secondary metabolites | Antibiotics | Metabolites | Natural products | Sarcosine | Peptide synthesis | Chemical synthesis | Binding sites | Crystal structure | nrps
Journal Article
Current Topics in Medicinal Chemistry, ISSN 1568-0266, 06/2016, Volume 16, Issue 15, pp. 1755 - 1762
Non-ribosomal peptides (NRPs) and polyketides (PKs) play key roles in pharmaceutical industry due to their promising biological activities. The structural... 
Polyketide synthase | Directed evolution | High-throughput screening | Natural product | Biosynthesis | Mutasynthesis | Non-ribosomal peptide synthetase | COMBINATORIAL BIOSYNTHESIS | CHEMISTRY, MEDICINAL | NRPS | SPECIFICITY | MECHANISM | NATURAL-PRODUCTS | THIOESTERASE DOMAIN | MICROORGANISMS | CATALYTIC DOMAINS | GENES | ADENYLATION DOMAIN
Journal Article
Drug discovery today, ISSN 1359-6446, 2008, Volume 13, Issue 19-20, pp. 894 - 901
Natural products have been the single most productive source of leads for the development of drugs. Over a 100 new products are in clinical development,... 
COMPOUND LIBRARY | CYANOBACTERIA | FLAVONOID ANALOGS | BIOLOGY | GENES | CHEMISTRY | TRADITIONAL CHINESE MEDICINE | PHARMACOLOGY & PHARMACY | FUTURE | INHIBITOR | MUTASYNTHESIS | Animals | Pharmacology - trends | Computer Simulation | Humans | Drug Design | Drug Evaluation, Preclinical | Biological Products - physiology
Journal Article
Synthesis, ISSN 0039-7881, 08/2014, Volume 46, Issue 16, pp. 2122 - 2132
Abstract Access to natural products and their analogues is crucial. Such compounds have, for many years, played a central role in the area of drug discovery as... 
short review | chemoselectivity | antifungal agents | alkyl halides | biosynthesis | cross-coupling | antibiotics | antitumor agents | DIVERSIFICATION | ANALOGS | POLYKETIDE SYNTHASE | STEREOCHEMISTRY | CHEMISTRY, ORGANIC | ENGINEERED BIOSYNTHESIS | GELDANAMYCIN | GENERATION | DERIVATIVES | MUTASYNTHESIS
Journal Article