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1. Adequacy of samples obtained by endobronchial ultrasound with transbronchial needle aspiration for molecular analysis in patients with non–small cell lung cancer: Systematic review and meta-analysis
by Labarca, Gonzalo and Folch, Erik and Jantz, Michael and Mehta, Hiren J and Majid, Adnan and Fernandez-Bussy, Sebastian
Annals of the American Thoracic Society, ISSN 2325-6621, 10/2018, Volume 15, Issue 10, pp. 1205 - 1216
Rationale: Endobronchial ultrasound and transbronchial needle aspiration (EBUS-TBNA) are commonly used for the diagnosis and mediastinal staging of lung... 
Molecular markers | Molecular analysis | Endobronchial ultrasound | Transbronchial needle aspiration | Immunotherapy | Lung cancer | MUTATION ANALYSIS | ALK | EBUS-TBNA | KRAS MUTATION | EGFR MUTATION | CYTOLOGY | lung cancer | GROWTH-FACTOR RECEPTOR | endobronchial ultrasound and transbronchial needle aspiration | SPECIMENS | RESPIRATORY SYSTEM | RE-BIOPSY | immunotherapy | molecular analysis | molecular markers | TUMOR GENOTYPING TECHNIQUES
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2. Full Text Prognosis of patients with peritoneal metastatic colorectal cancer given systemic therapy: an analysis of individual patient data from prospective randomised trials from the Analysis and Research in Cancers of the Digestive System (ARCAD) database
by Franko, Jan, Dr and Shi, Qian, PhD and Meyers, Jeffrey P, PhD and Maughan, Timothy S, Prof and Adams, Richard A, Prof and Seymour, Matthew T, Prof and Saltz, Leonard, Prof and Punt, Cornelis J A, Prof and Koopman, Miriam, MD and Tournigand, Christophe, Prof and Tebbutt, Niall C, Prof and Diaz-Rubio, Eduardo, Prof and Souglakos, John, MD and Falcone, Alfredo, Prof and Chibaudel, Benoist, MD and Heinemann, Volker, Prof and Moen, Joseph, MS and De Gramont, Aimery, Prof and Sargent, Daniel J, Prof and Grothey, Axel, Prof and Anal Res Canc Digestive Syst ARCAD and Analysis and Research in Cancers of the Digestive System (ARCAD) Group
Lancet Oncology, The, ISSN 1470-2045, 2016, Volume 17, Issue 12, pp. 1709 - 1719
Summary Background Patients with peritoneal metastatic colorectal cancer have reduced overall survival compared with patients with metastatic colorectal cancer... 
Hematology, Oncology and Palliative Medicine | SURVIVAL | 1ST-LINE TREATMENT | ONCOLOGY | RESECTION | BEVACIZUMAB | PHASE-III | COMBINATION CHEMOTHERAPY | IRINOTECAN | CARCINOMATOSIS | OXALIPLATIN | FLUOROURACIL | Colorectal Neoplasms - mortality | Prognosis | Prospective Studies | Humans | Middle Aged | Proportional Hazards Models | Male | Colorectal Neoplasms - drug therapy | Adolescent | Aged, 80 and over | Adult | Female | Aged | Peritoneal Neoplasms - secondary | Cancer patients | Databases | Analysis | Oncology, Experimental | Colorectal cancer | Radiation | Clinical trials | Metastasis | Research | Health aspects | Cancer | Index Medicus
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3. Full Text Fluctuation AnaLysis CalculatOR: a web tool for the determination of mutation rate using Luria-Delbrück fluctuation analysis
by Hall, Brandon M and Ma, Chang-Xing and Liang, Ping and Singh, Keshav K
Bioinformatics, ISSN 1367-4803, 6/2009, Volume 25, Issue 12, pp. 1564 - 1565
The program Fluctuation AnaLysis CalculatOR (FALCOR) is a web tool designed for use with Luria-Delbrück fluctuation analysis to calculate the frequency and... 
BIOTECHNOLOGY & APPLIED MICROBIOLOGY | SACCHAROMYCES-CEREVISIAE | BIOCHEMICAL RESEARCH METHODS | MATHEMATICAL & COMPUTATIONAL BIOLOGY | Databases, Genetic | Computational Biology - methods | Likelihood Functions | Software | Internet | Mutation - genetics | Index Medicus | Applications Note
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4. Full Text Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA
by Gao, Pu and Ascano, Manuel and Zillinger, Thomas and Wang, Weiyi and Dai, Peihong and Serganov, Artem A and Gaffney, Barbara L and Shuman, Stewart and Jones, Roger A and Deng, Liang and Hartmann, Gunther and Barchet, Winfried and Tuschl, Thomas and Patel, Dinshaw J and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Cell, ISSN 0092-8674, 08/2013, Volume 154, Issue 4, pp. 748 - 762
Binding of dsDNA by cyclic GMP-AMP (cGAMP) synthase (cGAS) triggers formation of the metazoan second messenger c[G(2′,5′)pA(3′,5′)p], which binds the signaling... 
2ND-MESSENGER | STIMULATOR | DINUCLEOTIDE | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | ADAPTER | CYTOSOLIC DNA | SENSOR | CYCLIC DI-GMP | AMP SYNTHASE | 5,6-DIMETHYLXANTHENONE-4-ACETIC ACID | CELL BIOLOGY | Nucleotides, Cyclic - metabolism | Antiviral Agents - pharmacology | Signal Transduction | Membrane Proteins - genetics | Humans | Models, Molecular | Crystallography, X-Ray | Structure-Activity Relationship | Xanthones - pharmacology | Animals | Cyclic GMP - metabolism | Membrane Proteins - antagonists & inhibitors | Membrane Proteins - chemistry | Mutagenesis | Interferon Regulatory Factor-3 - metabolism | Interferon Type I - metabolism | Protein Conformation | Membrane Proteins - metabolism | Mice | Antiviral agents | Gene mutations | Biological response modifiers | Analysis | Protein binding | Index Medicus
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5. Full Text Thermodynamic and structural analysis of HIV protease resistance to darunavir – analysis of heavily mutated patient‐derived HIV‐1 proteases
by Kožíšek, Milan and Lepšík, Martin and Grantz Šašková, Klára and Brynda, Jiří and Konvalinka, Jan and Řezáčová, Pavlína
FEBS Journal, ISSN 1742-464X, 04/2014, Volume 281, Issue 7, pp. 1834 - 1847
We report enzymologic, thermodynamic and structural analyses of a series of six clinically derived mutant HIV proteases (PR) resistant to darunavir. We show... 
protease inhibitors | isothermal titration calorimetry | HIV | resistance mutation | X‐ray crystallography | enthropic contribution | X-ray crystallography | HIV protease inhibitors | MOLECULAR-DYNAMICS | DESIGN | BIOCHEMISTRY & MOLECULAR BIOLOGY | CRYSTAL-STRUCTURES | DRUG-RESISTANCE | VIRUS TYPE-1 PROTEASE | ENTHALPY | 2 BINDING-SITES | GENERATION | INHIBITORS | MUTATIONS | Amino Acid Sequence | Darunavir | Sulfonamides - chemistry | HIV Protease - genetics | Molecular Sequence Data | HIV Protease Inhibitors - chemistry | Sulfonamides - pharmacology | HIV Protease Inhibitors - pharmacology | Thermodynamics | Drug Resistance, Viral - genetics | Protein Binding | Molecular Docking Simulation | HIV Protease - chemistry | Mutation | HIV Protease - metabolism | Protease inhibitors | Proteases | Hydrogen | Analysis | Crystals | HIV patients | HIV (Viruses) | Structure | Antiretroviral drugs | Drug resistance | Human immunodeficiency virus--HIV | Index Medicus
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6. Full Text Checkpoint Inhibitors in Metastatic EGFR-Mutated Non–Small Cell Lung Cancer—A Meta-Analysis
by Lee, Chee Khoon and Man, Johnathan and Lord, Sally and Links, Matthew and Gebski, Val and Mok, Tony and Yang, James Chih-Hsin
Journal of Thoracic Oncology, ISSN 1556-0864, 02/2017, Volume 12, Issue 2, pp. 403 - 407
We performed a meta-analysis to assess the role of immune checkpoint inhibitors as second-line therapy in -mutant advanced NSCLC. Randomized trials comparing... 
EGFR mutation | Immune checkpoint inhibitors | NSCLC | Predictive biomarker | AMPLIFICATION | ONCOLOGY | RESPIRATORY SYSTEM | ACQUIRED-RESISTANCE | ATEZOLIZUMAB | NIVOLUMAB | DOCETAXEL | POPLAR | Lung Neoplasms - genetics | Lung Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - genetics | Prognosis | Carcinoma, Non-Small-Cell Lung - genetics | Humans | Lung Neoplasms - pathology | Antineoplastic Agents - therapeutic use | Randomized Controlled Trials as Topic | Carcinoma, Non-Small-Cell Lung - secondary | Cell Cycle Checkpoints - drug effects | Immunotherapy | Carcinoma, Non-Small-Cell Lung - drug therapy | Mutation | Index Medicus
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7. Full Text Growth Stage-Based Phenotypic Analysis of Arabidopsis: A Model for High Throughput Functional Genomics in Plants
by Douglas C. Boyes and Adel M. Zayed and Robert Ascenzi and Amy J. McCaskill and Neil E. Hoffman and Keith R. Davis and Jörn Görlach
The Plant Cell, ISSN 1040-4651, 7/2001, Volume 13, Issue 7, pp. 1499 - 1510
With the completion of the Arabidopsis genome sequencing project, the next major challenge is the large-scale determination of gene function. As a model... 
Leaves | Phenotypes | Seeds | Plant growth | Developmental biology | Data collection | Plants | Flowers | Phenotypic traits | Plant cells | Genomics Article | MUTANT | BIOCHEMISTRY & MOLECULAR BIOLOGY | PLANT SCIENCES | CELL BIOLOGY | Phenotype | Genetic aspects | Research | Growth (Plants) | Arabidopsis | Plant genetics | Index Medicus
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8. Full Text Molecular analysis of pancreatic cyst fluid: A comparative analysis with current practice of diagnosis
by Shen, Jian and Brugge, William R and DiMaio, Christopher J and Pitman, Martha B
Cancer Cytopathology, ISSN 1934-662X, 2009, Volume 117, Issue 3, pp. 217 - 227
BACKGROUND: The management of patients with pancreatic cysts is based on the preoperative distinction of nonmucinous and mucinous cysts in general and of... 
Molecular diagnosis | Mucinous cystic neoplasm | Pancreatic neoplastic mucinous cysts | Loss of heterozygosity | Clinical consensus diagnosis | Intraductal papillary mucinous neoplasm | K-ras gene | ETHANOL LAVAGE | MANAGEMENT | intraductal papillary mucinous neoplasm | CYTOLOGY | PATHOLOGY | TUMORS | LESIONS | molecular diagnosis | PAPILLARY MUCINOUS NEOPLASMS | mucinous cystic neoplasm | FINE-NEEDLE-ASPIRATION | ONCOLOGY | INJECTION | clinical consensus diagnosis | SAMPLES | pancreatic neoplastic mucinous cysts | loss of heterozygosity | k-ras gene | Molecular Diagnostic Techniques - methods | Pancreatic Neoplasms - metabolism | Pancreatic Neoplasms - diagnosis | Humans | Middle Aged | Male | Loss of Heterozygosity | Sensitivity and Specificity | Mucins - metabolism | Aged, 80 and over | Adult | Female | Cyst Fluid - metabolism | Genes, ras - genetics | Diagnosis, Differential | Pancreas - pathology | Pancreatic Cyst - diagnosis | Pancreatic Neoplasms - genetics | Pancreas - metabolism | Pancreatic Cyst - genetics | Point Mutation | Algorithms | Aged | DNA, Neoplasm - genetics | Pancreatic Cyst - metabolism | Usage | Cytodiagnosis | Pancreatic tumors | Analysis | Cytology | Diagnosis | Methods | Index Medicus
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9. Full Text Selective 2'-hydroxyl acylation analyzed by primer extension and mutational profiling (SHAPE-MaP) for direct, versatile and accurate RNA structure analysis
by Smola, Matthew J and Rice, Greggory M and Busan, Steven and Siegfried, Nathan A and Weeks, Kevin M
Nature Protocols, ISSN 1754-2189, 11/2015, Volume 10, Issue 11, pp. 1643 - 1669
Selective 2'-hydroxyl acylation analyzed by primer extension (SHAPEAPEAPE) chemistries exploit small electrophilic reagents that react with 2'-hydroxyl groups... 
REAGENT | BIOCHEMICAL RESEARCH METHODS | ARCHITECTURE | SINGLE-NUCLEOTIDE RESOLUTION | SECONDARY STRUCTURE | PARTITION-FUNCTION | REVEALS | Computational Biology - methods | RNA Processing, Post-Transcriptional | Models, Molecular | Mutation | Nucleic Acid Conformation | RNA - chemistry | Molecular Biology - methods | Acylation | Hydroxides | RNA | Gene mutations | Analysis | DNA polymerases | Influence | Research | Methods | Index Medicus | motif discovery | mutational profiling | structure modeling | chemical probing
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10. Full Text The role of K- ras gene mutation analysis in EUS-guided FNA cytology specimens for the differential diagnosis of pancreatic solid masses: a meta-analysis of prospective studies
by Fuccio, Lorenzo, MD and Hassan, Cesare, MD and Laterza, Liboria, MD and Correale, Loredana, PhD and Pagano, Nico, MD and Bocus, Paolo, MD and Fabbri, Carlo, MD and Maimone, Antonella, MD and Cennamo, Vincenzo, MD and Repici, Alessandro, MD and Costamagna, Guido, MD and Bazzoli, Franco, MD and Larghi, Alberto, MD, PhD
Gastrointestinal Endoscopy, ISSN 0016-5107, 2013, Volume 78, Issue 4, pp. 596 - 608
Background Differential diagnosis of pancreatic solid masses with EUS-guided FNA (EUS-FNA) is still challenging in about 15% of cases. Mutation of the K- ras... 
Gastroenterology and Hepatology | pancreatic adenocarcinoma | PADC | QUADAS | Quality Assessment of Diagnostic Accuracy Studies | CANCER DIAGNOSIS | FINE-NEEDLE-ASPIRATION | CLINICAL UTILITY | ADENOCARCINOMA | KRAS MUTATION | BIOPSY | CYST FLUID | ENDOSCOPIC ULTRASOUND | GASTROENTEROLOGY & HEPATOLOGY | CARCINOMA | MOLECULAR ANALYSIS | ras Proteins - genetics | Diagnosis, Differential | Proto-Oncogene Proteins p21(ras) | Adenocarcinoma - pathology | Prospective Studies | Pancreatic Neoplasms - diagnosis | Humans | Pancreatic Neoplasms - pathology | Pancreatitis, Chronic - diagnosis | Pancreatic Neoplasms - genetics | Proto-Oncogene Proteins - genetics | Adenocarcinoma - diagnosis | DNA Mutational Analysis | Sensitivity and Specificity | Carcinoma, Pancreatic Ductal - diagnosis | Adenocarcinoma - genetics | Mutation | Genes, ras | Endoscopic Ultrasound-Guided Fine Needle Aspiration | Endoscopic surgery | Gene mutations | Pancreatic cancer | Genes | Genetic research | Genetic aspects | Diagnosis | Endoscopy | Medical imaging equipment | Index Medicus
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11. Full Text Comprehensive Flavonol Profiling and Transcriptome Coexpression Analysis Leading to Decoding Gene: Metabolite Correlations in Arabidopsis
by Keiko Yonekura-Sakakibara and Takayuki Tohge and Fumio Matsuda and Ryo Nakabayashi and Hiromitsu Takayama and Rie Niida and Akiko Watanabe-Takahashi and Eri Inoue and Kazuki Saito
The Plant Cell, ISSN 1040-4651, 8/2008, Volume 20, Issue 8, pp. 2160 - 2176
To complete the metabolic map for an entire class of compounds, it is essential to identify gene-metabolite correlations of a metabolic pathway. We used liquid... 
Transcriptomes | Flavonols | Flavonoids | Genes | Glycosides | Biosynthesis | Plants | Flowers | Metabolism | Plant cells | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHENYLPROPANOID METABOLISM | LEAVES | NETWORKS | IDENTIFICATION | GENOME | PLANT SCIENCES | CELL BIOLOGY | SEED COAT | THALIANA | BIOSYNTHESIS | ANTHOCYANIN | GLYCOSYLTRANSFERASES | Pentosyltransferases - genetics | Arabidopsis Proteins - genetics | Plants, Genetically Modified - genetics | Flavonols - metabolism | Substrate Specificity | Gene Expression Profiling - methods | Flavonols - chemistry | Pentosyltransferases - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Arabidopsis - metabolism | Arabidopsis - genetics | Arabidopsis Proteins - metabolism | Glucosyltransferases - metabolism | Plants, Genetically Modified - metabolism | Spectrometry, Mass, Electrospray Ionization | Chromatography, Liquid | Molecular Structure | Mutation | Glucosyltransferases - genetics | Arabidopsis thaliana | Isoflavones | Index Medicus
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12. Full Text Sox10—A Marker for Not Only Schwannian and Melanocytic Neoplasms But Also Myoepithelial Cell Tumors of Soft Tissue: A Systematic Analysis of 5134 Tumors
by Miettinen, Markku and McCue, Peter A and Sarlomo-Rikala, Maarit and Biernat, Wojciech and Czapiewski, Piotr and Kopczynski, Janusz and Thompson, Lester D and Lasota, Jerzy and Wang, Zengfeng and Fetsch, John F
The American Journal of Surgical Pathology, ISSN 0147-5185, 06/2015, Volume 39, Issue 6, pp. 826 - 835
Sox10 transcription factor is expressed in schwannian and melanocytic lineages and is important in their development and can be used as a marker for... 
breast cancer | immunohistochemistry | Schwann cell | myoepithelioma | Sox10 | SURGERY | DIAGNOSIS | MOUSE | PATHOLOGY | LESIONS | MELANOMA | GENE | TRANSCRIPTION FACTOR SOX10 | CARCINOMAS | HIRSCHSPRUNG-DISEASE | MUTATIONS | EXPRESSION | Immunohistochemistry | Melanoma - metabolism | Myoepithelioma - metabolism | Neurilemmoma - metabolism | Biomarkers, Tumor - analysis | SOXE Transcription Factors - metabolism | Tissue Array Analysis | Humans | Soft Tissue Neoplasms - metabolism | Melanoma - pathology | Myoepithelioma - pathology | Neurilemmoma - pathology | Index Medicus
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