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Nature Methods, ISSN 1548-7091, 2014, Volume 11, Issue 8, pp. 801 - 807
.... This approach-'deep mutational scanning'-yields large-scale data sets that can reveal intrinsic protein properties, protein behavior within cells and the consequences of human genetic variation... 
SPECIFICITY | HIGH-THROUGHPUT | FUNCTIONAL IMPACT | AFFINITY | STABILITY | BIOCHEMICAL RESEARCH METHODS | RESISTANCE | COMPUTATIONAL METHODS | EPISTASIS | DIRECTED EVOLUTION | BINDING | Genetic Variation | Proteins - genetics | Mutation | Proteins - chemistry | Humans | Protein Engineering | Protein research | Gene mutations | Genetic variation | Identification and classification | Proteins | Science | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2017, Volume 114, Issue 9, pp. 2265 - 2270
.... To address the trade-off between enzyme solubility and activity, we performed deep mutational scanning using two different screens/selections that purport to gauge protein solubility for two full-length enzymes... 
Fitness landscapes | High-throughput screening | Deep mutational scanning | Protein solubility | Yeast surface display | DESIGN | ARGININE TRANSLOCATION PATHWAY | fitness landscapes | deep mutational scanning | high throughput screening | STABILITY | MULTIDISCIPLINARY SCIENCES | SEQUENCE | protein solubility | QUALITY-CONTROL | yeast surface display | DIRECTED EVOLUTION | Phosphotransferases - metabolism | Structure-Activity Relationship | Peptide Library | Gene Products, tat - metabolism | beta-Lactamases - genetics | HIV - chemistry | HIV - metabolism | Protein Interaction Domains and Motifs | Protein Stability | beta-Lactamases - metabolism | Binding Sites | Phosphotransferases - genetics | Protein Conformation, alpha-Helical | Gene Expression | Escherichia coli - enzymology | Solubility | Aspergillus niger - enzymology | Models, Molecular | Gene Products, tat - chemistry | Escherichia coli - chemistry | Aspergillus niger - chemistry | Protein Transport | Phosphotransferases - chemistry | Two-Hybrid System Techniques | beta-Lactamases - chemistry | High-Throughput Screening Assays | Protein Conformation, beta-Strand | Escherichia coli - genetics | Protein Binding | Mutation | Amino Acid Substitution | Gene mutations | Observations | Enzyme kinetics | Protein-protein interactions | Biological Sciences | high-throughput screening
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2015, Volume 112, Issue 23, pp. 7159 - 7164
Journal Article
Biochemical Society Transactions, ISSN 0300-5127, 2009, Volume 37, Issue 2, pp. 433 - 437
Journal Article