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OncoImmunology, ISSN 2162-4011, 01/2014, Volume 3, Issue 1, p. e27817
Anti-PD-1/PD-L1 antibodies are emerging as promising anticancer therapeutics. Interestingly, elevated response rates to these agents are mostly documented... 
PD-L1 | mutational heterogeneity | PD-1 | immunotherapy | immune checkpoints | Immune checkpoints | Immunotherapy | Mutational heterogeneity | SIGNATURES | SAFETY | CANCER GENOME | ANTIBODY | IMMUNOLOGY | LUNG-CANCER | T-CELL RESPONSES | ONCOLOGY | PARALLEL DETECTION | ANTI-PD-1
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2004, Volume 101, Issue 10, pp. 3632 - 3637
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2016, Volume 113, Issue 48, pp. E7769 - E7777
Programmed cell death protein-1 (PD-1)/programmed death ligand-1 (PD-L1) checkpoint blockade has led to remarkable and durable objective responses in a number... 
PD-L1 | PD-L2 | Mutational load | PD-1 | Melanoma | ANALYSIS REVEALS | CTLA-4 BLOCKADE | IMMUNE CELLS | PD-L1 EXPRESSION | MULTIDISCIPLINARY SCIENCES | melanoma | CANCER | RENAL-CELL CARCINOMA | CD8(+) T-CELLS | mutational load | POOR-PROGNOSIS | LIGAND 1 | CLINICAL-SIGNIFICANCE | Genetic aspects | Gene mutations | Gene expression | Health aspects | Biological Sciences | PNAS Plus
Journal Article
Journal Article
Journal Article
Journal Article
Annals of Neurology, ISSN 0364-5134, 03/2010, Volume 67, Issue 3, pp. 308 - 316
Journal Article
Oncotarget, ISSN 1949-2553, 2015, Volume 6, Issue 33, pp. 34221 - 34227
Cancer gene panels (CGPs) are already used in clinical practice to match tumor's genetic profile with available targeted therapies. We aimed to determine if... 
PD-1 blockade | Mutational load | Immunotherapy | Response prediction | Cancer-gene panels | mutational load | cancer-gene panels | response prediction | MICROSATELLITE INSTABILITY | immunotherapy | TUMOR | NIVOLUMAB | IPILIMUMAB | LYMPHOCYTES | ANTIGEN | CELL BIOLOGY
Journal Article
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, ISSN 1940-087X, 07/2019, Issue 149
Hematopoietic stem and progenitor cells (HSPCs) gradually accumulate DNA mutations during a lifespan, which can contribute to age-associated diseases such as... 
leukemia | development | SIGNATURES | MULTIDISCIPLINARY SCIENCES | lineage tracing | somatic mutations | hematopoiesis | Issue 149 | clonality | mutational signatures | ADULT STEM-CELLS | Genetics | ACCUMULATION
Journal Article
Oncotarget, ISSN 1949-2553, 2018, Volume 9, Issue 8, pp. 7949 - 7960
Mutations in DNA repair genes lead to increased genomic instability and mutation frequency. These mutations represent potential biomarkers for cancer... 
Tumor mutational burden | Tumor infiltrating lymphocytes | DNA repair | Lung cancer | Neo-antigens
Journal Article
Journal of Neuro-Oncology, ISSN 0167-594X, 4/2018, Volume 137, Issue 2, pp. 269 - 278
Journal Article
Journal Article