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Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 15797 - 11
Accumulating of evidence suggests that activation of nuclear factor-kappa B (NF-kappa B) and mitogenactivated protein kinases (MAPKs) exacerbates early brain... 
SIGNALING PATHWAYS | RAT | MULTIDISCIPLINARY SCIENCES | CEREBRAL VASOSPASM | MODEL | PHARMACOLOGICAL INHIBITION | CEREBROSPINAL-FLUID | MITOCHONDRIAL CALCIUM UNIPORTER | EXPRESSION | RECEPTOR ANTAGONIST | MYD88 | Inflammation - pathology | Neurons - pathology | Apoptosis - drug effects | Male | Protein Transport - drug effects | Brain Injuries - physiopathology | Neuroprotection - drug effects | Proteolysis - drug effects | Cell Nucleus - metabolism | Myeloid Differentiation Factor 88 - antagonists & inhibitors | Neurons - metabolism | Neurons - drug effects | Subarachnoid Hemorrhage - complications | Down-Regulation - drug effects | Subarachnoid Hemorrhage - pathology | Rats, Sprague-Dawley | Heterocyclic Compounds, 2-Ring - pharmacology | Subarachnoid Hemorrhage - physiopathology | Animals | MAP Kinase Signaling System - drug effects | Transcription Factor RelA - metabolism | NF-KappaB Inhibitor alpha - metabolism | Brain Injuries - etiology | Cell Nucleus - drug effects | Brain Injuries - pathology | Myeloid Differentiation Factor 88 - metabolism | Spiro Compounds - pharmacology | Neuroprotection | NF-κB protein | Phosphorylation | Traumatic brain injury | TAK1 protein | Subarachnoid hemorrhage | MAP kinase | JNK protein | Inflammation | IL-1β | Kinases | Hemorrhage | Nuclear transport | Neurological diseases | Proteins | Signal transduction | Toll-like receptors | MyD88 protein | Brain injury | Apoptosis
Journal Article
BMC Research Notes, ISSN 1756-0500, 01/2019, Volume 12, Issue 1, pp. 52 - 4
Macrophages and dendritic cells (DCs) play key role in the recognition of mycobacterial infection and mounting of antimycobacterial immunity. In case of... 
Cytokine secretion | Tuberculosis | Dendritic cells | Immunity | MyD88 | Mycobacteria | Medicine, Experimental | Medical research | Bacterial infections | Research | Macrophages | Antigens | Cell survival | Cytokines | Secretion | BCG | Interleukin 12 | Infections | Tumor necrosis factor-α | Immunology | Interleukin 10 | Bone marrow | MyD88 protein | Adapter proteins
Journal Article
International Immunopharmacology, ISSN 1567-5769, 11/2013, Volume 17, Issue 3, pp. 638 - 650
Neutrophils play a critical role in the host defense against bacterial and fungal infections, but their inappropriate activation also contributes to tissue... 
Signaling | Receptors | Inflammation | Kinases | Neutrophils | ACTIVATED PROTEIN-KINASE | COLONY-STIMULATING FACTOR | LEUKOCYTE ADHESION DEFICIENCY | IMMUNOLOGY | SRC-FAMILY KINASES | HUMAN POLYMORPHONUCLEAR LEUKOCYTES | HIGH-AFFINITY RECEPTOR | TUMOR-NECROSIS-FACTOR | TOLL-LIKE RECEPTORS | PHARMACOLOGY & PHARMACY | BETA-GAMMA-SUBUNITS | NF-KAPPA-B | Signal Transduction - immunology | Animals | Receptors, Cell Surface - immunology | Humans | Neutrophils - immunology | Selectins - immunology | Mycoses | Lectins | Fc receptors | Integrins | FcR, Fc-receptor | GPI, glycosylphosphatidylinositol anchor | CLEC, C-type lectin | OSCAR, osteoclast-associated receptor | PKB, protein kinase B | DAG, diacyl-glycerol | Tyk2, tyrosine protein kinase 2 | VCAM-1, vascular cell adhesion molecule 1 | ICAM-1, intercellular adhesion molecule 1 | FADD, Fas-associated protein with death domain | IκB, inhibitor of NF-κB | GM-CSF, granulocyte | MyD88, myeloid differentiation protein 88 | TNF, tumor necrosis factor | LTβ, lymphotoxin β | TRADD, TNFR1-associated death domain protein | Abl, Abelson leukemia proto-oncogene | SLP-76, SH2 domain-containing leukocyte protein of 76 kDa | CALDAG-GEFI, calcium and DAG-regulated guanine nucleotide exchange factor I | IL, interleukin | Src, Rous sarcoma virus proto-oncogene | IRF, IFN regulatory factor | RIG, retinoic acid-inducible gene | PLC, phospholipase C | TCR, T-cell receptor | IKK, IκB kinase | ITAM, immunoreceptor tyrosine-based activation motif | CARD, caspase activation and recruitment domain | IP3, inositol-tris-phosphate | CHO, Chinese hamster ovary cells | MKK, MAP kinase kinase | fMLP, formly-Met-Leu-Phe | TRAF, TNF receptor-associated factor | MIP, macrophage inflammatory protein | Rac, Ras-related C3 botulinum toxin substrate | monocyte colony-stimulating factor | PIP3, phosphatidylinositol-3-phosphate | VLA-4, very late antigen 4 (α4β1 integrin) | PAF, platelet activating factor | STAT, signal transducer and activator of transcription | TAK, TGFβ-activated kinase 1 | Mac-1, macrophage antigen 1 (αMβ2 integrin) | FcRγ, Fc-receptor γ-chain | Asc, apoptosis-associated speck-like protein containing a CARD | cIAP, cellular inhibitor of apoptosis | BCR, B-cell receptor | Fgr, Gardner–Rasheed feline sarcoma proto-oncogene | VASP, vasodilator-stimulated phosphoprotein | Hck, hematopoietic cell kinase | TGFβ, transforming growth factor β | Rap, Ras-related protein | SHP-1, SH2 domain-containing protein tyrosine phosphatase 1 | Syk, spleen tyrosine kinase | GPCR, G protein-coupled receptor | G-CSF, granulocyte colony-stimulating factor | TREM, triggering receptor expressed on myeloid cells | DISC, death-inducing signaling complex | MDL-1, myeloid DAP12-associating lectin 1 | C3G, Crk SH3 domain-binding guanine nucleotide exchange factor (RapGEF1) | NF-κB, nuclear factor κB | ERM, ezrin-radixin-moesin | Epac1, exchange protein activated by cyclic AMP 1 | LTB4, leukotriene B4 | Mcl, macrophage C-type lectin | SAP130, Sin3A-associated protein of 130 kDa | SH2, Src-homology 2 domain | MAP kinase, mitogen-activated protein kinase | PSGL-1, P-selectin glycoprotein ligand | PI3K, phoshoinositide-3-kinase | ADAP, adhesion and degranulation promoting adapter protein (Fyb, SLAP-130) | NLRP3, NOD-like receptor family, pyrin domain containing 3 | MDA5, melanoma differentiation-associated protein 5 | TLR, Toll-like receptor | GRK, GPCR kinase | LAD, leukocyte adhesion deficiency | MAPKAP-kinase, MAP kinase-associated protein kinase | ZAP-70, ζ-chain-associated protein of 70 kDa | TRAIL, TNF-related apoptosis-inducing ligand | JNK, c-Jun N-terminal kinase | LFA-1, lymphocyte function-associated receptor 1 (αLβ2 integrin) | ROS, reactive oxygen species | RIP3, receptor-interacting serine-threonine protein kinase 3 | DAP12, DNAX activating protein 12 | IFN, interferon | PIR, paired immunoglobulin-like receptor | PKC, protein kinase C | PAK, p21-activated kinase | ESL-1, E-selectin ligand 1 | GAP, GTPase activating protein | ERK, extracellular signal-regulated kinase | SOCS, suppressor of cytokine signaling | JAK, Janus kinase | RANK, receptor activator of NF-κB | IRAK, IL-1 receptor-associated kinase | NOD, nucleotide-binding oligomerization domain containing protein | CEACAM3, carcinoembryonic antigen-related cell adhesion molecule 3 (CD66b)
Journal Article
Molecular Biotechnology, ISSN 1073-6085, 03/2007, Volume 35, Issue 3, pp. 253 - 261
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2013, Volume 288, Issue 42, pp. 30210 - 30222
Background: MyD88 is an adaptor protein that plays a crucial role in the immune response. Results: We identified residues within the TIR domain of MyD88... 
Signal Transduction | Toll IL-1 Receptor (TIR) Domain | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | Cellular Immune Response | Toll-like Receptor (TLR) | MyD88 | SIGNAL-TRANSDUCTION | RECEPTOR TIR DOMAIN | Mutagenesis | STRUCTURAL BASIS | TOLL-LIKE RECEPTORS | INTERACTION SITES | NF-KAPPA-B | ADAPTER PROTEIN | MOLECULAR-BASIS | FAST INTERACTION REFINEMENT | Interleukin-1 Receptor-Associated Kinases - metabolism | Interleukin-1 Receptor-Associated Kinases - genetics | Toll-Like Receptor 2 - genetics | Monocytes - cytology | Dendritic Cells - immunology | Humans | NF-kappa B - immunology | Monocytes - metabolism | NF-kappa B - metabolism | Monocytes - immunology | Mutation, Missense | Interleukin-1 Receptor-Associated Kinases - immunology | Protein Multimerization - physiology | HEK293 Cells | Myeloid Differentiation Factor 88 - immunology | Dendritic Cells - metabolism | Protein Structure, Tertiary | Mutagenesis, Site-Directed | Myeloid Differentiation Factor 88 - genetics | Toll-Like Receptor 4 - genetics | Toll-Like Receptor 4 - immunology | Toll-Like Receptor 2 - metabolism | Toll-Like Receptor 4 - metabolism | NF-kappa B - genetics | Cell Line, Tumor | Toll-Like Receptor 2 - immunology | Signal Transduction - physiology | Dendritic Cells - cytology | Myeloid Differentiation Factor 88 - metabolism | Amino Acid Substitution | Index Medicus
Journal Article