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Biochemical journal, ISSN 1470-8728, 2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Molecular cell, ISSN 1097-2765, 2016, Volume 64, Issue 3, pp. 493 - 506
.... However, pharmacological strategies that directly target N-Myc, the protein encoded by MYCN, remain elusive... 
BI6727 | targeted therapy | ubiquitination | Myc | PLK1 | neuroblastoma | Fbw7 | small cell lung carcinoma | ABT199 | TARGETED THERAPY | INHIBITOR VOLASERTIB | BIOCHEMISTRY & MOLECULAR BIOLOGY | N-MYC | C-MYC | F-BOX PROTEINS | AMPLIFIED NEUROBLASTOMA | AURORA KINASE | FBW7 UBIQUITIN LIGASE | CANCER-THERAPY | HUMAN NEUROBLASTOMA | CELL BIOLOGY | RNA, Small Interfering - genetics | Humans | Neuroblastoma - mortality | N-Myc Proto-Oncogene Protein - antagonists & inhibitors | Transcription, Genetic | Neurons - metabolism | Brain Neoplasms - mortality | Protein-Serine-Threonine Kinases - metabolism | Signal Transduction | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Brain Neoplasms - genetics | Brain Neoplasms - drug therapy | Sulfonamides - pharmacology | Drug Synergism | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Feedback, Physiological | Mice, Nude | Survival Analysis | Cell Line, Tumor | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | RNA, Small Interfering - metabolism | F-Box-WD Repeat-Containing Protein 7 | Neurons - pathology | Brain Neoplasms - pathology | Gene Expression Regulation, Neoplastic | N-Myc Proto-Oncogene Protein - genetics | Cell Cycle Proteins - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-2 - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Antineoplastic Agents - pharmacology | Neurons - drug effects | Neuroblastoma - pathology | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Pteridines - pharmacology | F-Box Proteins - metabolism | Neuroblastoma - genetics | Protein-Serine-Threonine Kinases - genetics | Proto-Oncogene Proteins - genetics | Xenograft Model Antitumor Assays | Animals | Tumor Burden - drug effects | N-Myc Proto-Oncogene Protein - metabolism | Neuroblastoma - drug therapy | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-2 - genetics | Ubiquitin | Polo | Ligases | Lung cancer | Therapeutics | Homeopathy | Materia medica and therapeutics | Cancer
Journal Article
PloS one, ISSN 1932-6203, 05/2016, Volume 11, Issue 5, p. e0155911
A considerable proportion of protein-protein interactions (PPIs) in the cell are estimated to be mediated by very short peptide segments that approximately conform to specific sequence patterns known as linear motifs (LMs... 
RECOGNITION | ROLES | MYC | MULTIDISCIPLINARY SCIENCES | BINDING SITES | INTERFACES | INTERACTION NETWORKS | LINEAR MOTIFS | IDENTIFICATION | WEB SERVER | DISCOVERY | Adenomatous Polyposis Coli Protein - genetics | Neoplasms - metabolism | Amino Acid Sequence | Computational Biology - methods | Proto-Oncogene Proteins c-mdm2 - genetics | Humans | Peptides - genetics | Neoplasm Proteins - chemistry | Neoplasm Proteins - metabolism | Proto-Oncogene Proteins c-mdm2 - chemistry | Proto-Oncogene Proteins c-myc - metabolism | Adenomatous Polyposis Coli Protein - chemistry | Protein Interaction Mapping | Neoplasms - chemistry | Peptides - metabolism | Neoplasms - genetics | Adenomatous Polyposis Coli Protein - metabolism | Protein Binding | Proto-Oncogene Proteins c-myc - genetics | Neoplasm Proteins - genetics | Proto-Oncogene Proteins c-myc - chemistry | Binding Sites | Proto-Oncogene Proteins c-mdm2 - metabolism | Physiological aspects | Genetic aspects | Research | Tumor proteins | Protein-protein interactions | Ubiquitin | Peptides | Identification | Myc protein | Modulators | Cdc4 protein | Proteins | Databases | Cell cycle | Bioinformatics | Ubiquitin-protein ligase | MDM2 protein | Therapeutic applications | Kalam, Abdul | Adenomatous polyposis coli | Inhibitors | Acids | Computation | Computer applications | Predictions | Proteasomes | Mutation | Protein interaction | Binding sites | Cancer
Journal Article
Journal of medicinal chemistry, ISSN 0022-2623, 04/2015, Volume 58, Issue 7, pp. 3002 - 3024
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2019, Volume 116, Issue 3, pp. 1027 - 1032
Merkel cell polyomavirus (MCV) contributes to approximately 80% of all Merkel cell carcinomas (MCCs), a highly aggressive neuroendocrine carcinoma of the skin.... 
MDM2–MDM4 | Lenalidomide | Merkel cell carcinoma | Casein kinase 1 alpha | P53 | UBIQUITINATION | casein kinase 1 alpha | POLYOMAVIRUS | MULTIDISCIPLINARY SCIENCES | GROWTH | DEGRADATION | MDM2-MDM4 | lenalidomide | p53 | T-ANTIGEN | Tumor Virus Infections - genetics | Proto-Oncogene Proteins c-mdm2 - genetics | Humans | Polyomavirus Infections - metabolism | Tumor Suppressor Protein p53 - genetics | DNA-Binding Proteins - metabolism | Retinoblastoma Binding Proteins - genetics | Nuclear Proteins - genetics | Retinoblastoma Binding Proteins - metabolism | DNA Helicases - genetics | Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors | Proto-Oncogene Proteins c-mdm2 - metabolism | Tumor Virus Infections - pathology | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Tumor Virus Infections - metabolism | Carcinoma, Merkel Cell - genetics | Tumor Suppressor Protein p53 - metabolism | Ubiquitin-Protein Ligases - metabolism | Merkel cell polyomavirus - metabolism | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | DNA-Binding Proteins - genetics | Polyomavirus Infections - pathology | DNA Helicases - metabolism | Nuclear Proteins - antagonists & inhibitors | Polyomavirus Infections - genetics | Carcinoma, Merkel Cell - metabolism | Merkel cell polyomavirus - genetics | Carcinoma, Merkel Cell - virology | Ubiquitin-Protein Ligases - genetics | Cell Cycle Proteins | Carcinoma, Merkel Cell - pathology | Physiological aspects | Care and treatment | Tumor proteins | Oncogenes | Chromatin | MDM2 protein | Carcinoma | p53 Protein | Antigen T (large) | Genes | Xenotransplantation | Viruses | Homology | Activation | Myc protein | Ribonucleic acid--RNA | Gene expression | Gene sequencing | Proteins | Depletion | Inhibitors | Rodents | Xenografts | Skin | Mutation | Cancer | Tumors | Apoptosis | Biological Sciences
Journal Article
Biochemical journal, ISSN 0264-6021, 12/2004, Volume 384, Issue 3, pp. 477 - 488
We detected a protein in rabbit skeletal muscle extracts that was phosphorylated rapidly by SGK1... 
Phosphorylation | Glycogen synthase kinase 3 (GSK3) | N-myc down-stream-regulated gene (NDRG) | p53 | Serum- and glucocorticoid-induced kinase 1 (SGK1) | glycogen synthase kinase 3 (GSK3) | SPECIFICITY | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | GLYCOGEN-SYNTHASE KINASE-3 | TRANSCRIPTION | SERUM | n-myc downstream-regulated gene (NDRG) | GENE | serum- and glucocorticoid-induced kinase 1 (SGK1) | MAPKAP KINASE-1 | DIFFERENTIATION | INHIBITORS | phosphorylation | Antibody Specificity | Multigene Family | Molecular Weight | Humans | Molecular Sequence Data | Substrate Specificity | Cell Cycle Proteins - classification | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Immediate-Early Proteins | Cell Cycle Proteins - immunology | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Antibodies - immunology | Cell Cycle Proteins - genetics | Proteins - classification | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | Cell Line | Rabbits | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Cell Cycle Proteins - metabolism | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Intracellular Signaling Peptides and Proteins | Nuclear Proteins - metabolism | Glycogen Synthase Kinase 3 - metabolism | Phosphoserine - metabolism | Proteins - immunology | Proteins - genetics | Proto-Oncogene Proteins c-akt | Animals | Proteins - metabolism | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Mice | HeLa Cells | Tumor Suppressor Proteins | SGK1, serum- and glucocorticoid-induced kinase 1 | PDK1, 3-phosphoinositide-dependent kinase 1 | LDS, lithium dodecyl sulphate | RSK, p90 ribosomal S6 kinase | ENaC, epithelial sodium channel | FOXO3a, forkhead box O3a | ERK, extracellular-signal-regulated kinase | MALDI-TOF, matrix-assisted laser-desorption ionization–time-of-flight | PKB, protein kinase B | SAPK, stress-activated protein kinase | CDK, cyclin-dependent kinase | IGF-1, insulin-like growth factor-1 | DYRK1A, dual-specificity tyrosine phosphorylated and regulated kinase 1A | GST, glutathione S-transferase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | GSK3, glycogen synthase kinase 3 | siRNA, small interfering RNA | KESTREL, kinase substrate tracking and elucidation | MAPK, mitogen-activated protein kinase | NDRG, n-myc downstream-regulated gene
Journal Article
Biochemical journal, ISSN 0264-6021, 07/2009, Volume 421, Issue 1, pp. 29 - 42
... (protein kinase A/protein kinase G/protein kinase Q family kinases such as Akt (protein kinase 13), S6K (p70 ribosomal S6 kinase... 
Phosphoinositide 3-kinase (PI3K) | Akt/protein kinase B (PKB) | Serum and glucocorticoid protein kinase (SGK) | P70 ribosomal S6 kinase (S6K) | Kinase inhibitor | Cancer | IN-VIVO ROLE | PROTEIN-KINASE B/AKT | BINDING PARTNER | RAG GTPASES | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | AKT | IDENTIFICATION | P70 S6 KINASE | kinase inhibitor | phosphoinositide 3-kinase (PI3K) | p70 ribosomal S6 kinase (S6K) | HYDROPHOBIC MOTIF | cancer | serum and glucocorticoid protein kinase (SGK) | PDK1 | Cell Line | Humans | Multiprotein Complexes | Morpholines - pharmacology | Transcription Factors - antagonists & inhibitors | Gene Expression Profiling | G1 Phase - drug effects | Pyrimidines - pharmacology | Morpholines - chemistry | Pyrimidines - chemistry | Mechanistic Target of Rapamycin Complex 1 | Gene Expression Regulation - drug effects | Proteins | Transcription Factors - metabolism | Animals | Fibroblasts - drug effects | Cell Proliferation - drug effects | Mice | TOR Serine-Threonine Kinases | Fibroblasts - metabolism | PI3K, phosphoinositide 3-kinase | PDK, 3-phosphoinositide-dependent protein kinase | AMPK, AMP-activated protein kinase | mTORC, mTOR complex | DTT, dithiothreitol | SPHK, sphingosine kinase | ERK, extracellular-signal-regulated kinase | RSK, ribosomal S6 kinase | PH domain, pleckstrin homology domain | protein kinase B (PKB) | protein kinase G | NDRG1, N-Myc downstream-regulated gene-1 | IGF, insulin-like growth factor | mTOR, mammalian target of rapamycin | GST, glutathione transferase | SGK, serum and glucocorticoid protein kinase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | eIF4E, eukaryotic initiation factor 4E | 4E-BP1, eIF4E-binding protein 1 | protein kinase C family | Akt | PRAS40, proline-rich Akt substrate of 40 kDa | HEK-293 cell, human embryonic kidney 293 cell | MEF, mouse embryonic fibroblast | AGC family, protein kinase A | MAPK, mitogen-activated protein kinase
Journal Article
Genes & development, ISSN 0890-9369, 2013, Volume 27, Issue 10, pp. 1101 - 1114
Tumorigenesis results from dysregulation of oncogenes and tumor suppressors that influence cellular proliferation, differentiation, apoptosis, and/or... 
Huwe1 | c-Myc | Mule | Ras | p21 | Miz1 | DNA-DAMAGE | KERATINOCYTE GROWTH | DEVELOPMENTAL BIOLOGY | CELL BIOLOGY | BASE EXCISION-REPAIR | HUWE1 UBIQUITIN LIGASE | NEGATIVE REGULATION | GENETICS & HEREDITY | ARF TUMOR-SUPPRESSOR | DIFFERENTIATION | MIZ-1 | HUMAN CANCER | Protein Inhibitors of Activated STAT - deficiency | Tetradecanoylphorbol Acetate - pharmacology | 9,10-Dimethyl-1,2-benzanthracene - pharmacology | Male | Protein Inhibitors of Activated STAT - metabolism | Cyclin-Dependent Kinase Inhibitor p15 - biosynthesis | Oncogene Protein p21(ras) - metabolism | Cyclin-Dependent Kinase Inhibitor p16 | Oncogene Protein p21(ras) - antagonists & inhibitors | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Cell Transformation, Neoplastic - genetics | Cyclin-Dependent Kinase Inhibitor p15 - genetics | Nuclear Proteins - deficiency | Protein Inhibitors of Activated STAT - genetics | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Female | Nuclear Proteins - genetics | Protein Inhibitors of Activated STAT - antagonists & inhibitors | Skin Neoplasms - pathology | Cyclin-Dependent Kinase Inhibitor p21 - biosynthesis | Signal Transduction | Down-Regulation | Cells, Cultured | Ubiquitin-Protein Ligases - metabolism | Nuclear Proteins - metabolism | Skin Neoplasms - chemically induced | Proto-Oncogene Proteins c-myc - metabolism | Mice, Knockout | Skin Neoplasms - metabolism | Keratinocytes - pathology | Animals | Tumor Suppressor Protein p53 | Keratinocytes - drug effects | Keratinocytes - metabolism | Nuclear Proteins - antagonists & inhibitors | Proto-Oncogene Proteins c-myc - deficiency | Skin Neoplasms - genetics | Proto-Oncogene Proteins c-myc - antagonists & inhibitors | Ubiquitin-Protein Ligases - deficiency | Mice | Proto-Oncogene Proteins c-myc - genetics | Cyclin-Dependent Kinase Inhibitor p15 - metabolism | Genes, ras | Ubiquitin-Protein Ligases - genetics | Oncogene Protein p21(ras) - genetics | Carcinogenesis | Ras genes | Analysis | Research Paper
Journal Article
PloS one, ISSN 1932-6203, 09/2015, Volume 10, Issue 9, p. e0137210
Mantle cell lymphoma (MCL) is an aggressive B-cell lymphoma characterized by the aberrant expression of several growth-regulating, oncogenic effectors.... 
SIGNAL | PROTEIN | CANCER CELLS | MANTLE CELL LYMPHOMA | CYCLIN D1 | MULTIDISCIPLINARY SCIENCES | RESPONSIVE TRANSCRIPTION FACTOR | KINASE | GENE-EXPRESSION | PROLIFERATION | CRM1 | Cyclin D1 - metabolism | Transcription, Genetic - drug effects | Humans | Gene Expression Regulation, Neoplastic | Proto-Oncogene Proteins c-pim-1 - metabolism | Elongation Factor 2 Kinase - metabolism | Ribosomes - metabolism | Tumor Suppressor Protein p53 - genetics | Elongation Factor 2 Kinase - genetics | Heat Shock Transcription Factors | DNA-Binding Proteins - metabolism | Organelle Biogenesis | Proto-Oncogene Proteins c-bcl-2 - metabolism | Acrylates - pharmacology | Antineoplastic Agents - pharmacology | B-Lymphocytes - pathology | Peptide Elongation Factor 1 - genetics | B-Lymphocytes - metabolism | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins - metabolism | Signal Transduction | Protein-Serine-Threonine Kinases - genetics | Tumor Suppressor Protein p53 - metabolism | HSP70 Heat-Shock Proteins - genetics | Proto-Oncogene Proteins - genetics | Receptors, Cytoplasmic and Nuclear - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Proto-Oncogene Proteins c-myc - metabolism | HSP70 Heat-Shock Proteins - metabolism | Transcription Factors - metabolism | Triazoles - pharmacology | B-Lymphocytes - drug effects | Karyopherins - metabolism | Cyclin D1 - genetics | Active Transport, Cell Nucleus - drug effects | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Ribosomes - drug effects | Cell Line, Tumor | Karyopherins - genetics | Proto-Oncogene Proteins c-pim-1 - genetics | Protein Biosynthesis - drug effects | Proto-Oncogene Proteins c-myc - genetics | Karyopherins - antagonists & inhibitors | Peptide Elongation Factor 1 - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Receptors, Cytoplasmic and Nuclear - metabolism | Physiological aspects | Genetic aspects | Research | Biological transport | Cell cycle | Ribosomes | Transcription factors | Biomedical research | Transcription | Bcl-2 protein | Laboratories | p53 Protein | Leukemia | c-Myc protein | Multiple myeloma | Immunoblotting | Biosynthesis | Myc protein | Glucose | Cyclin D1 | Cancer therapies | Anticancer properties | Heat shock factors | Proteins | Ribosomal subunits | Cell growth | Translation | Cell survival | Hematology | Hsp70 protein | Gene expression | Lymphoma | Nuclear transport | Molecular chains | Medicine | Molecular modelling | Lymphocytes B | Medical prognosis | Proteomics | Mantle cell lymphoma | Lymphomas | Viability | Heat shock | Apoptosis | Tumors | B-cell lymphoma
Journal Article
Scientific reports, ISSN 2045-2322, 2018, Volume 8, Issue 1, pp. 998 - 10
.... And histological evaluation and protein expressions of irradiated tissue were analyzed to confirm the potential anti-fibrosis effect of JQ1 and its underlying mechanisms... 
CANCER PATIENTS | BROMODOMAINS | TGF-BETA | THERAPY | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | BRD4 INHIBITION | PNEUMONITIS | MECHANISMS | PULMONARY-FIBROSIS | NORMAL TISSUE-INJURY | Humans | NF-kappa B - metabolism | Smad2 Protein - antagonists & inhibitors | Collagen Type I - genetics | MCF-7 Cells | Smad2 Protein - genetics | Lung - radiation effects | Pulmonary Fibrosis - etiology | Fibroblasts - metabolism | NF-kappa B - antagonists & inhibitors | Smad2 Protein - metabolism | Rats | Pulmonary Fibrosis - pathology | Rats, Sprague-Dawley | Smad3 Protein - antagonists & inhibitors | Fibroblasts - drug effects | Proto-Oncogene Proteins c-myc - antagonists & inhibitors | Pulmonary Fibrosis - prevention & control | Cell Line, Tumor | Gene Expression Regulation - radiation effects | Fibroblasts - cytology | Proto-Oncogene Proteins c-myc - genetics | Hydroxyproline - antagonists & inhibitors | Proteins - antagonists & inhibitors | Gamma Rays - adverse effects | Hydroxyproline - biosynthesis | Pulmonary Fibrosis - genetics | Smad3 Protein - metabolism | Molecular Targeted Therapy | Smad3 Protein - genetics | Transforming Growth Factor beta - antagonists & inhibitors | Female | Lung - metabolism | Nuclear Proteins - genetics | Lung - pathology | Collagen Type I - metabolism | Collagen Type I - antagonists & inhibitors | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Transcription Factors - genetics | Proto-Oncogene Proteins c-myc - metabolism | Azepines - pharmacology | Gene Expression Regulation - drug effects | Proteins - genetics | Transcription Factors - metabolism | Triazoles - pharmacology | Animals | Proteins - metabolism | Transforming Growth Factor beta - genetics | Fibroblasts - radiation effects | NF-kappa B - genetics | Nuclear Proteins - antagonists & inhibitors | Cell Proliferation - drug effects | Transforming Growth Factor beta - metabolism | NF-κB protein | Collagen (type I) | Animal models | Cell survival | Lung diseases | Hydroxyproline | Radiation | c-Myc protein | Smad3 protein | Thorax | Breast cancer | Inflammation | Radiation therapy | Myc protein | Esophagus | Computed tomography | Smad2 protein | Rodents | Fibrosis | Fibroblasts | Cancer
Journal Article