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Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Index Medicus | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Journal Article
Molecular Cell, ISSN 1097-2765, 11/2016, Volume 64, Issue 3, pp. 493 - 506
amplification in human cancers predicts poor prognosis and resistance to therapy. However, pharmacological strategies that directly target N-Myc, the protein... 
BI6727 | targeted therapy | ubiquitination | Myc | PLK1 | neuroblastoma | Fbw7 | small cell lung carcinoma | ABT199 | TARGETED THERAPY | INHIBITOR VOLASERTIB | BIOCHEMISTRY & MOLECULAR BIOLOGY | N-MYC | C-MYC | F-BOX PROTEINS | AMPLIFIED NEUROBLASTOMA | AURORA KINASE | FBW7 UBIQUITIN LIGASE | CANCER-THERAPY | HUMAN NEUROBLASTOMA | CELL BIOLOGY | RNA, Small Interfering - genetics | Humans | Neuroblastoma - mortality | N-Myc Proto-Oncogene Protein - antagonists & inhibitors | Transcription, Genetic | Neurons - metabolism | Brain Neoplasms - mortality | Protein-Serine-Threonine Kinases - metabolism | Signal Transduction | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Brain Neoplasms - genetics | Brain Neoplasms - drug therapy | Sulfonamides - pharmacology | Drug Synergism | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Feedback, Physiological | Mice, Nude | Survival Analysis | Cell Line, Tumor | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | RNA, Small Interfering - metabolism | F-Box-WD Repeat-Containing Protein 7 | Neurons - pathology | Brain Neoplasms - pathology | Gene Expression Regulation, Neoplastic | N-Myc Proto-Oncogene Protein - genetics | Cell Cycle Proteins - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-2 - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Antineoplastic Agents - pharmacology | Neurons - drug effects | Neuroblastoma - pathology | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Pteridines - pharmacology | F-Box Proteins - metabolism | Neuroblastoma - genetics | Protein-Serine-Threonine Kinases - genetics | Proto-Oncogene Proteins - genetics | Xenograft Model Antitumor Assays | Animals | Tumor Burden - drug effects | N-Myc Proto-Oncogene Protein - metabolism | Neuroblastoma - drug therapy | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-2 - genetics | Ubiquitin | Polo | Ligases | Lung cancer | Therapeutics | Homeopathy | Materia medica and therapeutics | Cancer | Index Medicus
Journal Article
Biochemical Journal, ISSN 0264-6021, 07/2009, Volume 421, Issue 1, pp. 29 - 42
mTOR (mammalian target of rapamycin) stimulates cell growth by phosphorylating and promoting activation of AGC (protein kinase A/protein kinase G/protein... 
Phosphoinositide 3-kinase (PI3K) | Akt/protein kinase B (PKB) | Serum and glucocorticoid protein kinase (SGK) | P70 ribosomal S6 kinase (S6K) | Kinase inhibitor | Cancer | IN-VIVO ROLE | PROTEIN-KINASE B/AKT | BINDING PARTNER | RAG GTPASES | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | P70 S6 KINASE | kinase inhibitor | phosphoinositide 3-kinase (PI3K) | p70 ribosomal S6 kinase (S6K) | SUBSTRATE-SPECIFICITY | HYDROPHOBIC MOTIF PHOSPHORYLATION | cancer | serum and glucocorticoid protein kinase (SGK) | COMPLEX 2 | PDK1 | Cell Line | Humans | Multiprotein Complexes | Morpholines - pharmacology | Transcription Factors - antagonists & inhibitors | Gene Expression Profiling | G1 Phase - drug effects | Pyrimidines - pharmacology | Morpholines - chemistry | Pyrimidines - chemistry | Mechanistic Target of Rapamycin Complex 1 | Gene Expression Regulation - drug effects | Proteins | Transcription Factors - metabolism | Animals | Fibroblasts - drug effects | Cell Proliferation - drug effects | Mice | TOR Serine-Threonine Kinases | Fibroblasts - metabolism | Index Medicus | PI3K, phosphoinositide 3-kinase | PDK, 3-phosphoinositide-dependent protein kinase | AMPK, AMP-activated protein kinase | mTORC, mTOR complex | DTT, dithiothreitol | SPHK, sphingosine kinase | ERK, extracellular-signal-regulated kinase | RSK, ribosomal S6 kinase | PH domain, pleckstrin homology domain | protein kinase B (PKB) | protein kinase G | NDRG1, N-Myc downstream-regulated gene-1 | IGF, insulin-like growth factor | mTOR, mammalian target of rapamycin | GST, glutathione transferase | SGK, serum and glucocorticoid protein kinase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | eIF4E, eukaryotic initiation factor 4E | 4E-BP1, eIF4E-binding protein 1 | protein kinase C family | Akt | PRAS40, proline-rich Akt substrate of 40 kDa | HEK-293 cell, human embryonic kidney 293 cell | MEF, mouse embryonic fibroblast | AGC family, protein kinase A | MAPK, mitogen-activated protein kinase
Journal Article
Genes and Development, ISSN 0890-9369, 05/2013, Volume 27, Issue 10, pp. 1101 - 1114
Tumorigenesis results from dysregulation of oncogenes and tumor suppressors that influence cellular proliferation, differentiation, apoptosis, and/or... 
Huwe1 | c-Myc | Mule | Ras | p21 | Miz1 | DNA-DAMAGE | KERATINOCYTE GROWTH | DEVELOPMENTAL BIOLOGY | CELL BIOLOGY | BASE EXCISION-REPAIR | HUWE1 UBIQUITIN LIGASE | NEGATIVE REGULATION | GENETICS & HEREDITY | ARF TUMOR-SUPPRESSOR | DIFFERENTIATION | MIZ-1 | HUMAN CANCER | Protein Inhibitors of Activated STAT - deficiency | Tetradecanoylphorbol Acetate - pharmacology | 9,10-Dimethyl-1,2-benzanthracene - pharmacology | Male | Protein Inhibitors of Activated STAT - metabolism | Cyclin-Dependent Kinase Inhibitor p15 - biosynthesis | Oncogene Protein p21(ras) - metabolism | Cyclin-Dependent Kinase Inhibitor p16 | Oncogene Protein p21(ras) - antagonists & inhibitors | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Cell Transformation, Neoplastic - genetics | Cyclin-Dependent Kinase Inhibitor p15 - genetics | Nuclear Proteins - deficiency | Protein Inhibitors of Activated STAT - genetics | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Female | Nuclear Proteins - genetics | Protein Inhibitors of Activated STAT - antagonists & inhibitors | Skin Neoplasms - pathology | Cyclin-Dependent Kinase Inhibitor p21 - biosynthesis | Signal Transduction | Down-Regulation | Cells, Cultured | Ubiquitin-Protein Ligases - metabolism | Nuclear Proteins - metabolism | Skin Neoplasms - chemically induced | Proto-Oncogene Proteins c-myc - metabolism | Mice, Knockout | Skin Neoplasms - metabolism | Keratinocytes - pathology | Animals | Tumor Suppressor Protein p53 | Keratinocytes - drug effects | Keratinocytes - metabolism | Nuclear Proteins - antagonists & inhibitors | Proto-Oncogene Proteins c-myc - deficiency | Skin Neoplasms - genetics | Proto-Oncogene Proteins c-myc - antagonists & inhibitors | Ubiquitin-Protein Ligases - deficiency | Mice | Proto-Oncogene Proteins c-myc - genetics | Cyclin-Dependent Kinase Inhibitor p15 - metabolism | Genes, ras | Ubiquitin-Protein Ligases - genetics | Oncogene Protein p21(ras) - genetics | Carcinogenesis | Ras genes | Analysis | Index Medicus | Research Paper
Journal Article
Nature, ISSN 0028-0836, 08/2005, Volume 436, Issue 7052, pp. 807 - 811
The c-Myc oncoprotein promotes proliferation and apoptosis, such that mutations that disable apoptotic programmes often cooperate with MYC during... 
APOPTOSIS | ONCOGENE | GENE | MULTIDISCIPLINARY SCIENCES | IN-VIVO | N-TERMINAL DOMAIN | C-MYC | TRANSFORMING ACTIVITY | BURKITT-LYMPHOMA CELLS | TRANSACTIVATION DOMAIN | MUTATIONS | Cell Proliferation | Humans | Adoptive Transfer | Cyclin-Dependent Kinase Inhibitor p16 | Burkitt Lymphoma - pathology | Stem Cell Transplantation | Proto-Oncogene Proteins c-bcl-2 - metabolism | Bcl-2-Like Protein 11 | Burkitt Lymphoma - genetics | Membrane Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Cyclin-Dependent Kinase Inhibitor p21 | Mice, Inbred C57BL | Cell Cycle Proteins - metabolism | Tumor Suppressor Protein p53 - metabolism | Burkitt Lymphoma - metabolism | Mutation - genetics | Proto-Oncogene Proteins c-myc - metabolism | Animals | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | Genes, myc - genetics | Alleles | Mice | Proto-Oncogene Proteins c-myc - genetics | Tumor Suppressor Protein p14ARF - metabolism | Apoptosis | Proteins | Oncology | Mutation | Cellular biology | Tumors | Index Medicus | Proto-Oncogene Proteins c-myc/genetics/metabolism | Mutation/genetics | Tumor Suppressor Protein p14ARF/metabolism | Cell Cycle Proteins/metabolism | Proto-Oncogene Proteins/metabolism | Tumor Suppressor Protein p53/metabolism | Burkitt Lymphoma/genetics/metabolism/pathology | Genes; myc/genetics | Membrane Proteins/metabolism | Mice; Inbred C57BL | Proto-Oncogene Proteins c-bcl-2/metabolism | Carrier Proteins/metabolism
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 998 - 10
Radiation-induced lung injury has restricted radiotherapy for thoracic cancer. The purpose of this study was to investigate the radioprotective effects of... 
CANCER PATIENTS | BROMODOMAINS | TGF-BETA | THERAPY | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | BRD4 INHIBITION | PNEUMONITIS | MECHANISMS | PULMONARY-FIBROSIS | NORMAL TISSUE-INJURY | Humans | NF-kappa B - metabolism | Smad2 Protein - antagonists & inhibitors | Collagen Type I - genetics | MCF-7 Cells | Smad2 Protein - genetics | Lung - radiation effects | Pulmonary Fibrosis - etiology | Fibroblasts - metabolism | NF-kappa B - antagonists & inhibitors | Smad2 Protein - metabolism | Rats | Pulmonary Fibrosis - pathology | Rats, Sprague-Dawley | Smad3 Protein - antagonists & inhibitors | Fibroblasts - drug effects | Proto-Oncogene Proteins c-myc - antagonists & inhibitors | Pulmonary Fibrosis - prevention & control | Cell Line, Tumor | Gene Expression Regulation - radiation effects | Fibroblasts - cytology | Proto-Oncogene Proteins c-myc - genetics | Hydroxyproline - antagonists & inhibitors | Proteins - antagonists & inhibitors | Gamma Rays - adverse effects | Hydroxyproline - biosynthesis | Pulmonary Fibrosis - genetics | Smad3 Protein - metabolism | Molecular Targeted Therapy | Smad3 Protein - genetics | Transforming Growth Factor beta - antagonists & inhibitors | Female | Lung - metabolism | Nuclear Proteins - genetics | Lung - pathology | Collagen Type I - metabolism | Collagen Type I - antagonists & inhibitors | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Transcription Factors - genetics | Proto-Oncogene Proteins c-myc - metabolism | Azepines - pharmacology | Gene Expression Regulation - drug effects | Proteins - genetics | Transcription Factors - metabolism | Triazoles - pharmacology | Animals | Proteins - metabolism | Transforming Growth Factor beta - genetics | Fibroblasts - radiation effects | NF-kappa B - genetics | Nuclear Proteins - antagonists & inhibitors | Cell Proliferation - drug effects | Transforming Growth Factor beta - metabolism | NF-κB protein | Collagen (type I) | Animal models | Cell survival | Lung | Lung diseases | Hydroxyproline | Radiation | c-Myc protein | Smad3 protein | Thorax | Breast cancer | Inflammation | Radiation therapy | Myc protein | Esophagus | Computed tomography | Smad2 protein | Rodents | Fibrosis | Fibroblasts | Cancer | Index Medicus
Journal Article
Oncogene, ISSN 0950-9232, 10/2017, Volume 36, Issue 42, pp. 5852 - 5860
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2013, Volume 8, Issue 7, pp. e68574 - e68574
F-box and WD repeat domain-containing 7 (Fbxw7/hAgo/hCdc4/Fbw7) is a p53-dependent tumor suppressor and leads to ubiquitination-mediated suppression of several... 
FBXW7 EXPRESSION | NETWORK | P53 GENE | MULTIDISCIPLINARY SCIENCES | MUTATION | TUMOR-SUPPRESSOR | DIFFERENTIATION | FBW7 | HCDC4 | CANCER | CLINICAL-SIGNIFICANCE | F-Box-WD Repeat-Containing Protein 7 | Genetic Therapy | Liver - pathology | Humans | Gene Expression Regulation, Neoplastic | Liver Neoplasms - therapy | Cyclin E - genetics | Tumor Suppressor Protein p53 - genetics | Tumor Suppressor Protein p53 - therapeutic use | RNA Interference | Carcinoma, Hepatocellular - genetics | Cell Cycle Proteins - genetics | Female | Liver Neoplasms - pathology | Liver Neoplasms - genetics | Signal Transduction | F-Box Proteins - metabolism | Liver - metabolism | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Proto-Oncogene Proteins c-myc - metabolism | Animals | Mice, Nude | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Cell Line, Tumor | Adenoviruses, Human - genetics | Carcinoma, Hepatocellular - therapy | Mice | Mice, Inbred BALB C | Proto-Oncogene Proteins c-myc - genetics | Cyclin E - metabolism | Mutation | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | Apoptosis | Carcinoma, Hepatocellular - metabolism | Ubiquitin | Hepatoma | Gene therapy | Tumor proteins | Adenoviruses | Cell culture | Biotechnology | Transcription factors | p53 Protein | c-Myc protein | Hepatocellular carcinoma | Myc protein | Tissues | Phase transitions | Cdc4 protein | Anticancer properties | Proteins | Liver cancer | Ubiquitination | Cell growth | Antitumor agents | Surgery | Cell cycle | Cyclin E | Recombinant | Enzymes | c-Jun protein | Pharmacology | Breast cancer | siRNA | Injection | Tumor cell lines | Chemical compounds | Medical prognosis | Cell lines | Proteasomes | Tumor suppressor genes | Protein expression | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 03/2012, Volume 483, Issue 7391, pp. 608 - 612
Deregulated expression of the MYC oncoprotein contributes to the genesis of many human tumours, yet strategies to exploit this for a rational tumour therapy... 
CANCER-CELLS | METABOLISM | GLUTAMINE | MITOCHONDRIAL BIOGENESIS | MULTIDISCIPLINARY SCIENCES | GROWTH | SYNTHETIC LETHAL INTERACTION | C-MYC | B KINASE | SUPPRESSION | ADDICTION | Protein Kinases - metabolism | AMP-Activated Protein Kinases - metabolism | Electron Transport | Protein Biosynthesis | Protein Kinases - genetics | TOR Serine-Threonine Kinases - metabolism | Humans | Multiprotein Complexes | Gene Expression Regulation, Neoplastic | Glutamine - metabolism | Homeostasis | Repressor Proteins - antagonists & inhibitors | Mechanistic Target of Rapamycin Complex 1 | Oncogene Protein p55(v-myc) - genetics | Carcinoma, Hepatocellular - drug therapy | Cell Respiration | RNA Interference | Repressor Proteins - deficiency | Cell Transformation, Neoplastic - genetics | Adenosine Triphosphate - metabolism | Carcinoma, Hepatocellular - genetics | Liver Neoplasms - pathology | Protein Kinases - deficiency | Repressor Proteins - metabolism | Disease Models, Animal | Oncogene Protein p55(v-myc) - metabolism | Liver Neoplasms - genetics | Signal Transduction | Cell Survival | Liver Neoplasms - drug therapy | Repressor Proteins - genetics | Mitochondria - metabolism | Animals | Proteins - metabolism | Genes, myc - genetics | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Cell Line, Tumor | Doxycycline - pharmacology | Mice | Proteins - antagonists & inhibitors | Apoptosis | Carcinoma, Hepatocellular - metabolism | Physiological aspects | Cellular signal transduction | Genetic aspects | Research | Drug therapy | Protein kinases | Tumors | Proteins | Liver cancer | Cell growth | Phosphorylation | Automation | Protein synthesis | Dependence | Glucose | Kinases | Autophagy | Index Medicus
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2015, Volume 58, Issue 7, pp. 3002 - 3024
Journal Article