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1. Full Text Leprosy and the adaptation of human toll-like receptor 1
by Wong, Sunny H and Gochhait, Sailesh and Malhotra, Dheeraj and Pettersson, Fredrik H and Teo, Yik Y and Khor, Chiea C and Rautanen, Anna and Chapman, Stephen J and Mills, Tara C and Srivastava, Amit and Rudko, Aleksey and Freidin, Maxim B and Puzyrev, Valery P and Ali, Shafat and Aggarwal, Shweta and Chopra, Rupali and Reddy, Belum S. N and Garg, Vijay K and Roy, Suchismita and Meisner, Sarah and Hazra, Sunil K and Saha, Bibhuti and Floyd, Sian and Keating, Brendan J and Kim, Cecilia and Fairfax, Benjamin P and Knight, Julian C and Hill, Philip C and Adegbola, Richard A and Hakonarson, Hakon and Fine, Paul E. M and Pitchappan, Ramasamy M and Bamezai, Rameshwar N. K and Hill, Adrian V. S and Vannberg, Fredrik O
PLoS Pathogens, ISSN 1553-7366, 07/2010, Volume 6, Issue 7, pp. 1 - 9
Leprosy is an infectious disease caused by the obligate intracellular pathogen Mycobacterium leprae and remains endemic in many parts of the world. Despite... 
VISUALIZATION | MORTALITY | GENOMEWIDE ASSOCIATION | INDIAN POPULATION | SUSCEPTIBILITY | MICROBIOLOGY | SEGREGATION | VIROLOGY | POSITIVE SELECTION | LEPROMATOUS LEPROSY | COMPLEX DISEASES | PARASITOLOGY | SINGLE NUCLEOTIDE POLYMORPHISMS | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Gene Frequency | Humans | Leprosy - immunology | HLA-DR Antigens - genetics | Mycobacterium leprae - immunology | Toll-Like Receptor 1 - genetics | HLA-DQ alpha-Chains | HLA-DQ Antigens - genetics | HLA-DRB1 Chains | Toll-Like Receptor 1 - immunology | Leprosy - genetics | Care and treatment | Demographic aspects | Genetic susceptibility | Genetic variation | Leprosy | Diagnosis | Research | Identification and classification | Index Medicus | Studies | Tuberculosis | Disease | Pathogenesis | Genetics | Population | Principal components analysis | Genomes | Gene loci
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2. Full Text After the bottleneck: Genome-wide diversification of the Mycobacterium tuberculosis complex by mutation, recombination, and natural selection
by Namouchi, Amine and Didelot, Xavier and Schöck, Ulrike and Gicquel, Brigitte and Rocha, Eduardo P. C
Genome Research, ISSN 1088-9051, 04/2012, Volume 22, Issue 4, pp. 721 - 734
Many of the most virulent bacterial pathogens show low genetic diversity and sexual isolation. Accordingly, Mycobacterium tuberculosis, the deadliest human... 
PHYLOGENETIC ANALYSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOLECULAR EVOLUTION | ESCHERICHIA-COLI | BACTERIAL | POLYMORPHISM | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | SIMULTANEOUS INFECTION | SEQUENCE | GENETICS & HEREDITY | POPULATION-STRUCTURE | HOMOLOGOUS RECOMBINATION | MULTIPLE STRAINS | Mycobacterium tuberculosis - classification | Species Specificity | Humans | Selection, Genetic | Tuberculosis - microbiology | Gene Transfer, Horizontal | Phylogeny | Genetic Variation | Genome, Bacterial - genetics | Recombination, Genetic | Polymorphism, Single Nucleotide | Mutation | Mycobacterium tuberculosis - metabolism | Cluster Analysis | Mycobacterium tuberculosis - genetics | Genetic aspects | Research | Gene mutations | Mycobacterium tuberculosis | Genetic recombination | Binding sites (Biochemistry) | Index Medicus | Mycobacterium tuberculosis/classification | Populations and Evolution | Horizontal | Quantitative Methods | Bacteriology | Life Sciences | Mycobacterium tuberculosis/metabolism | Microbiology and Parasitology | Mycobacterium tuberculosis/genetics | Bacterial/genetics | Tuberculosis/microbiology | Genetics | Gene Transfer | Genome
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3. Full Text Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
by Jostins, Luke and Ripke, Stephan and Weersma, Rinse K and Duerr, Richard H and McGovern, Dermot P and Hui, Ken Y and Lee, James C and Schumm, L. Philip and Sharma, Yashoda and Anderson, Carl A and Essers, Jonah and Mitrovic, Mitja and Ning, Kaida and Cleynen, Isabelle and Theatre, Emilie and Spain, Sarah L and Raychaudhuri, Soumya and Goyette, Philippe and Wei, Zhi and Abraham, Clara and Achkar, Jean-Paul and Ahmad, Tariq and Amininejad, Leila and Ananthakrishnan, Ashwin N and Andersen, Vibeke and Anews, Jane M and Baidoo, Leonard and Balschun, Tobias and Bampton, Peter A and Bitton, Alain and Boucher, Gabrielle and Brand, Stephan and Büning, Carsten and Cohain, Ariella and Cichon, Sven and D'Amato, Mauro and de Jong, Dirk and Devaney, Kathy L and Dubinsky, Marla and Edwards, Cathryn and Ellinghaus, David and Ferguson, Lynnette R and Franchimont, Denis and Fransen, Karin and Gearry, Richard and Georges, Michel and Gieger, Christian and Glas, Jürgen and Haritunians, Talin and Hart, Ailsa and Hawkey, Chris and Hedl, Matija and Hu, Xinli and Karlsen, Tom H and Kupcinskas, Limas and Kugathasan, Subra and Latiano, Anna and Laukens, Debby and Lawrance, Ian C and Lees, Charlie W and Louis, Edouard and Mahy, Gillian and Mansfield, John and Morgan, Angharad R and Mowat, Craig and Newman, William and Palmieri, Orazio and Ponsioen, Cyriel Y and Potocnik, Uros and Prescott, Natalie J and Regueiro, Miguel and Rotter, Jerome I and Russell, Richard K and Sanderson, Jeremy D and Sans, Miquel and Satsangi, Jack and Schreiber, Stefan and Simms, Lisa A and Sventoraityte, Jurgita and Targan, Stephan R and Taylor, Kent D and Tremelling, Mark and Verspaget, Hein W and de Vos, Martine and Wijmenga, Cisca and Wilson, David C and Winkelmann, Juliane and Xavier, Ramnik J and Zeissig, Sebastian and Zhang, Bin and Zhang, Clarence K and Zhao, Hongyu and Silverberg, Mark S and Annese, Vito and Hakonarson, Hakon and Brant, Steven R and Radford-Smith, Graham and Mathew, Christopher G and Rioux, John D and Schadt, Eric E and ... and Int IBD Genetics Consortium IIBDGC and International IBD Genetics Consortium (IIBDGC) and The International IBD Genetics Consortium (IIBDGC) and Region Örebro län and Örebro universitet and Institutionen för medicinska vetenskaper
Nature, ISSN 0028-0836, 2012, Volume 491, Issue 7422, pp. 119 - 124
Crohn's disease and ulcerative colitis, the two common forms of inflammatory bowel disease (IBD), affect over 2.5 million people of European ancestry, with... 
HYPER-IGE SYNDROME | RISK LOCI | NETWORK | NUMBER | METAANALYSIS | TUBERCULOSIS | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY | MUTATIONS | EXPRESSION | Crohn Disease - genetics | Humans | Inflammatory Bowel Diseases - immunology | Colitis, Ulcerative - genetics | Mycobacterium tuberculosis - immunology | Inflammatory Bowel Diseases - physiopathology | Colitis, Ulcerative - immunology | Host-Pathogen Interactions - immunology | Mycobacterium tuberculosis - pathogenicity | Haplotypes - genetics | Mycobacterium - pathogenicity | Mycobacterium Infections - genetics | Inflammatory Bowel Diseases - genetics | Crohn Disease - microbiology | Mycobacterium Infections - microbiology | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Reproducibility of Results | Mycobacterium - immunology | Crohn Disease - immunology | Genome, Human - genetics | Phenotype | Colitis, Ulcerative - microbiology | Host-Pathogen Interactions - genetics | Polymorphism, Single Nucleotide - genetics | Inflammatory Bowel Diseases - microbiology | Crohn Disease - physiopathology | Colitis, Ulcerative - physiopathology | Inflammatory bowel disease | Candidates | Tuberculosis | Architecture | Genetics | Genomes | Diabetes | Gene expression | Health risk assessment | Immune system | Index Medicus | Rheumatology and Autoimmunity | Basic Medicine | Medical Genetics | Medicinsk genetik | Clinical Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Reumatologi och inflammation | Medicinska och farmaceutiska grundvetenskaper | Klinisk medicin
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4. Full Text Mycobacterium tuberculosis complex genetic diversity: Mining the fourth international spoligotyping database (SpolDB4) for classification, population genetics and epidemiology
by Brudey, Karine and Driscoll, Jeffrey R and Rigouts, Leen and Prodinger, Wolfgang M and Gori, Andrea and Al-Hajoj, Sahal A and Allix, Caroline and Aristimuño, Liselotte and Arora, Jyoti and Baumanis, Viesturs and Binder, Lothar and Cafrune, Patricia and Cataldi, Angel and Cheong, Soonfatt and Diel, Roland and Ellermeier, Christopher and Evans, Jason T and Fauville-Dufaux, Maryse and Ferdinand, Séverine and De Viedma, Dario Garcia and Garzelli, Carlo and Gazzola, Lidia and Gomes, Harrison M and Guttierez, M. Cristina and Hawkey, Peter M and Van Helden, Paul D and Kadival, Gurujaj V and Kreiswirth, Barry N and Kremer, Kristin and Kubin, Milan and Kulkarni, Savita P and Liens, Benjamin and Lillebaek, Troels and Ho, Minh Ly and Martin, Carlos and Martin, Christian and Mokrousov, Igor and Narvskaïa, Olga and Yun, Fong Ngeow and Naumann, Ludmilla and Niemann, Stefan and Parwati, Ida and Rahim, Zeaur and Rasolofo-Razanamparany, Voahangy and Rasolonavalona, Tiana and Rossetti, M. Lucia and Rüsch-Gerdes, Sabine and Sajduda, Anna and Samper, Sofia and Shemyakin, Igor G and Singh, Urvashi B and Somoskovi, Akos and Skuce, Robin A and Van Soolingen, Dick and Streicher, Elisabeth M and Suffys, Philip N and Tortoli, Enrico and Tracevska, Tatjana and Vincent, Véronique and Victor, Tommie C and Warren, Robin M and Sook, Fan Yap and Zaman, Khadiza and Portaels, Françoise and Rastogi, Nalin and Sola, Christophe
BMC Microbiology, ISSN 1471-2180, 03/2006, Volume 6, Issue 1, pp. 23 - 23
Background: The Direct Repeat locus of the Mycobacterium tuberculosis complex (MTC) is a member of the CRISPR (Clustered regularly interspaced short... 
DIRECT REPEAT LOCUS | SPACER OLIGONUCLEOTIDES | STRAIN DIFFERENTIATION | TANDEM DNA REPEATS | VARIABLE-NUMBER | PULMONARY TUBERCULOSIS | MOLECULAR EPIDEMIOLOGY | MICROBIOLOGY | NUCLEOTIDE POLYMORPHISMS | COPY NUMBERS | GLOBAL DISTRIBUTION | Tuberculosis - epidemiology | Genetics, Population | Mycobacterium tuberculosis - classification | Computational Biology | Phylogeny | Mycobacterium tuberculosis - isolation & purification | Serotyping | Databases, Factual | Mycobacterium tuberculosis - genetics | Polymorphism, Genetic | Index Medicus
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5. Full Text Identification of Multiple Genetic Susceptibility Loci in Takayasu Arteritis
by Saruhan-Direskeneli, Güher and Hughes, Travis and Aksu, Kenan and Keser, Gokhan and Coit, Patrick and Aydin, Sibel Z and Alibaz-Oner, Fatma and Kamalı, Sevil and Inanc, Murat and Carette, Simon and Hoffman, Gary S and Akar, Servet and Onen, Fatos and Akkoc, Nurullah and Khalidi, Nader A and Koening, Curry and Karadag, Omer and Kiraz, Sedat and Langford, Carol A and McAlear, Carol A and Ozbalkan, Zeynep and Ates, Askin and Karaaslan, Yasar and Maksimowicz-McKinnon, Kathleen and Monach, Paul A and Ozer, Hüseyin T and Seyahi, Emire and Fresko, Izzet and Cefle, Ayse and Seo, Philip and Warrington, Kenneth J and Ozturk, Mehmet A and Ytterberg, Steven R and Cobankara, Veli and Onat, A. Mesut and Guthridge, Joel M and James, Judith A and Tunc, Ercan and Duzgun, Nurşen and Bıcakcıgil, Muge and Yentür, Sibel P and Merkel, Peter A and Direskeneli, Haner and Sawalha, Amr H
The American Journal of Human Genetics, ISSN 0002-9297, 08/2013, Volume 93, Issue 2, pp. 298 - 305
Takayasu arteritis is a rare inflammatory disease of large arteries. The etiology of Takayasu arteritis remains poorly understood, but genetic contribution to... 
MYCOBACTERIUM-TUBERCULOSIS | VISUALIZATION | POPULATION | TURKEY | ULCERATIVE-COLITIS | DISEASE | GENETICS & HEREDITY | HAPLOTYPES | HLA ALLELES | GENOME-WIDE ASSOCIATION | GIANT-CELL ARTERITIS | Interleukin-12 Subunit p40 - genetics | Genetic Predisposition to Disease | HLA-DRB1 Chains - genetics | Takayasu Arteritis - genetics | Takayasu Arteritis - ethnology | Humans | Male | Risk | Histocompatibility Antigens Class I - genetics | Genetic Loci | HLA-DQ beta-Chains - genetics | Genotyping Techniques | Receptors, IgG - genetics | Turkey - epidemiology | Female | Mutation | North America - epidemiology | HLA-B Antigens - genetics | Quantitative genetics | Physiological aspects | Disease susceptibility | Genetic aspects | Research | Arteritis | Genotype & phenotype | Custom design | Gene loci | Pathogenesis | Inflammatory diseases | Veins & arteries | Index Medicus | Report
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6. Full Text The genome of a pathogenic Rhodococcus: Cooptive virulence underpinned by key gene acquisitions
by Letek, Michal and González, Patricia and MacArthur, Iain and Rodríguez, Héctor and Freeman, Tom C and Valero-Rello, Ana and Blanco, Mónica and Buckley, Tom and Cherevach, Inna and Fahey, Ruth and Hapeshi, Alexia and Holdstock, Jolyon and Leadon, Desmond and Navas, Jesús and Ocampo, Alain and Quail, Michael A and Sanders, Mandy and Scortti, Mariela M and Prescott, John F and Fogarty, Ursula and Meijer, Wim G and Parkhill, Julian and Bentley, Stephen D and Vázquez-Boland, José A
PLoS Genetics, ISSN 1553-7390, 09/2010, Volume 6, Issue 9, pp. e1001145 - e1001145
We report the genome of the facultative intracellular parasite Rhodococcus equi, the only animal pathogen within the biotechnologically important... 
MYCOBACTERIUM-TUBERCULOSIS | ANTIMICROBIAL SUSCEPTIBILITY | EQUI | GRAM-POSITIVE BACTERIA | SEQUENCE-ANALYSIS | BACILLUS-SUBTILIS | PROTEIN FAMILIES | GENETICS & HEREDITY | SP-NOV | ISOCITRATE LYASE | EXPRESSION | Chromosomes, Bacterial - genetics | Gene Regulatory Networks - genetics | Genes, Bacterial - genetics | Genomics | Genetic Loci - genetics | Macrophages - cytology | Phylogeny | Mutation - genetics | Rhodococcus equi - pathogenicity | Rhodococcus equi - genetics | Rhodococcus equi - ultrastructure | Animals | Intracellular Space - microbiology | Virulence - genetics | Adaptation, Physiological - genetics | Rhodococcus equi - growth & development | Plasmids - genetics | Gene Duplication - genetics | Mice | Kinetics | Gene Transfer, Horizontal - genetics | Macrophages - microbiology | Evolution, Molecular | Physiological aspects | Gram-positive bacteria | Genetic aspects | Research | Genetic transcription | Genes | Index Medicus | Tuberculosis | Microbiology | Mortality | Evolution | Genomes | Acquisitions & mergers
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7. Full Text A digenic human immunodeficiency characterized by IFNAR1 and IFNGR2 mutations
by Hoyos-Bachiloglu, Rodrigo and Chou, Janet and Sodroski, Catherine N and Beano, Abdallah and Bainter, Wayne and Angelova, Magdalena and Al Idrissi, Eman and Habazi, Murad K and Alghamdi, Hamza Ali and Almanjomi, Fahd and Al Shehri, Mohamed and Elsidig, Nagi and Eldin, Morsi Alaa and Knipe, David M and AlZahrani, Mofareh and Geha, Raif S
Journal of Clinical Investigation, ISSN 0021-9738, 12/2017, Volume 127, Issue 12, pp. 4415 - 4420
Primary immunodeficiencies are often monogenic disorders characterized by vulnerability to specific infectious pathogens. Here, we performed whole-exome... 
MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNITY | ACTIVATOR | INTERFERON-GAMMA | MYCOBACTERIAL DISEASE | ALPHA/BETA | MENDELIAN SUSCEPTIBILITY | CLINICAL-FEATURES | DEFICIENCY | SIGNAL TRANSDUCER | INBORN-ERRORS | Bacteremia - immunology | Genetic Diseases, Inborn - microbiology | STAT2 Transcription Factor - immunology | Humans | Genetic Diseases, Inborn - genetics | Genetic Diseases, Inborn - virology | Male | Cytomegalovirus Infections - immunology | Cytomegalovirus Infections - genetics | Bacteremia - microbiology | Streptococcal Infections - genetics | Phosphorylation - genetics | Female | Phosphorylation - immunology | Receptor, Interferon alpha-beta - genetics | Fibroblasts - microbiology | Mycobacterium Infections, Nontuberculous - immunology | Immunologic Deficiency Syndromes - immunology | Receptors, Interferon - genetics | Fibroblasts - virology | Genetic Diseases, Inborn - immunology | Viremia - genetics | Viridans Streptococci - immunology | Bacteremia - genetics | Immunologic Deficiency Syndromes - virology | STAT1 Transcription Factor - genetics | Immunologic Deficiency Syndromes - microbiology | STAT1 Transcription Factor - immunology | Cytomegalovirus - immunology | Mycobacterium abscessus - immunology | Receptor, Interferon alpha-beta - immunology | Receptors, Interferon - immunology | Viremia - virology | STAT2 Transcription Factor - genetics | Immunologic Deficiency Syndromes - genetics | Fibroblasts - immunology | Viremia - immunology | Streptococcal Infections - immunology | Mutation | Mycobacterium Infections, Nontuberculous - genetics | Virus diseases | Usage | Immunotherapy | Genetic aspects | Disease susceptibility | Research | Mutation (Biology) | Stat2 protein | Cytomegalovirus | Phosphorylation | Viremia | Immunodeficiency | Stop codon | C-Terminus | Gene deletion | Bacteremia | Nuclear transport | α-Interferon | Clonal deletion | Fibroblasts | Interferon | Codons | Stat1 protein | Viral infections | Index Medicus | Abridged Index Medicus
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