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PLoS pathogens, ISSN 1553-7374, 07/2013, Volume 9, Issue 7, pp. e1003499 - e1003499
Defining the mechanisms of Mycobacterium tuberculosis (Mtb) persistence in the host macrophage and identifying mycobacterial factors responsible for it are keys to better understand tuberculosis pathogenesis... 
Parasitology | Life Sciences & Biomedicine | Microbiology | Science & Technology | Virology | Tuberculosis, Pulmonary - microbiology | Phagosomes - enzymology | Bone Marrow Cells - enzymology | Humans | Virulence | Mycobacterium tuberculosis - immunology | NADPH Oxidases - metabolism | Nucleoside-Diphosphate Kinase - metabolism | Mycobacterium tuberculosis - pathogenicity | Bone Marrow Cells - immunology | Mycobacterium tuberculosis - physiology | Female | Phagosomes - ultrastructure | Tuberculosis, Pulmonary - enzymology | Neuropeptides - genetics | Mutant Proteins - antagonists & inhibitors | Macrophages - immunology | Macrophages - microbiology | Nucleoside-Diphosphate Kinase - genetics | Recombinant Proteins - metabolism | Bacterial Proteins - antagonists & inhibitors | Macrophages - ultrastructure | Oligoribonucleotides, Antisense | Bone Marrow Cells - cytology | Mice, Inbred C57BL | NADPH Oxidases - antagonists & inhibitors | Bacterial Proteins - genetics | Cells, Cultured | Mutant Proteins - genetics | Recombinant Proteins - chemistry | Mutant Proteins - metabolism | Neuropeptides - metabolism | Tuberculosis, Pulmonary - pathology | Immunity, Innate | Mice, SCID | Nucleoside-Diphosphate Kinase - antagonists & inhibitors | Macrophages - enzymology | Tuberculosis, Pulmonary - immunology | Animals | Mycobacterium tuberculosis - enzymology | rac1 GTP-Binding Protein - antagonists & inhibitors | Bone Marrow Cells - microbiology | Bacterial Proteins - metabolism | Mice | Cell Line, Transformed | rac1 GTP-Binding Protein - metabolism | Neuropeptides - antagonists & inhibitors | rac1 GTP-Binding Protein - genetics | Mycobacterium tuberculosis | Physiological aspects | Host-parasite relationships | Research | Health aspects | Phosphotransferases | Guanosine triphosphatase | Index Medicus | Medical research | Tuberculosis | Biosynthesis | Kinases | Charitable foundations | Experiments | Apoptosis
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 09/2014, Volume 111, Issue 38, pp. E4024 - E4032
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 01/2005, Volume 307, Issue 5707, pp. 223 - 227
The incidence of tuberculosis has been increasing substantially on a worldwide basis over the past decade, but no tuberculosis-specific drugs have been discovered in 40 years... 
Antibacterials | Mycobacterium tuberculosis | Lungs | Half lives | Antituberculars | Multidrug resistant tuberculosis | Infections | Dosage | Bacterial load | Pharmacokinetics | Research Article | Antitubercular Agents - chemistry | Humans | Drug Resistance, Bacterial | Molecular Sequence Data | Male | Tuberculosis - microbiology | Mycobacterium tuberculosis - drug effects | Quinolines - pharmacology | Dose-Response Relationship, Drug | Microbial Sensitivity Tests | Quinolines - pharmacokinetics | Tuberculosis, Multidrug-Resistant - microbiology | Enzyme Inhibitors - chemistry | Tuberculosis - drug therapy | Bacterial Proton-Translocating ATPases - antagonists & inhibitors | Drug Evaluation, Preclinical | Drug Therapy, Combination | Mycobacterium smegmatis - enzymology | Antitubercular Agents - therapeutic use | Amino Acid Sequence | Mycobacterium smegmatis - growth & development | Bacterial Proton-Translocating ATPases - chemistry | Bacterial Proton-Translocating ATPases - metabolism | Quinolines - chemistry | Antitubercular Agents - pharmacology | Enzyme Inhibitors - pharmacology | Enzyme Inhibitors - therapeutic use | Point Mutation | Animals | Antitubercular Agents - pharmacokinetics | Mycobacterium tuberculosis - enzymology | Mycobacterium smegmatis - drug effects | Diarylquinolines | Mice | Protein Subunits - antagonists & inhibitors | Protein Subunits - chemistry | Quinolines - therapeutic use | Mycobacterium tuberculosis - growth & development | Tuberculosis, Multidrug-Resistant - drug therapy | Care and treatment | Usage | Tuberculosis | Respiratory agents | Research | Adenosine triphosphatase | Clinical trials | Drug resistance | Index Medicus
Journal Article
American journal of respiratory and critical care medicine, ISSN 1535-4970, 05/2012, Volume 185, Issue 9, pp. 989 - 997
Journal Article
Journal Article
PLoS pathogens, ISSN 1553-7374, 04/2018, Volume 14, Issue 4, pp. e1006974 - e1006974
Mycobacterium tuberculosis (Mtb) remains a grave threat to world health with emerging drug resistant strains... 
Parasitology | Life Sciences & Biomedicine | Microbiology | Science & Technology | Virology | Lung - microbiology | Small Molecule Libraries - pharmacology | Isoniazid - pharmacology | Granuloma, Respiratory Tract - drug therapy | Tuberculosis - enzymology | Mice, Inbred C57BL | Antitubercular Agents - pharmacology | Tuberculosis - microbiology | Granuloma, Respiratory Tract - enzymology | Mycobacterium tuberculosis - drug effects | Lung - enzymology | Matrix Metalloproteinase Inhibitors - pharmacology | Animals | Lung - drug effects | Mycobacterium tuberculosis - enzymology | Tuberculosis - drug therapy | Granuloma, Respiratory Tract - microbiology | Mice | Rifampin - pharmacology | Dosage and administration | Tuberculosis | Research | Drug therapy | Rifampin | Isoniazid | Drugs | Drug delivery systems | Laboratories | Funding | Colorectal cancer | Infections | Metastasis | Matrix metalloproteinase | Drug resistance | Cancer therapies | Environmental engineering | Immunology | Acquired immune deficiency syndrome--AIDS | Human immunodeficiency virus--HIV | Animal tissues | Metalloproteinase | Inhibition | Public health | Biomedical engineering | Medical research | Effectiveness | Health risks | Blood vessels | Computer engineering | Permeability | Inhibitors | Lungs | Antibiotics | Index Medicus | Acquired immune deficiency syndrome | AIDS | HIV | Human immunodeficiency virus
Journal Article
The Journal of pathology, ISSN 0022-3417, 03/2018, Volume 244, Issue 3, pp. 311 - 322
Tuberculosis (TB) is characterized by extensive pulmonary matrix breakdown. Interleukin‐17 (IL‐17) is key in host defence in TB but its role in TB... 
MMP | TH‐17 | immunopathology | innate immunity | mycobacteria | 17 | Pathology | Oncology | Life Sciences & Biomedicine | Science & Technology | Lung - microbiology | Stromal Cells - microbiology | Class I Phosphatidylinositol 3-Kinases - metabolism | Humans | Interleukin-17 - immunology | Mycobacterium tuberculosis - immunology | Interleukin-17 - pharmacology | Tuberculosis, Pulmonary - genetics | Interleukins - metabolism | Lung - enzymology | Mycobacterium tuberculosis - pathogenicity | Stromal Cells - enzymology | Th17 Cells - metabolism | Interleukins - immunology | Stromal Cells - drug effects | Tuberculosis, Pulmonary - enzymology | p38 Mitogen-Activated Protein Kinases - metabolism | Cells, Cultured | Enzyme Induction | Stromal Cells - immunology | Matrix Metalloproteinase 3 - biosynthesis | Interleukin-17 - metabolism | Tuberculosis, Pulmonary - immunology | Signal Transduction - drug effects | Lung - drug effects | Paracrine Communication - drug effects | Th17 Cells - immunology | Matrix Metalloproteinase 3 - genetics | Lung - immunology | Th17 Cells - microbiology | Tuberculosis | Interleukins | Gene expression | Analysis | Immunohistochemistry | Epithelial cells | Interleukin | Interleukin 22 | Interleukin 23 | Matrix metalloproteinase | Kinases | Assaying | Respiratory tract | Signal transduction | Pathways | Bronchoalveolar lavage | Metalloproteinase | Conditioning | Alveoli | Enzyme-linked immunosorbent assay | Stromelysin 1 | Cytokines | Bronchus | MAP kinase | siRNA | Patients | Interleukin 17 | Gelatinase B | 1-Phosphatidylinositol 3-kinase | Signaling | Monocytes | Index Medicus | Original Papers | Original Paper
Journal Article