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1. The Biosynthesis of mycotoxins
: a study in secondary metabolism
by Steyn, Pieter S
1980, ISBN 9780126706505, xv, 432
Fungi | Metabolism, Secondary | Physiology | Biosynthesis | Synthesis | Mycotoxins
Book
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2. Full Text Production of secondary metabolites in extreme environments: Food- and airborne wallemia spp. produce toxic metabolites at hypersaline conditions
by Jančič, Sašo and Frisvad, Jens C and Kocev, Dragi and Gostinčar, Cene and Džeroski, Sašo and Gunde-Cimerman, Nina
PLoS ONE, ISSN 1932-6203, 12/2016, Volume 11, Issue 12, pp. e0169116 - e0169116
The food- and airborne fungal genus Wallemia comprises seven xerophilic and halophilic species: W. sebi, W. mellicola, W. canadensis, W. tropicalis, W. muriae,... 
GENUS WALLEMIA | WATER ACTIVITY | FUNGUS | DEREPLICATION | BIOSYNTHESIS | MULTIDISCIPLINARY SCIENCES | GROWTH | HORTAEA-WERNECKII | GENOME | SEBI | LIFE | Sesquiterpenes - metabolism | Secondary Metabolism - genetics | Food Contamination | Magnesium Chloride - metabolism | Chromatography, High Pressure Liquid | Basidiomycota - metabolism | Food Microbiology | Extreme Environments | Basidiomycota - classification | Secondary Metabolism - physiology | Azasteroids - metabolism | Basidiomycota - genetics | Glucose - metabolism | Mycotoxins - metabolism | Cholestadienols - metabolism | Sodium Chloride - metabolism | Usage | Metabolites | Analysis | Physiological aspects | Environmental aspects | Research | High performance liquid chromatography | Production processes | Basidiomycota | Salts | Food contamination | Gram-positive bacteria | Genomes | Solutes | Biosynthesis | Biology | Extreme environments | Fungi | Spectrometry | Secondary metabolites | Microorganisms | Water activity | Bacteria | Product safety | Species | Sugar | Food | Adaptation | Data analysis | Data processing | Liquid chromatography | Sodium chloride | High-performance liquid chromatography | Learning algorithms | Growth media | Machine learning | Water pollution | Food safety | Index Medicus
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3. Full Text In vitro immune toxicity of ochratoxin A in porcine alveolar macrophages: A role for the ROS-relative TLR4/MyD88 signaling pathway
by Xu, Jing and Xu, Haibin and Hao, Shu and Gan, Fang and Wang, Hong and Liu, Dandan and Huang, Kehe
Chemico-Biological Interactions, ISSN 0009-2797, 06/2017, Volume 272, pp. 107 - 116
Ochratoxin A (OTA) frequently contaminates a wide variety of food and feeds, inducing immune toxicity of animals. However, the underlying mechanism remains... 
Immune toxicity | Ochratoxin A | TLR4 | MyD88 | ROS | CELLS | APOPTOSIS | OXIDATIVE STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MYCOTOXIN OCHRATOXIN | NECROSIS-FACTOR-ALPHA | AFLATOXIN B-1 | INFLAMMATION | TOLL-LIKE RECEPTORS | PHARMACOLOGY & PHARMACY | TOXICOLOGY | EXPRESSION | Tumor Necrosis Factor-alpha - metabolism | Reactive Oxygen Species - metabolism | Gene Expression - drug effects | Tumor Necrosis Factor-alpha - genetics | Interleukin-1beta - genetics | Proto-Oncogene Proteins c-bcl-2 - metabolism | Interleukin-1beta - metabolism | Swine | Hydro-Lyases - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Toll-Like Receptor 4 - antagonists & inhibitors | Cell Line | Cell Survival - drug effects | bcl-2-Associated X Protein - metabolism | Toll-Like Receptor 4 - genetics | Toll-Like Receptor 4 - metabolism | Ochratoxins - toxicity | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Transcription Factor RelA - metabolism | Macrophages, Alveolar - drug effects | Macrophages, Alveolar - cytology | Macrophages, Alveolar - metabolism | Myeloid Differentiation Factor 88 - metabolism | RNA, Small Interfering - metabolism | Antioxidants | RNA | Macrophages | Analysis | Food contamination | Index Medicus
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4. Full Text The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes
by Kasper, Lydia and Kasper, Lydia and König, Annika and König, Annika and Koenig, Paul-Albert and Gresnigt, Mark S and Gresnigt, Mark S and Westman, Johannes and Westman, Johannes and Drummond, Rebecca A and Drummond, Rebecca A and Lionakis, Michail S and Lionakis, Michail S and Groß, Olaf and Groß, Olaf and Ruland, Jürgen and Ruland, Jürgen and Naglik, Julian R and Naglik, Julian R and Hube, Bernhard and Hube, Bernhard
Nature communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 4260 - 20
Clearance of invading microbes requires phagocytes of the innate immune system. However, successful pathogens have evolved sophisticated strategies to evade... 
INTERLEUKIN-1 | RECOGNITION | GENE | FORMATION TRIGGERS ACTIVATION | HYPHAE | MULTIDISCIPLINARY SCIENCES | HOST-DEFENSE | IL-1-BETA | PYROPTOSIS | ALBICANS | CELL-DEATH | Inflammation - pathology | Leukocytes, Mononuclear - metabolism | Inflammasomes - metabolism | Humans | Actins - metabolism | Fungal Proteins - toxicity | Caspase 1 - metabolism | Necrosis | Interleukin-1beta - metabolism | Bone Marrow Cells - drug effects | Dendritic Cells - drug effects | Female | Phagocytes - cytology | Cell Death - drug effects | Dendritic Cells - metabolism | Phagosomes - drug effects | Leukocytes, Mononuclear - drug effects | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Phagocytes - drug effects | Mice, Inbred C57BL | Phagosomes - metabolism | Phagocytes - metabolism | Mycotoxins - toxicity | Potassium - pharmacology | Macrophages - metabolism | Animals | Leukocytes, Mononuclear - cytology | Macrophages - drug effects | Bone Marrow Cells - metabolism | Efflux | Pathogens | Cytolysis | Dendritic cells | Immune clearance | Opportunist infection | Leukocytes (mononuclear) | Activation | Glucose | Macrophages | Caspase-1 | Fungi | Phagocytes | Cell activation | Cell death | Hyphae | Lysis | Potassium | Immune system | Apoptosis
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5. The Metabolism of aflatoxins and other mycotoxins
by Bassir, Olumbe
1989, ISBN 9781211970, x, 166
Aflatoxins | Metabolism | Mocotoxins | Mycotoxins
Book
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6. Full Text Regulation of secondary metabolism in filamentous fungi
by Yu, Jae-Hyuk and Keller, Nancy
Annual Review of Phytopathology, ISSN 0066-4286, 2005, Volume 43, Issue 1, pp. 437 - 458
Fungal secondary metabolites are of intense interest to humankind due to their pharmaceutical (antibiotics) and/or toxic (mycotoxins) properties. In the past... 
Fungi | RGS proteins | G proteins | Transcriptional control | Mycotoxins | mycotoxins | ASPERGILLUS-NIDULANS | AFLATOXIN BIOSYNTHESIS | DNA-BINDING PROTEIN | FUSARIUM-SPOROTRICHIOIDES | PLANT SCIENCES | CARBON CATABOLITE REPRESSION | transcriptional control | BIOSYNTHETIC GENE-CLUSTER | fungi | PROTEIN BETA-SUBUNIT | TRANSCRIPTION FACTOR CPCR1 | SEXUAL DEVELOPMENT | PLANT-PATHOGENIC FUNGUS | Gene Expression Regulation, Fungal | Mycotoxins - metabolism | Signal Transduction | Fungi - metabolism | Fungi - genetics
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7. Full Text Candidalysin is a fungal peptide toxin critical for mucosal infection
by Moyes, David L and Wilson, Duncan and Richardson, Jonathan P and Mogavero, Selene and Tang, Shirley X and Wernecke, Julia and Höfs, Sarah and Gratacap, Remi L and Robbins, Jon and Runglall, Manohursingh and Murciano, Celia and Blagojevic, Mariana and Thavaraj, Selvam and Förster, Toni M and Hebecker, Betty and Kasper, Lydia and Vizcay, Gema and Iancu, Simona I and Kichik, Nessim and Häder, Antje and Kurzai, Oliver and Luo, Ting and Krüger, Thomas and Kniemeyer, Olaf and Cota, Ernesto and Bader, Oliver and Wheeler, Robert T and Gutsmann, Thomas and Hube, Bernhard and Naglik, Julian R
Nature, ISSN 0028-0836, 04/2016, Volume 532, Issue 7597, pp. 64 - 68
Cytolytic proteins and peptide toxins are classical virulence factors of several bacterial pathogens which disrupt epithelial barrier function, damage cells... 
PATHOGENICITY MECHANISMS | BETA-MANNOSYLATION | PROTEIN-KINASE HOMOLOG | OROPHARYNGEAL CANDIDIASIS | EPITHELIAL-CELLS | FILAMENTOUS GROWTH | MULTIDISCIPLINARY SCIENCES | HYPHAL DEVELOPMENT | ALBICANS ENCODES | SACCHAROMYCES-CEREVISIAE | TRANSCRIPTION FACTOR | Virulence - drug effects | Virulence Factors - genetics | Calcium - metabolism | Epithelial Cells - drug effects | Humans | Fungal Proteins - toxicity | Candida albicans - metabolism | Cytotoxins - secretion | Candidiasis - microbiology | Cytotoxins - toxicity | Host-Pathogen Interactions - immunology | Cytotoxins - metabolism | Mycotoxins - metabolism | Mycotoxins - genetics | Candidiasis - pathology | Virulence Factors - toxicity | Candida albicans - pathogenicity | Mycotoxins - secretion | Epithelial Cells - pathology | Fungal Proteins - genetics | Candida albicans - immunology | Mycotoxins - toxicity | Candidiasis - metabolism | Mucous Membrane - pathology | Signal Transduction - drug effects | Cell Membrane Permeability - drug effects | Epithelial Cells - immunology | Fungal Proteins - secretion | Virulence Factors - metabolism | Cytotoxins - genetics | Mucous Membrane - microbiology | Fungal Proteins - metabolism | Candida albicans | Fungi | Physiological aspects | Mucous membrane | Proteins | Yeast | Peptides | Cytokines | Pathogenesis | Toxins | Fungal infections
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8. Full Text Organ damage and hepatic lipid accumulation in carp (Cyprinus carpio L.) after feed-borne exposure to the Mycotoxin, Deoxynivalenol (DON)
by Pietsch, Constanze and Schulz, Carsten and Rovira, Pere and Kloas, Werner and Burkhardt-Holm, Patricia
Toxins, ISSN 2072-6651, 2014, Volume 6, Issue 2, pp. 756 - 778
Deoxynivalenol (DON) frequently contaminates animal feed, including fish feed used in aquaculture. This study intends to further investigate the effects of DON... 
Oxidative stress | Liver damage | Nutrient allocation | Aquaculture | nutrient allocation | COMMON CARP | FRESH-WATER FISH | aquaculture | GLUCOSE | LIVER | LACTATE | RAPID METHOD | TOXICOLOGY | TRICHOTHECENE MYCOTOXIN | liver damage | CARBOHYDRATE-METABOLISM | oxidative stress | BLOOD | L-Lactate Dehydrogenase - metabolism | Malondialdehyde - metabolism | Carps - growth & development | Carps - metabolism | Liver - pathology | Kidney - drug effects | Lactic Acid - metabolism | Liver - metabolism | Fish Proteins - metabolism | Blood Proteins - metabolism | L-Iditol 2-Dehydrogenase - metabolism | Aspartate Aminotransferases - metabolism | Kidney - metabolism | Trichothecenes - toxicity | Animals | Diet | Liver - drug effects | Muscles - drug effects | Lipid Metabolism - drug effects | Glucose - metabolism | Alanine Transaminase - metabolism | Lipid Peroxidation | Muscles - metabolism
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9. Full Text Metabolism of the masked mycotoxin deoxynivalenol-3-glucoside in pigs
by Nagl, Veronika and Woechtl, Bettina and Schwartz-Zimmermann, Heidi Elisabeth and Hennig-Pauka, Isabel and Moll, Wulf-Dieter and Adam, Gerhard and Berthiller, Franz
Toxicology Letters, ISSN 0378-4274, 08/2014, Volume 229, Issue 1, pp. 190 - 197
Plants can metabolize the mycotoxin deoxynivalenol (DON) by forming the masked mycotoxin deoxynivalenol-3-β- -glucoside (D3G). D3G might be cleaved during... 
Conjugated mycotoxins | ADME | Swine | Gut | DON | BIOMARKER | FUSARIUM TOXIN DEOXYNIVALENOL | EXCRETION | GROWTH-PERFORMANCE | MASS-SPECTROMETRY | LC-MS/MS | NATURALLY CONTAMINATED WHEAT | TOXICOLOGY | EXPOSURE | ZEARALENONE | Reproducibility of Results | Glucosides - urine | Injections, Intravenous | Administration, Oral | Biological Availability | Male | Trichothecenes - pharmacokinetics | Glucosides - pharmacokinetics | Chromatography, High Pressure Liquid | Weight Loss - drug effects | Glucosides - metabolism | Intestinal Absorption | Vomiting - chemically induced | Animals | Feces - chemistry | Trichothecenes - metabolism | Biotransformation | Mass Spectrometry | Anorexia - chemically induced | Indicators and Reagents | Mycotoxins - metabolism | Trichothecenes - urine | Physiological aspects | Cells | Index Medicus | Urine | Pigs | Metabolites | Mycotoxins | Biocompatibility | Digestion | Feces | Metabolism
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10. Full Text Metabolism of nivalenol and nivalenol-3-glucoside in rats
by Schwartz-Zimmermann, Heidi E and Binder, Sabina B and Hametner, Christian and Miró-Abella, Eugènia and Schwarz, Christiane and Michlmayr, Herbert and Reiterer, Nicole and Labudova, Silvia and Adam, Gerhard and Berthiller, Franz
Toxicology Letters, ISSN 0378-4274, 05/2019, Volume 306, pp. 43 - 52
Plant-derived mycotoxin conjugates like deoxynivalenol-3-glucoside can be partly hydrolyzed to their aglycones , albeit to different extent depending on the... 
Immuno affinity chromatography | Excretion | Modified mycotoxins | Metabolization | High performance liquid chromatography tandem mass spectrometry | Masked mycotoxins | TOXICITY | TOXICOLOGY | MASKED MYCOTOXIN DEOXYNIVALENOL-3-GLUCOSIDE | FUSARIUM | Glucosides - toxicity | Rats | Male | Trichothecenes - pharmacokinetics | Mycotoxins - pharmacokinetics | Glucosides - metabolism | Rats, Sprague-Dawley | Trichothecenes - toxicity | Animals | Feces - chemistry | Glucuronides - metabolism | Trichothecenes - metabolism | Biotransformation | Mycotoxins - metabolism | Leukocyte Count | Physiological aspects | Metabolites | Mass spectrometry | High performance liquid chromatography | Index Medicus
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11. Full Text Zearalenone-16- o -glucoside: A new masked mycotoxin
by Paris, Maria Paula Kovalsky and Schweiger, Wolfgang and Hametner, Christian and Stückler, Romana and Muehlbauer, Gary J and Varga, Elisabeth and Krska, Rudolf and Berthiller, Franz and Adam, Gerhard
Journal of Agricultural and Food Chemistry, ISSN 0021-8561, 02/2014, Volume 62, Issue 5, pp. 1181 - 1189
This paper reports the identification of a barley UDP-glucosyltransferase, HvUGT14077, which is able to convert the estrogenic Fusarium mycotoxin zearalenone... 
xenoestrogen | zearalenone | Fusarium | barley | Brachypodium | heterologous expression | wheat | UDP-glucosyltransferase | yeast | DETOXIFICATION | METABOLITES | GLYCOSIDE | FOOD SCIENCE & TECHNOLOGY | VALIDATION | DEOXYNIVALENOL | MS/MS | TRANSCRIPTOME ANALYSIS | AGRICULTURE, MULTIDISCIPLINARY | CHEMISTRY, APPLIED | GLYCOSYLTRANSFERASES | Brachypodium - metabolism | Food Contamination | Humans | Male | Intestines - metabolism | Hordeum - chemistry | Triticum - metabolism | Glucosyltransferases - metabolism | Hordeum - enzymology | Microbiota | Glucosides - chemistry | Adult | Female | Mycotoxins - metabolism | Plant Proteins - metabolism | Brachypodium - chemistry | Glucosyltransferases - genetics | Bacteria - metabolism | Mycotoxins - chemistry | Hordeum - metabolism | Zearalenone - chemistry | Glucosides - metabolism | Plant Proteins - genetics | Intestines - microbiology | Zearalenone - metabolism | Triticum - chemistry | Hordeum - genetics
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12. Full Text How Peroxisomes Affect Aflatoxin Biosynthesis in Aspergillus Flavus
by Reverberi, Massimo and Punelli, Marta and Smith, Carrie A and Zjalic, Slaven and Scarpari, Marzia and Scala, Valeria and Cardinali, Giorgia and Aspite, Nicaela and Pinzari, Flavia and Payne, Gary A and Fabbri, Anna A and Fanelli, Corrado
PLoS ONE, ISSN 1932-6203, 10/2012, Volume 7, Issue 10, p. e48097
In filamentous fungi, peroxisomes are crucial for the primary metabolism and play a pivotal role in the formation of some secondary metabolites. Further,... 
BETA-OXIDATION | OXIDATIVE STRESS | MYCOTOXIN PRODUCTION | PROTEIN | ACID | FUNGI | METABOLISM | MULTIDISCIPLINARY SCIENCES | PARASITICUS | LIPOPEROXIDATION | SACCHAROMYCES-CEREVISIAE | Promoter Regions, Genetic | Superoxide Dismutase - genetics | Reactive Oxygen Species - metabolism | Oxidation-Reduction | Oxidative Stress | Aspergillus flavus - drug effects | Aspergillus flavus - metabolism | Antioxidants - metabolism | Aflatoxins - biosynthesis | Tombusvirus - genetics | Bezafibrate - pharmacology | Fungal Proteins - genetics | Hypolipidemic Agents - pharmacology | Peroxisomes - metabolism | Gene Expression Regulation, Fungal - drug effects | Aspergillus flavus - genetics | Lipid Metabolism - drug effects | Genetic Vectors | Fatty Acids - metabolism | Superoxide Dismutase - metabolism | Fungal Proteins - metabolism | Aflatoxins | Oxidative stress | Peroxisomes | Molds (Fungi) | Research | Metabolism | Fatty acids | Health aspects | Unbalance | Reactive oxygen species | Seeds | Transcription | Viruses | Lipids | Biosynthesis | Fungi | Proteins | Antioxidants | Signal transduction | Secondary metabolites | Metabolites | Rodents | Oxidation | Lipid metabolism | Trends | Sod gene | Gene expression | Substrates | Zinc | Strain | Bezafibrate
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