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The New England Journal of Medicine, ISSN 0028-4793, 12/2011, Volume 365, Issue 25, pp. 2377 - 2388
The authors report that INF2 mutations are present in patients with focal segmental glomerulosclerosis (FSGS) associated with Charcot–Marie–Tooth neuropathy.... 
GLOMERULOSCLEROSIS | MEDICINE, GENERAL & INTERNAL | MYELIN | PROTEIN | NEUROPATHY | EPITHELIAL-CELLS | GENE | RHO | MEDIATED TRANSPORT | FORMIN | NEPHROPATHY | Humans | Middle Aged | Proteolipids - metabolism | Actins - metabolism | Male | Charcot-Marie-Tooth Disease - genetics | Young Adult | Kidney - metabolism | Glomerulosclerosis, Focal Segmental - etiology | Myelin and Lymphocyte-Associated Proteolipid Proteins | Adult | Female | Membrane Transport Proteins - metabolism | Microfilament Proteins - metabolism | Child | Microfilament Proteins - genetics | Charcot-Marie-Tooth Disease - complications | Schwann Cells - metabolism | Phenotype | Animals | Adolescent | Age of Onset | Heterozygote | Mice | Mutation | Myelin Proteins - metabolism | Glomerulonephritis | Gene mutations | Charcot-Marie-Tooth disease | Causes of | Genetic aspects | Research | Myelin proteins | Cdc42 protein | Disease | Exons | Genes | Amino acids | Nervous system | Neuropathy | Guanine nucleotide-binding protein | Proteins | Myelin P0 protein | Localization | Peripheral myelin protein 22 | Deoxyribonucleic acid--DNA | Kidneys | Schwann cells | Polymerization | Myelination | Genotyping | Biopsy | Glomerulus | Cytoskeleton | Genetic testing | Cytoplasm | Guanosinetriphosphatase | Schwann Cells | Genomics | Kidney | Charcot-Marie-Tooth Disease | Life Sciences | Proteolipids | Biochemistry, Molecular Biology | Actins | Microfilament Proteins | Membrane Transport Proteins | Myelin Proteins | Glomerulosclerosis, Focal Segmental
Journal Article
Cell, ISSN 0092-8674, 2006, Volume 124, Issue 3, pp. 573 - 586
How is the characteristic shape of a membrane bound organelle achieved? We have used an in vitro system to address the mechanism by which the tubular network... 
YEAST | LOCALIZATION | NEURITE OUTGROWTH | POLYPOSIS LOCUS | INTERACTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | NOGO-A | FUNCTIONAL DOMAINS | GENE FAMILY | IDENTIFICATION | SACCHAROMYCES-CEREVISIAE | CELL BIOLOGY | Saccharomyces cerevisiae - genetics | Humans | Cercopithecus aethiops | Endoplasmic Reticulum - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Saccharomyces cerevisiae - metabolism | Transfection | Membrane Transport Proteins - genetics | Female | Membrane Transport Proteins - metabolism | Membrane Proteins - metabolism | Nogo Proteins | Membrane Proteins - classification | Intracellular Signaling Peptides and Proteins - genetics | Calcium Signaling | Recombinant Proteins - metabolism | Membrane Proteins - genetics | Oocytes - metabolism | Rats | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Saccharomyces cerevisiae Proteins - genetics | Membrane Transport Proteins - chemistry | Animals | Membrane Proteins - chemistry | Intracellular Signaling Peptides and Proteins - chemistry | Saccharomyces cerevisiae Proteins - metabolism | Myelin Proteins | In Vitro Techniques | COS Cells | Saccharomyces cerevisiae Proteins - chemistry | Usage | Physiological aspects | Immunoblotting | Research | Brewer's yeast | Endoplasmic reticulum | Membrane proteins | Lipids | Aquaporins | Synthesis
Journal Article
Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Nature Immunology, ISSN 1529-2908, 02/2006, Volume 7, Issue 2, pp. 148 - 155
Journal Article
PLoS Pathogens, ISSN 1553-7366, 05/2015, Volume 11, Issue 5, p. e1004896
Clostridium perfringens epsilon-toxin (ETX) is a potent pore-forming toxin responsible for a central nervous system (CNS) disease in ruminant animals with... 
NERVOUS-SYSTEM | MDCK CELLS | MICROBIOLOGY | PLASMA-MEMBRANE | INTESTINAL INFECTIONS | DARBY CANINE KIDNEY | VIROLOGY | PORE-FORMING TOXIN | APICAL SORTING MACHINERY | RAFT-ASSOCIATED PROTEIN | HUMAN T-LYMPHOCYTES | PARASITOLOGY | INFLUENZA-VIRUS HEMAGGLUTININ | Injections, Intravenous | Cricetulus | Myelin and Lymphocyte-Associated Proteolipid Proteins - metabolism | Humans | Bacterial Toxins - toxicity | Recombinant Fusion Proteins - metabolism | Tissue Distribution | Protein Precursors - toxicity | Bacterial Toxins - genetics | Clostridium perfringens - metabolism | Protein Interaction Domains and Motifs | Cell Death - drug effects | Binding Sites | Clostridium perfringens - pathogenicity | Recombinant Fusion Proteins - administration & dosage | CHO Cells | Recombinant Proteins - metabolism | Protein Precursors - genetics | Protein Precursors - administration & dosage | Mice, Inbred C57BL | Rats | Recombinant Proteins - chemistry | Recombinant Fusion Proteins - toxicity | Recombinant Fusion Proteins - chemistry | Recombinant Proteins - administration & dosage | Mice, Knockout | Protein Precursors - metabolism | Toxicokinetics | Bacterial Toxins - metabolism | Animals | Myelin and Lymphocyte-Associated Proteolipid Proteins - chemistry | Recombinant Proteins - toxicity | Ligands | Mutagenesis, Insertional | Myelin and Lymphocyte-Associated Proteolipid Proteins - genetics
Journal Article
Neuron, ISSN 0896-6273, 02/2012, Volume 73, Issue 4, pp. 713 - 728
Myelination by oligodendrocytes in the central nervous system (CNS) is essential for proper brain function, yet the molecular determinants that control this... 
TRANSCRIPTION FACTORS | IN-VITRO | MULTIPLE-SCLEROSIS | BONE MORPHOGENETIC PROTEIN | OLIGODENDROCYTE PRECURSOR CELLS | DEMYELINATED LESIONS | MOWAT-WILSON-SYNDROME | DIFFERENTIATION | BETA-CATENIN | CNS MYELINATION | NEUROSCIENCES | Central Nervous System - ultrastructure | Microcephaly - genetics | Oligonucleotide Array Sequence Analysis | Embryo, Mammalian | Homeodomain Proteins - metabolism | Humans | Nerve Tissue Proteins - deficiency | Caspase 3 - metabolism | Ki-67 Antigen - metabolism | Gene Expression Profiling | Green Fluorescent Proteins - genetics | RNA, Messenger - metabolism | Zinc Finger E-box Binding Homeobox 2 | Central Nervous System - physiology | Bone Morphogenetic Proteins - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Facies | Repressor Proteins - metabolism | Smad7 Protein - metabolism | Animals, Newborn | Basic Helix-Loop-Helix Transcription Factors - genetics | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Hirschsprung Disease - pathology | Intellectual Disability - pathology | Models, Molecular | Smad Proteins - genetics | Oligodendrocyte Transcription Factor 2 | Signal Transduction - genetics | Mice, Knockout | Central Nervous System - cytology | Mice | Optic Nerve - metabolism | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Oligodendroglia - metabolism | Immunoprecipitation | Age Factors | Hirschsprung Disease - genetics | Gene Expression Regulation, Developmental - genetics | Intellectual Disability - genetics | Myelin Sheath - metabolism | Cell Differentiation - genetics | Transfection | Microcephaly - pathology | Optic Nerve - embryology | Smad7 Protein - genetics | Optic Nerve - growth & development | Microscopy, Electron, Transmission | Cells, Cultured | Nerve Tissue Proteins - genetics | Organogenesis | Nerve Tissue Proteins - metabolism | Animals | Signal Transduction - physiology | Smad Proteins - metabolism | Medical colleges | Neurosciences | Neurons | Central nervous system | Bone morphogenetic proteins | Universities and colleges | DNA binding proteins | Proteins | Multiple sclerosis | Transcription factors | Rodents | Nervous system | Genomes | Kinases | Gene expression | Antagonism
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 7, p. e22463
Trypanosoma brucei and related pathogens transcribe most genes as polycistronic arrays that are subsequently processed into monocistronic mRNAs. Expression is... 
METHIONYL-TRANSFER-RNA | MESSENGER-RNA | SURFACE PROTEIN | BLOOD-STREAM FORMS | MULTIDISCIPLINARY SCIENCES | 3 UNTRANSLATED REGION | RIBONUCLEASE-P | GENE-EXPRESSION | INSECT FORMS | ARCHAEBACTERIUM SULFOLOBUS-ACIDOCALDARIUS | PROCYCLIN EXPRESSION SITE | RNA-Binding Proteins - genetics | Protein Biosynthesis | Immunoprecipitation | Membrane Glycoproteins - metabolism | Trypanosoma brucei brucei - metabolism | RNA, Messenger - genetics | RNA-Binding Proteins - chemistry | Cytoplasm - metabolism | Phylogeny | Protozoan Proteins - genetics | RNA, Messenger - metabolism | Membrane Glycoproteins - genetics | Protein Transport | Multiprotein Complexes - metabolism | Chromatography, Affinity | Protozoan Proteins - metabolism | Cytoplasmic Granules - metabolism | Protein Binding | Protozoan Proteins - chemistry | RNA-Binding Proteins - metabolism | Regulatory Sequences, Ribonucleic Acid - genetics | Glycerin | Messenger RNA | Genes | Glycerol | Binding proteins | Genetic translation | Cells | Protein binding | Post-transcription | Poly(A) | Yeast | Sucrose | Transcription | Midgut | Protein purification | Biological evolution | Material requirements planning | Ribosomal protein P0 | Biology | Regulatory sequences | Mammalian cells | Proteins | Plasticity (functional) | Ribonuclease P | Ribonuclease MRP | DNA-binding protein | User interface | Cell cycle | Cap-binding protein | Phylogenetics | Polyribosomes | Myelin P0 protein | Sugars | Deoxyribonucleic acid--DNA | Parasitology | Starvation | Translation | Nucleotide sequence | RNA-mediated interference | mRNA turnover | Archaea | Heat shock proteins | Gene expression | Ribonucleic acid--RNA | RNA-binding protein | Acids | Insects | 3' Untranslated regions | Phenols | Column chromatography | Life Sciences | Microbiology and Parasitology | RNA | Deoxyribonucleic acid | Ribonucleic acid | DNA
Journal Article
Journal of Immunology, ISSN 0022-1767, 06/2011, Volume 186, Issue 11, pp. 6345 - 6356
T cell membrane receptors and signaling molecules assemble at the immunological synapse (IS) in a supramolecular activation cluster (SMAC), organized into two... 
MICROCLUSTERS | DYNAMIC POLARIZATION | APICAL TRANSPORT | RAFT LIPIDS | RECEPTOR | ANCHORED PROTEINS | TYROSINE KINASES | IMMUNOLOGY | IMMUNOLOGICAL SYNAPSE | PLASMA-MEMBRANE | CELL-ACTIVATION | Endosomes - immunology | Membrane Microdomains - metabolism | Humans | Proteolipids - metabolism | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - immunology | Green Fluorescent Proteins - genetics | Endosomes - metabolism | Membrane Microdomains - immunology | Microtubules - metabolism | Proteolipids - immunology | RNA Interference | T-Lymphocytes - metabolism | Membrane Transport Proteins - genetics | Myelin and Lymphocyte-Associated Proteolipid Proteins | Adaptor Proteins, Signal Transducing - immunology | Myelin Proteins - immunology | Membrane Transport Proteins - metabolism | Membrane Proteins - metabolism | Amino Acid Sequence | Green Fluorescent Proteins - metabolism | Proteolipids - genetics | Jurkat Cells | Membrane Proteins - genetics | Cells, Cultured | Microtubules - immunology | Membrane Proteins - immunology | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - metabolism | Myelin Proteins - genetics | Protein Transport | Microscopy, Confocal | Models, Immunological | Adaptor Proteins, Signal Transducing - genetics | Immunological Synapses - immunology | Cell Line, Tumor | Protein Binding | T-Lymphocytes - immunology | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - genetics | Adaptor Proteins, Signal Transducing - metabolism | Membrane Transport Proteins - immunology | Myelin Proteins - metabolism
Journal Article