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Nature neuroscience, ISSN 1546-1726, 2017, Volume 21, Issue 1, pp. 24 - 28
Journal Article
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 502, Issue 7471, pp. 327 - 332
Progressive phases of multiple sclerosis are associated with inhibited differentiation of the progenitor cell population that generates the mature... 
OLIGODENDROCYTE DIFFERENTIATION | PROGENITOR CELLS | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | MUSCARINIC RECEPTOR SUBTYPES | THYROID-HORMONE | MYELIN REPAIR | MULTIDISCIPLINARY SCIENCES | EMBRYONIC STEM-CELLS | SPINAL-CORD | CENTRAL-NERVOUS-SYSTEM | PRECURSOR CELLS | Cuprizone - therapeutic use | Oligodendroglia - metabolism | Optic Nerve - cytology | Recurrence | Antiparkinson Agents - pharmacology | Coculture Techniques | Myelin Sheath - drug effects | Receptor, Muscarinic M1 - antagonists & inhibitors | Stem Cells - cytology | Myelin Proteolipid Protein - pharmacology | Myelin Sheath - metabolism | Antiparkinson Agents - therapeutic use | Oligodendroglia - drug effects | Cuprizone - pharmacology | Encephalomyelitis, Autoimmune, Experimental - chemically induced | Propylene Glycols - therapeutic use | Immune System - immunology | Female | Oligodendroglia - cytology | Benztropine - therapeutic use | Propylene Glycols - pharmacology | Encephalomyelitis, Autoimmune, Experimental - pathology | Myelin Sheath - pathology | Encephalomyelitis, Autoimmune, Experimental - drug therapy | Mice, Inbred C57BL | Receptor, Muscarinic M3 - metabolism | Fingolimod Hydrochloride | Rats | Receptor, Muscarinic M3 - antagonists & inhibitors | Oligodendroglia - pathology | Sphingosine - pharmacology | Regeneration - drug effects | Sphingosine - analogs & derivatives | Animals | Cell Differentiation - drug effects | Models, Biological | Immune System - drug effects | Multiple Sclerosis - pathology | Stem Cells - drug effects | Sphingosine - therapeutic use | Mice | Benztropine - pharmacology | Receptor, Muscarinic M1 - metabolism | Multiple Sclerosis - drug therapy | Benztropine | Multiple sclerosis | Myelination | Physiological aspects | Oligodendroglia | Dosage and administration | Drug therapy | Cell differentiation | Cell culture | Dopamine | Drug dosages | Rodents | Cell cycle
Journal Article
Nature (London), ISSN 1476-4687, 2015, Volume 522, Issue 7555, pp. 216 - 220
...As repair of damaged myelin may provide therapeutic benefit in multiple sclerosis (MS) and other demyelinating disorders (6-12), we set out to identify drugs... 
MYELIN BASIC-PROTEIN | TRANSCRIPTS | GLUCOCORTICOIDS | MULTIPLE-SCLEROSIS | LYSOLECITHIN | RNA-SEQ | MULTIDISCIPLINARY SCIENCES | SPINAL-CORD | CENTRAL-NERVOUS-SYSTEM | DIFFERENTIATION | OLIGODENDROCYTE PROGENITOR CELLS | Oligodendroglia - metabolism | Encephalomyelitis, Autoimmune, Experimental - metabolism | Humans | Cerebellum - drug effects | Myelin Sheath - drug effects | Male | Receptors, Glucocorticoid - metabolism | Demyelinating Diseases - metabolism | MAP Kinase Signaling System | Myelin Sheath - metabolism | Oligodendroglia - drug effects | Female | Oligodendroglia - cytology | Demyelinating Diseases - pathology | Demyelinating Diseases - drug therapy | Disease Models, Animal | Multiple Sclerosis - metabolism | Germ Layers - drug effects | Germ Layers - pathology | Encephalomyelitis, Autoimmune, Experimental - pathology | Lysophosphatidylcholines | Pluripotent Stem Cells - cytology | Germ Layers - metabolism | Tissue Culture Techniques | Cerebellum - metabolism | Encephalomyelitis, Autoimmune, Experimental - drug therapy | Cerebellum - pathology | Pluripotent Stem Cells - metabolism | Phenotype | Regeneration - drug effects | Animals | Cell Differentiation - drug effects | Miconazole - pharmacology | Pluripotent Stem Cells - drug effects | Multiple Sclerosis - pathology | Mice | Clobetasol - pharmacology | Mitogen-Activated Protein Kinases - metabolism | Multiple Sclerosis - drug therapy | Medical research | Myelination | Multiple sclerosis | Stem cells | Physiological aspects | Medicine, Experimental | Research | Drugs | Proteins | Blood-brain barrier | Laboratories | Rodents | Clinical trials | FDA approval | Gene expression
Journal Article
Nature Neuroscience, ISSN 1097-6256, 08/2011, Volume 14, Issue 8, pp. 1009 - 1016
... sheaths are lost throu... 
FUNCTIONAL INTERACTION | MULTIPLE-SCLEROSIS | CNS REMYELINATION | MYELINATION | SIGNALING PATHWAY | TRANSCRIPTION | DIFFERENTIATION | BETA-CATENIN | NEUROSCIENCES | WHITE-MATTER INJURY | NEGATIVE REGULATOR | Humans | Ki-67 Antigen - metabolism | Male | Brain Injuries - metabolism | Wnt Proteins - metabolism | Oligodendroglia - drug effects | Hypoxia-Ischemia, Brain - therapy | Infant, Newborn | Organ Culture Techniques | Disease Models, Animal | Animals, Newborn | Basic Helix-Loop-Helix Transcription Factors - genetics | Mice, Transgenic | Oligodendrocyte Transcription Factor 2 | Brain Injuries - therapy | Multiple Sclerosis - therapy | Myelin Proteins - genetics | beta Catenin - metabolism | Heterocyclic Compounds, 3-Ring - therapeutic use | Spinal Cord - physiology | Axin Protein | Mice | Myelin Sheath - ultrastructure | beta-Galactosidase - genetics | Cerebellum - ultrastructure | Myelin Proteins - metabolism | Corpus Callosum - metabolism | Spinal Cord - drug effects | Heterocyclic Compounds, 3-Ring - pharmacology | Myelin Proteins - therapeutic use | Cerebellum - drug effects | Myelin Sheath - drug effects | Hypoxia-Ischemia, Brain - pathology | Cerebral Cortex - cytology | Cytoskeletal Proteins - deficiency | Dose-Response Relationship, Drug | Oligodendroglia - physiology | Wnt Proteins - genetics | beta-Galactosidase - metabolism | Adult | Cytoskeletal Proteins - metabolism | Female | Demyelinating Diseases - chemically induced | Demyelinating Diseases - pathology | Neurons - drug effects | Cell Differentiation - physiology | Hypoxia-Ischemia, Brain - metabolism | Microscopy, Electron, Transmission | Myelin Sheath - pathology | Gene Expression Regulation - genetics | Cerebellum - metabolism | Cells, Cultured | Gene Expression Regulation - physiology | Corpus Callosum - drug effects | Nerve Tissue Proteins - genetics | beta Catenin - genetics | Multiple Sclerosis - complications | Nerve Tissue Proteins - metabolism | Animals | Cell Differentiation - drug effects | Multiple Sclerosis - pathology | Stem Cells - drug effects | Brain Injuries - etiology | Lysophosphatidylcholines - toxicity | Postmortem Changes | Infants (Newborn) | Brain | Care and treatment | Physiological aspects | Research | Binding proteins | Health aspects | Injuries
Journal Article
Brain, behavior, and immunity, ISSN 0889-1591, 2015, Volume 45, pp. 233 - 244
.... These developmental changes make the adolescent brain particularly vulnerable to neurotoxic and behavioral effects of alcohol... 
Psychiatry | Allergy and Immunology | Adolescence | Cognitive behavior | Myelin alterations | TLR4 | Synaptic dysfunction | Binge ethanol treatment | ACTIVATION | SUBSTANCE USE | DRUG-USE | PSYCHIATRY | RECEPTOR | HMGB1 | IMMUNOLOGY | CHILDHOOD | NEUROSCIENCES | PREFRONTAL CORTEX | ALCOHOL-USE | NEUROINFLAMMATION | BRAIN MATURATION | Central Nervous System Depressants - adverse effects | Cognition Disorders - chemically induced | Mitogen-Activated Protein Kinase Kinases - immunology | NF-kappa B - immunology | Myelin Sheath - drug effects | HMGB1 Protein - immunology | Synapses - genetics | Alcohol-Related Disorders - genetics | Myelin Proteins - drug effects | Central Nervous System Depressants - pharmacology | Nitric Oxide Synthase Type II - immunology | Ethanol - adverse effects | Cyclooxygenase 2 - immunology | Synapses - drug effects | Nitric Oxide Synthase Type II - drug effects | Toll-Like Receptor 4 - genetics | Synapses - ultrastructure | Cognition Disorders - genetics | Cyclooxygenase 2 - drug effects | HMGB1 Protein - drug effects | Cognition - drug effects | Mice, Knockout | Ethanol - pharmacology | Animals | Signal Transduction - drug effects | Myelin Sheath - genetics | Mitogen-Activated Protein Kinase Kinases - drug effects | Mice | Myelin Sheath - ultrastructure | Myelin Proteins - metabolism | NF-kappa B - drug effects | Alcohol | Alcohol, Denatured | Cognition disorders | Index Medicus
Journal Article
Developmental cell, ISSN 1534-5807, 2017, Volume 40, Issue 6, pp. 566 - 582.e5
A lack of sufficient oligodendrocyte myelination contributes to remyelination failure in demyelinating disorders. miRNAs have been implicated in... 
microRNAs | experimental autoimmune encephalomyelitis | Lingo1 | myelination | miR-338 | gene regulatory network | miR-219 | remyelination | demyelinating injury | Etv5 | OLIGODENDROCYTE DIFFERENTIATION | REGULATOR | MULTIPLE-SCLEROSIS | RECOGNITION | PRECURSOR DIFFERENTIATION | REMYELINATION | TARGETS | DEVELOPMENTAL BIOLOGY | GLIOGENESIS | LESIONS | MICRORNA | CELL BIOLOGY | Oligodendroglia - metabolism | Optic Nerve - pathology | Central Nervous System - metabolism | Spinal Cord - drug effects | Spinal Cord - metabolism | Demyelinating Diseases - genetics | Central Nervous System - pathology | Myelin Sheath - drug effects | MicroRNAs - metabolism | Cell Lineage - drug effects | Myelin Sheath - metabolism | Oligodendroglia - drug effects | Spinal Cord - pathology | Gene Deletion | Membrane Proteins - metabolism | Encephalomyelitis, Autoimmune, Experimental - genetics | Wound Healing - genetics | Demyelinating Diseases - pathology | Wound Healing - drug effects | Disease Models, Animal | Lecithins - pharmacology | Nerve Regeneration - genetics | Encephalomyelitis, Autoimmune, Experimental - pathology | Myelin Sheath - pathology | Mice, Inbred C57BL | Multiple Sclerosis - genetics | Optic Nerve - ultrastructure | Multiple Sclerosis - therapy | Disease Progression | Mice, Knockout | Nerve Tissue Proteins - metabolism | Phenotype | Animals | Cell Differentiation - drug effects | Nerve Regeneration - drug effects | Central Nervous System - drug effects | Multiple Sclerosis - pathology | MicroRNAs - genetics | Multiple sclerosis | Analysis | Biotin | Genetic engineering | Birth defects | Cells | Neurophysiology
Journal Article
Nature neuroscience, ISSN 1546-1726, 2005, Volume 8, Issue 6, pp. 745 - 751
... and of the agents that facilitate oligodendrocyte differentiation is central to developing therapies for demyelinating diseases, as damage to the myelin sheath disrupts axonal... 
NERVOUS-SYSTEM | NEUREGULIN | FYN TYROSINE KINASE | ACTIVATION | MORPHOLOGICAL-DIFFERENTIATION | SHEATH THICKNESS | SCHWANN-CELLS | EXPRESSION | NEUROSCIENCES | RECEPTOR FAMILY-MEMBER | MOLECULES | Oligodendroglia - metabolism | RNA Interference - drug effects | Central Nervous System - metabolism | Coculture Techniques | Humans | Rats, Long-Evans | Myelin-Associated Glycoprotein - genetics | Myelin-Associated Glycoprotein - metabolism | Proto-Oncogene Proteins c-fyn | Gene Expression Regulation, Developmental - genetics | rhoA GTP-Binding Protein - metabolism | Nerve Fibers, Myelinated - ultrastructure | Ranvier's Nodes - metabolism | Receptors, Cell Surface - antagonists & inhibitors | Central Nervous System - embryology | Oligodendroglia - ultrastructure | Ranvier's Nodes - ultrastructure | Myelin Sheath - metabolism | Central Nervous System - growth & development | Cell Differentiation - genetics | Oligodendroglia - drug effects | src-Family Kinases - metabolism | Myelin-Associated Glycoprotein - antagonists & inhibitors | RNA Interference - physiology | Nerve Fibers, Myelinated - metabolism | Proto-Oncogene Proteins - metabolism | Microscopy, Electron, Transmission | Nerve Fibers, Myelinated - drug effects | Cells, Cultured | Gene Expression Regulation, Developmental - drug effects | Rats | Receptors, Cell Surface - metabolism | Proto-Oncogene Proteins - genetics | Nerve Tissue Proteins | Ranvier's Nodes - genetics | Signal Transduction - genetics | Down-Regulation - drug effects | Down-Regulation - genetics | Mice, Knockout | Membrane Proteins | Animals | Signal Transduction - drug effects | Cell Differentiation - drug effects | Myelin Sheath - genetics | Mice | Myelin Sheath - ultrastructure | src-Family Kinases - genetics | Receptors, Cell Surface - genetics | Myelination | Central nervous system | Physiological aspects | Oligodendroglia | Genetic aspects | Research | Diagnosis
Journal Article