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Publication DateBiochemical journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Index Medicus | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | drug discovery | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | inhibitor specificity | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | anti-cancer drugs | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | protein kinase | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | kinase profiling | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
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Loading RightsThe New England journal of medicine, ISSN 0028-4793, 12/2011, Volume 365, Issue 25, pp. 2377 - 2388
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Neurology | General aspects | Cerebrospinal fluid. Meninges. Spinal cord | Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases | Biological and medical sciences | Medical sciences | Nervous system (semeiology, syndromes) | Humans | Middle Aged | Proteolipids - metabolism | Actins - metabolism | Male | Charcot-Marie-Tooth Disease - genetics | Young Adult | Kidney - metabolism | Glomerulosclerosis, Focal Segmental - etiology | Myelin and Lymphocyte-Associated Proteolipid Proteins | Adult | Female | Membrane Transport Proteins - metabolism | Microfilament Proteins - metabolism | Child | Microfilament Proteins - genetics | Charcot-Marie-Tooth Disease - complications | Schwann Cells - metabolism | Phenotype | Animals | Adolescent | Age of Onset | Heterozygote | Mice | Mutation | Myelin Proteins - metabolism | Glomerulonephritis | Gene mutations | Charcot-Marie-Tooth disease | Causes of | Genetic aspects | Research | Myelin proteins | Cdc42 protein | Disease | Exons | Genes | Amino acids | Nervous system | Neuropathy | Guanine nucleotide-binding protein | Proteins | Myelin P0 protein | Peripheral myelin protein 22 | Localization | Deoxyribonucleic acid--DNA | Kidneys | Schwann cells | Polymerization | Guanosine triphosphatases | Myelination | Genotyping | Biopsy | Glomerulus | Cytoskeleton | Genetic testing | Cytoplasm | Index Medicus | Abridged Index Medicus | Schwann Cells | Genomics | Kidney | Charcot-Marie-Tooth Disease | Life Sciences | Proteolipids | Biochemistry, Molecular Biology | Actins | Microfilament Proteins | Membrane Transport Proteins | Myelin Proteins | Glomerulosclerosis, Focal Segmental
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Loading RightsCell (Cambridge), ISSN 0092-8674, 2006, Volume 124, Issue 3, pp. 573 - 586
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Saccharomyces cerevisiae - genetics | Humans | Cercopithecus aethiops | Endoplasmic Reticulum - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Saccharomyces cerevisiae - metabolism | Transfection | Membrane Transport Proteins - genetics | Female | Membrane Transport Proteins - metabolism | Membrane Proteins - metabolism | Nogo Proteins | Membrane Proteins - classification | Intracellular Signaling Peptides and Proteins - genetics | Calcium Signaling | Recombinant Proteins - metabolism | Membrane Proteins - genetics | Oocytes - metabolism | Rats | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Saccharomyces cerevisiae Proteins - genetics | Membrane Transport Proteins - chemistry | Animals | Membrane Proteins - chemistry | Intracellular Signaling Peptides and Proteins - chemistry | Saccharomyces cerevisiae Proteins - metabolism | Myelin Proteins | In Vitro Techniques | COS Cells | Saccharomyces cerevisiae Proteins - chemistry | Usage | Physiological aspects | Immunoblotting | Research | Brewer's yeast | Endoplasmic reticulum | Membrane proteins | Lipids | Aquaporins | Synthesis | Index Medicus
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Loading RightsNature immunology, ISSN 1529-2908, 02/2006, Volume 7, Issue 2, pp. 148 - 155
Life Sciences & Biomedicine | Immunology | Science & Technology | Phosphorylation | Humans | Proteolipids - metabolism | Transcriptional Activation | Ubiquitin - metabolism | Suppressor of Cytokine Signaling 1 Protein | Suppressor of Cytokine Signaling Proteins - deficiency | Transcription Factor RelA - genetics | Proteolipids - immunology | Myelin and Lymphocyte-Associated Proteolipid Proteins | Mice, Inbred CBA | Myelin Proteins - immunology | Membrane Transport Proteins - metabolism | Toll-Like Receptors - metabolism | Carrier Proteins - immunology | Repressor Proteins - metabolism | Cell Line | Signal Transduction | Suppressor of Cytokine Signaling Proteins - immunology | Repressor Proteins - genetics | Suppressor of Cytokine Signaling Proteins - genetics | Toll-Like Receptor 2 - metabolism | Immunity, Innate | Toll-Like Receptor 4 - metabolism | Mice, Knockout | Carrier Proteins - genetics | Tyrosine - metabolism | Animals | Carrier Proteins - metabolism | Transcription Factor RelA - metabolism | Repressor Proteins - immunology | Mice | Suppressor of Cytokine Signaling Proteins - metabolism | Membrane Transport Proteins - immunology | Myelin Proteins - metabolism | Index Medicus
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Loading RightsThe Journal of immunology (1950), ISSN 0022-1767, 06/2011, Volume 186, Issue 11, pp. 6345 - 6356
Life Sciences & Biomedicine | Immunology | Science & Technology | Endosomes - immunology | Membrane Microdomains - metabolism | Humans | Proteolipids - metabolism | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - immunology | Green Fluorescent Proteins - genetics | Endosomes - metabolism | Membrane Microdomains - immunology | Microtubules - metabolism | Proteolipids - immunology | RNA Interference | T-Lymphocytes - metabolism | Membrane Transport Proteins - genetics | Myelin and Lymphocyte-Associated Proteolipid Proteins | Adaptor Proteins, Signal Transducing - immunology | Myelin Proteins - immunology | Membrane Transport Proteins - metabolism | Membrane Proteins - metabolism | Amino Acid Sequence | Green Fluorescent Proteins - metabolism | Proteolipids - genetics | Jurkat Cells | Membrane Proteins - genetics | Cells, Cultured | Microtubules - immunology | Membrane Proteins - immunology | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - metabolism | Myelin Proteins - genetics | Protein Transport | Microscopy, Confocal | Models, Immunological | Adaptor Proteins, Signal Transducing - genetics | Immunological Synapses - immunology | Cell Line, Tumor | Protein Binding | T-Lymphocytes - immunology | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - genetics | Adaptor Proteins, Signal Transducing - metabolism | Membrane Transport Proteins - immunology | Myelin Proteins - metabolism | Index Medicus | Abridged Index Medicus
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Loading RightsNeuron (Cambridge, Mass.), ISSN 0896-6273, 02/2012, Volume 73, Issue 4, pp. 713 - 728
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Central Nervous System - ultrastructure | Microcephaly - genetics | Oligonucleotide Array Sequence Analysis | Embryo, Mammalian | Homeodomain Proteins - metabolism | Humans | Nerve Tissue Proteins - deficiency | Caspase 3 - metabolism | Ki-67 Antigen - metabolism | Gene Expression Profiling | Green Fluorescent Proteins - genetics | RNA, Messenger - metabolism | Zinc Finger E-box Binding Homeobox 2 | Central Nervous System - physiology | Bone Morphogenetic Proteins - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Facies | Repressor Proteins - metabolism | Smad7 Protein - metabolism | Animals, Newborn | Basic Helix-Loop-Helix Transcription Factors - genetics | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Hirschsprung Disease - pathology | Intellectual Disability - pathology | Models, Molecular | Smad Proteins - genetics | Oligodendrocyte Transcription Factor 2 | Signal Transduction - genetics | Mice, Knockout | Central Nervous System - cytology | Mice | Optic Nerve - metabolism | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Oligodendroglia - metabolism | Immunoprecipitation | Age Factors | Hirschsprung Disease - genetics | Gene Expression Regulation, Developmental - genetics | Intellectual Disability - genetics | Myelin Sheath - metabolism | Cell Differentiation - genetics | Transfection | Microcephaly - pathology | Optic Nerve - embryology | Smad7 Protein - genetics | Optic Nerve - growth & development | Microscopy, Electron, Transmission | Cells, Cultured | Nerve Tissue Proteins - genetics | Organogenesis | Nerve Tissue Proteins - metabolism | Animals | Signal Transduction - physiology | Smad Proteins - metabolism | Medical colleges | Neurons | Central nervous system | Bone morphogenetic proteins | Universities and colleges | DNA binding proteins | Proteins | Multiple sclerosis | Transcription factors | Rodents | Nervous system | Genomes | Kinases | Gene expression | Index Medicus | Antagonism
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Loading RightsFEBS letters, ISSN 0014-5793, 09/2002, Volume 527, Issue 1-3, pp. 43 - 50
Arabidopsis thaliana | Mitogen-activated protein kinase | Hypoosmotic stress | Hyperosmotic stress | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Protein Kinases - metabolism | Osmotic Pressure | Calcium - metabolism | Microtubule-Associated Proteins - metabolism | Sodium Chloride - pharmacology | Molecular Sequence Data | Protein Tyrosine Phosphatases - metabolism | Dual Specificity Phosphatase 6 | Mannitol - pharmacology | Arabidopsis Proteins - metabolism | Apigenin | Flavonoids - pharmacology | Mitogen-Activated Protein Kinases - immunology | Suspensions | Phosphoprotein Phosphatases | Amino Acid Sequence | Protein Kinases - drug effects | Arabidopsis - drug effects | Signal Transduction | Cells, Cultured | Arabidopsis - metabolism | Protein Kinases - immunology | Enzyme Activation | Mitogen-Activated Protein Kinases - drug effects | Mitogen-Activated Protein Kinases - metabolism | Viral antibodies | Tyrosine | Phosphatases | Antibodies | Mitogens | Protein kinases | Myelin proteins | Index Medicus | Mitogen-Activated Protein Kinases | Sodium Chloride | Calcium | Arabidopsis | Microtubule-Associated Proteins | Phosphoprotein Phosphatase | Protein-Tyrosine-Phosphatase | Life Sciences | Flavonoids | Arabidopsis Proteins | Protein Kinases | Mannitol | Vegetal Biology
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Loading RightsScientific reports, ISSN 2045-2322, 2012, Volume 2, Issue 1, pp. 899 - 899
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Actins - metabolism | Actins - ultrastructure | Molecular Sequence Data | Muscle, Skeletal - metabolism | Solutions - chemistry | Swine | X-Ray Diffraction | Actins - chemistry | Carrier Proteins - chemistry | Microfilament Proteins - metabolism | Circular Dichroism | Microfilament Proteins - genetics | Recombinant Proteins - metabolism | Amino Acid Sequence | Microfilament Proteins - chemistry | Protein Structure, Secondary | Rats | Recombinant Proteins - chemistry | Scattering, Small Angle | Microscopy, Electron | Sequence Homology, Amino Acid | Algorithms | Animals | Carrier Proteins - metabolism | Protein Binding | Software | Proteins | Spectroscopy | X-ray scattering | Myelin | Microfilaments | Actin | Oligodendrocytes | Central nervous system | Polymerization | Data processing | X radiation | Sedimentation | Index Medicus
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