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Nature, ISSN 0028-0836, 06/2018, Volume 558, Issue 7708, pp. 73 - 79
Journal Article
Blood, ISSN 0006-4971, 12/2007, Volume 110, Issue 12, pp. 4086 - 4095
Proteinase 3 (PR3), a serine proteinase contained in neutrophil azurophilic granules, is considered a risk factor for vasculitides and rheumatoid arthritis... 
MEMBRANE PROTEINASE-3 | IN-VITRO | TYROSINE PHOSPHORYLATION | SECRETORY VESICLES | DOWN-REGULATION | ANNEXIN-V | ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES | SERINE-PROTEASE | TNF-ALPHA | HEMATOLOGY | PLASMA-MEMBRANE | Neutrophil Activation - genetics | RNA, Small Interfering - genetics | Humans | Apoptosis - genetics | Phospholipid Transfer Proteins - immunology | Phagocytosis - genetics | Myeloblastin - genetics | Antigens, CD - genetics | Antibodies, Antineutrophil Cytoplasmic - immunology | Antigens, CD - metabolism | Pancreatic Elastase - immunology | Protein Transport - immunology | Secretory Vesicles - immunology | Secretory Vesicles - genetics | Vasculitis - genetics | Pancreatic Elastase - genetics | Neutrophils - metabolism | Granulomatosis with Polyangiitis - enzymology | Neutrophil Activation - immunology | Neutrophils - enzymology | Risk Factors | Rats | Arthritis, Rheumatoid - enzymology | Mast Cells - enzymology | Protein Transport - genetics | Macrophages - enzymology | Arthritis, Rheumatoid - genetics | Phospholipid Transfer Proteins - genetics | Cell Membrane - immunology | Antigens, CD - immunology | Cell Membrane - genetics | Mutation - immunology | Phospholipid Transfer Proteins - metabolism | Vasculitis - immunology | Granulomatosis with Polyangiitis - genetics | Antibodies, Antineutrophil Cytoplasmic - metabolism | RNA, Small Interfering - immunology | Granulomatosis with Polyangiitis - immunology | Secretory Vesicles - enzymology | Macrophages - immunology | Myeloblastin - metabolism | Cell Line | Mast Cells - immunology | Peroxidase - immunology | Myeloblastin - immunology | Neutrophils - immunology | Phagocytosis - immunology | Pancreatic Elastase - metabolism | Cell Membrane - enzymology | Animals | Apoptosis - immunology | Vasculitis - enzymology | Peroxidase - genetics | Gene Expression Regulation, Enzymologic - immunology | Arthritis, Rheumatoid - immunology | Peroxidase - metabolism
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 07/2012, Volume 367, Issue 3, pp. 214 - 223
Journal Article
Nature, ISSN 0028-0836, 06/2018, Volume 558, Issue 7708, p. 73
Journal Article
American Journal of Kidney Diseases, ISSN 0272-6386, 2013, Volume 62, Issue 6, pp. 1176 - 1187
The antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAVs) comprise granulomatosis with polyangiitis (GPA), primarily associated with... 
Nephrology | microscopic polyangiitis (MPA) | pathogenesis | granulomatosis with polyangiitis (GPA) | Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis | antibodies to myeloperoxidase (MPO-ANCA) | antibodies to proteinase 3 (PR3-ANCA) | WEGENERS-GRANULOMATOSIS | CRESCENTIC GLOMERULONEPHRITIS | HUMAN NEUTROPHILS | POLYANGIITIS WEGENERS | SMALL-VESSEL VASCULITIS | INTERACTIONS IN-VIVO | T-CELL-ACTIVATION | ENDOTHELIAL-CELLS | UROLOGY & NEPHROLOGY | ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES | PROTEINASE-3 PR3 | Genetic Predisposition to Disease - genetics | Peroxidase - immunology | Polyarteritis Nodosa - immunology | Staphylococcal Infections - genetics | Myeloblastin - immunology | Humans | Glomerulonephritis - genetics | Glomerulonephritis - immunology | Polyarteritis Nodosa - genetics | Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - genetics | Silicon Dioxide - adverse effects | Staphylococcal Infections - complications | Gene-Environment Interaction | Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - immunology | Complement Pathway, Alternative - immunology | Peroxidase - genetics | T-Lymphocytes - immunology | Microscopic Polyangiitis - immunology | Churg-Strauss Syndrome - immunology | Complement Pathway, Alternative - genetics | Histocompatibility Antigens Class II - genetics | Churg-Strauss Syndrome - genetics | Microscopic Polyangiitis - genetics
Journal Article
Arthritis & Rheumatology, ISSN 2326-5191, 05/2017, Volume 69, Issue 5, pp. 1054 - 1066
Objective To identify risk alleles relevant to the causal and biologic mechanisms of antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV).... 
WEGENERS-GRANULOMATOSIS | RACE/ETHNICITY | VARIANTS | DISEASE | GENE-EXPRESSION | PROTEINASE-3 PR3 | POLYANGIITIS WEGENERS | PEPTIDE BINDING | RHEUMATOLOGY | T-CELLS | HLA-DP EXPRESSION | Haplotypes | Humans | Middle Aged | Male | Monocytes - metabolism | Myeloblastin - genetics | Case-Control Studies | Granulomatosis with Polyangiitis - genetics | T-Lymphocytes - metabolism | Adult | Female | Odds Ratio | Neutrophils - metabolism | B-Lymphocytes - metabolism | Gene Expression | Genetic Predisposition to Disease | Genome-Wide Association Study | Peroxidase - immunology | alpha 1-Antitrypsin - genetics | Myeloblastin - immunology | Protein Tyrosine Phosphatase, Non-Receptor Type 22 - genetics | Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - genetics | HLA-DP beta-Chains - genetics | HLA-DP beta-Chains - metabolism | Autoantigens - immunology | HLA-DP Antigens - metabolism | T-Lymphocytes - immunology | Polymorphism, Single Nucleotide | Microscopic Polyangiitis - genetics | Pathogenesis | Proteinase | Granulomatosis | Scoring | Risk | Genomes | Lymphocytes T | Single-nucleotide polymorphism | Proteins | Vasculitis | Etiology | Lymphocytes | Antineutrophil cytoplasmic antibodies | Peroxidase | Health risks | Data processing | Leukocytes (neutrophilic) | Gene expression | Patients | DPB1 gene | Loci | DP protein | Monocytes | Lymphocytes B | Correlation analysis | Histocompatibility antigen HLA | Proteinase 3 | Protein-tyrosine-phosphatase | Polymorphism
Journal Article
Cell Reports, ISSN 2211-1247, 02/2016, Volume 14, Issue 7, pp. 1761 - 1773
Interleukin (IL)-11 has been shown to be a crucial factor for intestinal tumorigenesis, lung carcinomas, and asthma. IL-11 is thought to exclusively mediate... 
ADAM10 | ADAM17 | interleukin-11 | signal transduction | proteolysis | Signal transduction | Interleukin-11 | Proteolysis | MURINE INTERLEUKIN-11 | INFLAMMATION | GLYCOPROTEIN 130 | FAMILY CYTOKINE | SOLUBLE IL-6 | RECEPTOR ALPHA-CHAIN | EXPRESSION | TUMORIGENESIS | IL-6 RECEPTOR | CELL BIOLOGY
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2011, Volume 286, Issue 28, pp. 24638 - 24648
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2008, Volume 283, Issue 51, pp. 35976 - 35982
Proteinase 3 (PR3), the target antigen of antineutrophil cytoplasm autoantibodies, which are found in patients with Wegener granulomatosis, is a neutrophil... 
SITE | ANCA | BIOCHEMISTRY & MOLECULAR BIOLOGY | SURFACE | AUTOANTIGEN | CATHEPSIN-G | NEUTROPHIL ELASTASE | PLASMA-MEMBRANE | POLYMORPHONUCLEAR NEUTROPHILS | ANTIGEN | CD177 | Leukocyte Elastase - metabolism | Hylobates | Membrane Glycoproteins - metabolism | Species Specificity | Humans | GPI-Linked Proteins | Myeloblastin - genetics | Antibodies, Antineutrophil Cytoplasmic - immunology | Granulomatosis with Polyangiitis - genetics | Antibodies, Antineutrophil Cytoplasmic - metabolism | Granulomatosis with Polyangiitis - immunology | Isoantigens - immunology | Serine Endopeptidases - genetics | Serine Endopeptidases - immunology | Membrane Glycoproteins - immunology | Myeloblastin - metabolism | Cathepsins - immunology | Cell Line | Isoantigens - metabolism | Isoantigens - genetics | Myeloblastin - immunology | Cathepsin G | Leukocyte Elastase - genetics | Receptors, Cell Surface - metabolism | Antibodies, Antineutrophil Cytoplasmic - genetics | Receptors, Cell Surface - immunology | Membrane Glycoproteins - genetics | Protein Structure, Secondary - genetics | Animals | Cathepsins - genetics | Cathepsins - metabolism | Granulomatosis with Polyangiitis - metabolism | Hydrophobic and Hydrophilic Interactions | Protein Binding | Serine Endopeptidases - metabolism | Leukocyte Elastase - immunology | Receptors, Cell Surface - genetics
Journal Article
Journal of the American Society of Nephrology, ISSN 1046-6673, 02/2015, Volume 26, Issue 2, pp. 390 - 399
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2008, Volume 283, Issue 15, pp. 9513 - 9522
Journal Article
Molecular and Cellular Probes, ISSN 0890-8508, 12/2016, Volume 30, Issue 6, pp. 366 - 373
Journal Article