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Nature communications, ISSN 2041-1723, 07/2017, Volume 8, Issue 1, pp. 16078 - 16078
.... Using small cell lung cancer (SCLC) as a model, we demonstrated the presence of differential addiction of cancer cells to anti-apoptotic BCL-2, BCL-XL or MCL-1, which correlated with the respective protein expression ratio. ABT-263 (navitoclax... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Lung Neoplasms - drug therapy | Apoptosis - drug effects | Humans | Lung Neoplasms - metabolism | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | Drug Resistance, Neoplasm | Molecular Targeted Therapy | Apoptosis Regulatory Proteins - drug effects | Myeloid Cell Leukemia Sequence 1 Protein - drug effects | Small Cell Lung Carcinoma - drug therapy | Small Cell Lung Carcinoma - metabolism | bcl-X Protein - drug effects | Proto-Oncogene Proteins c-bcl-2 - metabolism | bcl-X Protein - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Myeloid Cell Leukemia Sequence 1 Protein - antagonists & inhibitors | Aniline Compounds - pharmacology | Cyclin-Dependent Kinase 9 - antagonists & inhibitors | Sulfonamides - pharmacology | Apoptosis Regulatory Proteins - metabolism | Drug Synergism | Pyridinium Compounds - pharmacology | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | High-Throughput Screening Assays | Apoptosis Regulatory Proteins - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-2 - drug effects | Cell Line, Tumor | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | bcl-X Protein - metabolism | Doxorubicin - pharmacology | Regulators | Bax protein | Bcl-2 protein | Small cell lung carcinoma | Lung cancer | High-throughput screening | Doxorubicin | BAK protein | Mcl-1 protein | Proteins | Mitochondria | Inhibitors | Bcl-x protein | Anthracycline | Addiction | Cell death | Sequestering | Cancer | Apoptosis | Index Medicus
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 03/2016, Volume 291, Issue 13, pp. 6689 - 6695
Journal Article
Cancer cell, ISSN 1535-6108, 11/2006, Volume 10, Issue 5, pp. 375 - 388
BCL-2 proteins are critical for cell survival and are overexpressed in many tumors... 
CELLCYCLE | Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | RNA, Small Interfering - genetics | bcl-2-Associated X Protein - chemistry | Humans | Leukemia, Myeloid, Acute - metabolism | Nitrophenols - metabolism | bcl-2 Homologous Antagonist-Killer Protein - genetics | Piperazines - metabolism | Neoplasm Proteins - metabolism | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Biphenyl Compounds - metabolism | Biphenyl Compounds - therapeutic use | Recombinant Fusion Proteins - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Nitrophenols - therapeutic use | Hematopoietic Stem Cells - physiology | Leukemia, Myeloid, Acute - drug therapy | Proto-Oncogene Proteins c-bcl-2 - chemistry | Dimerization | bcl-2-Associated X Protein - genetics | Protein Structure, Tertiary | Cell Line | bcl-2-Associated X Protein - metabolism | Piperazines - therapeutic use | Animals | Sulfonamides - therapeutic use | Myeloid Cell Leukemia Sequence 1 Protein | Sulfonamides - metabolism | Recombinant Fusion Proteins - genetics | Protein Conformation | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Mice | Apoptosis - physiology | Drug Resistance, Neoplasm - physiology | Proto-Oncogene Proteins c-bcl-2 - genetics | RNA, Small Interfering - metabolism | Proteins | Oncology, Experimental | Lung cancer | Bone marrow | Transplantation | Lymphomas | Research | Hematopoietic stem cells | Cancer | Apoptosis | Index Medicus
Journal Article
Leukemia, ISSN 1476-5551, 02/2015, Volume 29, Issue 6, pp. 1290 - 1300
PTPN11 encodes the Shp2 non-receptor protein-tyrosine phosphatase implicated in several signaling pathways... 
Oncology | Life Sciences & Biomedicine | Hematology | Science & Technology | RNA, Small Interfering - genetics | Oncogene Proteins, Fusion - metabolism | Cell Proliferation | Neoplastic Stem Cells - drug effects | Humans | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | Interleukin-3 - pharmacology | Clinical Trials, Phase III as Topic | Leukemia, Myeloid, Acute - drug therapy | Neoplastic Stem Cells - pathology | Female | Tumor Cells, Cultured | Real-Time Polymerase Chain Reaction | Myeloid Cell Leukemia Sequence 1 Protein - antagonists & inhibitors | Leukemia, Myeloid, Acute - pathology | Mice, Inbred C57BL | RNA, Messenger - genetics | Mutation - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Myeloid Cell Leukemia Sequence 1 Protein - genetics | Drug Resistance, Neoplasm - genetics | Animals | Apoptosis Regulatory Proteins | Oncogene Proteins, Fusion - genetics | Mice | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | Apoptosis | Leukemia, Myeloid, Acute - genetics | Genetic aspects | Gene mutations | Drug resistance | Identification and classification | Health aspects | Translocation | Tyrosine | Myelomonocytic leukemia | Myeloid leukemia | Leukemia | Genes | Hypersensitivity | Drug delivery | Gene expression | Neoplasms | Mcl-1 protein | Mutants | Sensitivity | Bcl-x protein | Interleukin 3 | Transcription activation | Stem cells | Leukemogenesis | Mutation | Acute myeloid leukemia | Protein-tyrosine-phosphatase | Index Medicus
Journal Article
Blood, ISSN 1528-0020, 07/2015, Volume 126, Issue 3, pp. 363 - 372
Journal Article
Nature (London), ISSN 1476-4687, 10/2016, Volume 538, Issue 7626, pp. 477 - 482
.... The pro-survival protein myeloid cell leukemia 1 (MCL1) is overexpressed in many cancers, but the development of small molecules targeting this protein that are amenable for clinical testing has been challenging... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Neoplasms - metabolism | Thiophenes - therapeutic use | Leukemia - pathology | Apoptosis - drug effects | Humans | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | Male | Antineoplastic Agents - therapeutic use | Leukemia - metabolism | Thiophenes - administration & dosage | Antineoplastic Agents - administration & dosage | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Lymphoma - metabolism | Lymphoma - drug therapy | Multiple Myeloma - drug therapy | Myeloid Cell Leukemia Sequence 1 Protein - chemistry | Female | Lymphoma - pathology | Antineoplastic Agents - pharmacology | Myeloid Cell Leukemia Sequence 1 Protein - antagonists & inhibitors | Pyrimidines - administration & dosage | bcl-2-Associated X Protein - metabolism | Leukemia - drug therapy | Models, Molecular | Thiophenes - pharmacology | Pyrimidines - pharmacology | Multiple Myeloma - metabolism | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Multiple Myeloma - pathology | Animals | Models, Biological | Pyrimidines - therapeutic use | Cell Line, Tumor | Mice | Neoplasms - pathology | Myelocytic leukemia | Physiological aspects | Nonlymphoid leukemia | Metastasis | Observations | Health aspects | Apoptosis | Proteins | Studies | Multiple myeloma | Cytotoxicity | Kinases | Drug dosages | Tumors | Cancer | Crystal structure | Index Medicus
Journal Article
Nature cell biology, ISSN 1465-7392, 09/2017, Volume 19, Issue 10, pp. 1226 - 1236
.... Anti-apoptotic BCL-2 proteins engage a BCL-2 homology (BH) domain sequence found in SUFU (suppressor of fused... 
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Neoplasms - metabolism | NIH 3T3 Cells | Transcription, Genetic - drug effects | Cell Proliferation | Zinc Finger Protein GLI1 - metabolism | Humans | Gene Expression Regulation, Neoplastic | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | bcl-X Protein - genetics | Proto-Oncogene Proteins c-bcl-2 - metabolism | Molecular Mimicry | Transfection | Neoplasms - genetics | RNA Interference | Time Factors | Tumor Suppressor Proteins - genetics | HEK293 Cells | Female | Antineoplastic Agents - pharmacology | Myeloid Cell Leukemia Sequence 1 Protein - deficiency | Repressor Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Peptide Fragments - metabolism | Tumor Suppressor Proteins - metabolism | Signal Transduction | Cell Survival | Zinc Finger Protein GLI1 - genetics | Repressor Proteins - genetics | Genotype | Myeloid Cell Leukemia Sequence 1 Protein - genetics | Mice, Knockout | Neoplasms - drug therapy | Phenotype | Animals | Mice, Nude | CRISPR-Cas Systems | Mice | Neoplasms - pathology | bcl-X Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Apoptosis | Genes | Genetic aspects | Genetic transcription | Drug resistance | Binding proteins | Tumors | Protein binding | Regulators | Cell survival | Bcl-2 protein | Transcription | Decision making | Homology | Gene expression | Mcl-1 protein | Proteins | Signaling | Mitochondria | DNA-binding protein | Bcl-x protein | Cell death | Feedforward | Deoxyribonucleic acid--DNA | Cancer | Index Medicus
Journal Article