X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (20198) 20198
Book Review (4315) 4315
Publication (2711) 2711
Book Chapter (145) 145
Conference Proceeding (34) 34
Dissertation (11) 11
Newsletter (11) 11
Book / eBook (7) 7
Data Set (2) 2
Magazine Article (2) 2
Government Document (1) 1
Presentation (1) 1
Reference (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (18275) 18275
humans (16264) 16264
oncology (7732) 7732
animals (6516) 6516
acute myeloid-leukemia (6182) 6182
hematology (5764) 5764
cancer (5191) 5191
leukemia (5130) 5130
female (4225) 4225
mice (4042) 4042
male (3966) 3966
apoptosis (3813) 3813
cell biology (3460) 3460
research (3250) 3250
cell line, tumor (3106) 3106
biochemistry & molecular biology (3093) 3093
gene expression (3082) 3082
genetic aspects (3004) 3004
mutation (2944) 2944
expression (2868) 2868
proteins (2702) 2702
middle aged (2621) 2621
adult (2603) 2603
leukemia, myeloid, acute - genetics (2529) 2529
analysis (2171) 2171
acute myeloid leukemia (2127) 2127
aged (2057) 2057
hemic and lymphatic diseases (1959) 1959
article (1947) 1947
chronic myeloid-leukemia (1943) 1943
genes (1913) 1913
genetics & heredity (1853) 1853
apoptosis - drug effects (1830) 1830
health aspects (1754) 1754
acute lymphoblastic-leukemia (1753) 1753
molecular sequence data (1743) 1743
stem cells (1734) 1734
base sequence (1706) 1706
signal transduction (1680) 1680
prognosis (1579) 1579
cells (1520) 1520
gene (1492) 1492
myeloid cell leukemia sequence 1 protein (1472) 1472
antineoplastic agents - pharmacology (1469) 1469
chronic myelogenous leukemia (1458) 1458
differentiation (1448) 1448
multidisciplinary sciences (1444) 1444
care and treatment (1395) 1395
chronic myeloid leukemia (1385) 1385
physiological aspects (1355) 1355
chemotherapy (1330) 1330
tumors (1292) 1292
leukemia, myeloid, acute - pathology (1283) 1283
kinases (1278) 1278
myeloid leukemia (1274) 1274
immunology (1266) 1266
proto-oncogene proteins c-bcl-2 - metabolism (1237) 1237
medicine, research & experimental (1228) 1228
cell line (1221) 1221
gene-expression (1207) 1207
research article (1207) 1207
cell proliferation (1201) 1201
reverse transcriptase polymerase chain reaction (1176) 1176
activation (1173) 1173
tumor cells, cultured (1169) 1169
adolescent (1140) 1140
phosphorylation (1137) 1137
dna methylation (1132) 1132
antineoplastic agents - therapeutic use (1097) 1097
bone marrow (1097) 1097
medicine (1097) 1097
acute myelogenous leukemia (1095) 1095
gene expression regulation, neoplastic (1092) 1092
hematology, oncology and palliative medicine (1091) 1091
polymerase chain reaction (1088) 1088
amino acid sequence (1078) 1078
transcription factors (1077) 1077
pharmacology & pharmacy (1067) 1067
dna-binding proteins - genetics (1051) 1051
cell differentiation (1034) 1034
myeloid-leukemia (1024) 1024
aml (1023) 1023
neoplasm proteins - genetics (1018) 1018
abridged index medicus (997) 997
biology (989) 989
flow cytometry (986) 986
down-regulation (980) 980
development and progression (968) 968
leukemia, myeloid, acute - metabolism (963) 963
translocation, genetic (958) 958
mutations (954) 954
cell cycle (950) 950
transcription factors - genetics (945) 945
aged, 80 and over (937) 937
leukemia, myelogenous, chronic, bcr-abl positive - genetics (936) 936
child (935) 935
methylation (928) 928
rna, messenger - genetics (919) 919
leukemia, myeloid - genetics (910) 910
genetics (909) 909
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (20205) 20205
Chinese (45) 45
Russian (10) 10
French (7) 7
German (7) 7
Japanese (6) 6
Korean (1) 1
Polish (1) 1
Portuguese (1) 1
Spanish (1) 1
Turkish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Nature, ISSN 0028-0836, 2016, Volume 538, Issue 7626, pp. 477 - 482
Avoidance of apoptosis is critical for the development and sustained growth of tumours. The pro-survival protein myeloid cell leukemia 1 (MCL1) is... 
MULTIPLE-MYELOMA | SURVIVAL | ANTI-APOPTOTIC MCL-1 | PROTEIN | DEPENDENCY | BCL-XL | MULTIDISCIPLINARY SCIENCES | HIGH-AFFINITY | TUMOR-CELLS | COMBINATION | NAVITOCLAX | Neoplasms - metabolism | Thiophenes - therapeutic use | Leukemia - pathology | Apoptosis - drug effects | Humans | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | Male | Antineoplastic Agents - therapeutic use | Leukemia - metabolism | Thiophenes - administration & dosage | Antineoplastic Agents - administration & dosage | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Lymphoma - metabolism | Lymphoma - drug therapy | Multiple Myeloma - drug therapy | Myeloid Cell Leukemia Sequence 1 Protein - chemistry | Female | Lymphoma - pathology | Antineoplastic Agents - pharmacology | Myeloid Cell Leukemia Sequence 1 Protein - antagonists & inhibitors | Pyrimidines - administration & dosage | bcl-2-Associated X Protein - metabolism | Leukemia - drug therapy | Models, Molecular | Thiophenes - pharmacology | Pyrimidines - pharmacology | Multiple Myeloma - metabolism | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Multiple Myeloma - pathology | Animals | Models, Biological | Pyrimidines - therapeutic use | Cell Line, Tumor | Mice | Neoplasms - pathology | Myelocytic leukemia | Physiological aspects | Nonlymphoid leukemia | Metastasis | Observations | Health aspects | Apoptosis | Proteins | Studies | Multiple myeloma | Cytotoxicity | Kinases | Drug dosages | Tumors | Cancer | Crystal structure | Index Medicus
Journal Article
Journal Article
Nature Immunology, ISSN 1529-2908, 02/2016, Volume 17, Issue 2, pp. 179 - 186
Intestinal T cells and group 3 innate lymphoid cells (ILC3 cells) control the composition of the microbiota and gut immune responses. Within the gut, ILC3... 
IL-22 PRODUCTION | NATURAL-KILLER-CELLS | NK CELLS | COMMENSAL BACTERIA | INFLAMMATION | HOST-DEFENSE | INTERLEUKIN-22 | INFECTION | T-CELL | IMMUNOLOGY | LYMPHOCYTES | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | Transcriptome | Homeostasis | Male | Gene Expression Profiling | Lymphocyte Subsets - immunology | Enterobacteriaceae Infections - immunology | Lymphocyte Subsets - metabolism | Lymphocytes - immunology | Enterobacteriaceae Infections - genetics | Female | Interleukins - biosynthesis | Myeloid Cell Leukemia Sequence 1 Protein - deficiency | Disease Models, Animal | Lymphocytes - metabolism | Citrobacter rodentium - immunology | Signal Transduction | T-Box Domain Proteins - deficiency | Enterobacteriaceae Infections - metabolism | Enterobacteriaceae Infections - mortality | Gene Expression Regulation | Mice, Transgenic | Enterobacteriaceae Infections - pathology | Immunity, Innate | T-Box Domain Proteins - genetics | Myeloid Cell Leukemia Sequence 1 Protein - genetics | T-Box Domain Proteins - metabolism | Mice, Knockout | Animals | Natural Cytotoxicity Triggering Receptor 1 - metabolism | Mice | Cluster Analysis | Complications and side effects | Care and treatment | Microbiota (Symbiotic organisms) | Interleukins | Gastrointestinal diseases | Influence | Research | Health aspects | Index Medicus | Life Sciences | Immunology
Journal Article
Cancer Cell, ISSN 1535-6108, 2006, Volume 10, Issue 5, pp. 375 - 388
BCL-2 proteins are critical for cell survival and are overexpressed in many tumors. ABT-737 is a small-molecule BH3 mimetic that exhibits single-agent activity... 
CELLCYCLE | PROGRAMMED CELL-DEATH | CANCER-CELLS | STEM-CELLS | PROAPOPTOTIC ACTIVITY | ONCOLOGY | X-L | ACUTE MYELOGENOUS LEUKEMIA | IN-VIVO | MITOCHONDRIAL-MEMBRANE | BCL-2 FAMILY-MEMBERS | BH3-ONLY PROTEINS | RNA, Small Interfering - genetics | bcl-2-Associated X Protein - chemistry | Humans | Leukemia, Myeloid, Acute - metabolism | Nitrophenols - metabolism | bcl-2 Homologous Antagonist-Killer Protein - genetics | Piperazines - metabolism | Neoplasm Proteins - metabolism | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Biphenyl Compounds - metabolism | Biphenyl Compounds - therapeutic use | Recombinant Fusion Proteins - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Nitrophenols - therapeutic use | Hematopoietic Stem Cells - physiology | Leukemia, Myeloid, Acute - drug therapy | Proto-Oncogene Proteins c-bcl-2 - chemistry | Dimerization | bcl-2-Associated X Protein - genetics | Protein Structure, Tertiary | Cell Line | bcl-2-Associated X Protein - metabolism | Piperazines - therapeutic use | Animals | Sulfonamides - therapeutic use | Myeloid Cell Leukemia Sequence 1 Protein | Sulfonamides - metabolism | Recombinant Fusion Proteins - genetics | Protein Conformation | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Mice | Apoptosis - physiology | Drug Resistance, Neoplasm - physiology | Proto-Oncogene Proteins c-bcl-2 - genetics | RNA, Small Interfering - metabolism | Proteins | Oncology, Experimental | Lung cancer | Bone marrow | Transplantation | Lymphomas | Research | Hematopoietic stem cells | Cancer | Apoptosis | Index Medicus
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 02/2012, Volume 30, Issue 5, pp. 488 - 496
Purpose BCL2 overexpression is a hallmark of chronic lymphocytic leukemia (CLL). The novel BH3 mimetic navitoclax (ABT-263) specifically inhibits BCL2 and... 
APOPTOSIS | LYMPHOMA-CELLS | ANTAGONIST ABT-737 | ONCOLOGY | SENSITIVITY | RESISTANCE | BH3 MIMETIC ABT-737 | CANCER | CHEMOTHERAPY | CELL-DEATH | FAMILY | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Male | Antineoplastic Agents - administration & dosage | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Proto-Oncogene Proteins c-bcl-2 - metabolism | Bcl-2-Like Protein 11 | Antineoplastic Agents - adverse effects | Biomarkers, Tumor - metabolism | Female | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Membrane Proteins - metabolism | Aniline Compounds - administration & dosage | Chromosome Deletion | Proto-Oncogene Proteins - metabolism | Aniline Compounds - pharmacology | Drug Administration Schedule | Administration, Oral | In Situ Hybridization, Fluorescence | Treatment Outcome | Thrombocytopenia - chemically induced | Aniline Compounds - pharmacokinetics | Sulfonamides - pharmacology | Sulfonamides - pharmacokinetics | Apoptosis Regulatory Proteins - metabolism | Leukemia, Lymphocytic, Chronic, B-Cell - metabolism | Myeloid Cell Leukemia Sequence 1 Protein | Sulfonamides - adverse effects | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Aged | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Aniline Compounds - adverse effects | Sulfonamides - administration & dosage | Index Medicus | Hema7 | ORIGINAL REPORTS
Journal Article
Journal Article
Blood, ISSN 0006-4971, 07/2015, Volume 126, Issue 3, pp. 363 - 372
Overexpression of antiapoptotic Bcl-2 proteins such as Bcl-2, Bcl-xL, and Mcl-1 is widely associated with tumor initiation, progression, and chemoresistance.... 
SURVIVAL | ANTI-APOPTOTIC MCL-1 | POTENT | BIM | BAX | ANTITUMOR-ACTIVITY | PROTEINS | CLEAVAGE | HEMATOLOGY | BCL-2 FAMILY | CELL-DEATH | Immunoprecipitation | Apoptosis - drug effects | Neoplastic Stem Cells - drug effects | Humans | Leukemia, Myeloid, Acute - metabolism | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | Stem Cells - cytology | Stem Cells - metabolism | Immunoenzyme Techniques | Proto-Oncogene Proteins c-bcl-2 - metabolism | Mesenchymal Stromal Cells - cytology | Flow Cytometry | Biphenyl Compounds - pharmacology | Neoplastic Stem Cells - metabolism | Nitrophenols - pharmacology | Leukemia, Myeloid, Acute - drug therapy | Neoplastic Stem Cells - pathology | Female | Tumor Cells, Cultured | Mesenchymal Stromal Cells - drug effects | Myeloid Cell Leukemia Sequence 1 Protein - antagonists & inhibitors | Leukemia, Myeloid, Acute - pathology | Mesenchymal Stromal Cells - metabolism | Naphthoquinones - pharmacology | Mice, SCID | Sulfonamides - pharmacology | Piperazines - pharmacology | Blotting, Western | Xenograft Model Antitumor Assays | Gossypol - pharmacology | Animals | Gossypol - analogs & derivatives | Stem Cells - drug effects | Mice, Inbred NOD | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Cell Proliferation - drug effects | Mice | Drug Resistance, Neoplasm - drug effects | Index Medicus | Abridged Index Medicus | Myeloid Neoplasia
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 04/2010, Volume 120, Issue 4, pp. 1310 - 1323
In vivo resistance to first-line chemotherapy, including to glucocorticoids, is a strong predictor of poor outcome in children with acute lymphoblastic... 
MEDICINE, RESEARCH & EXPERIMENTAL | APOPTOSIS | DEXAMETHASONE | DEATH PATHWAY | GENE | BCL-2 FAMILY PROTEINS | OBATOCLAX MESYLATE | BH3 MIMETIC ABT-737 | NF-KAPPA-B | PHASE-I | EXPRESSION | Beclin-1 | Glucocorticoids - therapeutic use | RNA-Binding Proteins - physiology | Apoptosis - drug effects | Drug Resistance, Multiple | Apoptosis Regulatory Proteins - chemistry | Humans | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Drug Resistance, Neoplasm | Autophagy | Xenograft Model Antitumor Assays | Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Dexamethasone - therapeutic use | Nuclear Pore Complex Proteins - physiology | Pyrroles - pharmacology | Membrane Proteins - chemistry | Membrane Proteins - physiology | Myeloid Cell Leukemia Sequence 1 Protein | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Apoptosis Regulatory Proteins - physiology | Proto-Oncogene Proteins c-bcl-2 - chemistry | TOR Serine-Threonine Kinases | Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology | Autophagy (Cytology) | Care and treatment | Corticosteroids | Leukemia in children | Lymphocytic leukemia in children | Development and progression | Drug resistance | Lymphoblastic leukemia in children | Physiological aspects | Dosage and administration | Acute lymphocytic leukemia | Observations | Apoptosis | Index Medicus | Abridged Index Medicus
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 12/2015, Volume 22, Issue 12, pp. 2098 - 2106
Breast cancer is the second-most frequently diagnosed malignancy in US women. The triple-negative breast cancer (TNBC) subtype, which lacks expression of the... 
MCL-1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | ABT-737 | CHEMORESISTANCE | MELANOMA-CELLS | BCL-2 PROTEINS | INHIBITOR | ADDICTION | ABT-199 | INDEX PREDICTS | FAMILY | CELL BIOLOGY | Apoptosis - drug effects | Humans | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | bcl-2 Homologous Antagonist-Killer Protein - genetics | bcl-X Protein - genetics | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Bcl-2-Like Protein 11 | RNA Interference | bcl-X Protein - antagonists & inhibitors | Triple Negative Breast Neoplasms - pathology | Apoptosis Regulatory Proteins - genetics | Female | Membrane Proteins - metabolism | bcl-2-Associated X Protein - genetics | Proto-Oncogene Proteins - metabolism | Cell Survival - drug effects | Myeloid Cell Leukemia Sequence 1 Protein - antagonists & inhibitors | Membrane Proteins - genetics | bcl-2-Associated X Protein - metabolism | Proto-Oncogene Proteins - genetics | Sulfonamides - pharmacology | Myeloid Cell Leukemia Sequence 1 Protein - genetics | Apoptosis Regulatory Proteins - metabolism | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Triple Negative Breast Neoplasms - metabolism | Cell Line, Tumor | bcl-X Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | RNA, Small Interfering - metabolism | Index Medicus | Original Paper
Journal Article