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Nature, ISSN 0028-0836, 2016, Volume 538, Issue 7626, pp. 477 - 482
Avoidance of apoptosis is critical for the development and sustained growth of tumours. The pro-survival protein myeloid cell leukemia 1 (MCL1) is... 
MULTIPLE-MYELOMA | SURVIVAL | ANTI-APOPTOTIC MCL-1 | PROTEIN | DEPENDENCY | BCL-XL | MULTIDISCIPLINARY SCIENCES | HIGH-AFFINITY | TUMOR-CELLS | COMBINATION | NAVITOCLAX | Neoplasms - metabolism | Thiophenes - therapeutic use | Leukemia - pathology | Apoptosis - drug effects | Humans | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | Male | Antineoplastic Agents - therapeutic use | Leukemia - metabolism | Thiophenes - administration & dosage | Antineoplastic Agents - administration & dosage | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Lymphoma - metabolism | Lymphoma - drug therapy | Multiple Myeloma - drug therapy | Myeloid Cell Leukemia Sequence 1 Protein - chemistry | Female | Lymphoma - pathology | Antineoplastic Agents - pharmacology | Myeloid Cell Leukemia Sequence 1 Protein - antagonists & inhibitors | Pyrimidines - administration & dosage | bcl-2-Associated X Protein - metabolism | Leukemia - drug therapy | Models, Molecular | Thiophenes - pharmacology | Pyrimidines - pharmacology | Multiple Myeloma - metabolism | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Multiple Myeloma - pathology | Animals | Models, Biological | Pyrimidines - therapeutic use | Cell Line, Tumor | Mice | Neoplasms - pathology | Myelocytic leukemia | Physiological aspects | Nonlymphoid leukemia | Metastasis | Observations | Health aspects | Apoptosis | Proteins | Studies | Multiple myeloma | Cytotoxicity | Kinases | Drug dosages | Tumors | Cancer | Crystal structure
Journal Article
Nature Immunology, ISSN 1529-2908, 02/2016, Volume 17, Issue 2, pp. 179 - 186
Intestinal T cells and group 3 innate lymphoid cells (ILC3 cells) control the composition of the microbiota and gut immune responses. Within the gut, ILC3... 
IL-22 PRODUCTION | NATURAL-KILLER-CELLS | NK CELLS | COMMENSAL BACTERIA | INFLAMMATION | HOST-DEFENSE | INTERLEUKIN-22 | INFECTION | T-CELL | IMMUNOLOGY | LYMPHOCYTES | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | Transcriptome | Homeostasis | Male | Gene Expression Profiling | Lymphocyte Subsets - immunology | Enterobacteriaceae Infections - immunology | Lymphocyte Subsets - metabolism | Lymphocytes - immunology | Enterobacteriaceae Infections - genetics | Female | Interleukins - biosynthesis | Myeloid Cell Leukemia Sequence 1 Protein - deficiency | Disease Models, Animal | Lymphocytes - metabolism | Citrobacter rodentium - immunology | Signal Transduction | T-Box Domain Proteins - deficiency | Enterobacteriaceae Infections - metabolism | Enterobacteriaceae Infections - mortality | Gene Expression Regulation | Mice, Transgenic | Enterobacteriaceae Infections - pathology | Immunity, Innate | T-Box Domain Proteins - genetics | Myeloid Cell Leukemia Sequence 1 Protein - genetics | T-Box Domain Proteins - metabolism | Mice, Knockout | Animals | Natural Cytotoxicity Triggering Receptor 1 - metabolism | Mice | Cluster Analysis | Complications and side effects | Care and treatment | Microbiota (Symbiotic organisms) | Interleukins | Gastrointestinal diseases | Influence | Research | Health aspects | Life Sciences | Immunology
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2016, Volume 291, Issue 13, pp. 6689 - 6695
Intrinsically disordered proteins (IDPs) are characterized by a lack of persistent structure. Since their identification more than a decade ago, many questions... 
signaling | residual structure | electrostatics | coupled folding and binding | BIOCHEMISTRY & MOLECULAR BIOLOGY | protein electrostatics | C-MYB | TRANSITION-STATE | INDUCED FIT | protein-protein interactions | INTRINSICALLY DISORDERED PROTEINS | LINEAGE LEUKEMIA PROTEIN | IDP | MOLECULAR RECOGNITION | KIX DOMAIN | SEQUENCE | protein folding | phi-value | TRANSACTIVATION DOMAIN | kinetics | biophysics | protein dynamic | CONFORMATIONAL SELECTION | Cyclic AMP Response Element-Binding Protein - chemistry | Humans | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | CREB-Binding Protein - chemistry | Proto-Oncogene Proteins - chemistry | CREB-Binding Protein - genetics | CREB-Binding Protein - metabolism | Thermodynamics | Apoptosis Regulatory Proteins - genetics | Myeloid Cell Leukemia Sequence 1 Protein - chemistry | Protein Interaction Domains and Motifs | Proto-Oncogene Proteins - metabolism | Signal Transduction | Apoptosis Regulatory Proteins - chemistry | Proto-Oncogene Proteins - genetics | Static Electricity | Intrinsically Disordered Proteins - genetics | Molecular Dynamics Simulation | Myeloid Cell Leukemia Sequence 1 Protein - genetics | Protein Folding | Apoptosis Regulatory Proteins - metabolism | Cyclic AMP Response Element-Binding Protein - genetics | Intrinsically Disordered Proteins - chemistry | Cyclic AMP Response Element-Binding Protein - metabolism | Hydrophobic and Hydrophilic Interactions | Protein Binding | Kinetics | Intrinsically Disordered Proteins - metabolism | Minireviews
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 12/2015, Volume 22, Issue 12, pp. 2098 - 2106
Breast cancer is the second-most frequently diagnosed malignancy in US women. The triple-negative breast cancer (TNBC) subtype, which lacks expression of the... 
MCL-1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | ABT-737 | CHEMORESISTANCE | MELANOMA-CELLS | BCL-2 PROTEINS | INHIBITOR | ADDICTION | ABT-199 | INDEX PREDICTS | FAMILY | CELL BIOLOGY | Apoptosis - drug effects | Humans | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | bcl-2 Homologous Antagonist-Killer Protein - genetics | bcl-X Protein - genetics | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Bcl-2-Like Protein 11 | RNA Interference | bcl-X Protein - antagonists & inhibitors | Triple Negative Breast Neoplasms - pathology | Apoptosis Regulatory Proteins - genetics | Female | Membrane Proteins - metabolism | bcl-2-Associated X Protein - genetics | Proto-Oncogene Proteins - metabolism | Cell Survival - drug effects | Myeloid Cell Leukemia Sequence 1 Protein - antagonists & inhibitors | Membrane Proteins - genetics | bcl-2-Associated X Protein - metabolism | Proto-Oncogene Proteins - genetics | Sulfonamides - pharmacology | Myeloid Cell Leukemia Sequence 1 Protein - genetics | Apoptosis Regulatory Proteins - metabolism | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Triple Negative Breast Neoplasms - metabolism | Cell Line, Tumor | bcl-X Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | RNA, Small Interfering - metabolism | Original Paper
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2014, Volume 111, Issue 23, pp. 8512 - 8517
Antiapoptotic B-cell lymphoma 2 (Bcl-2) family members such as Bcl-2, myeloid cell leukemia 1 (Mcl-1), and B-cell lymphoma-X large (Bcl-xL) are proposed to... 
Myeloid cells | Starvation | Cell death | Cell lines | Fibroblasts | Cultured cells | Gene expression regulation | Viability | Family members | Apoptosis | ABT-737 | LC3B | LC3 | BH3 mimetic | Bim | SURVIVAL | APOPTOSIS | MCL-1 | MULTIDISCIPLINARY SCIENCES | KINASE | CELL-DEATH | CONNECTION | BECLIN-1 | ROLES | BH3-ONLY PROTEINS | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | bcl-2 Homologous Antagonist-Killer Protein - genetics | Cell Survival - genetics | Apoptosis - genetics | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Autophagy | Proto-Oncogene Proteins c-bcl-2 - metabolism | Flow Cytometry | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | RNA Interference | bcl-2-Associated X Protein - genetics | Fibroblasts - metabolism | Phagosomes - metabolism | Cells, Cultured | bcl-2-Associated X Protein - metabolism | Sulfonamides - pharmacology | Piperazines - pharmacology | Blotting, Western | Myeloid Cell Leukemia Sequence 1 Protein - genetics | Mice, Knockout | Animals | Autophagy-Related Protein 5 | Embryo, Mammalian - cytology | Fibroblasts - drug effects | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Fibroblasts - cytology | Mice | Proto-Oncogene Proteins c-bcl-2 - genetics | Cell Line, Transformed | Autophagy (Cytology) | Cell research | Oncology, Experimental | Physiological aspects | Lymphomas | Research | B cells | Health aspects | Cancer | Biological Sciences
Journal Article
Journal Article
Blood, ISSN 0006-4971, 07/2015, Volume 126, Issue 3, pp. 363 - 372
Overexpression of antiapoptotic Bcl-2 proteins such as Bcl-2, Bcl-xL, and Mcl-1 is widely associated with tumor initiation, progression, and chemoresistance.... 
SURVIVAL | ANTI-APOPTOTIC MCL-1 | POTENT | BIM | BAX | ANTITUMOR-ACTIVITY | PROTEINS | CLEAVAGE | HEMATOLOGY | BCL-2 FAMILY | CELL-DEATH | Immunoprecipitation | Apoptosis - drug effects | Neoplastic Stem Cells - drug effects | Humans | Leukemia, Myeloid, Acute - metabolism | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | Stem Cells - cytology | Stem Cells - metabolism | Immunoenzyme Techniques | Proto-Oncogene Proteins c-bcl-2 - metabolism | Mesenchymal Stromal Cells - cytology | Flow Cytometry | Biphenyl Compounds - pharmacology | Neoplastic Stem Cells - metabolism | Nitrophenols - pharmacology | Leukemia, Myeloid, Acute - drug therapy | Neoplastic Stem Cells - pathology | Female | Tumor Cells, Cultured | Mesenchymal Stromal Cells - drug effects | Myeloid Cell Leukemia Sequence 1 Protein - antagonists & inhibitors | Leukemia, Myeloid, Acute - pathology | Mesenchymal Stromal Cells - metabolism | Naphthoquinones - pharmacology | Mice, SCID | Sulfonamides - pharmacology | Piperazines - pharmacology | Blotting, Western | Xenograft Model Antitumor Assays | Gossypol - pharmacology | Animals | Gossypol - analogs & derivatives | Stem Cells - drug effects | Mice, Inbred NOD | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Cell Proliferation - drug effects | Mice | Drug Resistance, Neoplasm - drug effects | Myeloid Neoplasia
Journal Article
Nature Communications, ISSN 2041-1723, 07/2017, Volume 8, Issue 1, p. 16078
BCL-2 family proteins are central regulators of mitochondrial apoptosis and validated anticancer targets. Using small cell lung cancer (SCLC) as a model, we... 
CELL LUNG-CANCER | SELECTIVE-INHIBITION | BAK ACTIVATION | POTENT | MULTIDISCIPLINARY SCIENCES | BIM | TRANSCRIPTION | DEATH | CDK INHIBITOR | ABT-263 | BH3 DOMAIN | Lung Neoplasms - drug therapy | Apoptosis - drug effects | Humans | Lung Neoplasms - metabolism | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | Drug Resistance, Neoplasm | Molecular Targeted Therapy | Apoptosis Regulatory Proteins - drug effects | Myeloid Cell Leukemia Sequence 1 Protein - drug effects | Small Cell Lung Carcinoma - drug therapy | Small Cell Lung Carcinoma - metabolism | bcl-X Protein - drug effects | Proto-Oncogene Proteins c-bcl-2 - metabolism | bcl-X Protein - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Myeloid Cell Leukemia Sequence 1 Protein - antagonists & inhibitors | Aniline Compounds - pharmacology | Cyclin-Dependent Kinase 9 - antagonists & inhibitors | Sulfonamides - pharmacology | Apoptosis Regulatory Proteins - metabolism | Drug Synergism | Pyridinium Compounds - pharmacology | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | High-Throughput Screening Assays | Apoptosis Regulatory Proteins - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-2 - drug effects | Cell Line, Tumor | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | bcl-X Protein - metabolism | Doxorubicin - pharmacology | Regulators | Bax protein | Bcl-2 protein | Small cell lung carcinoma | Lung cancer | High-throughput screening | Doxorubicin | BAK protein | Mcl-1 protein | Proteins | Mitochondria | Inhibitors | Bcl-x protein | Anthracycline | Addiction | Cell death | Sequestering | Cancer | Apoptosis
Journal Article
Cell Reports, ISSN 2211-1247, 03/2015, Volume 10, Issue 8, pp. 1422 - 1432
Journal Article
Journal Article
Journal Article
Blood, ISSN 0006-4971, 02/2017, Volume 129, Issue 6, pp. 771 - 782
Acute myeloid leukemia (AML) is an aggressive malignancy where despite improvements in conventional chemotherapy and bone marrow transplantation, overall... 
AML | APOPTOSIS | IN-VITRO | PROTEIN | MCL-1 | ACUTE MYELOGENOUS LEUKEMIA | GROWTH | INHIBITOR | HEMATOLOGY | EXPRESSION | CANCER | Lysophospholipids - metabolism | Caspase Inhibitors - pharmacology | Receptors, Lysosphingolipid - antagonists & inhibitors | Neoplastic Stem Cells - drug effects | Humans | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | Amino Alcohols - pharmacology | Molecular Targeted Therapy | Quinolines - pharmacology | Caspases - metabolism | Neoplastic Stem Cells - metabolism | Amino Acid Chloromethyl Ketones - pharmacology | Leukemia, Myeloid, Acute - drug therapy | Neoplastic Stem Cells - pathology | Receptors, Lysosphingolipid - genetics | Bone Marrow Cells - drug effects | Female | Sphingosine - metabolism | Cell Death - drug effects | Receptors, Lysosphingolipid - metabolism | Myeloid Cell Leukemia Sequence 1 Protein - antagonists & inhibitors | Signal Transduction | Caspases - genetics | Leukemia, Myeloid, Acute - pathology | Bone Marrow Cells - pathology | Phosphotransferases (Alcohol Group Acceptor) - genetics | Gene Expression Regulation, Leukemic | Myeloid Cell Leukemia Sequence 1 Protein - genetics | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Leukemia, Myeloid, Acute - mortality | Xenograft Model Antitumor Assays | Phosphotransferases (Alcohol Group Acceptor) - antagonists & inhibitors | Sphingosine - analogs & derivatives | Animals | Survival Analysis | Cell Line, Tumor | Mice, Inbred NOD | Mice | Protein Kinase Inhibitors - pharmacology | Bone Marrow Cells - metabolism | Leukemia, Myeloid, Acute - genetics
Journal Article