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Bioimpacts, ISSN 2228-5660, 12/2018, Volume 8, Issue Suppl 1, pp. S1 - S129
Journal Article
Nature (London), ISSN 1476-4687, 2015, Volume 525, Issue 7570, pp. 538 - 542
...). Early clinical trials have shown promise, especially in acute myeloid leukaemia(3), and therefore the evaluation of resistance mechanismsis crucial to optimize the clinical efficacy of these drugs... 
SELECTIVE-INHIBITION | ACCURATE | CHROMATIN | MECHANISM | MULTIDISCIPLINARY SCIENCES | ACUTE MYELOID-LEUKEMIA | DRUG-RESISTANCE | MUTATIONS | SEQUENCING DATA | CANCER | DISCOVERY | Chromatin - metabolism | Transcription, Genetic - drug effects | Clone Cells - drug effects | Neoplastic Stem Cells - drug effects | Epigenesis, Genetic | Humans | Leukemia, Myeloid, Acute - metabolism | Molecular Targeted Therapy | Neoplastic Stem Cells - metabolism | Leukemia, Myeloid, Acute - drug therapy | Neoplastic Stem Cells - pathology | Gene Expression Regulation, Neoplastic - drug effects | Hematopoietic Stem Cells - drug effects | Benzodiazepines - pharmacology | Leukemia, Myeloid, Acute - pathology | Cells, Cultured | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Hematopoietic Stem Cells - metabolism | Clone Cells - metabolism | beta Catenin - metabolism | Azepines - pharmacology | Transcription Factors - metabolism | Triazoles - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Clone Cells - pathology | Wnt Signaling Pathway - drug effects | Genes, myc - genetics | Hematopoietic Stem Cells - cytology | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Mice | Cell Cycle Proteins | Drug Resistance, Neoplasm - drug effects | Leukemia, Myeloid, Acute - genetics | Proteins | Leukemia | Cloning | Cell cycle | Stem cells | Epigenetics | Apoptosis
Journal Article
Nature (London), ISSN 1476-4687, 2016, Volume 539, Issue 7629, pp. 443 - 447
Journal Article
Journal of Immunology, ISSN 0022-1767, 08/2010, Volume 185, Issue 4, pp. 2080 - 2088
Cross-talk between NK cells and dendritic cells (DCs) is critical for the potent therapeutic response to dsRNA, but the receptors involved remained controversial... 
TOLL-LIKE RECEPTOR-3 | CROSS-TALK | ADAPTIVE IMMUNITY | NATURAL-KILLER-CELLS | ACTIVATION | INNATE RESISTANCE | RECOGNITION | PATHWAY | IMMUNOLOGY | BACTERIAL PEPTIDOGLYCAN | CYTOTOXICITY | Myeloid Cells - cytology | Humans | Interferon-gamma - metabolism | Interferon-Induced Helicase, IFIH1 | Dose-Response Relationship, Drug | Transfection | Dendritic Cells - drug effects | Myeloid Cells - drug effects | Toll-Like Receptor 3 - genetics | DEAD-box RNA Helicases - metabolism | Dendritic Cells - metabolism | Cell Line | DEAD Box Protein 58 | Poly I-C - pharmacology | Mice, Inbred C57BL | Cells, Cultured | Poly A-U - pharmacology | Toll-Like Receptor 3 - metabolism | Mice, Knockout | DEAD-box RNA Helicases - genetics | Killer Cells, Natural - cytology | Animals | Lymphocyte Activation - drug effects | Adaptor Proteins, Signal Transducing - genetics | RNA, Double-Stranded - pharmacology | Myeloid Cells - metabolism | Dendritic Cells - cytology | Killer Cells, Natural - drug effects | Mice | Killer Cells, Natural - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Poly A-U | Interferon-gamma | Toll-Like Receptor 3 | DEAD-box RNA Helicases | Dendritic Cells | Killer Cells, Natural | Lymphocyte Activation | Myeloid Cells | Life Sciences | Adaptor Proteins, Signal Transducing | Immunology | RNA, Double-Stranded | Poly I-C
Journal Article
The Journal of experimental medicine, ISSN 1540-9538, 2010, Volume 207, Issue 6, pp. 1247 - 1260
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 2009, Volume 119, Issue 5, pp. 1109 - 1123
...), but the frequency of resistance increases in advancing stages of disease. Elimination of BCR/ABL-dependent intracellular signals triggers apoptosis, but it is unclear whether this activates additional cell survival and/or death pathways... 
CHRONIC MYELOGENOUS LEUKEMIA | MEDICINE, RESEARCH & EXPERIMENTAL | MALIGNANT GLIOMA-CELLS | BLAST CRISIS | CLINICAL RESISTANCE | BCR-ABL MUTATIONS | ENDOPLASMIC-RETICULUM | CYTOCHROME-C RELEASE | CASPASE ACTIVATION | IMATINIB RESISTANCE | CHRONIC MYELOID-LEUKEMIA | Transcription Factor CHOP - genetics | Neoplastic Stem Cells - cytology | Gene Expression - drug effects | Calcium - metabolism | Gene Expression - genetics | Microtubule-Associated Proteins - metabolism | Neoplastic Stem Cells - drug effects | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Endoplasmic Reticulum - metabolism | Antineoplastic Agents - therapeutic use | Autophagy - physiology | Thiazoles - therapeutic use | Autophagy - drug effects | Chloroquine - pharmacology | Neoplastic Stem Cells - metabolism | RNA Interference | Endoplasmic Reticulum - drug effects | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology | Macrolides - pharmacology | Antineoplastic Agents - pharmacology | Cell Death - drug effects | Dasatinib | Chloroquine - therapeutic use | Piperazines - therapeutic use | Pyrimidines - pharmacology | Imatinib Mesylate | Piperazines - pharmacology | Mice, Inbred C3H | Xenograft Model Antitumor Assays | Fusion Proteins, bcr-abl - genetics | Animals | Cell Death - physiology | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Fusion Proteins, bcr-abl - antagonists & inhibitors | Cell Line, Tumor | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism | Mice | Protein Kinase Inhibitors - pharmacology | Thiazoles - pharmacology | Benzamides | Macrolides - therapeutic use | Protein-Tyrosine Kinases - antagonists & inhibitors | Causes of | Physiological aspects | Genetic aspects | Chronic myeloid leukemia | Research | Drug therapy | Phagocytosis
Journal Article
Cell metabolism, ISSN 1550-4131, 2016, Volume 24, Issue 6, pp. 795 - 806
.... Without any obvious toxicity or deleterious effects, NMN suppressed age-associated body weight gain, enhanced energy metabolism, promoted physical activity, improved insulin sensitivity and plasma... 
NAD | NAD+ precursor | insulin sensitivity | eye function | anti-aging | mitochondria | aging | nicotinamide mononucleotide | glucose metabolism | NMN | energy metabolism | precursor | LIFE-SPAN | STEM-CELLS | ACTIVATION | MITOCHONDRIAL | NAD BIOSYNTHESIS | INSULIN-SECRETION | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | RIBOSIDE | SIRT1 | ADIPOSE-TISSUE | CELL BIOLOGY | Darkness | Aging - drug effects | Male | Muscle, Skeletal - metabolism | Nicotinamide Mononucleotide - administration & dosage | Aging - genetics | Time Factors | Lipids - blood | Muscle, Skeletal - drug effects | Cell Respiration - drug effects | Myeloid Cells - drug effects | Weight Gain - drug effects | NAD - metabolism | Physical Conditioning, Animal | Food | Lymphocytes - metabolism | Insulin - pharmacology | Administration, Oral | Mice, Inbred C57BL | Mitochondria - metabolism | Mitochondria - drug effects | Gene Expression Regulation - drug effects | Eating - drug effects | Bone Density - drug effects | Animals | Aging - physiology | Lymphocytes - drug effects | Myeloid Cells - metabolism | Nicotinamide Mononucleotide - pharmacology | Drinking - drug effects | Nicotinamide Mononucleotide - blood | Energy Metabolism - drug effects | Niacinamide | Medical colleges | Exercise | Pharmacy | Genes | Body weight | Physiological aspects | Muscles | Mice | Ophthalmology | Gene expression
Journal Article
Cell Stem Cell, ISSN 1934-5909, 09/2012, Volume 11, Issue 3, pp. 346 - 358
.... In this study, we show that this expansion begins with overproliferation within a compartment of normally quiescent long-term hematopoietic stem cells (LT-HSCs... 
PROGENITOR CELLS | INTERNAL TANDEM DUPLICATION | CONSTITUTIVE ACTIVATION | ACUTE MYELOGENOUS LEUKEMIA | GENE-EXPRESSION | SELF-RENEWAL | C-KIT | ACUTE MYELOID-LEUKEMIA | PROGNOSTIC-SIGNIFICANCE | MYELODYSPLASTIC SYNDROME | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Niacinamide - analogs & derivatives | Small Molecule Libraries - pharmacology | Neoplastic Stem Cells - drug effects | Hematopoietic Stem Cells - pathology | Male | Bone Marrow Neoplasms - genetics | RNA, Messenger - metabolism | Promoter Regions, Genetic - genetics | Side-Population Cells - drug effects | fms-Like Tyrosine Kinase 3 - genetics | Neoplastic Stem Cells - metabolism | Side-Population Cells - metabolism | Bone Marrow - metabolism | Neoplastic Stem Cells - pathology | Female | Gene Expression Regulation, Neoplastic - drug effects | Homeostasis - drug effects | Tandem Repeat Sequences - genetics | Bone Marrow - drug effects | Gene Duplication - drug effects | Hematopoietic Stem Cells - drug effects | RNA, Messenger - genetics | Hematopoietic Stem Cell Transplantation | Hematopoietic Stem Cells - metabolism | Enzyme Activation - drug effects | Side-Population Cells - pathology | fms-Like Tyrosine Kinase 3 - metabolism | Gene Knock-In Techniques | Phenotype | Animals | Bone Marrow Neoplasms - pathology | Signal Transduction - drug effects | Bone Marrow - pathology | Cell Compartmentation - drug effects | Cell Proliferation - drug effects | Mice | Phenylurea Compounds - pharmacology | Niacinamide - pharmacology | Cell Cycle - drug effects | Homeostasis - genetics
Journal Article
Cell stem cell, ISSN 1934-5909, 2016, Volume 19, Issue 1, pp. 23 - 37
Journal Article
Journal of Immunology, ISSN 0022-1767, 12/2010, Volume 185, Issue 11, pp. 6636 - 6645
.... DEP increase oxidative stress and influence human bronchial epithelial cell (HBEC)-dendritic cell interactions via cytokines, including thymic stromal lymphopoietin (TSLP... 
AMBIENT PARTICULATE MATTER | TH2 RESPONSES | AIR-POLLUTION | CYTOKINE PRODUCTION | CD4 T-CELLS | IMMUNE-RESPONSES | IN-VIVO | GATA3 EXPRESSION | ANTIGEN-PRESENTING CELLS | MEDIATED ALLERGIC INFLAMMATION | IMMUNOLOGY | Particulate Matter - toxicity | Vehicle Emissions - toxicity | Respiratory Mucosa - drug effects | Coculture Techniques | Dendritic Cells - immunology | Humans | Intercellular Signaling Peptides and Proteins - biosynthesis | Th2 Cells - immunology | OX40 Ligand - biosynthesis | Bronchi - immunology | Reactive Oxygen Species - toxicity | Th2 Cells - drug effects | Cytokines - physiology | Bronchi - drug effects | Signal Transduction - immunology | Receptors, Notch - biosynthesis | Myeloid Cells - immunology | Serrate-Jagged Proteins | Respiratory Mucosa - immunology | Stromal Cells - drug effects | Dendritic Cells - drug effects | Myeloid Cells - drug effects | Cell Polarity - drug effects | Bronchi - cytology | Dendritic Cells - metabolism | Jagged-1 Protein | Cell Polarity - immunology | Calcium-Binding Proteins - biosynthesis | Respiratory Mucosa - cytology | Stromal Cells - metabolism | Cells, Cultured | Thymus Gland - cytology | Stromal Cells - immunology | Thymus Gland - drug effects | Th2 Cells - metabolism | Up-Regulation - drug effects | Membrane Proteins - biosynthesis | Signal Transduction - drug effects | Up-Regulation - immunology | Myeloid Cells - metabolism | Thymus Gland - immunology
Journal Article