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Science (American Association for the Advancement of Science), ISSN 1095-9203, 2008, Volume 321, Issue 5889, pp. 691 - 696
...). MyD88 deficiency in mice leads to susceptibility to a broad range of pathogens in experimental settings of infection... 
Receptors | Phenotypes | Transfection | Cytokines | HEK293 cells | Genes | Cell lines | Fibroblasts | Agonists | Reports | Children | MYD88-DEFICIENT MICE | HERPES-SIMPLEX-VIRUS | PROTECTIVE IMMUNITY | MYELOID DIFFERENTIATION FACTOR-88 | PSEUDOMONAS-AERUGINOSA | MULTIDISCIPLINARY SCIENCES | HUMORAL IMMUNITY | STAPHYLOCOCCUS-AUREUS | AERUGINOSA LUNG INFECTION | HOST RESPONSE | CUTTING EDGE | Humans | Child, Preschool | Male | Mutation, Missense | Bacterial Infections - genetics | Pneumococcal Infections - immunology | Bacterial Infections - immunology | Gene Deletion | Pneumococcal Infections - genetics | Female | Toll-Like Receptors - metabolism | Child | Staphylococcal Infections - genetics | Disease Susceptibility | Cytokines - metabolism | Signal Transduction | Staphylococcal Infections - immunology | Receptors, Interleukin-1 - immunology | Toll-Like Receptors - immunology | Myeloid Differentiation Factor 88 - genetics | Immunity, Innate | Pseudomonas Infections - genetics | Pseudomonas Infections - immunology | Receptors, Interleukin-1 - metabolism | Animals | Myeloid Differentiation Factor 88 - deficiency | Adolescent | Mice | Myeloid Differentiation Factor 88 - metabolism | Cell Line, Transformed | Genetic aspects | Bacterial infections | Pediatrics | Bacteria | Biomedical research | Genetic disorders | Immunology | Pneumococcal Infections | Life Sciences | Toll-Like Receptors | Bacterial Infections | Myeloid Differentiation Factor 88 | Bacteriology | Staphylococcal Infections | Microbiology and Parasitology | Pseudomonas Infections | Receptors, Interleukin-1
Journal Article
PloS one, ISSN 1932-6203, 2010, Volume 5, Issue 9, pp. 1 - 7
Journal Article
The Journal of immunology (1950), ISSN 1550-6606, 2008, Volume 180, Issue 7, pp. 4763 - 4773
.... The impact of TLR-activated B cells on T cell-mediated inflammation is unknown. In this study, we have used mice carrying B cell-restricted deficiencies in MyD88... 
MYCOBACTERIUM-TUBERCULOSIS | REGULATORY-CELLS | MULTIPLE-SCLEROSIS | DENDRITIC CELLS | NONOBESE DIABETIC MICE | IN-VIVO | TOLL-LIKE RECEPTORS | CENTRAL-NERVOUS-SYSTEM | IMMUNOLOGY | BACTERIAL-DNA | CUTTING EDGE | Interleukin-10 - deficiency | Encephalomyelitis, Autoimmune, Experimental - metabolism | Dendritic Cells - immunology | Mice, Inbred C57BL | Toll-Like Receptors - immunology | Mycobacterium tuberculosis - immunology | Myeloid Differentiation Factor 88 - genetics | Encephalomyelitis, Autoimmune, Experimental - immunology | Toll-Like Receptors - agonists | Mice, Knockout | Signal Transduction - immunology | Lymphocyte Activation - immunology | Animals | B-Lymphocytes - immunology | Myeloid Differentiation Factor 88 - deficiency | Autoimmunity - immunology | Interleukin-10 - genetics | Myeloid Differentiation Factor 88 - immunology | Interleukin-10 - metabolism | T-Lymphocytes - immunology | Mice | Encephalomyelitis, Autoimmune, Experimental - genetics | Interleukin-10 - immunology | Myeloid Differentiation Factor 88 - metabolism | Autoimmunity | Dendritic Cells | Interleukin-10 | Signal Transduction | T-Lymphocytes | Lymphocyte Activation | B-Lymphocytes | Myeloid Differentiation Factor 88 | Life Sciences | Toll-Like Receptors | Encephalomyelitis, Autoimmune, Experimental | Immunology | Mycobacterium tuberculosis
Journal Article
Immunity (Cambridge, Mass.), ISSN 1074-7613, 2013, Volume 39, Issue 2, pp. 372 - 385
Endogenous tryptophan (Trp) metabolites have an important role in mammalian gut immune homeostasis, yet the potential contribution of Trp metabolites from... 
INTESTINAL INFLAMMATION | LACTOBACILLUS-PLANTARUM | CANDIDA-ALBICANS | GASTROINTESTINAL-TRACT | GUT | REGULATORY T-CELLS | MICE | COLONIZATION | JOHNSONII STRAIN NCC533 | INNATE LYMPHOID-CELLS | IMMUNOLOGY | Indoleamine-Pyrrole 2,3,-Dioxygenase - genetics | Lactobacillus reuteri - metabolism | Receptors, Aryl Hydrocarbon - deficiency | Toll-Like Receptor 2 - genetics | Tryptophan - chemistry | Indoleamine-Pyrrole 2,3,-Dioxygenase - deficiency | Lactobacillus reuteri - immunology | Tryptophan - metabolism | Interleukins - metabolism | Gastrointestinal Tract - immunology | Toll-Like Receptor 2 - deficiency | Indoles - metabolism | Receptors, Aryl Hydrocarbon - metabolism | Female | Candidiasis - immunology | Basic Helix-Loop-Helix Transcription Factors - deficiency | Basic Helix-Loop-Helix Transcription Factors - genetics | Mice, Inbred C57BL | Myeloid Differentiation Factor 88 - genetics | Receptors, Aryl Hydrocarbon - genetics | Gastrointestinal Tract - microbiology | Interleukin-17 - genetics | Interleukin-17 - deficiency | Candida albicans - immunology | Mice, SCID | Gastrointestinal Tract - metabolism | Mice, Inbred C3H | Mice, Knockout | Probiotics | Animals | Myeloid Differentiation Factor 88 - deficiency | Energy Metabolism | Lactobacillus reuteri - growth & development | Mice | Mice, Inbred BALB C | Metagenome | Tryptophan | Metabolites | Interleukins | Aldehydes | Medical research | Stomach | Colleges & universities | Homeostasis | Ligands | Software | Infections | Metabolism | Experiments
Journal Article
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1524-4636, 2011, Volume 31, Issue 12, pp. 2813 - 2819
Journal Article
Journal Article
The Journal of Immunology, ISSN 0022-1767, 12/2003, Volume 171, Issue 11, pp. 6145 - 6153
.... Myeloid differentiation factor 88 (MyD88) is a Toll/IL-1R domain containing adaptor molecule known to have a central role in both IL-1R/IL-18R and TLR signaling... 
RHEUMATOID-ARTHRITIS | CPG MOTIFS | INTERLEUKIN-1 | PROINFLAMMATORY ROLE | GAMMA PRODUCTION | SYNOVIAL TISSUE | TOLL-LIKE RECEPTORS | INDUCED ARTHRITIS | NECROSIS-FACTOR-ALPHA | IMMUNOLOGY | MYD88 | Toll-Like Receptor 2 | Arthritis, Experimental - genetics | Cell Wall - immunology | Receptors, Immunologic - physiology | Interleukin-18 - physiology | Membrane Glycoproteins - biosynthesis | Male | Arthritis, Experimental - metabolism | Arthritis, Experimental - pathology | Signal Transduction - immunology | Toll-Like Receptors | Membrane Glycoproteins - physiology | Cartilage, Articular - metabolism | Inflammation Mediators - metabolism | Interleukin-1 - physiology | Inflammation Mediators - antagonists & inhibitors | Receptors, Cell Surface - biosynthesis | Receptors, Cell Surface - physiology | Neutrophil Infiltration - immunology | Proteoglycans - immunology | Streptococcus pyogenes - immunology | Mice, Inbred C57BL | Receptors, Immunologic - deficiency | Proteoglycans - metabolism | Receptors, Interleukin-1 - biosynthesis | Arthritis, Experimental - immunology | Signal Transduction - genetics | Myeloid Differentiation Factor 88 | Neutrophil Infiltration - genetics | Down-Regulation - genetics | Antigens, Differentiation - physiology | Membrane Glycoproteins - genetics | Mice, Knockout | Adaptor Proteins, Signal Transducing | Animals | Down-Regulation - immunology | Receptors, Cell Surface - deficiency | Tumor Necrosis Factor-alpha - physiology | Receptors, Interleukin-1 - physiology | Antigens, Differentiation - genetics | Mice | Multigene Family - immunology | Receptors, Immunologic - genetics | Receptors, Interleukin-1 - antagonists & inhibitors | Cartilage, Articular - immunology | Membrane Glycoproteins - deficiency | Receptors, Cell Surface - genetics
Journal Article
Journal of virology, ISSN 1098-5514, 2012, Volume 86, Issue 18, pp. 9888 - 9898
Chikungunya virus (CHIKV) infections can produce severe disease and mortality. Here we show that CHIKV infection of adult mice deficient in interferon response factors 3 and 7 (IRF3/7 ) is lethal... 
ANTIBODY-DEPENDENT ENHANCEMENT | VIROLOGY | IFN-ALPHA-BETA | DENDRITIC CELLS | INNATE IMMUNE-RESPONSES | NONHEMATOPOIETIC CELLS | SIGNALING PATHWAY | POSITIVE FEEDBACK | DENGUE VIRUS | HUMAN KERATINOCYTES | VIRAL-INFECTION | Interferon-alpha - pharmacology | Shock, Hemorrhagic - prevention & control | Humans | Adaptor Proteins, Vesicular Transport - deficiency | Adaptor Proteins, Vesicular Transport - genetics | Receptor, Interferon alpha-beta - physiology | Interferon Regulatory Factor-7 - genetics | Interferon Regulatory Factor-3 - genetics | Host-Pathogen Interactions - immunology | Alphavirus Infections - prevention & control | Interferon Regulatory Factor-7 - physiology | Chikungunya virus - physiology | Receptor, Interferon alpha-beta - genetics | Chikungunya virus - pathogenicity | Chikungunya Fever | Virus Replication - drug effects | Adaptor Proteins, Vesicular Transport - physiology | Interferon-alpha - biosynthesis | Receptor, Interferon alpha-beta - deficiency | Mice, Inbred C57BL | Myeloid Differentiation Factor 88 - genetics | Interferon-beta - biosynthesis | Alphavirus Infections - immunology | Chikungunya virus - immunology | Alphavirus Infections - pathology | Interferon Regulatory Factor-3 - physiology | Mice, Knockout | Animals | Interferon Regulatory Factor-3 - deficiency | Myeloid Differentiation Factor 88 - deficiency | Host-Pathogen Interactions - genetics | Interferon Regulatory Factor-7 - deficiency | Myeloid Differentiation Factor 88 - physiology | Mice | Shock, Hemorrhagic - immunology | Life Sciences | Santé publique et épidémiologie | Pathogenesis and Immunity
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 01/2013, Volume 123, Issue 1, pp. 236 - 246
Nephrocalcinosis, acute calcium oxalate (CaOx) nephropathy, and renal stone disease can lead to inflammation and subsequent renal failure, but the underlying... 
KIDNEY-DISEASE | NEPHROLITHIASIS | MEDICINE, RESEARCH & EXPERIMENTAL | DANGER | ACTIVATION | DENDRITIC CELLS | NLRP3 INFLAMMASOME | STONE FORMATION | FAILURE | NEPHROPATHY | NALP3 INFLAMMASOME | Interleukin-18 - immunology | Cytoskeletal Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Dendritic Cells - immunology | Nephrocalcinosis - immunology | Receptors, Interleukin-1 - genetics | Interleukin-1beta - genetics | Inflammation - metabolism | Nephrocalcinosis - metabolism | Myeloid Differentiation Factor 88 - immunology | Cytoskeletal Proteins - metabolism | Kidney Tubules - pathology | Immunologic Deficiency Syndromes - immunology | Kidney Tubules - metabolism | Carrier Proteins - immunology | Dendritic Cells - metabolism | Interleukin-1beta - secretion | Kidney Tubules - immunology | Calcium Oxalate - immunology | Receptors, Interleukin-1 - immunology | Myeloid Differentiation Factor 88 - genetics | Interleukin-1beta - immunology | Inflammation - immunology | Calcium Oxalate - metabolism | Mice, Knockout | Receptors, Interleukin-1 - metabolism | Carrier Proteins - genetics | Nephrocalcinosis - pathology | Animals | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | Cytoskeletal Proteins - immunology | Nephrocalcinosis - genetics | CARD Signaling Adaptor Proteins | Immunologic Deficiency Syndromes - genetics | Immunologic Deficiency Syndromes - metabolism | Inflammation - genetics | Mice | Interleukin-18 - genetics | Myeloid Differentiation Factor 88 - metabolism | Interleukin-18 - metabolism | Phagocytosis
Journal Article