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Blood, ISSN 0006-4971, 2016, Volume 127, Issue 14, pp. 1780 - 1789
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2012, Volume 7, Issue 10, p. e47038
Myeloid differentiation factor 88 (MyD88) is a universal and essential signaling protein in Toll-like receptor/interleukin-1 receptor-induced activation of nuclear factor-kappa B... 
MOLECULAR CHARACTERIZATION | TOLL-LIKE-RECEPTORS | IMMUNITY | SHRIMP PENAEUS-MONODON | RECOGNITION | CLONING | MULTIDISCIPLINARY SCIENCES | ANTIMICROBIAL PEPTIDE GENES | INFECTION | CDNA | NF-KAPPA-B | Hemocytes - physiology | Molecular Sequence Data | Phylogeny | White spot syndrome virus 1 - pathogenicity | Hemocytes - virology | Base Sequence | Cloning, Molecular | Penaeidae - metabolism | Antimicrobial Cationic Peptides - genetics | Drosophila - genetics | Amino Acid Sequence | Promoter Regions, Genetic | Penaeidae - virology | Signal Transduction | Penaeidae - genetics | Gene Expression Regulation | Myeloid Differentiation Factor 88 - genetics | Penaeidae - microbiology | Drosophila - cytology | Staphylococcus aureus - pathogenicity | Vibrio parahaemolyticus - pathogenicity | Sequence Homology, Amino Acid | Animals | Hemocytes - drug effects | Lipopolysaccharides - pharmacology | Myeloid Differentiation Factor 88 - metabolism | Penaeidae - immunology | Physiological aspects | Research | Gene expression | Blood cells | Water-borne diseases | Peptides | Shellfish | Laboratories | Genes | Interleukin | Viruses | White spot syndrome | Infections | Activation | Antiinfectives and antibacterials | Proteins | Signal transduction | Crustaceans | Transcription activation | Hepatopancreas | Interleukin 1 | Toll-like receptors | Deoxyribonucleic acid--DNA | CpG islands | Immune system | NF-κB protein | Cytokines | Drosophila | Cloning | Low level | IE1 protein | Signaling | MyD88 protein | Invertebrates | Differentiation | Hemocytes | Deoxyribonucleic acid | DNA
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2008, Volume 321, Issue 5889, pp. 691 - 696
MyD88 is a key downstream adapter for most Toll-like receptors (TLRs) and interleukin-1 receptors (IL-1Rs). MyD88 deficiency in mice leads to susceptibility to... 
Receptors | Phenotypes | Transfection | Cytokines | HEK293 cells | Genes | Cell lines | Fibroblasts | Agonists | Reports | Children | MYD88-DEFICIENT MICE | HERPES-SIMPLEX-VIRUS | PROTECTIVE IMMUNITY | MYELOID DIFFERENTIATION FACTOR-88 | PSEUDOMONAS-AERUGINOSA | MULTIDISCIPLINARY SCIENCES | HUMORAL IMMUNITY | STAPHYLOCOCCUS-AUREUS | AERUGINOSA LUNG INFECTION | HOST RESPONSE | CUTTING EDGE | Humans | Child, Preschool | Male | Mutation, Missense | Bacterial Infections - genetics | Pneumococcal Infections - immunology | Bacterial Infections - immunology | Gene Deletion | Pneumococcal Infections - genetics | Female | Toll-Like Receptors - metabolism | Child | Staphylococcal Infections - genetics | Disease Susceptibility | Cytokines - metabolism | Signal Transduction | Staphylococcal Infections - immunology | Receptors, Interleukin-1 - immunology | Toll-Like Receptors - immunology | Myeloid Differentiation Factor 88 - genetics | Immunity, Innate | Pseudomonas Infections - genetics | Pseudomonas Infections - immunology | Receptors, Interleukin-1 - metabolism | Animals | Myeloid Differentiation Factor 88 - deficiency | Adolescent | Mice | Myeloid Differentiation Factor 88 - metabolism | Cell Line, Transformed | Genetic aspects | Bacterial infections | Pediatrics | Bacteria | Biomedical research | Genetic disorders | Immunology | Pneumococcal Infections | Life Sciences | Toll-Like Receptors | Bacterial Infections | Myeloid Differentiation Factor 88 | Bacteriology | Staphylococcal Infections | Microbiology and Parasitology | Pseudomonas Infections | Receptors, Interleukin-1
Journal Article
Nature immunology, ISSN 1529-2916, 2010, Volume 11, Issue 5, pp. 411 - 418
.... and its downstream target, the transcription factor XBP1. Previously described ER-stress target genes of XBP1 were not induced by TLR signaling... 
UNFOLDED PROTEIN RESPONSE | PATHWAY | ER STRESS | HOST-DEFENSE | ENDOPLASMIC-RETICULUM STRESS | FRANCISELLA-TULARENSIS INFECTION | IMMUNOLOGY | LIVE VACCINE STRAIN | INFLAMMATORY RESPONSE | NEGATIVE REGULATOR | SYSTEMS BIOLOGY | RNA, Small Interfering - genetics | Endoribonucleases - genetics | Tularemia - metabolism | Toll-Like Receptor 2 - genetics | Membrane Glycoproteins - metabolism | Lipopeptides - pharmacology | Transcriptional Activation - drug effects | NADPH Oxidases - metabolism | Tularemia - genetics | Protein Splicing - genetics | Transcriptional Activation - immunology | X-Box Binding Protein 1 | Protein Splicing - drug effects | NADPH Oxidases - genetics | Stress, Physiological - drug effects | TNF Receptor-Associated Factor 6 - genetics | Transcription Factor CHOP - biosynthesis | Transcription Factors - immunology | Cytokines - genetics | Protein-Serine-Threonine Kinases - metabolism | DNA-Binding Proteins - immunology | Endoribonucleases - metabolism | Macrophages - pathology | Stress, Physiological - genetics | Myeloid Differentiation Factor 88 - genetics | Toll-Like Receptor 4 - genetics | Signal Transduction - genetics | Toll-Like Receptor 4 - immunology | Toll-Like Receptor 2 - metabolism | Toll-Like Receptor 4 - metabolism | Mice, Knockout | Macrophages - metabolism | Signal Transduction - drug effects | Tunicamycin - pharmacology | Lipopolysaccharides - pharmacology | Toll-Like Receptor 2 - immunology | Mice | Stress, Physiological - immunology | Endoribonucleases - immunology | Transcription Factor CHOP - genetics | NADPH Oxidases - immunology | DNA-Binding Proteins - metabolism | Signal Transduction - immunology | Macrophages - virology | Mice, Mutant Strains | Tularemia - immunology | Membrane Glycoproteins - immunology | Macrophages - immunology | Cytokines - immunology | Cell Line | Francisella tularensis - immunology | Protein Splicing - immunology | Protein-Serine-Threonine Kinases - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Immunity, Innate | NADPH Oxidase 2 | Regulatory Factor X Transcription Factors | Mice, Inbred C3H | Membrane Glycoproteins - genetics | Transcription Factors - metabolism | Animals | TNF Receptor-Associated Factor 6 - metabolism | Macrophages - drug effects | Protein-Serine-Threonine Kinases - immunology | Francisella tularensis - pathogenicity | Myeloid Differentiation Factor 88 - metabolism | Cytokines - biosynthesis | Cell receptors | Transcription factors | Immune response | Physiological aspects | Genetic aspects | Research | Health aspects | Francisella tularensis
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2004, Volume 101, Issue 29, pp. 10679 - 10684
Toll-like receptors (TLRs) and the downstream adaptor molecule myeloid differentiation factor 88 (MyD88... 
Sinus of Valsalva | Molecules | Biological Sciences | Receptors | Cytokines | Atherosclerosis | Lipids | Aorta | Leukocytes | Macrophages | Lesions | EARLY CAROTID ATHEROSCLEROSIS | INFECTIOUS AGENTS | ACTIVATION | TOLL-LIKE RECEPTOR-4 | CYCLOOXYGENASE-2 | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | LESION FORMATION | ANTIBIOTIC-TREATMENT | NF-KAPPA-B | PROGRESSION | Toll-Like Receptor 4 | Cyclooxygenase 2 | Humans | Male | Arteriosclerosis - genetics | Apolipoproteins E - metabolism | Interleukin-12 - blood | Toll-Like Receptors | Lipids - chemistry | Immunity, Innate - physiology | Isoenzymes - metabolism | Arteriosclerosis - immunology | Female | Chemokine CCL2 - metabolism | Membrane Glycoproteins - immunology | Receptors, Immunologic - immunology | Endothelial Cells - metabolism | Mice, Inbred C57BL | Cells, Cultured | Lipid Metabolism | Myeloid Differentiation Factor 88 | Receptors, Cell Surface - immunology | Membrane Glycoproteins - genetics | Mice, Knockout | Aorta - pathology | Membrane Proteins | Adaptor Proteins, Signal Transducing | Macrophages - metabolism | Phenotype | Animals | Endothelial Cells - cytology | Prostaglandin-Endoperoxide Synthases - metabolism | Apolipoproteins E - genetics | Signal Transduction - physiology | Antigens, Differentiation - genetics | Mice | Aorta - cytology | Receptors, Immunologic - genetics | Arteriosclerosis - pathology | Antigens, Differentiation - immunology | Receptors, Cell Surface - genetics | Proteins | Research
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 9, pp. 1 - 7
Journal Article
The Journal of experimental medicine, ISSN 1540-9538, 2008, Volume 205, Issue 7, pp. 1543 - 1550
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 08/2000, Volume 192, Issue 4, pp. 595 - 600
.... However, the signaling pathways involved are poorly understood. Here we show that CpG-DNA activates the TLR/IL-1R signaling pathway via the molecules myeloid differentiation marker 88 (MyD88... 
Signal transduction | Interleukin 12 | CpG-DNA | Mice, knockout | Toll | interleukin 12 | MEDICINE, RESEARCH & EXPERIMENTAL | INTERLEUKIN-1 | signal transduction | KINASE | KAPPA-B | INDUCTION | IMMUNOLOGY | mice, knockout | FACTOR-ALPHA | GENE | TRAF6 | LIPOPOLYSACCHARIDE | ADAPTER PROTEIN | MYD88
Journal Article
Biochemical journal, ISSN 1470-8728, 2013, Volume 451, Issue 3, pp. 427 - 437
The compound BAY 11-7082 inhibits IκBα [inhibitor of NF-κB (nuclear factor κB)α] phosphorylation in cells and has been used to implicate the canonical IKKs (IκB kinases) and NF-κB in >350 publications... 
Linear ubiquitin assembly complex (LUBAC) | Myeloid differentiation factor 88 (MyD88) | Nuclear factor κB (NF-κB) | Lymphoma | Ubiquitin conjugating 13 (Ubc13) | Proteasome | nuclear factor kappa B (NF-kappa B) | proteasome | ACTIVATION | CELL LYMPHOMA-CELLS | LINEAR POLYUBIQUITIN CHAINS | linear ubiquitin assembly complex (LUBAC) | BIOCHEMISTRY & MOLECULAR BIOLOGY | lymphoma | KINASE | IKK | myeloid differentiation factor 88 (MyD88) | CROSS-TALK | IN-VIVO | CONJUGATING ENZYMES | NF-KAPPA-B | NEMO | ubiquitin conjugating 13 (Ubc13) | Nitriles - pharmacology | Humans | Receptors, Interleukin-1 - genetics | Ubiquitin - metabolism | Molecular Sequence Data | Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors | I-kappa B Proteins - metabolism | Sulfones - pharmacology | Proteasome Endopeptidase Complex - drug effects | Ubiquitination - drug effects | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Myeloid Differentiation Factor 88 - antagonists & inhibitors | Amino Acid Sequence | NF-KappaB Inhibitor alpha | Ubiquitin - antagonists & inhibitors | NF-kappa B p50 Subunit - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Myeloid Differentiation Factor 88 - genetics | Ubiquitin-Conjugating Enzymes - genetics | Macrophages - cytology | Interleukin-1 - pharmacology | Receptors, Interleukin-1 - metabolism | Gene Expression Regulation - drug effects | Macrophages - metabolism | Animals | Signal Transduction - drug effects | Ubiquitin-Conjugating Enzymes - metabolism | Lipopolysaccharides - pharmacology | Cell Line, Tumor | Macrophages - drug effects | Mice | Proteasome Endopeptidase Complex - metabolism | Ubiquitin-Conjugating Enzymes - antagonists & inhibitors | Myeloid Differentiation Factor 88 - metabolism | TRAF, tumour-necrosis-factor-receptor-associated factor | HRMS, high-resolution mass spectra | K48-pUb, Lys48-linked polyubiquitin | UBE, ubiquitin-activating enzyme | IKK, IκB kinase | NEMO, NF-κB essential modifier | HEK, human embryonic kidney | TBK1, tumour-necrosis-factor-receptor-associated factor-associated NF-κB activator-binding kinase 1 | JNK, c-Jun N-terminal kinase | HOIP, haem-oxidized IRP2 ligase-1-interacting protein | LUBAC, linear ubiquitin assembly complex | ERK, extracellular-signal-regulated kinase | HTLV-1, human T-cell lymphotropic virus 1 | K63-pUb, Lys63-linked polyubiquitin | IRAK, IL-receptor-associated kinase | pUb, polyubiquitin | IκB, inhibitor of NF-κB | MALDI–TOF, matrix-assisted laser-desorption ionization–time-of-flight | GAPDH, glyceraldehyde-3-phosphate dehydrogenase | MyD88, myeloid differentiation factor 88 | DLBCL, diffuse large B-cell lymphoma | GFP, green fluorescent protein | NF-κB, nuclear factor κB | MS, tandem MS | Ubc, ubiquitin conjugating | TAK1, transforming growth factor β-activated kinase 1 | DAPI, 4′,6-diamidino-2-phenylindole | IL-1R, IL-1 receptor | DMEM, Dulbecco’s modified Eagle’s medium | HIF1α, hypoxia-inducible factor 1α | IL, interleukin | NEDD8, neural-precursor-cell-expressed developmentally down-regulated 8 | RBR, RING-between-RING, TAB, TAK1-binding protein | LPS, lipopolysaccharide | nuclear factor κB (NF-κB) | MAPK, mitogen-activated protein kinase | PAMP, pathogen-associated molecular pattern
Journal Article