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The Journal of immunology (1950), ISSN 1550-6606, 2008, Volume 180, Issue 7, pp. 4763 - 4773
TLR sense microbial infections, and control activation of immune responses. Dendritic cells, macrophages, and B lymphocytes express TLR and the TLR-signaling... 
MYCOBACTERIUM-TUBERCULOSIS | REGULATORY-CELLS | MULTIPLE-SCLEROSIS | DENDRITIC CELLS | NONOBESE DIABETIC MICE | IN-VIVO | TOLL-LIKE RECEPTORS | CENTRAL-NERVOUS-SYSTEM | IMMUNOLOGY | BACTERIAL-DNA | CUTTING EDGE | Interleukin-10 - deficiency | Encephalomyelitis, Autoimmune, Experimental - metabolism | Dendritic Cells - immunology | Mice, Inbred C57BL | Toll-Like Receptors - immunology | Mycobacterium tuberculosis - immunology | Myeloid Differentiation Factor 88 - genetics | Encephalomyelitis, Autoimmune, Experimental - immunology | Toll-Like Receptors - agonists | Mice, Knockout | Signal Transduction - immunology | Lymphocyte Activation - immunology | Animals | B-Lymphocytes - immunology | Myeloid Differentiation Factor 88 - deficiency | Autoimmunity - immunology | Interleukin-10 - genetics | Myeloid Differentiation Factor 88 - immunology | Interleukin-10 - metabolism | T-Lymphocytes - immunology | Mice | Encephalomyelitis, Autoimmune, Experimental - genetics | Interleukin-10 - immunology | Myeloid Differentiation Factor 88 - metabolism | Autoimmunity | Dendritic Cells | Interleukin-10 | Signal Transduction | T-Lymphocytes | Lymphocyte Activation | B-Lymphocytes | Myeloid Differentiation Factor 88 | Life Sciences | Toll-Like Receptors | Encephalomyelitis, Autoimmune, Experimental | Immunology | Mycobacterium tuberculosis
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2008, Volume 321, Issue 5889, pp. 691 - 696
MyD88 is a key downstream adapter for most Toll-like receptors (TLRs) and interleukin-1 receptors (IL-1Rs). MyD88 deficiency in mice leads to susceptibility to... 
Receptors | Phenotypes | Transfection | Cytokines | HEK293 cells | Genes | Cell lines | Fibroblasts | Agonists | Reports | Children | MYD88-DEFICIENT MICE | HERPES-SIMPLEX-VIRUS | PROTECTIVE IMMUNITY | MYELOID DIFFERENTIATION FACTOR-88 | PSEUDOMONAS-AERUGINOSA | MULTIDISCIPLINARY SCIENCES | HUMORAL IMMUNITY | STAPHYLOCOCCUS-AUREUS | AERUGINOSA LUNG INFECTION | HOST RESPONSE | CUTTING EDGE | Humans | Child, Preschool | Male | Mutation, Missense | Bacterial Infections - genetics | Pneumococcal Infections - immunology | Bacterial Infections - immunology | Gene Deletion | Pneumococcal Infections - genetics | Female | Toll-Like Receptors - metabolism | Child | Staphylococcal Infections - genetics | Disease Susceptibility | Cytokines - metabolism | Signal Transduction | Staphylococcal Infections - immunology | Receptors, Interleukin-1 - immunology | Toll-Like Receptors - immunology | Myeloid Differentiation Factor 88 - genetics | Immunity, Innate | Pseudomonas Infections - genetics | Pseudomonas Infections - immunology | Receptors, Interleukin-1 - metabolism | Animals | Myeloid Differentiation Factor 88 - deficiency | Adolescent | Mice | Myeloid Differentiation Factor 88 - metabolism | Cell Line, Transformed | Genetic aspects | Bacterial infections | Pediatrics | Bacteria | Biomedical research | Genetic disorders | Immunology | Pneumococcal Infections | Life Sciences | Toll-Like Receptors | Bacterial Infections | Myeloid Differentiation Factor 88 | Bacteriology | Staphylococcal Infections | Microbiology and Parasitology | Pseudomonas Infections | Receptors, Interleukin-1
Journal Article
Nature immunology, ISSN 1529-2916, 2010, Volume 11, Issue 5, pp. 411 - 418
.... and its downstream target, the transcription factor XBP1. Previously described ER-stress target genes of XBP1 were not induced by TLR signaling... 
UNFOLDED PROTEIN RESPONSE | PATHWAY | ER STRESS | HOST-DEFENSE | ENDOPLASMIC-RETICULUM STRESS | FRANCISELLA-TULARENSIS INFECTION | IMMUNOLOGY | LIVE VACCINE STRAIN | INFLAMMATORY RESPONSE | NEGATIVE REGULATOR | SYSTEMS BIOLOGY | RNA, Small Interfering - genetics | Endoribonucleases - genetics | Tularemia - metabolism | Toll-Like Receptor 2 - genetics | Membrane Glycoproteins - metabolism | Lipopeptides - pharmacology | Transcriptional Activation - drug effects | NADPH Oxidases - metabolism | Tularemia - genetics | Protein Splicing - genetics | Transcriptional Activation - immunology | X-Box Binding Protein 1 | Protein Splicing - drug effects | NADPH Oxidases - genetics | Stress, Physiological - drug effects | TNF Receptor-Associated Factor 6 - genetics | Transcription Factor CHOP - biosynthesis | Transcription Factors - immunology | Cytokines - genetics | Protein-Serine-Threonine Kinases - metabolism | DNA-Binding Proteins - immunology | Endoribonucleases - metabolism | Macrophages - pathology | Stress, Physiological - genetics | Myeloid Differentiation Factor 88 - genetics | Toll-Like Receptor 4 - genetics | Signal Transduction - genetics | Toll-Like Receptor 4 - immunology | Toll-Like Receptor 2 - metabolism | Toll-Like Receptor 4 - metabolism | Mice, Knockout | Macrophages - metabolism | Signal Transduction - drug effects | Tunicamycin - pharmacology | Lipopolysaccharides - pharmacology | Toll-Like Receptor 2 - immunology | Mice | Stress, Physiological - immunology | Endoribonucleases - immunology | Transcription Factor CHOP - genetics | NADPH Oxidases - immunology | DNA-Binding Proteins - metabolism | Signal Transduction - immunology | Macrophages - virology | Mice, Mutant Strains | Tularemia - immunology | Membrane Glycoproteins - immunology | Macrophages - immunology | Cytokines - immunology | Cell Line | Francisella tularensis - immunology | Protein Splicing - immunology | Protein-Serine-Threonine Kinases - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Immunity, Innate | NADPH Oxidase 2 | Regulatory Factor X Transcription Factors | Mice, Inbred C3H | Membrane Glycoproteins - genetics | Transcription Factors - metabolism | Animals | TNF Receptor-Associated Factor 6 - metabolism | Macrophages - drug effects | Protein-Serine-Threonine Kinases - immunology | Francisella tularensis - pathogenicity | Myeloid Differentiation Factor 88 - metabolism | Cytokines - biosynthesis | Cell receptors | Transcription factors | Immune response | Physiological aspects | Genetic aspects | Research | Health aspects | Francisella tularensis
Journal Article
PloS one, ISSN 1932-6203, 10/2012, Volume 7, Issue 10, p. e47038
Myeloid differentiation factor 88 (MyD88) is a universal and essential signaling protein in Toll-like receptor/interleukin-1 receptor-induced activation of nuclear factor-kappa B... 
MOLECULAR CHARACTERIZATION | TOLL-LIKE-RECEPTORS | IMMUNITY | SHRIMP PENAEUS-MONODON | RECOGNITION | CLONING | MULTIDISCIPLINARY SCIENCES | ANTIMICROBIAL PEPTIDE GENES | INFECTION | CDNA | NF-KAPPA-B | Hemocytes - physiology | Molecular Sequence Data | Phylogeny | White spot syndrome virus 1 - pathogenicity | Hemocytes - virology | Base Sequence | Cloning, Molecular | Penaeidae - metabolism | Antimicrobial Cationic Peptides - genetics | Drosophila - genetics | Amino Acid Sequence | Promoter Regions, Genetic | Penaeidae - virology | Signal Transduction | Penaeidae - genetics | Gene Expression Regulation | Myeloid Differentiation Factor 88 - genetics | Penaeidae - microbiology | Drosophila - cytology | Staphylococcus aureus - pathogenicity | Vibrio parahaemolyticus - pathogenicity | Sequence Homology, Amino Acid | Animals | Hemocytes - drug effects | Lipopolysaccharides - pharmacology | Myeloid Differentiation Factor 88 - metabolism | Penaeidae - immunology | Physiological aspects | Research | Gene expression | Blood cells | Water-borne diseases | Peptides | Shellfish | Laboratories | Genes | Interleukin | Viruses | White spot syndrome | Infections | Activation | Antiinfectives and antibacterials | Proteins | Signal transduction | Crustaceans | Transcription activation | Hepatopancreas | Interleukin 1 | Toll-like receptors | Deoxyribonucleic acid--DNA | CpG islands | Immune system | NF-κB protein | Cytokines | Cloning | Low level | IE1 protein | Signaling | MyD88 protein | Invertebrates | Differentiation | Hemocytes | Deoxyribonucleic acid | Drosophila | DNA
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2004, Volume 101, Issue 29, pp. 10679 - 10684
Toll-like receptors (TLRs) and the downstream adaptor molecule myeloid differentiation factor 88 (MyD88... 
Sinus of Valsalva | Molecules | Biological Sciences | Receptors | Cytokines | Atherosclerosis | Lipids | Aorta | Leukocytes | Macrophages | Lesions | EARLY CAROTID ATHEROSCLEROSIS | INFECTIOUS AGENTS | ACTIVATION | TOLL-LIKE RECEPTOR-4 | CYCLOOXYGENASE-2 | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | LESION FORMATION | ANTIBIOTIC-TREATMENT | NF-KAPPA-B | PROGRESSION | Toll-Like Receptor 4 | Cyclooxygenase 2 | Humans | Male | Arteriosclerosis - genetics | Apolipoproteins E - metabolism | Interleukin-12 - blood | Toll-Like Receptors | Lipids - chemistry | Immunity, Innate - physiology | Isoenzymes - metabolism | Arteriosclerosis - immunology | Female | Chemokine CCL2 - metabolism | Membrane Glycoproteins - immunology | Receptors, Immunologic - immunology | Endothelial Cells - metabolism | Mice, Inbred C57BL | Cells, Cultured | Lipid Metabolism | Myeloid Differentiation Factor 88 | Receptors, Cell Surface - immunology | Membrane Glycoproteins - genetics | Mice, Knockout | Aorta - pathology | Membrane Proteins | Adaptor Proteins, Signal Transducing | Macrophages - metabolism | Phenotype | Animals | Endothelial Cells - cytology | Prostaglandin-Endoperoxide Synthases - metabolism | Apolipoproteins E - genetics | Signal Transduction - physiology | Antigens, Differentiation - genetics | Mice | Aorta - cytology | Receptors, Immunologic - genetics | Arteriosclerosis - pathology | Antigens, Differentiation - immunology | Receptors, Cell Surface - genetics | Proteins | Research
Journal Article
Journal Article
The Journal of immunology (1950), ISSN 1550-6606, 2008, Volume 180, Issue 9, pp. 5799 - 5803
Journal Article
PloS one, ISSN 1932-6203, 2010, Volume 5, Issue 9, pp. 1 - 7
Journal Article
PLoS pathogens, ISSN 1553-7374, 2017, Volume 13, Issue 1, p. e1006092
Toll/interleukin-1 receptor (TIR) domains in Toll-like receptors are essential for initiating and propagating the eukaryotic innate immune signaling cascade.... 
Laboratory of Phytopathology | EPS | Laboratorium voor Phytopathologie | Laboratorium voor Fytopathologie | STRAINS | SYSTEM | CONTAINING PROTEINS | MICROBIOLOGY | CASSETTE CHROMOSOME MEC | VECTOR | FAMILY | EVOLUTION | VIROLOGY | GENOMES | BTPB | CLONES | PARASITOLOGY | Virulence Factors - genetics | Humans | Receptors, Interleukin-1 - genetics | Penicillin-Binding Proteins - genetics | Virulence Factors - immunology | Signal Transduction - immunology | Staphylococcal Skin Infections - drug therapy | HEK293 Cells | Bacterial Proteins - immunology | Fusidic Acid - pharmacology | Membrane Glycoproteins - immunology | Macrophages - immunology | Disease Models, Animal | Staphylococcus aureus - genetics | Cell Line | Receptors, Interleukin-1 - immunology | Mice, Inbred C57BL | Bacterial Proteins - genetics | Myeloid Differentiation Factor 88 - genetics | Neutrophils - immunology | Staphylococcus aureus - pathogenicity | Membrane Glycoproteins - genetics | Mice, Knockout | Animals | Myeloid Differentiation Factor 88 - deficiency | Toll-Like Receptors - genetics | Staphylococcus aureus - immunology | Mice | Staphylococcal Skin Infections - microbiology | Bacterial infections | Disease transmission | Gene mutations | Analysis | Genetic aspects | Research | Bacterial genetics | Epidemiology | Risk factors | Studies | Pathogens | Medical research | Enzymes | Cytokines | Laboratories | Genes | Antimicrobial agents | Staphylococcus infections | Genetic engineering | Experiments | Life Sciences | Microbiology and Parasitology | Immunology | Bacteriology | Virology
Journal Article
The Journal of Immunology, ISSN 0022-1767, 12/2003, Volume 171, Issue 11, pp. 6145 - 6153
.... Myeloid differentiation factor 88 (MyD88) is a Toll/IL-1R domain containing adaptor molecule known to have a central role in both IL-1R/IL-18R and TLR signaling... 
RHEUMATOID-ARTHRITIS | CPG MOTIFS | INTERLEUKIN-1 | PROINFLAMMATORY ROLE | GAMMA PRODUCTION | SYNOVIAL TISSUE | TOLL-LIKE RECEPTORS | INDUCED ARTHRITIS | NECROSIS-FACTOR-ALPHA | IMMUNOLOGY | MYD88 | Toll-Like Receptor 2 | Arthritis, Experimental - genetics | Cell Wall - immunology | Receptors, Immunologic - physiology | Interleukin-18 - physiology | Membrane Glycoproteins - biosynthesis | Male | Arthritis, Experimental - metabolism | Arthritis, Experimental - pathology | Signal Transduction - immunology | Toll-Like Receptors | Membrane Glycoproteins - physiology | Cartilage, Articular - metabolism | Inflammation Mediators - metabolism | Interleukin-1 - physiology | Inflammation Mediators - antagonists & inhibitors | Receptors, Cell Surface - biosynthesis | Receptors, Cell Surface - physiology | Neutrophil Infiltration - immunology | Proteoglycans - immunology | Streptococcus pyogenes - immunology | Mice, Inbred C57BL | Receptors, Immunologic - deficiency | Proteoglycans - metabolism | Receptors, Interleukin-1 - biosynthesis | Arthritis, Experimental - immunology | Signal Transduction - genetics | Myeloid Differentiation Factor 88 | Neutrophil Infiltration - genetics | Down-Regulation - genetics | Antigens, Differentiation - physiology | Membrane Glycoproteins - genetics | Mice, Knockout | Adaptor Proteins, Signal Transducing | Animals | Down-Regulation - immunology | Receptors, Cell Surface - deficiency | Tumor Necrosis Factor-alpha - physiology | Receptors, Interleukin-1 - physiology | Antigens, Differentiation - genetics | Mice | Multigene Family - immunology | Receptors, Immunologic - genetics | Receptors, Interleukin-1 - antagonists & inhibitors | Cartilage, Articular - immunology | Membrane Glycoproteins - deficiency | Receptors, Cell Surface - genetics
Journal Article