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Cancer Cell, ISSN 1535-6108, 2010, Volume 17, Issue 6, pp. 584 - 596
We report a knockin mouse myeloproliferative neoplasm (MPN) model resembling human polycythemia vera (PV). The MPN is serially transplantable and we... 
CELLCYCLE | POLYCYTHEMIA-VERA | ACTIVATING MUTATION | ONCOLOGY | IN-VIVO | TYROSINE KINASE JAK2 | CONDITIONAL EXPRESSION | MYELODYSPLASTIC-SYNDROMES | ESSENTIAL THROMBOCYTHEMIA | VERA-LIKE DISEASE | CHRONIC MYELOMONOCYTIC LEUKEMIA | CHRONIC MYELOID-LEUKEMIA | Erythropoietin - pharmacology | Gene Expression - genetics | Cell Count | Humans | Hematocrit | Hematopoietic Stem Cells - pathology | Polycythemia Vera - genetics | Gene Expression Profiling | Myeloproliferative Disorders - pathology | Spleen - drug effects | Antigens, CD - metabolism | Bone Marrow Transplantation | Megakaryocyte-Erythroid Progenitor Cells - transplantation | Polycythemia Vera - pathology | Janus Kinase 2 - antagonists & inhibitors | Disease Models, Animal | Megakaryocyte-Erythroid Progenitor Cells - metabolism | Hematopoietic Stem Cell Transplantation | Mice, Transgenic | Myeloid Progenitor Cells - pathology | Megakaryocyte-Erythroid Progenitor Cells - drug effects | Sulfonamides - pharmacology | Megakaryocyte Progenitor Cells - metabolism | Erythroid Precursor Cells - pathology | Survival Analysis | Erythroid Precursor Cells - metabolism | Mice | Megakaryocyte Progenitor Cells - pathology | Myeloproliferative Disorders - genetics | Pyrrolidines - pharmacology | Pyrrolidines - therapeutic use | Cell Differentiation - genetics | Janus Kinase 2 - metabolism | Bone Marrow Cells - drug effects | Spleen - pathology | Hematopoietic Stem Cells - drug effects | Myeloid Progenitor Cells - metabolism | Mice, Inbred C57BL | Janus Kinase 2 - genetics | Hematopoietic Stem Cells - metabolism | Myeloproliferative Disorders - drug therapy | Animals | Sulfonamides - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Bone Marrow - pathology | Heterozygote | Protein Kinase Inhibitors - pharmacology | Amino Acid Substitution | Megakaryocyte-Erythroid Progenitor Cells - pathology | Physiological aspects | Medical colleges | Analysis | Hematopoietic stem cells | Tumors
Journal Article
Nature, ISSN 0028-0836, 09/2017, Volume 549, Issue 7672, pp. 389 - 393
The pathophysiology of neurodegenerative diseases is poorly understood and there are few therapeutic options. Neurodegenerative diseases are characterized by... 
DENDRITIC CELLS | PATTERN | LANGERHANS CELL HISTIOCYTOSIS | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | KINASE | MICE | MODEL | ERDHEIM-CHESTER-DISEASE | EXPRESSION | Microglia - metabolism | Clone Cells - enzymology | Humans | Male | Myeloid Progenitor Cells - enzymology | Extracellular Signal-Regulated MAP Kinases - metabolism | MAP Kinase Signaling System | Erythroid Precursor Cells - enzymology | Histiocytosis - pathology | Microglia - pathology | Female | Proto-Oncogene Proteins B-raf - metabolism | Disease Models, Animal | Histiocytosis - enzymology | Myeloid Progenitor Cells - metabolism | Neurodegenerative Diseases - pathology | Macrophages - pathology | Microglia - enzymology | Neurodegenerative Diseases - genetics | Myeloid Progenitor Cells - pathology | Histiocytosis - metabolism | Neurodegenerative Diseases - metabolism | Clone Cells - metabolism | Macrophages - enzymology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Erythroid Precursor Cells - pathology | Macrophages - metabolism | Animals | Clone Cells - pathology | Proto-Oncogene Proteins B-raf - genetics | Histiocytosis - genetics | Erythroid Precursor Cells - metabolism | Mosaicism | Mice | Mutation | Neurodegenerative Diseases - enzymology | Physiological aspects | Nervous system | Development and progression | Degeneration | Genetic aspects | Research | Histiocytosis | Mitogen-activated protein kinases | Intervention | Disease | Stem cell transplantation | Activation | Genomes | Kinases | Macrophages | Neuronal-glial interactions | Genotype & phenotype | Allografts | Neurodegeneration | Rodents | Bone marrow | Ataxia | Alzheimer's disease | Myeloid cells | Cytokines | Neurodegenerative diseases | Fetuses | Extracellular signal-regulated kinase | MAP kinase | Cell lineage | Gene expression | Patients | Amyloid precursor protein | Microglia | Organogenesis | Diseases | Neurological diseases | Gliosis | Stem cells | Neural stem cells
Journal Article
Cancer Cell, ISSN 1535-6108, 12/2004, Volume 6, Issue 6, pp. 587 - 596
Journal Article
Journal Article
Journal Article
Cell Metabolism, ISSN 1550-4131, 05/2013, Volume 17, Issue 5, pp. 695 - 708
Diabetes is a major risk factor for atherosclerosis. Although atherosclerosis is initiated by deposition of cholesterol-rich lipoproteins in the artery wall,... 
DIABETES-MELLITUS | PLAQUE REGRESSION | INSULIN-RESISTANCE | ADVANCED GLYCATION ENDPRODUCTS | ENDOCRINOLOGY & METABOLISM | LEUKOCYTE COUNT | RECEPTOR | STEM-CELL PROLIFERATION | APOE(-/-) MICE | DEFICIENT MICE | G-CSF | CELL BIOLOGY | Leukocytes - pathology | Humans | Diabetes Mellitus, Type 1 - metabolism | Male | Monocytes - metabolism | NF-kappa B - metabolism | Leukocytosis - metabolism | Coronary Disease - metabolism | Bone Marrow - metabolism | Hyperglycemia - pathology | Monocytes - pathology | Diabetes Mellitus, Experimental - metabolism | Neutrophils - metabolism | Receptor for Advanced Glycation End Products | Leukocytosis - pathology | Neutrophils - pathology | Myeloid Progenitor Cells - metabolism | Atherosclerosis - pathology | Myelopoiesis - physiology | Cytokines - metabolism | Mice, Inbred C57BL | Diabetes Mellitus, Type 1 - pathology | Myeloid Progenitor Cells - pathology | Atherosclerosis - metabolism | Hyperglycemia - metabolism | Coronary Disease - pathology | Animals | Bone Marrow - pathology | Glycation End Products, Advanced - metabolism | Glucose - metabolism | Mice | Leukocytes - metabolism | Receptors, Immunologic - metabolism | Hyperglycemia | Type 1 diabetes | Atherosclerosis | Development and progression | Universities and colleges | Blood lipids | Coronary heart disease | Medicine, Preventive | Cholesterol | Preventive health services
Journal Article
Journal Article
European Journal of Immunology, ISSN 0014-2980, 06/2011, Volume 41, Issue 6, pp. 1675 - 1686
Journal Article
Cancer Epidemiology Biomarkers & Prevention, ISSN 1055-9965, 01/2010, Volume 19, Issue 1, pp. 80 - 88
Journal Article