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Nature (London), ISSN 1476-4687, 2017, Volume 543, Issue 7644, pp. 270 - 274
Recurrent chromosomal translocations producing a chimaeric MLL oncogene give rise to a highly aggressive acute leukaemia associated with poor clinical outcome(1... 
H3K79 METHYLATION | CELLS | ESSENTIAL GENES | PROTEIN | CHROMATIN | MULTIDISCIPLINARY SCIENCES | IN-VIVO | C-MYC | BET BROMODOMAIN INHIBITION | HISTONE CROTONYLATION | MIXED-LINEAGE LEUKEMIA | Myeloid-Lymphoid Leukemia Protein - metabolism | Cell Proliferation | Leukemia - pathology | Transcription Factors - chemistry | Epigenesis, Genetic | Humans | Leukemia, Myeloid, Acute - metabolism | Gene Expression Regulation, Neoplastic | Genome - genetics | Transcriptional Elongation Factors - chemistry | Leukemia - metabolism | RNA Polymerase II - metabolism | DNA-Binding Proteins - metabolism | Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Proteolysis | Protein Domains | Transcription, Genetic | Transcriptional Elongation Factors - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology | Leukemia - genetics | Leukemia, Myeloid, Acute - pathology | Transcription Factors - genetics | DNA-Binding Proteins - genetics | DNA-Binding Proteins - chemistry | Gene Editing | Transcription Elongation, Genetic | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Transcription Factors - metabolism | Transcriptional Elongation Factors - metabolism | Animals | Histone-Lysine N-Methyltransferase - metabolism | CRISPR-Cas Systems | Cell Line, Tumor | Mice | Leukemia, Myeloid, Acute - genetics | Development and progression | Genetic aspects | Genetic transcription | Research | Analysis | Leukemia | Proteins | Pathogenesis | Medical prognosis | Mutation | RNA polymerase | Gene expression | Localization
Journal Article
Nature reviews. Cancer, ISSN 1474-1768, 2007, Volume 7, Issue 11, pp. 823 - 833
.... A key feature of MLL fusion proteins is their ability to efficiently transform haematopoietic cells into leukaemia stem cells... 
CHROMOSOMAL TRANSLOCATIONS | ONCOLOGY | GENE-EXPRESSION | METHYLTRANSFERASE ACTIVITY | ALL-1 GENE | ACUTE MYELOID-LEUKEMIA | FUSION PARTNERS | HOX EXPRESSION | BREAKPOINT CLUSTER REGION | PARTIAL TANDEM DUPLICATION | HEMATOPOIETIC STEM | Protein Methyltransferases | Neoplastic Stem Cells - cytology | Prognosis | Humans | Myeloid-Lymphoid Leukemia Protein - deficiency | Infant | Myeloid-Lymphoid Leukemia Protein - chemistry | Epigenesis, Genetic - physiology | Oncogene Proteins, Fusion - physiology | Oncogene Proteins, Fusion - chemistry | Myeloid-Lymphoid Leukemia Protein - physiology | Cell Transformation, Neoplastic - genetics | Gene Expression Regulation, Developmental | Adult | Child | Leukemia - genetics | Chromatin - ultrastructure | Histone-Lysine N-Methyltransferase - genetics | Gene Expression Regulation - genetics | Gene Expression Regulation - physiology | Hematopoietic Stem Cells - metabolism | Cell Division - physiology | Animals | Histone Methyltransferases | Epigenesis, Genetic - genetics | Myeloid-Lymphoid Leukemia Protein - genetics | Oncogene Proteins, Fusion - genetics | Hematopoietic Stem Cells - cytology | Mice | Protein Processing, Post-Translational | Histones - metabolism | Methylation | Histone-Lysine N-Methyltransferase - physiology | Leukemia | Stem cells | Histones | Physiological aspects | Genetic aspects | Research | Gene expression
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2011, Volume 108, Issue 38, pp. 15751 - 15756
Journal Article
Cancer cell, ISSN 1535-6108, 2008, Volume 13, Issue 6, pp. 483 - 495
Faithful modeling of mixed-lineage leukemia in murine cells has been difficult to achieve... 
STEMCELL | CELLCYCLE | HEMATOPOIETIC-CELLS | B-CELLS | STEM-CELLS | ONCOLOGY | MLL REARRANGEMENTS | ACUTE LYMPHOBLASTIC-LEUKEMIA | ACUTE MYELOGENOUS LEUKEMIA | THERAPEUTIC TARGET | GENE-EXPRESSION PROFILES | ACUTE MYELOID-LEUKEMIA | FLT3 MUTATIONS | Translocation, Genetic | Antigens, CD34 - analysis | Myeloid-Lymphoid Leukemia Protein - metabolism | Cell Proliferation | Fetal Stem Cells - metabolism | Humans | Leukemia, Myeloid, Acute - metabolism | Multipotent Stem Cells - metabolism | rac GTP-Binding Proteins - metabolism | Aneuploidy | Gene Expression Profiling | Stem Cell Transplantation | Neoplastic Stem Cells - metabolism | Time Factors | Cell Transformation, Neoplastic - genetics | rac GTP-Binding Proteins - genetics | Neoplastic Stem Cells - pathology | Cell Culture Techniques | Fetal Blood - immunology | Transduction, Genetic | Signal Transduction | Leukemia, Myeloid, Acute - pathology | Genotype | Cell Lineage | Multipotent Stem Cells - pathology | Phenotype | Environment | Mice, Inbred NOD | Mice | Fetal Stem Cells - pathology | Oncogene Proteins, Fusion - metabolism | Species Specificity | Gene Expression Regulation, Neoplastic | Neoplastic Stem Cells - immunology | Multipotent Stem Cells - immunology | Fetal Stem Cells - immunology | Intercellular Signaling Peptides and Proteins - metabolism | Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology | Leukemia, Experimental - pathology | Fetal Blood - metabolism | Mice, SCID | Cell Transformation, Neoplastic - metabolism | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Animals | Myeloid-Lymphoid Leukemia Protein - genetics | Oncogene Proteins, Fusion - genetics | Chromosomes, Human, Pair 11 | Cell Transformation, Neoplastic - pathology | Cell Line, Transformed | Leukemia, Experimental - metabolism | Apoptosis | Leukemia, Myeloid, Acute - genetics | Cytogenetics | Models | Growth factors | Analysis | Leukemia | Stem cells
Journal Article
Cancer cell, ISSN 1535-6108, 2008, Volume 14, Issue 1, pp. 36 - 46
...), a chromatin-associated protein previously implicated in leukemia, autoimmunity, and HIV-1 pathogenesis... 
CELLCYCLE | Protein Methyltransferases | Chromatin - metabolism | Myeloid-Lymphoid Leukemia Protein - metabolism | Leukemia - pathology | Homeodomain Proteins - metabolism | Humans | Myeloid Progenitor Cells - enzymology | Leukemia - metabolism | Multiple Endocrine Neoplasia Type 1 - genetics | Multiple Endocrine Neoplasia Type 1 - metabolism | RNA Interference | Time Factors | Cell Transformation, Neoplastic - genetics | U937 Cells | Tumor Suppressor Proteins - genetics | Transcription, Genetic | Leukemia - genetics | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Myeloid Progenitor Cells - metabolism | Tumor Suppressor Proteins - metabolism | Transduction, Genetic | Leukemia - enzymology | Mice, Inbred C57BL | Chromatin Assembly and Disassembly | Proto-Oncogene Proteins - genetics | Gene Expression Regulation, Leukemic | Transcription Factors - genetics | Cell Transformation, Neoplastic - metabolism | Homeodomain Proteins - genetics | Transcription Factors - metabolism | Animals | Histone Methyltransferases | Histone-Lysine N-Methyltransferase - metabolism | Myeloid-Lymphoid Leukemia Protein - genetics | Adaptor Proteins, Signal Transducing - genetics | Protein Binding | Mice | HeLa Cells | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Cell Transformation, Neoplastic - pathology | Autoimmunity | Histones | Genetic aspects | Leukemia | Genes | Cancer | leukemia | menin | MLL | LEDGF | MEN1
Journal Article
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 08/2012, Volume 287, Issue 33, pp. 27275 - 27289
Journal Article
PloS one, ISSN 1932-6203, 03/2014, Volume 9, Issue 3, p. e91116
Journal Article
The New England journal of medicine, ISSN 1533-4406, 2008, Volume 358, Issue 18, pp. 1909 - 1918
Journal Article
Experimental Hematology, ISSN 0301-472X, 2014, Volume 42, Issue 12, pp. 995 - 1012
...) alleles encoding mixed-lineage leukemia fusion proteins (MLL-FPs) or internal gene rearrangement products... 
Hematology, Oncology and Palliative Medicine | Advanced Basic Science | RNA-POLYMERASE-II | MEDICINE, RESEARCH & EXPERIMENTAL | ACUTE LYMPHOBLASTIC-LEUKEMIA | HEMATOPOIETIC STEM-CELLS | MEDIATED TRANSFORMATION | FUSION GENE | ACUTE MYELOID-LEUKEMIA | ABERRANT HOX EXPRESSION | HEMATOLOGY | HISTONE METHYLTRANSFERASE | PARTIAL TANDEM DUPLICATION | REPRESSIVE COMPLEX 2 | Leukemia - pathology | Epigenesis, Genetic | Humans | Multiprotein Complexes | Neoplasm Proteins - physiology | Myeloid-Lymphoid Leukemia Protein - chemistry | Oncogene Proteins, Fusion - physiology | Heterografts | Oncogene Proteins, Fusion - chemistry | Myeloid-Lymphoid Leukemia Protein - physiology | Neoplasm Proteins - genetics | Leukemia - genetics | Leukemia, Experimental - genetics | Leukemia, Experimental - pathology | Protein Structure, Tertiary | Histone-Lysine N-Methyltransferase - genetics | Transcription Factors - physiology | Signal Transduction | Chromatin Assembly and Disassembly | Neoplasm Proteins - chemistry | Gene Expression Regulation, Leukemic | Gene Knock-In Techniques | Protein Interaction Mapping | Histone-Lysine N-Methyltransferase - chemistry | Animals | Cell Transformation, Neoplastic | Intracellular Signaling Peptides and Proteins - chemistry | Myeloid-Lymphoid Leukemia Protein - genetics | Oncogene Proteins, Fusion - genetics | Alleles | Mice | Intracellular Signaling Peptides and Proteins - physiology | Histone-Lysine N-Methyltransferase - physiology | Proteins | Epigenetic inheritance | Analysis | Lubrication and lubricants | Genomics | Leukemia | Drug resistance
Journal Article