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Journal Article
Nature, ISSN 0028-0836, 03/2017, Volume 543, Issue 7644, pp. 270 - 274
Recurrent chromosomal translocations producing a chimaeric MLL oncogene give rise to a highly aggressive acute leukaemia associated with poor clinical... 
H3K79 METHYLATION | CELLS | ESSENTIAL GENES | PROTEIN | CHROMATIN | MULTIDISCIPLINARY SCIENCES | IN-VIVO | C-MYC | BET BROMODOMAIN INHIBITION | HISTONE CROTONYLATION | MIXED-LINEAGE LEUKEMIA | Myeloid-Lymphoid Leukemia Protein - metabolism | Cell Proliferation | Leukemia - pathology | Transcription Factors - chemistry | Epigenesis, Genetic | Humans | Leukemia, Myeloid, Acute - metabolism | Gene Expression Regulation, Neoplastic | Genome - genetics | Transcriptional Elongation Factors - chemistry | Leukemia - metabolism | RNA Polymerase II - metabolism | DNA-Binding Proteins - metabolism | Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Proteolysis | Protein Domains | Transcription, Genetic | Transcriptional Elongation Factors - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology | Leukemia - genetics | Leukemia, Myeloid, Acute - pathology | Transcription Factors - genetics | DNA-Binding Proteins - genetics | DNA-Binding Proteins - chemistry | Gene Editing | Transcription Elongation, Genetic | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Transcription Factors - metabolism | Transcriptional Elongation Factors - metabolism | Animals | Histone-Lysine N-Methyltransferase - metabolism | CRISPR-Cas Systems | Cell Line, Tumor | Mice | Leukemia, Myeloid, Acute - genetics | Development and progression | Genetic aspects | Genetic transcription | Research | Analysis | Leukemia | Proteins | Pathogenesis | Medical prognosis | Mutation | RNA polymerase | Gene expression | Localization
Journal Article
Nature, ISSN 0028-0836, 10/2011, Volume 478, Issue 7370, pp. 529 - 533
Journal Article
Cancer Cell, ISSN 1535-6108, 2008, Volume 13, Issue 6, pp. 483 - 495
Faithful modeling of mixed-lineage leukemia in murine cells has been difficult to achieve. We show that expression of in human CD34+ cells induces acute... 
STEMCELL | CELLCYCLE | HEMATOPOIETIC-CELLS | B-CELLS | STEM-CELLS | ONCOLOGY | MLL REARRANGEMENTS | ACUTE LYMPHOBLASTIC-LEUKEMIA | ACUTE MYELOGENOUS LEUKEMIA | THERAPEUTIC TARGET | GENE-EXPRESSION PROFILES | ACUTE MYELOID-LEUKEMIA | FLT3 MUTATIONS | Translocation, Genetic | Antigens, CD34 - analysis | Myeloid-Lymphoid Leukemia Protein - metabolism | Cell Proliferation | Fetal Stem Cells - metabolism | Humans | Leukemia, Myeloid, Acute - metabolism | Multipotent Stem Cells - metabolism | rac GTP-Binding Proteins - metabolism | Aneuploidy | Gene Expression Profiling | Stem Cell Transplantation | Neoplastic Stem Cells - metabolism | Time Factors | Cell Transformation, Neoplastic - genetics | rac GTP-Binding Proteins - genetics | Neoplastic Stem Cells - pathology | Cell Culture Techniques | Fetal Blood - immunology | Transduction, Genetic | Signal Transduction | Leukemia, Myeloid, Acute - pathology | Genotype | Cell Lineage | Multipotent Stem Cells - pathology | Phenotype | Environment | Mice, Inbred NOD | Mice | Fetal Stem Cells - pathology | Oncogene Proteins, Fusion - metabolism | Species Specificity | Gene Expression Regulation, Neoplastic | Neoplastic Stem Cells - immunology | Multipotent Stem Cells - immunology | Fetal Stem Cells - immunology | Intercellular Signaling Peptides and Proteins - metabolism | Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology | Leukemia, Experimental - pathology | Fetal Blood - metabolism | Mice, SCID | Cell Transformation, Neoplastic - metabolism | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Animals | Myeloid-Lymphoid Leukemia Protein - genetics | Oncogene Proteins, Fusion - genetics | Chromosomes, Human, Pair 11 | Cell Transformation, Neoplastic - pathology | Cell Line, Transformed | Leukemia, Experimental - metabolism | Apoptosis | Leukemia, Myeloid, Acute - genetics | Cytogenetics | Models | Growth factors | Analysis | Leukemia | Stem cells
Journal Article
Molecular Cell, ISSN 1097-2765, 01/2014, Volume 53, Issue 2, pp. 247 - 261
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 2012, Volume 8, Issue 3, pp. 277 - 284
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 08/2015, Volume 11, Issue 8, pp. 571 - 578
The CEBPA gene is mutated in 9% of patients with acute myeloid leukemia (AML). Selective expression of a short (30-kDa) CCAAT-enhancer binding protein-alpha... 
DNA-BINDING | PROTEIN | HISTONE H3 | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | MYELOID DIFFERENTIATION | SELF-RENEWAL | MIXED-LINEAGE LEUKEMIA | PROTEOMIC IDENTIFICATION | EXPRESSION | H3K4 METHYLTRANSFERASE ACTIVITY | Small Molecule Libraries - pharmacology | Myeloid-Lymphoid Leukemia Protein - metabolism | Humans | Leukemia, Myeloid, Acute - metabolism | Gene Expression Regulation, Neoplastic | Molecular Sequence Data | Molecular Targeted Therapy | Histone-Lysine N-Methyltransferase - antagonists & inhibitors | Protein Isoforms - metabolism | Biphenyl Compounds - pharmacology | Antineoplastic Agents - pharmacology | CCAAT-Enhancer-Binding Proteins - genetics | Tumor Cells, Cultured | CCAAT-Enhancer-Binding Proteins - metabolism | Protein Structure, Tertiary | Amino Acid Sequence | Histone-Lysine N-Methyltransferase - genetics | Signal Transduction | Leukemia, Myeloid, Acute - pathology | Animals | Histones - genetics | Histone-Lysine N-Methyltransferase - metabolism | Cell Differentiation - drug effects | Myeloid-Lymphoid Leukemia Protein - genetics | Dihydropyridines - pharmacology | Protein Binding | Cell Proliferation - drug effects | Mice | Molecular Docking Simulation | Histones - metabolism | Mutation | Leukemia, Myeloid, Acute - genetics | Myeloid-Lymphoid Leukemia Protein - antagonists & inhibitors | Protein Isoforms - genetics | Index Medicus
Journal Article
Journal Article
Cancer Cell, ISSN 1535-6108, 07/2008, Volume 14, Issue 1, pp. 36 - 46
Menin displays the unique ability to either promote oncogenic function in the hematopoietic lineage or suppress tumorigenesis in the endocrine lineage;... 
CELLCYCLE | Protein Methyltransferases | Chromatin - metabolism | Myeloid-Lymphoid Leukemia Protein - metabolism | Leukemia - pathology | Homeodomain Proteins - metabolism | Humans | Myeloid Progenitor Cells - enzymology | Leukemia - metabolism | Multiple Endocrine Neoplasia Type 1 - genetics | Multiple Endocrine Neoplasia Type 1 - metabolism | RNA Interference | Time Factors | Cell Transformation, Neoplastic - genetics | U937 Cells | Tumor Suppressor Proteins - genetics | Transcription, Genetic | Leukemia - genetics | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Myeloid Progenitor Cells - metabolism | Tumor Suppressor Proteins - metabolism | Transduction, Genetic | Leukemia - enzymology | Mice, Inbred C57BL | Chromatin Assembly and Disassembly | Proto-Oncogene Proteins - genetics | Gene Expression Regulation, Leukemic | Transcription Factors - genetics | Cell Transformation, Neoplastic - metabolism | Homeodomain Proteins - genetics | Transcription Factors - metabolism | Animals | Histone Methyltransferases | Histone-Lysine N-Methyltransferase - metabolism | Myeloid-Lymphoid Leukemia Protein - genetics | Adaptor Proteins, Signal Transducing - genetics | Protein Binding | Mice | HeLa Cells | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Cell Transformation, Neoplastic - pathology | Autoimmunity | Histones | Genetic aspects | Leukemia | Genes | Cancer | Index Medicus | leukemia | menin | MLL | LEDGF | MEN1
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2011, Volume 108, Issue 38, pp. 15751 - 15756
A number of acute leukemias arise from fusion of the mixed lineage leukemia 1 protein (MLL) N terminus to a variety of fusion partners that have been reported... 
Proteins | Up regulation | Leukemia | Genes | Histones | Peptide elongation factors | Bone marrow cells | Methylation | English language learners | Family members | H3K79 METHYLATION | GENE | ELL | POLYMERASE-II ELONGATION | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION ELONGATION | HIV-1 TAT | MICE | HISTONE MODIFICATIONS | AFF4 | AF4 | Myeloid-Lymphoid Leukemia Protein - metabolism | Oncogene Proteins, Fusion - metabolism | Leukemia - pathology | Homeodomain Proteins - metabolism | Humans | Methyltransferases - metabolism | Methyltransferases - genetics | Immunoblotting | Multiprotein Complexes - genetics | Leukemia - metabolism | Positive Transcriptional Elongation Factor B - metabolism | Positive Transcriptional Elongation Factor B - genetics | Spodoptera | DNA-Binding Proteins - metabolism | Multiprotein Complexes - metabolism | HEK293 Cells | Nuclear Proteins - genetics | Leukemia - genetics | Cell Line | Cells, Cultured | Nuclear Proteins - metabolism | Binding Sites - genetics | DNA-Binding Proteins - genetics | Homeodomain Proteins - genetics | Animals | Cell Transformation, Neoplastic | Myeloid-Lymphoid Leukemia Protein - genetics | Oncogene Proteins, Fusion - genetics | Protein Binding | Mice | Histones - metabolism | Mutation | Physiological aspects | Genetic aspects | Research | Molecular structure | Cells | Binding sites | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2013, Volume 110, Issue 29, pp. 11994 - 11999
Journal Article