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1.
Full Text
Heterodimeric JAK-STAT activation as a mechanism of persistence to JAK2 inhibitor therapy
Nature (London), ISSN 0028-0836, 09/2012, Volume 489, Issue 7414, pp. 155 - 159
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Hematologic and hematopoietic diseases | Chemotherapy | Pharmacology. Drug treatments | Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis | Biological and medical sciences | Medical sciences | Antineoplastic agents | Myeloproliferative Disorders - enzymology | Phosphorylation | Protein Biosynthesis | Humans | Protein Multimerization | STAT Transcription Factors - metabolism | TYK2 Kinase - metabolism | Janus Kinase 1 - deficiency | TYK2 Kinase - deficiency | Myeloproliferative Disorders - pathology | Janus Kinase 1 - biosynthesis | Gene Knockdown Techniques | Janus Kinase 2 - deficiency | Janus Kinase 1 - metabolism | Granulocytes - drug effects | RNA Interference | Janus Kinase 1 - genetics | Janus Kinase 2 - metabolism | Myeloproliferative Disorders - metabolism | Granulocytes - metabolism | Janus Kinase 2 - antagonists & inhibitors | Disease Models, Animal | Cell Line | Janus Kinase 2 - genetics | Myeloproliferative Disorders - drug therapy | Enzyme Activation - drug effects | TYK2 Kinase - biosynthesis | Granulocytes - enzymology | Animals | Signal Transduction - drug effects | HSP90 Heat-Shock Proteins - antagonists & inhibitors | HSP90 Heat-Shock Proteins - metabolism | Mice | TYK2 Kinase - genetics | Drug Resistance, Neoplasm - drug effects | Enzyme inhibitors | Gene mutations | Cancer cells | Dosage and administration | Genetic aspects | Cellular signal transduction | Identification and classification | Physiological aspects | Care and treatment | Research | Myeloproliferative disorders | Cancer | Index Medicus | tyrosine kinase inhibitors | persistence | MPN | JAK2 | resistance
Journal Article
The New England journal of medicine, ISSN 0028-4793, 12/2006, Volume 355, Issue 23, pp. 2452 - 2466
Hematologic and hematopoietic diseases | Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis | Biological and medical sciences | General aspects | Medical sciences | Multipotent Stem Cells | Myeloproliferative Disorders - diagnosis | Signal Transduction | Humans | Myeloproliferative Disorders - classification | Janus Kinase 2 - genetics | Myeloproliferative Disorders - drug therapy | Genetic Markers | Mutation | Myeloproliferative Disorders - genetics | Causes of | Myelofibrosis | Diagnosis | Drug therapy | Myeloproliferative disorders | Index Medicus | Abridged Index Medicus
Journal Article
Leukemia, ISSN 0887-6924, 01/2008, Volume 22, Issue 1, pp. 23 - 30
Oncology | Life Sciences & Biomedicine | Hematology | Science & Technology | Hematologic and hematopoietic diseases | Polycythemias | Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis | Biological and medical sciences | Medical sciences | Diseases of red blood cells | Myeloproliferative Disorders - enzymology | Animals | Humans | Antineoplastic Agents - therapeutic use | Clinical Trials as Topic | Myeloproliferative Disorders - drug therapy | Drug Evaluation, Preclinical | Janus Kinase 2 - antagonists & inhibitors | Care and treatment | Enzyme inhibitors | Dosage and administration | Genetic aspects | Cellular signal transduction | Diagnosis | Health aspects | Myeloproliferative disorders | Index Medicus
Journal Article
Blood, ISSN 0006-4971, 09/2008, Volume 112, Issue 6, pp. 2190 - 2198
Life Sciences & Biomedicine | Hematology | Science & Technology | Hematologic and hematopoietic diseases | Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis | Biological and medical sciences | Medical sciences | Primary Myelofibrosis | History, 21st Century | History, 20th Century | Humans | Janus Kinase 2 - genetics | Myeloproliferative Disorders - drug therapy | Myeloproliferative Disorders - history | Myeloproliferative Disorders - genetics | Protein Kinase Inhibitors - therapeutic use | Myeloproliferative Disorders - etiology | Thrombocytosis | Polycythemia Vera | Janus Kinase 2 - antagonists & inhibitors | Index Medicus | Abridged Index Medicus | ASH 50th Anniversary Reviews
Journal Article
American journal of hematology, ISSN 0361-8609, 10/2019, Volume 94, Issue 10, pp. 1149 - 1167
Life Sciences & Biomedicine | Hematology | Science & Technology | Eosinophilia - therapy | Prognosis | Humans | Middle Aged | Symptom Assessment | Male | Antineoplastic Agents - therapeutic use | Eosinophilia - epidemiology | Myelodysplastic Syndromes - blood | Adrenal Cortex Hormones - therapeutic use | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Young Adult | fms-Like Tyrosine Kinase 3 - genetics | Myeloproliferative Disorders - blood | Receptor, Platelet-Derived Growth Factor alpha - antagonists & inhibitors | Adult | Female | mRNA Cleavage and Polyadenylation Factors - genetics | Eosinophilia - diagnosis | Myelodysplastic Syndromes - drug therapy | mRNA Cleavage and Polyadenylation Factors - antagonists & inhibitors | Myeloproliferative Disorders - diagnosis | Hematologic Neoplasms - diagnosis | Eosinophilia - etiology | World Health Organization | Risk Assessment | Janus Kinase 2 - genetics | Immunophenotyping | In Situ Hybridization, Fluorescence | Myeloproliferative Disorders - drug therapy | Bone Marrow Examination | Myelodysplastic Syndromes - diagnosis | Clone Cells - pathology | Hematologic Neoplasms - blood | Oncogene Proteins, Fusion - genetics | Receptor, Platelet-Derived Growth Factor alpha - genetics | Hematologic Neoplasms - drug therapy | Oncogene Proteins, Fusion - antagonists & inhibitors | Aged | Disease Management | Corticoids | Imatinib | Eosinophilic leukemia | Leukocytes (eosinophilic) | Stem cell transplantation | Cytotoxicity | Hydroxyurea | Hybridization | Eosinophilia | Hematopoietic stem cells | Hemopoiesis | Chemotherapy | Janus kinase 2 | Peripheral blood | Cytogenetics | Interferon | Diagnosis | Fibroblast growth factor receptor 1 | Index Medicus
Journal Article
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Targeting nuclear β-catenin as therapy for post-myeloproliferative neoplasm secondary AML
Leukemia, ISSN 0887-6924, 2018, Volume 33, Issue 6, pp. 1373 - 1386