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Cell Stem Cell, ISSN 1934-5909, 01/2015, Volume 16, Issue 1, pp. 51 - 66
Mesenchymal stem cells (MSCs) reside in the perivascular niche of many organs, including kidney, lung, liver, and heart, although their roles in these tissues... 
REGULATOR | ORIGIN | SONIC HEDGEHOG | PATHWAY | BONE-MARROW NICHE | MYOFIBROBLASTS | NG2 PROTEOGLYCAN | EXPRESSION | MESENCHYMAL STEM-CELLS | GROWTH FACTOR-AA | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Organ Specificity - drug effects | Diphtheria Toxin - pharmacology | Neovascularization, Physiologic - drug effects | Pericytes - drug effects | Blood Vessels - metabolism | Blood Vessels - pathology | Humans | Fibrosis - metabolism | Cell Lineage - drug effects | Myofibroblasts - metabolism | Mesenchymal Stromal Cells - cytology | Mesenchymal Stromal Cells - ultrastructure | Kruppel-Like Transcription Factors - metabolism | Pericytes - pathology | Bone Marrow Cells - drug effects | Colony-Forming Units Assay | Aorta - physiopathology | Homeostasis - drug effects | Heart Ventricles - pathology | Receptor, Platelet-Derived Growth Factor beta - metabolism | Mesenchymal Stromal Cells - drug effects | Endothelial Cells - metabolism | Aorta - drug effects | Pericytes - metabolism | Cells, Cultured | Proteoglycans - metabolism | Antigens - metabolism | Aorta - pathology | Myofibroblasts - cytology | Animals | Heart Ventricles - physiopathology | Cell Differentiation - drug effects | Endothelial Cells - cytology | Blood Vessels - drug effects | Mice | Stem Cell Niche - drug effects | Zinc Finger Protein GLI1 | Fibrosis - pathology | Bone Marrow Cells - metabolism | Endothelial Cells - drug effects | Heart Ventricles - drug effects | Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 04/2015, Volume 6, Issue 1, pp. 6656 - 6656
Honokiol (HKL) is a natural biphenolic compound derived from the bark of magnolia trees with anti-inflammatory, anti-oxidative, anti-tumour and neuroprotective... 
METABOLISM | GENE | SIRT3-MEDIATED DEACETYLATION | PATHWAY | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | HOMOLOG | AKT | SIRTUINS | CALORIE RESTRICTION | CELL-DEATH | Mitochondria - enzymology | Fibroblasts - enzymology | Superoxide Dismutase - genetics | Reactive Oxygen Species - metabolism | Sirtuin 3 - metabolism | Myofibroblasts - enzymology | Superoxide Dismutase - antagonists & inhibitors | Cardiomegaly - pathology | Isoproterenol | Lignans - pharmacology | Myocytes, Cardiac - enzymology | Phenylephrine - pharmacology | Biphenyl Compounds - pharmacology | Membrane Proteins - metabolism | Superoxide Dismutase - metabolism | Myofibroblasts - pathology | Sirtuin 3 - genetics | Signal Transduction | Membrane Proteins - genetics | Carrier Proteins - antagonists & inhibitors | Gene Expression Regulation | Adenosine Triphosphatases - metabolism | Myocardium - pathology | Cardiotonic Agents - pharmacology | Mitochondria - drug effects | Mitochondria - pathology | Fibroblasts - pathology | Myofibroblasts - drug effects | Adenosine Triphosphatases - antagonists & inhibitors | Carrier Proteins - genetics | Myocytes, Cardiac - pathology | Acetylation - drug effects | Myocardium - enzymology | Reactive Oxygen Species - antagonists & inhibitors | Animals | Cardiomegaly - prevention & control | Carrier Proteins - metabolism | Myocytes, Cardiac - drug effects | Membrane Proteins - antagonists & inhibitors | Cell Differentiation - drug effects | Fibroblasts - drug effects | Cardiomegaly - chemically induced | Adenosine Triphosphatases - genetics | Cell Proliferation - drug effects | Mice | Enzyme Activation | Primary Cell Culture | Cardiomegaly - genetics | Index Medicus
Journal Article
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 07/2012, Volume 342, Issue 1, pp. 81 - 90
Nuclear factor erythroid 2-related factor 2 (Nrf2) is an antioxidant-activated transcription factor that recently emerged as a critical regulator of cellular... 
TRANSCRIPTION FACTOR NRF2 | CARCINOGENESIS | PROTECTION | PHENOLIC ANTIOXIDANTS | INDUCED LUNG INJURY | RATS | PHARMACOLOGY & PHARMACY | EXPRESSION | PULMONARY-FIBROSIS | MICE LACKING | MOLECULAR-MECHANISMS | Tumor Necrosis Factor-alpha - metabolism | NF-E2-Related Factor 2 - antagonists & inhibitors | Epithelial Cells - metabolism | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Antioxidants - metabolism | Epithelial Cells - drug effects | Humans | Transforming Growth Factor beta1 - metabolism | Tumor Necrosis Factor-alpha - genetics | Apoptosis - genetics | Stilbenes - pharmacology | Paraquat - antagonists & inhibitors | Myofibroblasts - metabolism | Inflammation - metabolism | Cell Death - genetics | Mitochondria - genetics | Inflammation - drug therapy | Cytoprotection - drug effects | NF-E2-Related Factor 2 - genetics | Response Elements - genetics | Cell Death - drug effects | Paraquat - pharmacology | Interleukin-6 - metabolism | Fibroblasts - metabolism | Interleukin-6 - genetics | Cells, Cultured | Oxidative Stress - genetics | Mitochondria - metabolism | Signal Transduction - genetics | Transforming Growth Factor beta1 - genetics | Mitochondria - drug effects | Myofibroblasts - drug effects | Mice, Knockout | Response Elements - drug effects | Animals | Signal Transduction - drug effects | Fibroblasts - drug effects | NF-E2-Related Factor 2 - metabolism | Cytoprotection - genetics | Mice | Oxidative Stress - drug effects | Index Medicus
Journal Article
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, ISSN 0022-3565, 05/2014, Volume 349, Issue 2, pp. 209 - 220
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2012, Volume 7, Issue 7, pp. e39969 - e39969
Fibroblasts residing in connective tissues throughout the body are responsible for extracellular matrix (ECM) homeostasis and repair. In response to tissue... 
SMOOTH MUSCLE ACTIN | GROWTH-FACTOR-BETA | HEPATIC STELLATE CELLS | PHOTODEGRADABLE HYDROGELS | LUNG MYOFIBROBLASTS | GRANULATION-TISSUE | MULTIDISCIPLINARY SCIENCES | TRANSFORMING GROWTH-FACTOR-BETA-1 | EXTRACELLULAR-MATRIX | IDIOPATHIC PULMONARY-FIBROSIS | AORTIC-VALVE DISEASE | Aortic Valve - radiation effects | Gene Expression - drug effects | Hydrogels | Actins - metabolism | Aortic Valve - drug effects | Polyethylene Glycols - chemistry | Actins - genetics | Myofibroblasts - metabolism | Collagen Type I - genetics | Swine | Light | Myofibroblasts - radiation effects | Biomimetic Materials - chemistry | Transforming Growth Factor beta1 - pharmacology | Biomarkers - metabolism | Cell Differentiation - radiation effects | Oligopeptides - chemical synthesis | Collagen Type I - metabolism | Acrylates - chemistry | Cell Cycle - radiation effects | Aortic Valve - cytology | Myofibroblasts - drug effects | Aortic Valve - metabolism | Gene Expression - radiation effects | Fibronectins - metabolism | Elastic Modulus - radiation effects | Myofibroblasts - cytology | Animals | Cell Differentiation - drug effects | Cell Proliferation - drug effects | Connective Tissue Growth Factor - genetics | Fibronectins - genetics | Primary Cell Culture | Cell Cycle - drug effects | Connective Tissue Growth Factor - metabolism | Cell Proliferation - radiation effects | Fibronectins | Collagen | Genes | Bone morphogenetic proteins | Transforming growth factors | Intermediate filament proteins | Apoptosis | Vimentin | Bioengineering | Collagens | Homeostasis | Smooth muscle | Kinases | Tissues | Fibronectin | Mimicry | Connective tissues | Proteins | Engineering | Genotype & phenotype | Reduction | Cell fate | Actin | Topography | Rodents | Cell cycle | Fibroblasts | Extracellular matrix | Stiffness | Repair | Growth factors | Heart diseases | Phenotypes | Developmental biology | Contractility | Organs | Muscles | Mechanical properties | Connective tissue growth factor | Modulus of elasticity | Stiffening | Muscle contraction | Substrates | Fibrosis | Stem cells | Molecular biology | Index Medicus
Journal Article
American Journal of Pathology, The, ISSN 0002-9440, 2015, Volume 185, Issue 4, pp. 969 - 986
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 01/2018, Volume 233, Issue 1, pp. 447 - 462
In this study, we examined functional properties of human periodontal ligament stem cells (PDLSCs) in presence of LPS ( E. coli ). Our results indicated that... 
immunomodulation | periodontal ligament stem cells | differentiation | myofibroblasts | LPS | PROGENITOR CELLS | MIGRATION | ACTIVATION | PHYSIOLOGY | OSTEOGENIC DIFFERENTIATION | CELL BIOLOGY | IL-17 | RECEPTORS | EXPRESSION | BLOOD | Stem Cells - immunology | Chondrogenesis - drug effects | Myofibroblasts - immunology | Adipogenesis - drug effects | Humans | Alkaline Phosphatase - metabolism | Osteocalcin - genetics | Myofibroblasts - enzymology | Periodontal Ligament - immunology | PPAR gamma - metabolism | Periodontal Ligament - drug effects | Cell Lineage - drug effects | Core Binding Factor Alpha 1 Subunit - metabolism | Dose-Response Relationship, Drug | Transendothelial and Transepithelial Migration - drug effects | Periodontal Ligament - enzymology | Stem Cells - enzymology | Time Factors | Cyclooxygenase 2 - genetics | Interleukin-6 - metabolism | PPAR gamma - genetics | SOX9 Transcription Factor - metabolism | Alkaline Phosphatase - genetics | Interleukin-6 - genetics | Osteocalcin - metabolism | Osteogenesis - drug effects | Cells, Cultured | Gene Expression Regulation | Cellular Microenvironment | Myofibroblasts - drug effects | Phenotype | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Cell Differentiation - drug effects | Cyclooxygenase 2 - metabolism | Lipopolysaccharides - pharmacology | Stem Cells - drug effects | Cell Proliferation - drug effects | SOX9 Transcription Factor - genetics | Core Binding Factor Alpha 1 Subunit - genetics | Mitogen-Activated Protein Kinase 1 - metabolism | Fibronectins | Gene expression | Mitogens | Stem cells | Leukocyte migration | Escherichia coli | Leukocytes (mononuclear) | CD29 antigen | CD14 antigen | Fibronectin | CD45 antigen | Lipopolysaccharides | Interleukin 6 | Biomedical materials | Lymphocytes | Cell cycle | CD25 antigen | Biocompatibility | Inhibition | Chondrogenesis | Adipogenesis | CD34 antigen | Cbfa-1 protein | Immunomodulation | Contractility | Extracellular signal-regulated kinase | Inflammation | CD4 antigen | Cyclooxygenase-2 | Differentiation | Viability | Cell migration | Osteogenesis | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 5, pp. e19809 - e19809
Growing evidence suggests the Wnt family of secreted glycoproteins and their associated signaling pathways, linked to development, are recapitulated during... 
CELLS | SMOOTH-MUSCLE | PATHWAY | TRANSFORMING GROWTH-FACTOR-BETA-1 | DISEASE | KINASE | BIOLOGY | STROMA | CANCER | EXPRESSION | Wnt Proteins - pharmacology | Stress Fibers - drug effects | Actins - metabolism | Myofibroblasts - metabolism | Muscle, Smooth - drug effects | Phosphorylation - drug effects | Gels | Smad2 Protein - metabolism | Muscle, Smooth - metabolism | Myofibroblasts - drug effects | beta Catenin - metabolism | Cell Shape - drug effects | Myofibroblasts - cytology | Up-Regulation - drug effects | Cell Movement - drug effects | Collagen - metabolism | Phenotype | Stress Fibers - metabolism | Animals | Signal Transduction - drug effects | Cell Differentiation - drug effects | Wnt3 Protein | Cell Proliferation - drug effects | Mice | Wnt3A Protein | Transforming Growth Factor beta - metabolism | Heart | Regulators | Wnt protein | Leukocyte migration | Laboratories | Blocking antibodies | Cytology | Smooth muscle | Kinases | Experiments | Contraction | Cell morphology | Cell adhesion & migration | Fibers | Proteins | β-catenin | Signal transduction | Cell growth | Actin | Smad2 protein | Fibroblasts | Aging | Tumorigenesis | Repair | Growth factors | Recombinant | Wound healing | Contractility | Glycoproteins | siRNA | Gene expression | Muscle contraction | Medicine | Pathology | Signaling | Urban regeneration | Pulmonary fibrosis | Collagen | Morphology | Ligands | Aberration | Prostate cancer | Cell migration | Neutralization | Index Medicus
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 09/2013, Volume 72, Issue 9, pp. 1575 - 1580
Journal Article