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Molecular Human Reproduction, ISSN 1360-9947, 09/2017, Volume 23, Issue 9, pp. 628 - 645
STUDY QUESTION: Does A20 regulate mediators involved in the terminal processes of human labour in primary myometrial and amnion cells? SUMMARY ANSWER: A20 is a... 
Myometrium | Pro-labour mediators | Inflammation | Preterm birth | Foetal membranes | A20 | preterm birth | TOLL-LIKE RECEPTOR | foetal membranes | NECROSIS-FACTOR-ALPHA | DEVELOPMENTAL BIOLOGY | PRETERM LABOR | TERM LABOR | OBSTETRICS & GYNECOLOGY | myometrium | PRO-LABOR MEDIATORS | IN-VITRO | REPRODUCTIVE BIOLOGY | EPITHELIAL-CELLS | inflammation | pro-labour mediators | SMOOTH-MUSCLE-CELLS | NF-KAPPA-B | EXPRESSION | Interleukin-8 - genetics | Myometrium - drug effects | RNA, Small Interfering - genetics | Interleukin-1beta - pharmacology | Premature Birth - genetics | Humans | NF-kappa B - metabolism | Tumor Necrosis Factor alpha-Induced Protein 3 - metabolism | Chemokine CXCL1 - genetics | Dinoprost - metabolism | Flagellin - pharmacology | Matrix Metalloproteinase 9 - metabolism | Term Birth - metabolism | Premature Birth - physiopathology | Cyclooxygenase 2 - genetics | Matrix Metalloproteinase 9 - genetics | Myometrium - metabolism | Interleukin-1alpha - genetics | Interleukin-8 - metabolism | Chemokine CXCL1 - metabolism | Interleukin-6 - metabolism | Poly I-C - pharmacology | Term Birth - genetics | Interleukin-6 - genetics | Signal Transduction | Amnion - cytology | Labor, Obstetric - metabolism | Tumor Necrosis Factor-alpha - pharmacology | Dinoprost - genetics | Intercellular Adhesion Molecule-1 - metabolism | Intercellular Adhesion Molecule-1 - genetics | Vascular Cell Adhesion Molecule-1 - metabolism | RNA, Small Interfering - metabolism | Interleukin-1alpha - metabolism | Receptors, Prostaglandin - metabolism | Amnion - metabolism | Receptors, Prostaglandin - genetics | Gene Expression Regulation, Developmental | Female | Vascular Cell Adhesion Molecule-1 - genetics | Amnion - drug effects | Chemokine CCL2 - metabolism | Premature Birth - metabolism | Chemokine CCL2 - genetics | Myometrium - cytology | Pregnancy | Tumor Necrosis Factor alpha-Induced Protein 3 - genetics | NF-kappa B - genetics | Cyclooxygenase 2 - metabolism | Labor, Obstetric - genetics | Primary Cell Culture | Tumor Necrosis Factor alpha-Induced Protein 3 - antagonists & inhibitors | Index Medicus
Journal Article
Molecular Endocrinology, ISSN 0888-8809, 07/2006, Volume 20, Issue 7, pp. 1519 - 1534
Journal Article
FASEB Journal, ISSN 0892-6638, 2014, Volume 28, Issue 5, pp. 2358 - 2368
Journal Article
FASEB Journal, ISSN 0892-6638, 12/2012, Volume 26, Issue 12, pp. 4876 - 4885
Uterine spiral artery remodeling is required for successful human pregnancy; impaired remodeling is associated with pregnancy complications, including late... 
Proteases | Vascular smooth muscle cells | Angiogenic growth factors | TROPHOBLAST INVASION | GRANULATED LYMPHOCYTES | BIOCHEMISTRY & MOLECULAR BIOLOGY | proteases | CELL BIOLOGY | angiogenic growth factors | EXTRAVILLOUS TROPHOBLAST | SMOOTH-MUSCLE | IN-VITRO | BIOLOGY | CARDIOVASCULAR-DISEASE | MATERNAL ARTERIES | GROWTH-FACTOR | vascular smooth muscle cells | EXPRESSION | FACTS | Immunohistochemistry | Muscle, Smooth, Vascular - metabolism | Decidua - cytology | Humans | Extracellular Matrix - metabolism | Culture Media, Conditioned - pharmacology | Interferon-gamma - metabolism | Angiopoietin-1 - metabolism | Angiopoietin-2 - pharmacology | Angiopoietin-2 - metabolism | Uterine Artery - physiology | Placenta - cytology | Myometrium - metabolism | Female | Trophoblasts - cytology | Uterine Artery - drug effects | Myocytes, Smooth Muscle - drug effects | Uterus - blood supply | Myocytes, Smooth Muscle - metabolism | Angiopoietin-1 - pharmacology | Cell Line | Trophoblasts - metabolism | Uterine Artery - cytology | Tissue Culture Techniques | Extracellular Matrix - drug effects | Cells, Cultured | Muscle, Smooth, Vascular - cytology | Killer Cells, Natural - physiology | Decidua - metabolism | Myometrium - cytology | Placenta - metabolism | Pregnancy | Trophoblasts - physiology | Vascular Endothelial Growth Factor C - metabolism | Uterus - cytology | Killer Cells, Natural - metabolism | Interferon-gamma - pharmacology | Culture Media, Conditioned - metabolism | Vascular Endothelial Growth Factor C - pharmacology | Index Medicus
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 03/2015, Volume 403, Issue C, pp. 64 - 77
Human labour, both at term and preterm, is preceded by NF-κB-mediated inflammatory activation within the uterus, leading to myometrial activation, fetal... 
Amnion | NF-κB | Parturition | Myometrium | Inflammation | Oxytocin | HUMAN PARTURITION | PROTEIN-KINASE-C | TRANSCRIPTIONAL ACTIVATION | HUMAN AMNION CELLS | HUMAN FETAL MEMBRANES | PRETERM LABOR | CELL BIOLOGY | HUMAN MYOMETRIAL CELLS | PROSTAGLANDIN PRODUCTION | TUMOR-NECROSIS-FACTOR | NF-kappa B | ENDOCRINOLOGY & METABOLISM | CYCLOOXYGENASE-2 EXPRESSION | Interleukin-8 - genetics | Receptors, Oxytocin - genetics | Humans | Oxytocin - metabolism | Transcription Factor RelA - genetics | MAP Kinase Kinase 1 - genetics | Inflammation - metabolism | Amnion - metabolism | I-kappa B Kinase - metabolism | Cyclooxygenase 2 - genetics | I-kappa B Kinase - antagonists & inhibitors | Myometrium - metabolism | Adult | Female | Chemokine CCL5 - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Interleukin-8 - metabolism | Interleukin-6 - metabolism | MAP Kinase Kinase 2 - genetics | Interleukin-6 - genetics | Signal Transduction | Amnion - cytology | Gene Expression Regulation | p38 Mitogen-Activated Protein Kinases - genetics | MAP Kinase Kinase 1 - metabolism | Parturition - genetics | MAP Kinase Kinase 2 - metabolism | I-kappa B Kinase - genetics | Myometrium - cytology | Pregnancy | Receptors, Oxytocin - metabolism | Transcription Factor RelA - metabolism | Transcription Factor RelA - agonists | Chemokine CCL5 - genetics | Cyclooxygenase 2 - metabolism | Inflammation - genetics | Oxytocin - genetics | Primary Cell Culture | Parturition - metabolism | Index Medicus
Journal Article
Journal Article
Human Reproduction, ISSN 0268-1161, 9/2013, Volume 28, Issue 9, pp. 2407 - 2416
STUDY QUESTION Can biologically active vitamin D3 [1,25(OH)2D3] regulate the expression and activity of matrix metalloproteinases (MMPs) in human uterine... 
TIMP-2 | VDR | fibroids | MMPs | vitamin D3 | MYCOBACTERIUM-TUBERCULOSIS | HEART-FAILURE | TISSUE INHIBITORS | 1-ALPHA,25-DIHYDROXYVITAMIN D-3 | OBSTETRICS & GYNECOLOGY | IN-VITRO | REPRODUCTIVE BIOLOGY | GENE-EXPRESSION | EXTRACELLULAR-MATRIX | COLLAGEN FIBRILS | D-RECEPTOR | NORMAL MYOMETRIUM | Tissue Inhibitor of Metalloproteinase-1 - biosynthesis | Uterine Neoplasms - pathology | Humans | Enzyme Precursors - genetics | Gene Expression Regulation, Neoplastic | Neoplasm Proteins - antagonists & inhibitors | Leiomyoma - metabolism | Neoplasm Proteins - metabolism | RNA, Messenger - metabolism | Receptors, Calcitriol - genetics | Tissue Inhibitor of Metalloproteinase-2 - genetics | Receptors, Calcitriol - biosynthesis | Uterine Neoplasms - enzymology | Antineoplastic Agents - metabolism | Leiomyoma - pathology | Tissue Inhibitor of Metalloproteinase-1 - metabolism | Tissue Inhibitor of Metalloproteinase-2 - metabolism | Matrix Metalloproteinase 9 - metabolism | Osmolar Concentration | Matrix Metalloproteinase 9 - genetics | Leiomyoma - enzymology | Myometrium - metabolism | Tissue Inhibitor of Metalloproteinase-2 - biosynthesis | Enzyme Precursors - antagonists & inhibitors | Female | Calcitriol - metabolism | Matrix Metalloproteinase 2 - chemistry | Tumor Cells, Cultured | Neoplasm Proteins - genetics | Uterine Neoplasms - metabolism | Myometrium - pathology | Matrix Metalloproteinase 2 - metabolism | Myometrium - enzymology | Receptors, Calcitriol - metabolism | Matrix Metalloproteinase 2 - genetics | Tissue Inhibitor of Metalloproteinase-1 - genetics | Enzyme Precursors - metabolism | Cell Line, Tumor | Matrix Metalloproteinase 9 - chemistry | Index Medicus | Original
Journal Article
Endocrinology, ISSN 0013-7227, 01/2012, Volume 153, Issue 1, pp. 481 - 491
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 06/2008, Volume 93, Issue 6, pp. 2366 - 2374
Context: Experimental and clinical studies in a variety of nonprimate species demonstrate that progesterone withdrawal leads to changes in gene expression that... 
17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE-2 | UTERINE CERVIX | ENDOCRINOLOGY & METABOLISM | PRETERM BIRTH | 5-ALPHA-REDUCTASE TYPE-1 | DEHYDROGENASE-ACTIVITY | HUMAN-ENDOMETRIUM | GUINEA-PIG | RECEPTOR-A | EXPRESSION | INTERLEUKIN-8 PRODUCTION | Cervical Ripening - metabolism | Cervix Uteri - metabolism | Humans | RNA, Messenger - metabolism | Hydroxyprostaglandin Dehydrogenases - metabolism | Myometrium - metabolism | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism | 3-Hydroxysteroid Dehydrogenases - metabolism | Female | Hydroxysteroid Dehydrogenases - metabolism | Estrogens - metabolism | 20-Hydroxysteroid Dehydrogenases - genetics | Oxidoreductases - metabolism | Oxidoreductases - genetics | Cervix Uteri - enzymology | Parturition - genetics | Hydroxysteroid Dehydrogenases - genetics | 20-Hydroxysteroid Dehydrogenases - metabolism | Gestational Age | Hydroxyprostaglandin Dehydrogenases - genetics | Gene Expression Regulation, Enzymologic | Pregnancy | Animals | Aldo-Keto Reductase Family 1 Member C3 | Estradiol Dehydrogenases | Models, Biological | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - genetics | Cervix Uteri - physiology | Progesterone - metabolism | Mice | 3-Hydroxysteroid Dehydrogenases - genetics | 17-Hydroxysteroid Dehydrogenases - metabolism | Parturition - metabolism | Index Medicus | Abridged Index Medicus | Original
Journal Article
Fertility and Sterility, ISSN 0015-0282, 2010, Volume 93, Issue 5, pp. 1500 - 1508
Objective To examine the effect of transforming growth factor (TGF) β3 on immortalized myometrial and leiomyoma cell lines cloned from primary cell cultures of... 
Internal Medicine | Obstetrics and Gynecology | myometrium | connective tissue growth factor | fibronectin | collagen | Transforming growth factor β3 | matrix metalloproteinases | extracellular matrix | leiomyoma | UTERINE LEIOMYOMA CELLS | TGF-BETA | DIFFERENTIAL EXPRESSION | GONADOTROPIN-RELEASING-HORMONE | REPERFUSION INJURY | TISSUE INHIBITORS | MATRIX METALLOPROTEINASE INDUCER | OBSTETRICS & GYNECOLOGY | REPRODUCTIVE BIOLOGY | Transforming growth factor beta 3 | GENE-EXPRESSION | SMOOTH-MUSCLE-CELLS | HUMAN STROMELYSIN-3 | Cell Proliferation | Uterine Neoplasms - pathology | Humans | Gene Expression Regulation, Neoplastic | Extracellular Matrix - metabolism | Leiomyoma - metabolism | RNA, Messenger - metabolism | Transforming Growth Factor beta3 - metabolism | Leiomyoma - pathology | Extracellular Matrix - genetics | Cell Transformation, Neoplastic - genetics | Myometrium - metabolism | Female | Extracellular Matrix Proteins - metabolism | Recombinant Proteins - metabolism | Uterine Neoplasms - genetics | Uterine Neoplasms - metabolism | Collagen Type I - metabolism | Myometrium - pathology | Matrix Metalloproteinase 2 - metabolism | Extracellular Matrix Proteins - genetics | Matrix Metalloproteinase 11 - metabolism | Cell Transformation, Neoplastic - metabolism | Fibronectins - metabolism | Phenotype | Fibrosis | Cell Line, Tumor | Connective Tissue Growth Factor - metabolism | Leiomyoma - genetics | Index Medicus
Journal Article
Prostaglandins and Other Lipid Mediators, ISSN 1098-8823, 03/2016, Volume 123, pp. 9 - 15
Proliferating cells exhibit accelerated rates of substrate utilization, favoring glucose over fatty acids (FA’s) oxidation. Protein-mediated transport is... 
FATP-4 | Fibroids | FATP-1 | GLUT-4 | GLUT-1 | FAT/CD36 | PROTEIN | MANAGEMENT | BIOCHEMISTRY & MOLECULAR BIOLOGY | TISSUE | FATTY-ACIDS | ENDOMETRIAL CANCER | CELL BIOLOGY | METABOLISM | GLUCOSE | GROWTH | MEMBRANE-TRANSPORT | LIPIDS | Cadherins - metabolism | Glucose Transporter Type 4 - metabolism | Humans | Middle Aged | 3-Hydroxyacyl CoA Dehydrogenases - metabolism | Glucose Transporter Type 1 - metabolism | Leiomyoma - metabolism | Fatty Acid-Binding Proteins - metabolism | 3-Hydroxyacyl CoA Dehydrogenases - genetics | Electron Transport Complex IV - metabolism | Glycolysis - genetics | Leiomyoma - pathology | Fatty Acid Transport Proteins - metabolism | Biological Transport | Diglycerides - metabolism | Leiomyoma - surgery | Myometrium - metabolism | Adult | Female | Cadherins - genetics | Fatty Acids - metabolism | Ceramides - metabolism | Glucose Transporter Type 4 - genetics | Myometrium - pathology | Gene Expression Regulation | Oxidative Phosphorylation | Electron Transport Complex IV - genetics | Hysterectomy | Fatty Acid-Binding Proteins - genetics | Triglycerides - metabolism | Myometrium - surgery | Glucose Transporter Type 1 - genetics | Fatty Acid Binding Protein 3 | Glucose - metabolism | Fatty Acid Transport Proteins - genetics | Leiomyoma | Glucose metabolism | Physiological aspects | Triglycerides | Glucose | Binding proteins | Fatty acids | Dextrose | Protein binding | Index Medicus
Journal Article