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by Verhoeven, Virginie J. M and Hysi, Pirro G and Wojciechowski, Robert and Fan, Qiao and Guggenheim, Jeremy A and Höhn, René and Macgregor, Stuart and Hewitt, Alex W and Nag, Abhishek and Cheng, Ching-Yu and Yonova-Doing, Ekaterina and Zhou, Xin and Ikram, M. Kamran and Buitendijk, Gabriëlle H. S and McMahon, George and Kemp, John P and Pourcain, Beate St and Simpson, Claire L and Mäkelä, Kari-Matti and Lehtimäki, Terho and Kähönen, Mika and Paterson, Anew D and Hosseini, S. Mohsen and Wong, Hoi Suen and Xu, Liang and Jonas, Jost B and Pärssinen, Olavi and Wedenoja, Juho and Yip, Shea Ping and Ho, Daniel W. H and Pang, Chi Pui and Chen, Li Jia and Burdon, Kathryn P and Craig, Jamie E and Klein, Barbara E. K and Klein, Ronald and Haller, Toomas and Metspalu, Anes and Khor, Chiea-Chuen and Tai, E.-Shyong and Aung, Tin and Vithana, Eranga and Tay, Wan-Ting and Barathi, Veluchamy A and Chen, Peng and Li, Ruoying and Liao, Jiemin and Zheng, Yingfeng and Ong, Rick T and Döring, Angela and Evans, David M and Timpson, Nicholas J and Verkerk, Annemieke J. M. H and Meitinger, Thomas and Raitakari, Olli and Hawthorne, Felicia and Spector, Tim D and Karssen, Lennart C and Pirastu, Mario and Murgia, Federico and Ang, Wei and Mishra, Aniket and Montgomery, Grant W and Pennell, Craig E and Cumberland, Phillippa M and Cotlarciuc, Ioana and Mitchell, Paul and Wang, Jie Jin and Schache, Maria and Janmahasathian, Sarayut and Igo, Robert P and Lass, Jonathan H and Chew, Emily and Iyengar, Sudha K and Gorgels, Theo G. M. F and Rudan, Igor and Hayward, Caroline and Wright, Alan F and Polasek, Ozren and Vatavuk, Zoran and Wilson, James F and Fleck, Brian and Zeller, Tanja and Mirshahi, Alireza and Müller, Christian and Uitterlinden, Ané G and Rivadeneira, Fernando and Vingerling, Johannes R and Hofman, Albert and Oostra, Ben A and Amin, Najaf and Bergen, Arthur A. B and teo, Yik-Ying and Rahi, Jugnoo S and Vitart, Veronique and Williams, Cathy and Baird, Paul N and Wong, Tien-Yin and Oexle, Konrad and Pfeiffer, Norbert and ... and Fuchs' Genetics Multi-Ctr Study Gr and Diabet Control Complications Trial and WTCCC2 and CREAM and Consortium for Refractive Error and Myopia (CREAM) and Fuchs' Genetics Multi-Center Study Group and Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Research Group and Wellcome Trust Case Control Consortium 2 (WTCCC2) and The Fuchs' Genetics Multi-Center Study Group and The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Research Group
Nature genetics, ISSN 1061-4036, 2013, Volume 45, Issue 3, pp. 314 - 318
Journal Article
The American Journal of Human Genetics, ISSN 0002-9297, 05/2013, Volume 92, Issue 5, pp. 820 - 826
Journal Article
by Iglesias, Adriana I and Mishra, Aniket and Vitart, Veronique and Bykhovskaya, Yelena and Höhn, René and Springelkamp, Henriët and Cuellar-Partida, Gabriel and Gharahkhani, Puya and Bailey, Jessica N. Cooke and Willoughby, Colin E and Li, Xiaohui and Yazar, Seyhan and Nag, Abhishek and Khawaja, Anthony P and Polašek, Ozren and Siscovick, David and Mitchell, Paul and Tham, Yih Chung and Haines, Jonathan L and Kearns, Lisa S and Hayward, Caroline and Shi, Yuan and Van Leeuwen, Elisabeth M and Taylor, Kent D and Wang, Jie Jin and Rochtchina, Elena and Attia, John and Scott, Rodney and Holliday, Elizabeth G and Baird, Paul N and Xie, Jing and Inouye, Michael and Viswanathan, Ananth and Sim, Xueling and Bonnemaijer, Pieter and Rotter, Jerome I and Martin, Nicholas G and Zeller, Tanja and Mills, Richard A and Staffieri, Sandra E and Jonas, Jost B and Schmidtmann, Irene and Boutin, Thibaud and Kang, Jae H and Lucas, Sionne E. M and Wong, Tien Yin and Beutel, Manfred E and Wilson, James F and Allingham, R. Rand and Brilliant, Murray H and Budenz, Donald L and Christen, William G and Fingert, John and Friedman, David S and Gaasterland, Douglas and Gaasterland, Terry and Hauser, Michael A and Kraft, Peter and Lee, Richard K and Lichter, Paul R and Liu, Yutao and Loomis, Stephanie J and Moroi, Sayoko E and Pericak-Vance, Margaret A and Realini, Anthony and Richards, Julia E and Schuman, Joel S and Scott, William K and Singh, Kuldev and Sit, Arthur J and Vollrath, Douglas and Weinreb, Robert N and Wollstein, Gadi and Zack, Donald J and Zhang, Kang and Donnelly, Peter and Barroso, Ines and Blackwell, Jenefer M and Bramon, Elvira and Brown, Matthew A and Casas, Juan P and Corvin, Aiden and Deloukas, Panos and Duncanson, Audrey and Jankowski, Janusz and Markus, Hugh S and Mathew, Christopher G and Palmer, Colin N. A and Plomin, Robert and Rautanen, Anna and Sawcer, Stephen J and Trembath, Richard C and Wood, Nicholas W and Spencer, Chris C. A and Band, Gavin and Bellenguez, Céline and Freeman, Colin and Hellenthal, Garrett and Giannoulatou, Eleni and Pirinen, Matti and ... and Blue Mountains Eye Study-GWAS Grp and NEIGHBORHOOD Consortium and Wellcome Trust Case Control Consor and Blue Mountains Eye Study—GWAS group and Wellcome Trust Case Control Consortium 2 (WTCCC2)
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1 - 11
Central corneal thickness (CCT) is a highly heritable trait associated with complex eye diseases such as keratoconus and glaucoma. We perform a genome-wide... 
DECORIN | CHROMATIN STATES | POLYMORPHISMS | RISK-FACTOR | MULTIDISCIPLINARY SCIENCES | MOUSE | GENE-EXPRESSION | MUTATIONS | HERITABILITY | LUMICAN | KERATOCONUS | Glaucoma | Cornea | Genes | Myopia | Association analysis | Genomes | Gene expression | Tissues | Connective tissues | Keratoconus | Collagen | Eye diseases | Extracellular matrix | Index Medicus
Journal Article
Journal Article
Journal Article
Cellular and Molecular Life Sciences, ISSN 1420-682X, 11/2018, Volume 75, Issue 21, pp. 4021 - 4040
Mitochondrial intracrines are extracellular signaling proteins, targeted to the mitochondria. The pathway for mitochondrial targeting of mitochondrial... 
Life Sciences | Biomedicine, general | Biochemistry, general | PIKfyve | Sonic hedgehog | Life Sciences, general | Vitamin D | ApoE | OCRL1 | Cell Biology | Proteinuria | ANGIOTENSIN SYSTEM | BIOCHEMISTRY & MOLECULAR BIOLOGY | RENAL ISCHEMIA/REPERFUSION INJURY | MAMMALIAN-CELLS | SIRT3 | CELL BIOLOGY | RECEPTOR MEGALIN | DONNAI-BARROW | PROTEIN TRAFFICKING | STANNIOCALCIN-1 | TRANS-GOLGI NETWORK | MICE | Oculocerebrorenal Syndrome - genetics | Oculocerebrorenal Syndrome - pathology | Hernias, Diaphragmatic, Congenital - pathology | Humans | rab GTP-Binding Proteins - genetics | Cell Membrane - genetics | Renal Tubular Transport, Inborn Errors - genetics | Proteinuria - pathology | Myopia - metabolism | Brain - metabolism | Renal Tubular Transport, Inborn Errors - metabolism | Mitochondria - genetics | Amyloid beta-Peptides - genetics | Hernias, Diaphragmatic, Congenital - metabolism | Agenesis of Corpus Callosum - genetics | Amyloid beta-Peptides - metabolism | HEK293 Cells | Low Density Lipoprotein Receptor-Related Protein-2 - genetics | Glycoproteins - genetics | rab GTP-Binding Proteins - metabolism | Agenesis of Corpus Callosum - metabolism | Sirtuin 3 - genetics | Hearing Loss, Sensorineural - metabolism | Signal Transduction | Renal Tubular Transport, Inborn Errors - pathology | Hearing Loss, Sensorineural - pathology | Proteinuria - metabolism | Low Density Lipoprotein Receptor-Related Protein-2 - metabolism | Myopia - pathology | Hearing Loss, Sensorineural - genetics | Mitochondria - metabolism | Proteinuria - genetics | Agenesis of Corpus Callosum - pathology | Myopia - genetics | Hernias, Diaphragmatic, Congenital - genetics | Animals | Transforming Growth Factor beta - genetics | Brain - pathology | Oculocerebrorenal Syndrome - metabolism | RAW 264.7 Cells | Mice | Medical colleges | Angiotensin | Physiological aspects | Calcifediol | Bone morphogenetic proteins | Alfacalcidol | Kidney diseases | Apolipoproteins | Transforming growth factors | Stanniocalcin | Brain | LRP2 protein | Pathogenesis | Crosstalk | Metabolism | Vitamins | Defects | Golgi apparatus | Proteins | Signal transduction | Signaling | Mitochondria | Glycolysis | Amyloid | Mutation | Angiotensin II | Index Medicus
Journal Article
Nature communications, ISSN 2041-1723, 05/2018, Volume 9, Issue 1, p. 1864
Central corneal thickness (CCT) is a highly heritable trait associated with complex eye diseases such as keratoconus and glaucoma. We perform a genome-wide... 
Lumican - metabolism | Glaucoma, Open-Angle - genetics | Humans | Corneal Diseases - metabolism | Corneal Dystrophies, Hereditary - ethnology | Corneal Diseases - genetics | Ehlers-Danlos Syndrome - genetics | Corneal Dystrophies, Hereditary - pathology | Loeys-Dietz Syndrome - metabolism | Mendelian Randomization Analysis | Fibrillin-1 - metabolism | Cornea - pathology | Keratoconus - pathology | Corneal Diseases - pathology | Decorin - genetics | Gene Expression | Eye Diseases, Hereditary - pathology | Lumican - genetics | ADAMTS Proteins - metabolism | Proteoglycans - metabolism | Ehlers-Danlos Syndrome - ethnology | European Continental Ancestry Group | Myopia - pathology | Cornea - metabolism | Myopia - ethnology | Loeys-Dietz Syndrome - pathology | Corneal Diseases - ethnology | Marfan Syndrome - metabolism | Marfan Syndrome - pathology | Cornea - abnormalities | Quantitative Trait Loci | Proteoglycans - genetics | ADAMTS Proteins - genetics | Transforming Growth Factor beta2 - metabolism | Corneal Dystrophies, Hereditary - genetics | Glaucoma, Open-Angle - pathology | Keratoconus - metabolism | Loeys-Dietz Syndrome - ethnology | Glaucoma, Open-Angle - ethnology | Myopia - metabolism | Ehlers-Danlos Syndrome - pathology | Marfan Syndrome - ethnology | Keratoconus - genetics | Glaucoma, Open-Angle - metabolism | Fibrillin-1 - genetics | Eye Diseases, Hereditary - ethnology | Genome-Wide Association Study | Quantitative Trait, Heritable | Corneal Dystrophies, Hereditary - metabolism | Marfan Syndrome - genetics | Eye Diseases, Hereditary - genetics | Myopia - genetics | Asian Continental Ancestry Group | Keratoconus - ethnology | Ehlers-Danlos Syndrome - metabolism | Loeys-Dietz Syndrome - genetics | Polymorphism, Single Nucleotide | Transforming Growth Factor beta2 - genetics | Genome, Human | Decorin - metabolism | Eye Diseases, Hereditary - metabolism | Cornea | Decorin | Corneal Dystrophies, Hereditary | Myopia | Corneal Diseases | Marfan Syndrome | Keratoconus | ADAMTS Proteins | Lumican | Transforming Growth Factor beta2 | Ehlers-Danlos Syndrome | Glaucoma, Open-Angle | Fibrillin-1 | Eye Diseases, Hereditary | Proteoglycans | Wellcome Trust Case Control Consortium 2 (WTCCC2) | Blue Mountains Eye Study—GWAS group | Loeys-Dietz Syndrome | NEIGHBORHOOD Consortium
Journal Article
The American Journal of Human Genetics, ISSN 0002-9297, 06/2011, Volume 88, Issue 6, pp. 805 - 813
Journal Article
PLoS Genetics, ISSN 1553-7390, 06/2012, Volume 8, Issue 6, pp. e1002753 - e1002753
Journal Article