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Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Index Medicus | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2014, Volume 9, Issue 4, pp. e93473 - e93473
Journal Article
Theriogenology, ISSN 0093-691X, 04/2017, Volume 92, pp. 176 - 189
Journal Article
Circulation Research: Journal of The American Heart Association, ISSN 0009-7330, 07/2002, Volume 91, Issue 2, pp. 112 - 119
Although recent investigations have suggested that a Rho-kinase–mediated Ca sensitization of vascular smooth muscle contraction plays a critical role in the... 
Rho-kinase | Sphingolipid | Membrane permeabilization | Vasospasm | Protein kinase C | SIGNALING PATHWAYS | CARDIAC & CARDIOVASCULAR SYSTEMS | SKINNED MUSCLE | sphingolipid | PERMEABILIZED SMOOTH-MUSCLE | PHOSPHORYLATION | vasospasm | membrane permeabilization | ARACHIDONIC-ACID | ENDOTHELIAL-CELLS | SUBARACHNOID HEMORRHAGE | PERIPHERAL VASCULAR DISEASE | CHRONIC VASOSPASM | HEMATOLOGY | MYOSIN LIGHT-CHAIN | protein kinase C | CALCIUM SENSITIZATION | Protein-Serine-Threonine Kinases - analysis | Culture Techniques | Phorbol 12,13-Dibutyrate - pharmacology | Phosphorylcholine - analogs & derivatives | Cerebral Arteries - drug effects | Cattle | Phosphorylcholine - pharmacology | rho-Associated Kinases | Escin - pharmacology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Calcium Signaling | Muscle, Smooth, Vascular - physiology | Muscle, Smooth, Vascular - drug effects | GTP-Binding Proteins - physiology | Protein Kinase C - physiology | Protein-Serine-Threonine Kinases - physiology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Intracellular Signaling Peptides and Proteins | Protein Kinase C - antagonists & inhibitors | Cerebral Arteries - physiology | Sphingosine - pharmacology | Cell Membrane - enzymology | Sphingosine - analogs & derivatives | Animals | Cerebral Arteries - enzymology | Cerebral Arteries - metabolism | Muscle Contraction - drug effects | Cell Membrane Permeability - drug effects | Kinetics | Index Medicus
Journal Article
Journal Article
The Biochemical journal, ISSN 0264-6021, 07/2014, Volume 461, Issue 2, pp. 233 - 245
NUAK1 (NUAK family SnF1-like kinase-1) and NUAK2 protein kinases are activated by the LKB1 tumour suppressor and have been implicated in regulating multiple... 
Protein Kinases - metabolism | Cell Cycle - genetics | Protein Kinases - genetics | Cell Proliferation | SKP Cullin F-Box Protein Ligases - genetics | Humans | Molecular Sequence Data | Repressor Proteins - antagonists & inhibitors | Cell Cycle Proteins - antagonists & inhibitors | Myosin-Light-Chain Phosphatase - metabolism | HEK293 Cells | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Repressor Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | Proto-Oncogene Proteins - antagonists & inhibitors | Signal Transduction | Myosin-Light-Chain Phosphatase - genetics | Cell Cycle Proteins - metabolism | Gene Expression Regulation | Protein-Serine-Threonine Kinases - genetics | Ubiquitin-Protein Ligases - metabolism | Repressor Proteins - genetics | Proto-Oncogene Proteins - genetics | SKP Cullin F-Box Protein Ligases - metabolism | Sequence Alignment | Animals | Cell Line, Tumor | Protein Binding | Protein Kinase Inhibitors - pharmacology | Ubiquitin-Protein Ligases - genetics | Index Medicus | Polo kinase (PLK) ubiquitylation | WT, wild-type | HEK, human embryonic kidney | AMPK, AMP-activated protein kinase | HRP, horseradish peroxidase | PP1, protein phosphatase 1 | AMP-activated protein kinase (AMPK) | PEI, polyethylenimine | CDK, cyclin-dependent kinase | Wee1, WEE1 G2 checkpoint kinase | GST, glutathione transferase | DTB, double thymidine block | IKK, inhibitor of nuclear factor κB kinase | LKB1, liver kinase B1 | NEM, N-ethylmaleimide | cell cycle | PI, propidium iodide | PLK1, Polo kinase 1 | SKP1, S-phase kinase-associated protein 1 | Emi1, early mitotic inhibitor 1 | mitosis | HA, haemagglutinin | NUAK, NUAK family SnF1-like kinase | degron | CK1, casein kinase 1 | XIC, extracted ion chromatogram analysis | DMEM, Dulbecco’s modified Eagle’s medium | AMPK-related kinase 5 (ARK5) | MEF, mouse embryonic fibroblast | SCFβTrCP, Skp, Cullin and F-boxβTrCP | Cul1, cullin 1
Journal Article
Journal of Neuroscience Research, ISSN 0360-4012, 06/2011, Volume 89, Issue 6, pp. 852 - 861
Myosin light chain kinase (MLCK) plays an important role in the reorganization of the cytoskeleton, leading to disruption of vascular barrier integrity in... 
traumatic brain injury | blood–brain barrier | transforming growth factor | myosin light chain kinase | astrocyte | Traumatic brain injury | Astrocyte | Blood-brain barrier | Myosin light chain kinase | Transforming growth factor | blood-brain barrier | PERMEABILITY | PHOSPHORYLATION | SUSCEPTIBILITY | INVOLVEMENT | INDUCED LUNG INJURY | RHO-KINASE | EPILEPTOGENESIS | NEUROSCIENCES | INHIBITION | BRAIN-BARRIER DISRUPTION | DYSFUNCTION | Animals, Newborn | Astrocytes - drug effects | Myosin-Light-Chain Kinase | Mice, Inbred C57BL | Cells, Cultured | Enzyme Inhibitors - pharmacology | Rats | Brain Injuries - metabolism | Brain Injuries - physiopathology | Glial Fibrillary Acidic Protein - metabolism | Rats, Sprague-Dawley | Gene Expression Regulation - drug effects | Albumins - pharmacology | Animals | Signal Transduction - drug effects | Time Factors | rho-Associated Kinases - metabolism | Statistics, Nonparametric | Signal Transduction - physiology | Mice | p38 Mitogen-Activated Protein Kinases - metabolism | Brain Injuries - pathology | Astrocytes - metabolism | Disease Models, Animal | Index Medicus | Astrocytes | Albumin | Extracellular signal-regulated kinase | Parenchyma | MAP kinase | Nervous system | Smad3 protein | Myosin-light-chain kinase | Rho-associated kinase | Endothelium | Signal transduction | c-Jun amino-terminal kinase | Extravasation | Cytoskeleton | Glia | Transforming growth factor- beta | blood brain barrier
Journal Article
Biochemical Journal, ISSN 0264-6021, 05/2006, Volume 396, Issue 1, pp. 193 - 200
Sustained smooth-muscle contraction or its experimental counterpart, Ca2+ sensitization, by G(q/13)-coupled receptor agonists is mediated via RhoA-dependent... 
p21-activated kinase | Smooth muscle | Integrin-linked kinase | Myosin light chain phosphatase | coupled receptor | Protein kinase C potentiated inhibitor 17 kDa protein (CPI-17) | Receptor, Muscarinic M2 - agonists | Receptor, Adenosine A1 - physiology | GTP-Binding Protein alpha Subunits, Gi-Go - physiology | Receptor, Muscarinic M2 - physiology | Somatostatin - pharmacology | Calcium - physiology | Estrenes - pharmacology | Myosin-Light-Chain Phosphatase - metabolism | Receptors, Somatostatin - physiology | Phosphorylation - drug effects | Chromones - pharmacology | Receptors, G-Protein-Coupled - physiology | Rabbits | Cells, Cultured - drug effects | p38 Mitogen-Activated Protein Kinases - physiology | Imidazoles - pharmacology | Proto-Oncogene Proteins c-akt - physiology | Adenosine - pharmacology | Muscle Contraction - drug effects | Adenosine - analogs & derivatives | Muscle Contraction - physiology | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Cells, Cultured - metabolism | Myosin Light Chains - metabolism | Receptors, Opioid, delta - agonists | Adenosine A1 Receptor Agonists | p21-Activated Kinases | Recombinant Fusion Proteins - physiology | Phosphoproteins - metabolism | Proto-Oncogene Proteins c-akt - genetics | Receptors, Somatostatin - agonists | Transfection | Protein Processing, Post-Translational - drug effects | Pyrrolidinones - pharmacology | Muscle Proteins - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Myocytes, Smooth Muscle - metabolism | Protein-Serine-Threonine Kinases - physiology | RNA, Small Interfering - pharmacology | Protein-Serine-Threonine Kinases - genetics | Morpholines - pharmacology | Protein Processing, Post-Translational - physiology | Azepines - pharmacology | Animals | Enkephalin, D-Penicillamine (2,5)- - pharmacology | Phosphatidylinositol 3-Kinases - physiology | Signal Transduction - physiology | Pyridines - pharmacology | Receptors, Opioid, delta - physiology | Index Medicus | MEK, MAPK | PI3K, phosphoinositide 3-kinase | smooth muscle | myosin light chain phosphatase | PP1c, protein phosphatase 1 catalytic subunit | Gi-coupled receptor | protein kinase C potentiated inhibitor 17 kDa protein (CPI-17) | ERK kinase | DTT, dithiothreitol | ETA receptor, endothelin A receptor | ERK, extracellular-signal-regulated kinase | PKB, protein kinase B | IP3, inositol 1,4,5-trisphosphate | 4-DAMP, 4-diphenylacetoxy-N-methylpiperidine | integrin-linked kinase | Pen, penicillamine | PAK1, p21-activated kinase 1 | CPA, cyclopentyl adenosine | PI, phosphoinositide | PKC, protein kinase C | Cdc42, cell division cycle 42 | ILK, integrin-linked kinase | MLC, myosin light chain | MYPT1, myosin phosphatase targeting subunit 1 | MLC20, 20 kDa regulatory light chain of myosin II | PHI-1, phosphatase holoenzyme inhibitor-1 | ML-9, 1-(5-chloronaphthalene-1-sulphonyl)-1H-hexahydro-1,4-diazepine hydrochloride | siRNA, small interfering RNA | CPI-17, protein kinase C potentiated inhibitor 17 kDa protein | ACh, acetylcholine | DPDPE, [D-Pen2,D-Pen5]enkephalin | MBP, myelin basic protein | MLCK, MLC kinase | ZIP kinase, zipper-interacting protein kinase | PLC-β3, phospholipase C-β3 | MAPK, mitogen-activated protein kinase
Journal Article
Nature Cell Biology, ISSN 1465-7392, 02/2004, Volume 6, Issue 2, pp. 154 - 161
Journal Article