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Science Translational Medicine, ISSN 1946-6234, 09/2015, Volume 7, Issue 303, pp. 303ra137 - 303ra137
Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder characterized by episodically exuberant heterotopic ossification (HO), whereby skeletal... 
Animals | Myositis Ossificans - genetics | Tacrolimus Binding Protein 1A - metabolism | Protein Binding | Activin Receptors, Type I - metabolism | Activins - metabolism | Mice, Transgenic | Mice | Mutation | Activin Receptors, Type I - genetics
Journal Article
Journal Article
Nature Genetics, ISSN 1061-4036, 2014, Volume 46, Issue 5, pp. 457 - 461
Journal Article
STEM CELLS, ISSN 1066-5099, 05/2014, Volume 32, Issue 5, pp. 1289 - 1300
Bone morphogenetic protein (BMP) signaling is a critical regulator of cartilage differentiation and endochondral ossification. Gain‐of‐function mutations in... 
Fibrodysplasia ossificans progressiva | Bone morphogenetic protein signaling | Chondrogenesis | Endochondral ossification | Alk2 | PROGENITOR CELLS | STEM-CELLS | R206H MUTATION | I RECEPTOR | OSTEOGENIC DIFFERENTIATION | CHONDROCYTE DIFFERENTIATION | CELL & TISSUE ENGINEERING | CELL BIOLOGY | CARTILAGE FORMATION | MOUSE EMBRYONIC FIBROBLASTS | ONCOLOGY | BONE-FORMATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | STROMAL CELLS | HEMATOLOGY | Chondrocytes - cytology | Chondrogenesis - drug effects | Chondrogenesis - genetics | Immunoblotting | Embryo, Mammalian - metabolism | Cell Differentiation - genetics | Mesenchymal Stromal Cells - cytology | Time Factors | Ossification, Heterotopic - metabolism | Myositis Ossificans - pathology | Chondrocytes - metabolism | Fibroblasts - metabolism | Myositis Ossificans - metabolism | Bone Morphogenetic Protein Receptors, Type II - genetics | Ossification, Heterotopic - pathology | Mice, Inbred C57BL | Cells, Cultured | Bone Morphogenetic Protein Receptors, Type I - genetics | Mesenchymal Stromal Cells - metabolism | Activin Receptors, Type I - metabolism | Mice, Transgenic | Signal Transduction - genetics | Bone Morphogenetic Protein Receptors, Type I - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Activin Receptors, Type I - genetics | Bone Morphogenetic Protein 4 - pharmacology | Bone Morphogenetic Protein Receptors, Type II - metabolism | Mice, Knockout | Animals | Signal Transduction - drug effects | Cell Differentiation - drug effects | Embryo, Mammalian - cytology | Myositis Ossificans - genetics | Fibroblasts - cytology | Ossification, Heterotopic - genetics | Bone morphogenetic proteins | Stem cells | Rodents | Mutation
Journal Article
Trends in Biochemical Sciences, ISSN 0968-0004, 02/2016, Volume 41, Issue 2, pp. 119 - 121
Fibrodysplasia ossificans progressiva (FOP), characterized by extra bone formation in soft tissues, is caused by a gain-of-function mutation in ACVR1, a... 
heterotopic ossification | intracellular signaling | bone morphogenetic protein (BMP) | receptor | activin | ligand | Bone morphogenetic protein (BMP) | Heterotopic ossification | Activin | Intracellular signaling | Ligand | Receptor | Animals | Humans | Myositis Ossificans - genetics | Myositis Ossificans - pathology | Mice | Mutation | Disease Progression
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2012, Volume 287, Issue 44, pp. 36990 - 36998
Journal Article
Journal Article