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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2015, Volume 112, Issue 50, pp. 15438 - 15443
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 09/2017, Volume 127, Issue 9, pp. 3339 - 3352
Fibrodysplasia ossificans progressiva (FOP) is a rare and intractable disease characterized by extraskeletal bone formation through endochondral ossification.... 
PLURIPOTENT STEM-CELLS | PROGENITOR CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | GROWTH-CONTROL | I RECEPTOR | DISEASE | BONE MORPHOGENETIC PROTEINS | OSTEOGENIC DIFFERENTIATION | REGULATORS | ALK2 | HETEROTOPIC OSSIFICATION | Lysophospholipids - metabolism | Chondrocytes - cytology | Embryonic Stem Cells - cytology | Oligonucleotide Array Sequence Analysis | TOR Serine-Threonine Kinases - metabolism | Humans | Activins - metabolism | Male | Inhibitory Concentration 50 | Female | Cell Differentiation | Chondrogenesis | Induced Pluripotent Stem Cells - cytology | Recombinant Proteins - metabolism | Myositis Ossificans - metabolism | Phosphoric Diester Hydrolases - metabolism | Signal Transduction | Mice, Inbred C57BL | Mesenchymal Stromal Cells - metabolism | Mice, Transgenic | Mice, Inbred C3H | Point Mutation | Animals | Mice | Transforming Growth Factor beta - metabolism | Rare diseases | Physiological aspects | Rapamycin | Genetic disorders | Health aspects | TOR protein | Animal models | Mesenchyme | Hyperactivity | Stem cell transplantation | High-throughput screening | Kinases | Signal transduction | Bone growth | Allografts | Bones | Bone morphogenetic proteins | Bone (endochondral) | Myositis ossificans | Patients | Lysophosphatidic acid | Stromal cells | Stem cells | Genetic engineering | Mutation | Activin | Ossification (ectopic) | Osteogenesis | Pluripotency | Inhibitory postsynaptic potentials | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
STEM CELLS, ISSN 1066-5099, 05/2014, Volume 32, Issue 5, pp. 1289 - 1300
Bone morphogenetic protein (BMP) signaling is a critical regulator of cartilage differentiation and endochondral ossification. Gain‐of‐function mutations in... 
Fibrodysplasia ossificans progressiva | Bone morphogenetic protein signaling | Chondrogenesis | Endochondral ossification | Alk2 | PROGENITOR CELLS | STEM-CELLS | R206H MUTATION | I RECEPTOR | OSTEOGENIC DIFFERENTIATION | CHONDROCYTE DIFFERENTIATION | CELL & TISSUE ENGINEERING | CELL BIOLOGY | CARTILAGE FORMATION | MOUSE EMBRYONIC FIBROBLASTS | ONCOLOGY | BONE-FORMATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | STROMAL CELLS | HEMATOLOGY | Chondrocytes - cytology | Chondrogenesis - drug effects | Chondrogenesis - genetics | Immunoblotting | Embryo, Mammalian - metabolism | Cell Differentiation - genetics | Mesenchymal Stromal Cells - cytology | Time Factors | Ossification, Heterotopic - metabolism | Myositis Ossificans - pathology | Chondrocytes - metabolism | Fibroblasts - metabolism | Myositis Ossificans - metabolism | Bone Morphogenetic Protein Receptors, Type II - genetics | Ossification, Heterotopic - pathology | Mice, Inbred C57BL | Cells, Cultured | Bone Morphogenetic Protein Receptors, Type I - genetics | Mesenchymal Stromal Cells - metabolism | Activin Receptors, Type I - metabolism | Mice, Transgenic | Signal Transduction - genetics | Bone Morphogenetic Protein Receptors, Type I - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Activin Receptors, Type I - genetics | Bone Morphogenetic Protein 4 - pharmacology | Bone Morphogenetic Protein Receptors, Type II - metabolism | Mice, Knockout | Animals | Signal Transduction - drug effects | Cell Differentiation - drug effects | Embryo, Mammalian - cytology | Myositis Ossificans - genetics | Fibroblasts - cytology | Ossification, Heterotopic - genetics | Bone morphogenetic proteins | Stem cells | Rodents | Mutation | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2009, Volume 284, Issue 11, pp. 7149 - 7156
Journal Article
Bone, ISSN 8756-3282, 2016, Volume 84, pp. 169 - 180
Abstract Fibrodysplasia ossificans progressiva is a rare genetic disorder characterized by progressive heterotopic ossification. FOP patients develop soft... 
Orthopedics | Inflammation | Fibrodyplasia ossificans progressiva | Transforming growth factor β | Fibroblast | Osteogenic differentiation | Ossification | STEM-CELLS | RECEPTOR INHIBITION | MECHANISM | PLATELET LYSATE | Transforming growth factor beta | NATURAL-HISTORY | HETEROTOPIC OSSIFICATION | ALKALINE-PHOSPHATASE ACTIVITY | ENDOCRINOLOGY & METABOLISM | SKIN | STROMAL CELLS | EXPRESSION | Humans | Middle Aged | Alkaline Phosphatase - metabolism | Ki-67 Antigen - metabolism | Male | Cell Transdifferentiation - genetics | RNA, Messenger - metabolism | Young Adult | Cell Transdifferentiation - drug effects | Adult | Female | Myositis Ossificans - pathology | Benzamides - pharmacology | Osteogenesis - genetics | Fibroblasts - metabolism | Pyrazoles - pharmacology | Calcification, Physiologic - genetics | Myositis Ossificans - metabolism | Calcification, Physiologic - drug effects | Osteogenesis - drug effects | RNA, Messenger - genetics | Cells, Cultured | Activin Receptors, Type I - metabolism | Signal Transduction - genetics | Fibroblasts - pathology | Gene Expression Regulation - drug effects | Animals | Signal Transduction - drug effects | Blood Platelets - metabolism | Models, Biological | Fibroblasts - drug effects | Adolescent | Myositis Ossificans - genetics | Smad Proteins - metabolism | Transforming Growth Factor beta - metabolism | Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 12/2010, Volume 16, Issue 12, pp. 1400 - 1406
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2019, Volume 1891, pp. 155 - 163
Journal Article
Orphanet Journal of Rare Diseases, ISSN 1750-1172, 12/2013, Volume 8, Issue 1, pp. 190 - 190
Journal Article