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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2015, Volume 112, Issue 50, pp. 15438 - 15443
Journal Article
Journal of Bone and Mineral Research, ISSN 0884-0431, 08/2012, Volume 27, Issue 8, pp. 1746 - 1756
Fibrodysplasia ossificans progressiva (FOP; MIM #135100) is a debilitating genetic disorder of dysregulated cellular differentiation characterized by... 
ACVR1 | ALK2 | HETEROTOPIC OSSIFICATION | ENDOCHONDRAL BONE | FIBRODYSPLASIA OSSIFICANS PROGRESSIVA | CELLS | MUSCLE | MECHANISMS | BONE-FORMATION | MUTATION | DISEASE | ENDOCRINOLOGY & METABOLISM | GROWTH-PLATE | BMP RECEPTOR | CHONDROGENESIS | Myositis Ossificans - diagnostic imaging | Inflammation - pathology | Receptor, TIE-2 | Humans | Molecular Sequence Data | Muscle, Skeletal - injuries | Stem Cells - metabolism | Inflammation - complications | Base Sequence | Myositis Ossificans - pathology | Chondrogenesis | Ossification, Heterotopic - complications | Gene Targeting | Myositis Ossificans - complications | Connective Tissue - pathology | Ossification, Heterotopic - pathology | Mice, Inbred C57BL | Activin Receptors, Type I - metabolism | Receptor Protein-Tyrosine Kinases - metabolism | Activin Receptors, Type I - genetics | Gene Knock-In Techniques | Radiography | Lymphocytes - pathology | Ossification, Heterotopic - physiopathology | Animals | Myositis Ossificans - physiopathology | Alleles | Amino Acid Substitution - genetics | Mice | Muscle, Skeletal - pathology | Osteogenesis | Apoptosis | Cell Movement | Medical colleges | Embryonic development | Genetic disorders | Analysis | Genes | Muscles | Bone morphogenetic proteins | Limbs | Animal models | Inflammation | Myositis ossificans | Nucleotides | Skeletal muscle | Ossification | Cartilage | Bone growth | Embryogenesis | Gene targeting | Stem cells | Mutation | Differentiation | Bone (endochondral) | Ossification (ectopic) | Index Medicus | heterotopic ossification | endochondral bone | fibrodysplasia ossificans progressiva | FOP
Journal Article
Trends in Biochemical Sciences, ISSN 0968-0004, 02/2016, Volume 41, Issue 2, pp. 119 - 121
Fibrodysplasia ossificans progressiva (FOP), characterized by extra bone formation in soft tissues, is caused by a gain-of-function mutation in ACVR1, a... 
heterotopic ossification | intracellular signaling | bone morphogenetic protein (BMP) | receptor | activin | ligand | Bone morphogenetic protein (BMP) | Heterotopic ossification | Activin | Intracellular signaling | Ligand | Receptor | Animals | Humans | Myositis Ossificans - genetics | Myositis Ossificans - pathology | Mice | Mutation | Disease Progression | Index Medicus
Journal Article
American Journal of Medical Genetics Part A, ISSN 1552-4825, 10/2015, Volume 167, Issue 10, pp. 2265 - 2271
Journal Article
STEM CELLS, ISSN 1066-5099, 05/2014, Volume 32, Issue 5, pp. 1289 - 1300
Bone morphogenetic protein (BMP) signaling is a critical regulator of cartilage differentiation and endochondral ossification. Gain‐of‐function mutations in... 
Fibrodysplasia ossificans progressiva | Bone morphogenetic protein signaling | Chondrogenesis | Endochondral ossification | Alk2 | PROGENITOR CELLS | STEM-CELLS | R206H MUTATION | I RECEPTOR | OSTEOGENIC DIFFERENTIATION | CHONDROCYTE DIFFERENTIATION | CELL & TISSUE ENGINEERING | CELL BIOLOGY | CARTILAGE FORMATION | MOUSE EMBRYONIC FIBROBLASTS | ONCOLOGY | BONE-FORMATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | STROMAL CELLS | HEMATOLOGY | Chondrocytes - cytology | Chondrogenesis - drug effects | Chondrogenesis - genetics | Immunoblotting | Embryo, Mammalian - metabolism | Cell Differentiation - genetics | Mesenchymal Stromal Cells - cytology | Time Factors | Ossification, Heterotopic - metabolism | Myositis Ossificans - pathology | Chondrocytes - metabolism | Fibroblasts - metabolism | Myositis Ossificans - metabolism | Bone Morphogenetic Protein Receptors, Type II - genetics | Ossification, Heterotopic - pathology | Mice, Inbred C57BL | Cells, Cultured | Bone Morphogenetic Protein Receptors, Type I - genetics | Mesenchymal Stromal Cells - metabolism | Activin Receptors, Type I - metabolism | Mice, Transgenic | Signal Transduction - genetics | Bone Morphogenetic Protein Receptors, Type I - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Activin Receptors, Type I - genetics | Bone Morphogenetic Protein 4 - pharmacology | Bone Morphogenetic Protein Receptors, Type II - metabolism | Mice, Knockout | Animals | Signal Transduction - drug effects | Cell Differentiation - drug effects | Embryo, Mammalian - cytology | Myositis Ossificans - genetics | Fibroblasts - cytology | Ossification, Heterotopic - genetics | Bone morphogenetic proteins | Stem cells | Rodents | Mutation | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2009, Volume 284, Issue 11, pp. 7149 - 7156
Journal Article
Orphanet Journal of Rare Diseases, ISSN 1750-1172, 12/2013, Volume 8, Issue 1, pp. 190 - 190
Journal Article