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PLoS ONE, ISSN 1932-6203, 07/2015, Volume 10, Issue 7, p. e0132478
Journal Article
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, ISSN 1079-5006, 01/2019, Volume 74, Issue 1, pp. 129 - 136
Growth and differentiation factors 8 (GDF8) and 11 (GDF11) have attracted attention as targets for rejuvenating interventions. The biological activity of these... 
GDF11 | Follistatin | PROTEIN | WFIKKN1 | Growth and differentiation factor 11 | WFIKKN2 | ACTIVIN | FAMILY | GERIATRICS & GERONTOLOGY | LATENT MYOSTATIN | BIOLOGICAL-ACTIVITY | Aging | GERONTOLOGY | Growth and differentiation factor 8 | GDF-8 | BINDING | PROPEPTIDE
Journal Article
Journal Article
International Journal of Biochemistry and Cell Biology, ISSN 1357-2725, 10/2013, Volume 45, Issue 10, pp. 2333 - 2347
Journal Article
The FEBS Journal, ISSN 1742-464X, 08/2013, Volume 280, Issue 16, pp. 3822 - 3839
Myostatin, a negative regulator of skeletal muscle growth, is produced from myostatin precursor by multiple steps of proteolytic processing. After cleavage by... 
WFIKKN1 | latent myostatin | promyostatin | myostatin | WFIKKN2 | ACTIVATION | SKELETAL-MUSCLE MASS | BIOCHEMISTRY & MOLECULAR BIOLOGY | GDF-8 PROPEPTIDE | CATTLE | GENE CAUSES | MDX MICE | PROTEASE-INHIBITORY MODULES | MULTIPLE TYPES | GROWTH | MUTATIONS | Activin Receptors, Type II - metabolism | Protein Precursors - chemistry | Humans | Protein Precursors - antagonists & inhibitors | Protein Isoforms - metabolism | Protein Isoforms - chemistry | Proteolysis | Myostatin - genetics | Protein Interaction Domains and Motifs | Myostatin - metabolism | Peptide Fragments - genetics | Genes, Reporter | Carrier Proteins | Myostatin - chemistry | Recombinant Proteins - metabolism | Cell Line | Peptide Fragments - metabolism | Recombinant Proteins - antagonists & inhibitors | Immobilized Proteins - chemistry | Protein Precursors - genetics | Immobilized Proteins - genetics | Recombinant Proteins - chemistry | Immobilized Proteins - antagonists & inhibitors | Myostatin - antagonists & inhibitors | Protein Precursors - metabolism | Proteins - genetics | Peptide Fragments - chemistry | Proteins - metabolism | Peptide Fragments - antagonists & inhibitors | Immobilized Proteins - metabolism | Protein Array Analysis | Protein Processing, Post-Translational | Kinetics | Proteins - chemistry | Protein Isoforms - genetics | Muscles | Bone morphogenetic proteins | Immunoglobulins | Proteases | Protein binding | Proteins | Musculoskeletal system | Original
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, 11/2008, Volume 283, Issue 47, pp. 32831 - 32838
Transforming growth factor beta family ligands are neutralized by a number of structurally divergent antagonists. Follistatin-type antagonists, which include... 
GENE | RECOGNITION | BONE-MORPHOGENETIC PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | MYOSTATIN | ACTIVIN-BINDING | TGF-BETA SUPERFAMILY | MECHANISMS | CELL | RECEPTOR-BINDING | FAMILY
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2015, Volume 290, Issue 32, pp. 19976 - 19986
Cachexia is an exacerbating event in many types of cancer that is strongly associated with a poor prognosis. We have identified cytokine, signaling, and... 
SKELETAL-MUSCLE | CELLS | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | STAT3 | MYOSTATIN | TRANSCRIPTION | COLON-26 ADENOCARCINOMA | MICE | DIFFERENTIATION | INTERLEUKIN-6 | Colonic Neoplasms - genetics | Adenocarcinoma - pathology | Luciferases - metabolism | Transcription Factor AP-1 - genetics | Gene Expression Regulation, Neoplastic | Culture Media, Conditioned - pharmacology | Male | Green Fluorescent Proteins - genetics | Leukemia Inhibitory Factor - genetics | Muscle Fibers, Skeletal - drug effects | Muscle Fibers, Skeletal - metabolism | Transcription Factor AP-1 - metabolism | Colonic Neoplasms - metabolism | Leukemia Inhibitory Factor - metabolism | Luciferases - genetics | Oncostatin M - antagonists & inhibitors | Adenocarcinoma - metabolism | Janus Kinase 2 - metabolism | Oncostatin M - metabolism | Adenocarcinoma - genetics | Leukemia Inhibitory Factor - antagonists & inhibitors | Phosphorylation - drug effects | Cachexia - metabolism | Genes, Reporter | Janus Kinase 2 - antagonists & inhibitors | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Green Fluorescent Proteins - metabolism | Cachexia - genetics | Signal Transduction | Janus Kinase 2 - genetics | Antibodies, Neutralizing - pharmacology | Cell Size | Animals | Cachexia - pathology | Colonic Neoplasms - pathology | Muscle Fibers, Skeletal - pathology | Cell Line, Tumor | Mice | Protein Kinase Inhibitors - pharmacology | Oncostatin M - genetics | C26 colon carcinoma | leukemia inhibitory factor (LIF) | Molecular Bases of Disease | colorectal cancer | JAK | cancer cachexia | muscle atrophy | skeletal muscle
Journal Article
Journal Article
BMC Biology, ISSN 1741-7007, 03/2017, Volume 15, Issue 1, p. 19
Background: Growth/differentiation factor 8 (GDF8) and GDF11 are two highly similar members of the transforming growth factor beta(TGF beta) family. While GDF8... 
Transforming growth factor β (TGFβ) | Ligands | Myostatin | Structure | Receptor | II RECEPTOR-BINDING | SKELETAL-MUSCLE MASS | BONE MORPHOGENETIC PROTEIN-2 | SUPERFAMILY MEMBER | PROTEASE-INHIBITORY MODULES | GROWTH-FACTOR-BETA | ACTIVIN-A | Transforming growth factor beta (TGF beta) | BIOLOGICAL-ACTIVITY | BIOLOGY | DIFFERENTIATION FACTOR 11 | FOLLICLE-STIMULATING-HORMONE | Bone Morphogenetic Proteins - antagonists & inhibitors | Phosphorylation | Injections, Intravenous | Luciferases - metabolism | Humans | Follistatin - metabolism | Crystallography, X-Ray | Structure-Activity Relationship | Bone Morphogenetic Proteins - metabolism | Myoblasts - metabolism | Myocardium - metabolism | Myostatin - metabolism | Genes, Reporter | Protein-Serine-Threonine Kinases - metabolism | Myostatin - chemistry | Amino Acid Sequence | Signal Transduction | Cells, Cultured | Models, Molecular | Myostatin - antagonists & inhibitors | Growth Differentiation Factors - metabolism | Sequence Alignment | Animals | Receptors, Transforming Growth Factor beta - metabolism | Protein Binding | Growth Differentiation Factors - antagonists & inhibitors | Mice | Structural Homology, Protein | Bone Morphogenetic Proteins - chemistry | Smad Proteins - metabolism | Growth Differentiation Factors - chemistry | Proteins | Signal transduction | Musculoskeletal system | Smad2 protein | Transforming growth factor | Activin | Kinases | Growth factors | Age
Journal Article