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American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 06/2009, Volume 296, Issue 6, pp. 1258 - 1270
Myostatin is a negative regulator of skeletal muscle size, previously shown to inhibit muscle cell differentiation. Myostatin requires both Smad2 and Smad3... 
MAFbx | Mammalian target of rapamycin complex signaling | MuRF1 | S6 kinase | Smad signaling | Human skeletal muscle cells | Transducer of regulated Ca | responsive element-binding protein activity | MuRF-1 | Atrogin | Transforming growth factor-β-like molecules | IGF-I | PHYSIOLOGY | ATROPHY | RAPID DISUSE | human skeletal muscle cells | transforming growth factor-beta-like molecules | SKELETAL-MUSCLE HYPERTROPHY | FOXO TRANSCRIPTION FACTORS | UBIQUITIN LIGASES | transducer of regulated Ca2+-responsive element-binding protein activity | CELL BIOLOGY | atrogin | PATHWAY | GROWTH | GENE-EXPRESSION | mammalian target of rapamycin complex signaling | CONDITIONAL ACTIVATION | Activin Receptors, Type I - antagonists & inhibitors | Protein Kinases - metabolism | Phosphorylation | Protein Kinases - genetics | Humans | Smad3 Protein - metabolism | Muscle Fibers, Skeletal - drug effects | Tripartite Motif Proteins | Smad3 Protein - genetics | Transfection | RNA Interference | Myoblasts, Skeletal - pathology | Smad2 Protein - genetics | Muscle Proteins - metabolism | Dioxoles - pharmacology | Regulatory-Associated Protein of mTOR | Benzamides - pharmacology | Myostatin - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Rapamycin-Insensitive Companion of mTOR Protein | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Signal Transduction | Cell Size - drug effects | Cells, Cultured | Smad2 Protein - metabolism | Ubiquitin-Protein Ligases - metabolism | Organ Size | Activin Receptors, Type I - metabolism | Myoblasts, Skeletal - enzymology | SKP Cullin F-Box Protein Ligases - metabolism | Mice, SCID | Myostatin - antagonists & inhibitors | Adaptor Proteins, Signal Transducing | Animals | Carrier Proteins - metabolism | Proteins - metabolism | Cell Differentiation - drug effects | Follistatin - pharmacology | Muscle Fibers, Skeletal - pathology | Creatine Kinase - metabolism | Mice | Protein Kinase Inhibitors - pharmacology | TOR Serine-Threonine Kinases | Myoblasts, Skeletal - drug effects | Insulin-Like Growth Factor I - metabolism | Muscle Fibers, Skeletal - enzymology | RNA, Small Interfering - metabolism
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 06/2013, Volume 210, Issue 6, pp. 1137 - 1151
Journal Article
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 06/2009, Volume 296, Issue 6, pp. 1248 - 1257
Loss of muscle mass occurs in a variety of diseases, including cancer, chronic heart failure, aquired immunodeficiency syndrome, diabetes, and renal failure,... 
Myostatin | Muscle atrophy | Akt | Hypertrophy | MYOBLAST DIFFERENTIATION | PHYSIOLOGY | hypertrophy | MYOSTATIN GENE | UBIQUITIN LIGASES | myostatin | CELL BIOLOGY | SKELETAL-MUSCLE | IN-VIVO | GROWTH | ATROPHY INVOLVE | MICE | muscle atrophy | EXPRESSION | Phosphorylation | Receptors, Transforming Growth Factor beta - genetics | Age Factors | Muscle Denervation | Male | Muscle, Skeletal - innervation | Muscle, Skeletal - metabolism | Smad3 Protein - metabolism | Proto-Oncogene Proteins c-akt - genetics | Tripartite Motif Proteins | Muscle Development | Muscular Atrophy - physiopathology | Transfection | RNA Interference | Muscle Proteins - metabolism | Cell Differentiation | Muscular Atrophy - prevention & control | Myostatin - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | Muscular Atrophy - metabolism | Signal Transduction | Muscular Atrophy - pathology | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Smad2 Protein - metabolism | Ubiquitin-Protein Ligases - metabolism | Mice, Transgenic | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Animals | Carrier Proteins - metabolism | Receptors, Transforming Growth Factor beta - metabolism | Sciatic Nerve - surgery | Muscle, Skeletal - physiopathology | Mice | TOR Serine-Threonine Kinases | Muscle, Skeletal - pathology | Mutation | Transforming Growth Factor beta - metabolism | RNA, Small Interfering - metabolism
Journal Article
Journal of the American Society of Nephrology, ISSN 1046-6673, 09/2017, Volume 28, Issue 9, pp. 2631 - 2640
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2016, Volume 291, Issue 23, pp. 12184 - 12194
Skeletal muscle atrophy promotes muscle weakness, limiting activities of daily living. However, mechanisms underlying atrophy remain unclear. Here, we show... 
HYPERTROPHY | MYOSTATIN GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CAPILLARY-ELECTROPHORESIS | RECEPTOR | MICE | FOXO TRANSCRIPTION FACTORS | F-BOX PROTEIN | MASS-SPECTROMETRY | GROWTH-FACTOR-I | SCF UBIQUITIN LIGASE | Receptor, IGF Type 1 - metabolism | Insulin-Like Growth Factor I - pharmacology | SKP Cullin F-Box Protein Ligases - genetics | Amino Acids, Branched-Chain - metabolism | Muscle Denervation | Muscle, Skeletal - innervation | Muscle, Skeletal - metabolism | Smad3 Protein - metabolism | Muscle Fibers, Skeletal - drug effects | Muscle Fibers, Skeletal - metabolism | Smad3 Protein - genetics | Smad2 Protein - genetics | Muscle Proteins - metabolism | Myostatin - genetics | Restraint, Physical - adverse effects | Myostatin - metabolism | Muscular Atrophy - etiology | Cell Line | Muscular Atrophy - metabolism | Smad2 Protein - metabolism | Ubiquitin-Protein Ligases - metabolism | Tripartite Motif Proteins - genetics | Mice, Transgenic | SKP Cullin F-Box Protein Ligases - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Receptor, IGF Type 1 - genetics | Blotting, Western | Mice, Knockout | Muscle Proteins - genetics | Animals | Glucose - metabolism | Muscle Fibers, Skeletal - cytology | Tripartite Motif Proteins - metabolism | Muscle, Skeletal - pathology | Ubiquitin-Protein Ligases - genetics | Insulin-Like Growth Factor I - metabolism | Molecular Bases of Disease | SMAD transcription factor | metabolism | muscle atrophy | myostatin | muscle
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2015, Volume 290, Issue 17, pp. 11177 - 11187
Cachexia occurs in patients with advanced cancers. Despite the adverse clinical impact of cancer-induced muscle wasting, pathways causing cachexia are... 
TRANSCRIPTION FACTORS | SKELETAL-MUSCLE | PROTEIN-DEGRADATION | MYOSTATIN GENE | PATHWAY | ATROPHY | BIOCHEMISTRY & MOLECULAR BIOLOGY | KAPPA-B | UP-REGULATION | EXPRESSION | CATABOLIC CONDITIONS | Colonic Neoplasms - genetics | SKP Cullin F-Box Protein Ligases - genetics | Caspase 3 - metabolism | Ubiquitin - metabolism | Muscle, Skeletal - metabolism | Colonic Neoplasms - metabolism | Tripartite Motif Proteins | Proteolysis | Caspase 3 - genetics | Muscle Proteins - metabolism | Myostatin - genetics | CCAAT-Enhancer-Binding Protein-delta - metabolism | Myostatin - metabolism | Cachexia - metabolism | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Cachexia - genetics | Ubiquitin-Protein Ligases - metabolism | SKP Cullin F-Box Protein Ligases - metabolism | Ubiquitin - genetics | Carcinoma, Lewis Lung - metabolism | Mice, Knockout | Muscle Proteins - genetics | Proteasome Endopeptidase Complex - genetics | Animals | Carcinoma, Lewis Lung - genetics | CCAAT-Enhancer-Binding Protein-delta - genetics | Cachexia - pathology | Colonic Neoplasms - pathology | Carcinoma, Lewis Lung - pathology | Cell Line, Tumor | Mice | Muscle, Skeletal - pathology | Proteasome Endopeptidase Complex - metabolism | Ubiquitin-Protein Ligases - genetics | Ubiquitin | Signal Transduction | STAT3 | Caspase | Cancer Cachexia | Cancer Biology | Muscle Atrophy | Caspase-3
Journal Article
The American Journal of Sports Medicine, ISSN 0363-5465, 12/2014, Volume 42, Issue 12, pp. 2860 - 2868
Background: The repair and restoration of function after chronic rotator cuff tears are often complicated by muscle atrophy, fibrosis, and fatty degeneration... 
fatty degeneration | rotator cuff | myosteatosis | licofelone | SPORT SCIENCES | REGENERATION | CYCLOOXYGENASE | PROTEIN-SYNTHESIS | INFILTRATION | SKELETAL-MUSCLE | TEARS | MYOSTATIN-DEFICIENT MICE | 5-LIPOXYGENASE | ORTHOPEDICS | Muscle Fibers, Fast-Twitch - drug effects | Vesicular Transport Proteins - metabolism | Male | Muscle, Skeletal - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | PPAR gamma - metabolism | Phosphoproteins - metabolism | RNA, Messenger - metabolism | Rotator Cuff - surgery | Muscle Proteins - metabolism | Apoptosis Regulatory Proteins - genetics | Interleukin-10 - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Wound Healing - drug effects | Fibrocartilage - pathology | PPAR gamma - genetics | Beclin-1 | Rotator Cuff - pathology | Hydroxyproline - metabolism | Vesicular Transport Proteins - genetics | Enzyme Inhibitors - pharmacology | Phosphoproteins - genetics | Rats, Sprague-Dawley | Apoptosis Regulatory Proteins - metabolism | Acetyl-CoA C-Acetyltransferase - genetics | Muscle Proteins - genetics | Proteins - genetics | Carrier Proteins - genetics | Biomechanical Phenomena | Pyrroles - pharmacology | Animals | Carrier Proteins - metabolism | Proteins - metabolism | Autophagy-Related Protein 5 | Diacylglycerol O-Acyltransferase - genetics | Muscle Contraction - drug effects | Interleukin-10 - genetics | Fibrosis | Lipid Metabolism - drug effects | Wound Healing - physiology | Muscle, Skeletal - pathology | Acetyl-CoA C-Acetyltransferase - metabolism | Diacylglycerol O-Acyltransferase - metabolism | Perilipin-1
Journal Article
Journal Article