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Molecular Cell, ISSN 1097-2765, 03/2012, Volume 45, Issue 6, pp. 764 - 776
Aberrant ErbB2 receptor tyrosine kinase activation in breast cancer is strongly linked to an invasive disease. The molecular basis of ErbB2-driven invasion is... 
PATHWAYS | ONCOGENE | METASTASIS | EPITHELIAL-CELLS | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | CYSTEINE CATHEPSINS | FIBROBLASTS | MULTISTAGE TUMORIGENESIS | ERBB RECEPTORS | CELL BIOLOGY | Cathepsin L - genetics | Protein Kinase C-alpha - metabolism | Proto-Oncogene Protein c-ets-1 - metabolism | Receptor, ErbB-2 - genetics | Protein-Tyrosine Kinases - metabolism | Cathepsin B - genetics | Humans | Protein Kinase C-alpha - genetics | Gene Expression Regulation, Neoplastic | Receptor, ErbB-2 - metabolism | Cathepsin L - metabolism | Breast Neoplasms - metabolism | Protein-Tyrosine Kinases - genetics | Kruppel-Like Transcription Factors - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | Female | Promoter Regions, Genetic | p21-Activated Kinases - genetics | Myotonin-Protein Kinase | Response Elements | Signal Transduction | Neoplasm Invasiveness | Cathepsin B - metabolism | p21-Activated Kinases - metabolism | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Cell Line, Tumor | Proto-Oncogene Protein c-ets-1 - genetics | Kruppel-Like Transcription Factors - genetics | Mitogen-Activated Protein Kinase 1 - metabolism | Tyrosine | Cysteine | Oncology, Experimental | Genes | Cathepsins | Breast cancer | DNA binding proteins | Genetic transcription | Research | Cystine | Analysis | Universities and colleges | Protein kinases | Phosphotransferases | Protein binding | Cancer | Protein kinase C | Transcription factors | Introns | Invasiveness | cathepsins | AKT protein | ErbB-2 protein | Zinc | Enhancers | Cathepsin B | Protein-tyrosine kinase receptors | Protein-serine/threonine kinase
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 02/2017, Volume 127, Issue 2, pp. 549 - 563
Myotonic dystrophy type I (DM1) is a disabling multisystemic disease that predominantly affects skeletal muscle. It is caused by expanded CTG repeats in the... 
MEDICINE, RESEARCH & EXPERIMENTAL | SKELETAL-MUSCLE | MESSENGER-RNA | RYANODINE RECEPTOR | PROTEIN-KINASE | EXPANDED CUG REPEATS | MUSCULAR-DYSTROPHIES | BINDING PROTEIN | AMPK ACTIVATION | MOUSE MODELS | CHLORIDE CHANNELOPATHY | AMP-Activated Protein Kinases - metabolism | TOR Serine-Threonine Kinases - metabolism | Humans | Middle Aged | Male | Multiprotein Complexes - genetics | Aminoimidazole Carboxamide - pharmacology | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - antagonists & inhibitors | Ribonucleotides - pharmacology | TOR Serine-Threonine Kinases - antagonists & inhibitors | Multiprotein Complexes - metabolism | TOR Serine-Threonine Kinases - genetics | Mice, Mutant Strains | Myotonic Dystrophy - genetics | Adult | Female | Myotonic Dystrophy - enzymology | Disease Models, Animal | Myotonin-Protein Kinase - metabolism | Signal Transduction - genetics | Sirolimus - pharmacokinetics | Sirolimus - pharmacology | Myotonin-Protein Kinase - genetics | Myotonic Dystrophy - physiopathology | Animals | Aminoimidazole Carboxamide - analogs & derivatives | Signal Transduction - drug effects | Muscle Relaxation - genetics | Myotonic Dystrophy - drug therapy | Mice | Muscle Relaxation - drug effects | AMP-Activated Protein Kinases - genetics | Muscle Fibers, Skeletal - enzymology | Care and treatment | Myotonic dystrophy | Development and progression | Genetic aspects | Cellular signal transduction | Gene expression | Health aspects | Protein kinases | Phosphorylation | Disease | Genes | Colleges & universities | Kinases | Metabolism | Proteins | Pathology | Musculoskeletal system | Microscopy | Biopsy | Rodents | Fibroblasts
Journal Article
Nature, ISSN 0028-0836, 08/2012, Volume 488, Issue 7409, pp. 111 - 115
Antisense oligonucleotides (ASOs) hold promise for gene-specific knockdown in diseases that involve RNA or protein gain-of-function effects. In the hereditary... 
CTG REPEAT | 3' END | PROTEIN | MESSENGER-RNA | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | TOXIC RNA | MODIFIED ANTISENSE OLIGONUCLEOTIDE | PHOSPHOROTHIOATE OLIGONUCLEOTIDES | MOUSE MODELS | TRINUCLEOTIDE REPEAT | Humans | Muscle, Skeletal - metabolism | RNA, Messenger - metabolism | RNA, Untranslated - genetics | Gene Knockdown Techniques | RNA - genetics | Myotonic Dystrophy - pathology | Base Sequence | Muscle, Skeletal - drug effects | Oligonucleotides, Antisense - therapeutic use | RNA, Messenger - antagonists & inhibitors | Mice, Inbred mdx | Myotonic Dystrophy - genetics | Disease Models, Animal | RNA - metabolism | Oligonucleotides, Antisense - pharmacology | Myotonin-Protein Kinase | RNA - antagonists & inhibitors | Mice, Inbred C57BL | RNA, Messenger - genetics | Gene Silencing | Protein-Serine-Threonine Kinases - genetics | Mice, Transgenic | Myotonic Dystrophy - therapy | Transcriptome - drug effects | Transcriptome - genetics | Myotonic Dystrophy - physiopathology | Animals | Oligonucleotides, Antisense - genetics | Cell Nucleus - genetics | RNA, Long Noncoding | Alleles | Trinucleotide Repeat Expansion - genetics | Mice | Mice, Inbred BALB C | Cell Nucleus - drug effects | Ribonuclease H - metabolism | Myotonic dystrophy | RNA | Oligonucleotides | Physiological aspects | Development and progression | Genetic aspects | Health aspects
Journal Article
JOURNAL OF CELL BIOLOGY, ISSN 0021-9525, 09/2013, Volume 202, Issue 6, pp. 901 - 916
Reorganization of the actin cytoskeleton is responsible for dynamic regulation of endothelial cell (EC) barrier function. Circumferential actin bundles (CAB)... 
P21-ACTIVATED KINASE | EXCHANGE FACTOR | SMOOTH-MUSCLE | REGULATORY LIGHT-CHAIN | RHO-KINASE | BARRIER FUNCTION | VE-CADHERIN | ADHERENS JUNCTIONS | CDC42-BINDING KINASE | GROWTH-FACTOR | CELL BIOLOGY | RNA, Small Interfering - genetics | Phosphorylation | Cell Proliferation | rho GTP-Binding Proteins - antagonists & inhibitors | Human Umbilical Vein Endothelial Cells - metabolism | Protein-Tyrosine Kinases - metabolism | Humans | Actins - metabolism | cdc42 GTP-Binding Protein - metabolism | Immunoenzyme Techniques | rho-Associated Kinases - antagonists & inhibitors | Telomere-Binding Proteins - genetics | Protein-Tyrosine Kinases - genetics | Myosin Type II - metabolism | rho-Associated Kinases - metabolism | Human Umbilical Vein Endothelial Cells - cytology | cdc42 GTP-Binding Protein - antagonists & inhibitors | Cell Membrane - metabolism | Myosin Type II - genetics | Telomere-Binding Proteins - metabolism | Myotonin-Protein Kinase | rho GTP-Binding Proteins - genetics | Cells, Cultured | Intercellular Junctions - metabolism | rho-Associated Kinases - genetics | Cell Adhesion | Telomere-Binding Proteins - antagonists & inhibitors | Blotting, Western | cdc42 GTP-Binding Protein - genetics | rho GTP-Binding Proteins - metabolism | Cell Movement | Protein-Tyrosine Kinases - antagonists & inhibitors | Junctional complexes (Epithelium) | Cell junctions | Physiological aspects | Actin | Myosin | Endothelium
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2014, Volume 289, Issue 39, pp. 26989 - 27003
Journal Article
Genome Research, ISSN 1088-9051, 11/2015, Volume 25, Issue 11, pp. 1646 - 1655
Journal Article
Molecular Therapy, ISSN 1525-0016, 01/2017, Volume 25, Issue 1, pp. 24 - 43
Journal Article
Journal Article