Proteins: Structure, Function, and Bioinformatics, ISSN 0887-3585, 10/2016, Volume 84, Issue 10, pp. 1375 - 1389
ABSTRACT The oxygen sensor histidine kinase AfGcHK from the bacterium Anaeromyxobacter sp. Fw 109‐5 forms a two‐component signal transduction system together...
heme‐based oxygen sensor | analytical ultracentrifugation | homology modeling | two‐component signal transduction system | protein–protein interaction | hydrogen‐deuterium exchange | histidine kinase | protein–protein docking | hydrogen-deuterium exchange | two-component signal transduction system | heme-based oxygen sensor | COMPLEX | protein-protein docking | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSDUCTION | MASS-SPECTROMETRY | COUPLED HISTIDINE KINASE | PROTEIN INTERACTIONS | BIOPHYSICS | protein-protein interaction | SEDIMENTATION-VELOCITY | EXCHANGE | BINDING | AUTOPHOSPHORYLATION | Histidine Kinase - chemistry | Histidine Kinase - metabolism | Phosphorylation | Heme - metabolism | Bacterial Proteins - chemistry | Histidine - metabolism | Oxygen - metabolism | Deuterium Exchange Measurement | Heme - chemistry | Cloning, Molecular | Escherichia coli - metabolism | Oxygen - chemistry | Protein Domains | Aeromonas salmonicida - metabolism | Recombinant Proteins - metabolism | Protein Structure, Secondary | Signal Transduction | Iron - chemistry | Bacterial Proteins - genetics | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Iron - metabolism | Myxococcales - chemistry | Escherichia coli - genetics | Histidine Kinase - genetics | Myxococcales - enzymology | Aspartic Acid - metabolism | Bacterial Proteins - metabolism | Structural Homology, Protein | Aspartic Acid - chemistry | Histidine - chemistry | Aeromonas salmonicida - genetics | Proteins | Phosphates | Hydrogen | Analysis | Heme | Cellular signal transduction | Mass spectrometry | Protein-protein interactions
heme‐based oxygen sensor | analytical ultracentrifugation | homology modeling | two‐component signal transduction system | protein–protein interaction | hydrogen‐deuterium exchange | histidine kinase | protein–protein docking | hydrogen-deuterium exchange | two-component signal transduction system | heme-based oxygen sensor | COMPLEX | protein-protein docking | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSDUCTION | MASS-SPECTROMETRY | COUPLED HISTIDINE KINASE | PROTEIN INTERACTIONS | BIOPHYSICS | protein-protein interaction | SEDIMENTATION-VELOCITY | EXCHANGE | BINDING | AUTOPHOSPHORYLATION | Histidine Kinase - chemistry | Histidine Kinase - metabolism | Phosphorylation | Heme - metabolism | Bacterial Proteins - chemistry | Histidine - metabolism | Oxygen - metabolism | Deuterium Exchange Measurement | Heme - chemistry | Cloning, Molecular | Escherichia coli - metabolism | Oxygen - chemistry | Protein Domains | Aeromonas salmonicida - metabolism | Recombinant Proteins - metabolism | Protein Structure, Secondary | Signal Transduction | Iron - chemistry | Bacterial Proteins - genetics | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Iron - metabolism | Myxococcales - chemistry | Escherichia coli - genetics | Histidine Kinase - genetics | Myxococcales - enzymology | Aspartic Acid - metabolism | Bacterial Proteins - metabolism | Structural Homology, Protein | Aspartic Acid - chemistry | Histidine - chemistry | Aeromonas salmonicida - genetics | Proteins | Phosphates | Hydrogen | Analysis | Heme | Cellular signal transduction | Mass spectrometry | Protein-protein interactions
Journal Article
Natural Product Reports, ISSN 0265-0568, 08/2010, Volume 27, Issue 8, pp. 1114 - 1116
The central proposition advanced herein is that complex target oriented synthesis, enabled by historic advances in methodology, has enormously expanded the...
CHEMISTRY, ORGANIC | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | Piperidones - chemical synthesis | Epothilones - chemistry | Streptomyces - chemistry | Epothilones - pharmacology | Biological Products - pharmacology | Epothilones - chemical synthesis | Piperidones - pharmacology | Drug Discovery | Myxococcales - chemistry | Biological Products - chemical synthesis | Piperidones - chemistry | Biological Products - chemistry | Animals | Macrolides - chemistry | Macrolides - chemical synthesis | Macrolides - pharmacology | Mice | Molecular Structure
CHEMISTRY, ORGANIC | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | Piperidones - chemical synthesis | Epothilones - chemistry | Streptomyces - chemistry | Epothilones - pharmacology | Biological Products - pharmacology | Epothilones - chemical synthesis | Piperidones - pharmacology | Drug Discovery | Myxococcales - chemistry | Biological Products - chemical synthesis | Piperidones - chemistry | Biological Products - chemistry | Animals | Macrolides - chemistry | Macrolides - chemical synthesis | Macrolides - pharmacology | Mice | Molecular Structure
Journal Article
3.
Full Text
Characterization of an Unusual Glycerate Esterification Process in Vioprolide Biosynthesis
ACS Chemical Biology, ISSN 1554-8929, 11/2018, Volume 13, Issue 11, pp. 3123 - 3130
Bacteria produce a large number of secondary metabolites with extraordinary chemical structures and bioactivities. Vioprolides are promising anticancer and...
MYXOCOCCUS-XANTHUS | GENE-CLUSTER | SPECIFICITY | POLYKETIDE SYNTHASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | VIRULENCE FACTOR | SECONDARY METABOLITE | ADENYLATION DOMAIN | FATTY-ACIDS | STRUCTURE ELUCIDATION | PEPTIDE | Antifungal Agents - pharmacology | Myxococcales - genetics | HCT116 Cells | Humans | Ligases - genetics | Bacterial Proteins - chemistry | Bacterial Proteins - genetics | Glyceric Acids - chemistry | Antifungal Agents - chemistry | Depsipeptides - pharmacology | Ligases - chemistry | Antineoplastic Agents - chemistry | Esterification | Mycobacterium - genetics | Myxococcales - chemistry | Escherichia coli - genetics | Protein Domains | Antineoplastic Agents - pharmacology | Palmitic Acid - chemistry | Depsipeptides - chemistry
MYXOCOCCUS-XANTHUS | GENE-CLUSTER | SPECIFICITY | POLYKETIDE SYNTHASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | VIRULENCE FACTOR | SECONDARY METABOLITE | ADENYLATION DOMAIN | FATTY-ACIDS | STRUCTURE ELUCIDATION | PEPTIDE | Antifungal Agents - pharmacology | Myxococcales - genetics | HCT116 Cells | Humans | Ligases - genetics | Bacterial Proteins - chemistry | Bacterial Proteins - genetics | Glyceric Acids - chemistry | Antifungal Agents - chemistry | Depsipeptides - pharmacology | Ligases - chemistry | Antineoplastic Agents - chemistry | Esterification | Mycobacterium - genetics | Myxococcales - chemistry | Escherichia coli - genetics | Protein Domains | Antineoplastic Agents - pharmacology | Palmitic Acid - chemistry | Depsipeptides - chemistry
Journal Article
Chemistry - A European Journal, ISSN 0947-6539, 07/2013, Volume 19, Issue 28, pp. 9319 - 9324
Marine myxobacteria (Enhygromyxa, Plesiocystis, Pseudoenhygromyxa, Haliangium) are phylogenetically distant from their terrestrial counterparts. Salimabromide...
enhygromyxa | natural products | NMR spectroscopy | polyketides | myxobacteria | Myxococcales - chemistry | Myxococcales - genetics | Animals | Arthrobacter - drug effects | Anti-Bacterial Agents - pharmacology | Anti-Bacterial Agents - isolation & purification | Phylogeny | Heterocyclic Compounds, 4 or More Rings - pharmacology | Aquatic Organisms | Heterocyclic Compounds, 4 or More Rings - isolation & purification
enhygromyxa | natural products | NMR spectroscopy | polyketides | myxobacteria | Myxococcales - chemistry | Myxococcales - genetics | Animals | Arthrobacter - drug effects | Anti-Bacterial Agents - pharmacology | Anti-Bacterial Agents - isolation & purification | Phylogeny | Heterocyclic Compounds, 4 or More Rings - pharmacology | Aquatic Organisms | Heterocyclic Compounds, 4 or More Rings - isolation & purification
Journal Article
FEBS Letters, ISSN 0014-5793, 12/2016, Volume 590, Issue 24, pp. 4638 - 4648
In this study, we report the crystal structure of the cytochrome P450 CYP260A1 (PDB 5LIV) from the myxobacterium Sorangium cellulosum So ce56. In addition, we...
crystal structure of CYP260A1 | steroid hydroxylation | P450 | S326N | mineralocorticoid | MOLECULAR REPLACEMENT | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | HYDROXYLATION | IDENTIFICATION | CELL BIOLOGY | BIOPHYSICS | INTEGRATION | CYTOCHROME-P450 ENZYMES | CE56 | PROTON DELIVERY | Ferredoxin-NADP Reductase - metabolism | Bacterial Proteins - chemistry | Adrenodoxin - metabolism | Cytochrome P-450 Enzyme System - metabolism | Substrate Specificity | Crystallography, X-Ray | Structure-Activity Relationship | Mineralocorticoids - chemistry | Ferredoxin-NADP Reductase - genetics | Protein Domains | Recombinant Proteins - metabolism | Gene Expression | Hydroxylation | Mineralocorticoids - metabolism | Oxidation-Reduction | Protein Structure, Secondary | Bacterial Proteins - genetics | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Myxococcales - chemistry | Cytochrome P-450 Enzyme System - chemistry | Myxococcales - enzymology | Desoxycorticosterone - chemistry | Desoxycorticosterone - metabolism | Cytochrome P-450 Enzyme System - genetics | Adrenodoxin - chemistry | Bacterial Proteins - metabolism | Molecular Docking Simulation | Kinetics | Mutation
crystal structure of CYP260A1 | steroid hydroxylation | P450 | S326N | mineralocorticoid | MOLECULAR REPLACEMENT | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | HYDROXYLATION | IDENTIFICATION | CELL BIOLOGY | BIOPHYSICS | INTEGRATION | CYTOCHROME-P450 ENZYMES | CE56 | PROTON DELIVERY | Ferredoxin-NADP Reductase - metabolism | Bacterial Proteins - chemistry | Adrenodoxin - metabolism | Cytochrome P-450 Enzyme System - metabolism | Substrate Specificity | Crystallography, X-Ray | Structure-Activity Relationship | Mineralocorticoids - chemistry | Ferredoxin-NADP Reductase - genetics | Protein Domains | Recombinant Proteins - metabolism | Gene Expression | Hydroxylation | Mineralocorticoids - metabolism | Oxidation-Reduction | Protein Structure, Secondary | Bacterial Proteins - genetics | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Myxococcales - chemistry | Cytochrome P-450 Enzyme System - chemistry | Myxococcales - enzymology | Desoxycorticosterone - chemistry | Desoxycorticosterone - metabolism | Cytochrome P-450 Enzyme System - genetics | Adrenodoxin - chemistry | Bacterial Proteins - metabolism | Molecular Docking Simulation | Kinetics | Mutation
Journal Article
Molecules, ISSN 1420-3049, 2018, Volume 23, Issue 3, p. 542
Two new secondary metabolites, labindole A [2-methyl-3-(2-nitroethyl)-3H-indole] (1) and labindole B [2-methyl-3-(2-nitrovinyl)-3H-indole] (2), were isolated...
Antimicrobial activity | HCV | Fermentation | Nitroindole | Natural products | Antiviral activity | natural products | CARBAZOLE | nitroindole | BIOCHEMISTRY & MOLECULAR BIOLOGY | fermentation | antiviral activity | antimicrobial activity | DERIVATIVES | CHEMISTRY, MULTIDISCIPLINARY | ALKALOIDS | Hepacivirus - drug effects | Antiviral Agents - pharmacology | Magnetic Resonance Spectroscopy | Anti-Infective Agents - pharmacology | Heterocyclic Compounds - pharmacology | Biological Products - pharmacology | Myxococcales - metabolism | Secondary Metabolism | Microbial Sensitivity Tests | Myxococcales - chemistry | Biological Products - chemistry | Heterocyclic Compounds - chemistry | Antiviral Agents - chemistry | Anti-Infective Agents - chemistry | Molecular Structure | Nuclear magnetic resonance--NMR | Fungicides | Indole | Overhauser effect | Viruses | Mass spectroscopy | Carbazole | Coupling (molecular) | Hepatitis | Secondary metabolites | Carbazoles | Metabolites | Ionization | Quinoline | Hepatitis C virus | Hepatitis C | Mass spectrometry
Antimicrobial activity | HCV | Fermentation | Nitroindole | Natural products | Antiviral activity | natural products | CARBAZOLE | nitroindole | BIOCHEMISTRY & MOLECULAR BIOLOGY | fermentation | antiviral activity | antimicrobial activity | DERIVATIVES | CHEMISTRY, MULTIDISCIPLINARY | ALKALOIDS | Hepacivirus - drug effects | Antiviral Agents - pharmacology | Magnetic Resonance Spectroscopy | Anti-Infective Agents - pharmacology | Heterocyclic Compounds - pharmacology | Biological Products - pharmacology | Myxococcales - metabolism | Secondary Metabolism | Microbial Sensitivity Tests | Myxococcales - chemistry | Biological Products - chemistry | Heterocyclic Compounds - chemistry | Antiviral Agents - chemistry | Anti-Infective Agents - chemistry | Molecular Structure | Nuclear magnetic resonance--NMR | Fungicides | Indole | Overhauser effect | Viruses | Mass spectroscopy | Carbazole | Coupling (molecular) | Hepatitis | Secondary metabolites | Carbazoles | Metabolites | Ionization | Quinoline | Hepatitis C virus | Hepatitis C | Mass spectrometry
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2011, Volume 21, Issue 22, pp. 6778 - 6781
Tubuylsins are extremely potent cytotoxic agents which inhibit tubulin polymerization and lead to cell cycle arrest and apoptosis. Tubulysins have been...
N-Acyl- N,O-acetals | N,N′-Diacyl-aminals | Tubulysin | N-Acyl- N,S-thioacetals | N-Acyliminium ion | C–C bond formation | N-Acyl-N,O-acetals | C-C bond formation | N-Acyl-N,S-thioacetals | N,N '-Diacyl-aminals | CHEMISTRY, MEDICINAL | ANTICANCER | CHEMISTRY, ORGANIC | INHIBITORS | BIOLOGICAL-PROPERTIES | MYXOBACTERIA | Chemistry Techniques, Synthetic - economics | Oligopeptides - chemical synthesis | Ions - chemistry | Tubulin Modulators - chemistry | Pipecolic Acids - chemical synthesis | Acetic Acid - chemistry | Chemistry Techniques, Synthetic - methods | Myxococcales - chemistry | Tubulin Modulators - chemical synthesis | Biological Products - chemical synthesis | Biological Products - chemistry | Imines - chemistry | Oligopeptides - chemistry | Pipecolic Acids - chemistry
N-Acyl- N,O-acetals | N,N′-Diacyl-aminals | Tubulysin | N-Acyl- N,S-thioacetals | N-Acyliminium ion | C–C bond formation | N-Acyl-N,O-acetals | C-C bond formation | N-Acyl-N,S-thioacetals | N,N '-Diacyl-aminals | CHEMISTRY, MEDICINAL | ANTICANCER | CHEMISTRY, ORGANIC | INHIBITORS | BIOLOGICAL-PROPERTIES | MYXOBACTERIA | Chemistry Techniques, Synthetic - economics | Oligopeptides - chemical synthesis | Ions - chemistry | Tubulin Modulators - chemistry | Pipecolic Acids - chemical synthesis | Acetic Acid - chemistry | Chemistry Techniques, Synthetic - methods | Myxococcales - chemistry | Tubulin Modulators - chemical synthesis | Biological Products - chemical synthesis | Biological Products - chemistry | Imines - chemistry | Oligopeptides - chemistry | Pipecolic Acids - chemistry
Journal Article
Analytical Biochemistry, ISSN 0003-2697, 11/2016, Volume 513, pp. 28 - 35
Direct electrochemistry and bioelectrocatalysis of a newly discovered C-19 steroid 1α-hydroxylase (CYP260A1) from the myxobacterium So ce56 were investigated....
Enzyme electrodes | Analytical bioelectrochemistry | Electrocatalysis | Direct electron transfer | C-19 steroid 1α-hydroxylase | Sorangium cellulosum So ce56 | GOLD NANOPARTICLES | RAT-LIVER | CHEMISTRY, ANALYTICAL | C-19 steroid 1 alpha-hydroxylase | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | BIOELECTROCHEMISTRY | MONOOXYGENASE | CYTOCHROME-P450 2B4 | REDUCTION | ENZYMES | P450 | PEROXYGENASE PROPERTIES | DIRECT ELECTRON-TRANSFER | Gold - chemistry | Enzymes, Immobilized - chemistry | Cytochrome P-450 Enzyme System - chemistry | Electrochemical Techniques | Androsterone - analysis | Metal Nanoparticles - chemistry | Myxococcales - enzymology | Bacterial Proteins - chemistry | Catalysis | Graphite - chemistry
Enzyme electrodes | Analytical bioelectrochemistry | Electrocatalysis | Direct electron transfer | C-19 steroid 1α-hydroxylase | Sorangium cellulosum So ce56 | GOLD NANOPARTICLES | RAT-LIVER | CHEMISTRY, ANALYTICAL | C-19 steroid 1 alpha-hydroxylase | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | BIOELECTROCHEMISTRY | MONOOXYGENASE | CYTOCHROME-P450 2B4 | REDUCTION | ENZYMES | P450 | PEROXYGENASE PROPERTIES | DIRECT ELECTRON-TRANSFER | Gold - chemistry | Enzymes, Immobilized - chemistry | Cytochrome P-450 Enzyme System - chemistry | Electrochemical Techniques | Androsterone - analysis | Metal Nanoparticles - chemistry | Myxococcales - enzymology | Bacterial Proteins - chemistry | Catalysis | Graphite - chemistry
Journal Article
Biochemistry, ISSN 0006-2960, 08/2015, Volume 54, Issue 32, pp. 5017 - 5029
The globin-coupled histidine kinase, AfGcHK, is a part of the two-component signal transduction system from the soil bacterium Anaeromyxobacter sp. Fw109-5....
SIGNAL-TRANSDUCTION | OXYGEN SENSOR | TRUNCATED HEMOGLOBIN | DISTAL SIDE | RESONANCE RAMAN-SPECTROSCOPY | BIOCHEMISTRY & MOLECULAR BIOLOGY | MYCOBACTERIUM-TUBERCULOSIS DOSS | ESCHERICHIA-COLI | SENSOR DIGUANYLATE CYCLASE | LIGAND-BINDING DYNAMICS | COLI EC DOS | Protein Kinases - metabolism | Phosphorylation | Protein Kinases - genetics | Bacterial Proteins - chemistry | Protein Kinases - chemistry | Globins - metabolism | Carbon Monoxide - metabolism | Oxygen - metabolism | Heme - chemistry | Adenosine Triphosphate - metabolism | Cations, Divalent - chemistry | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Myxococcales - genetics | Mutagenesis, Site-Directed | Oxidation-Reduction | Signal Transduction | Iron - chemistry | Bacterial Proteins - genetics | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Histidine Kinase | Myxococcales - enzymology | Bacterial Proteins - metabolism | Enzyme Activation | Kinetics | Hydrogen-Ion Concentration | Oxidation-reduction reaction | Iron compounds | Research | Chemical properties | Catalysis | Life Sciences | Chemical Physics | Biochemistry, Molecular Biology | Physics
SIGNAL-TRANSDUCTION | OXYGEN SENSOR | TRUNCATED HEMOGLOBIN | DISTAL SIDE | RESONANCE RAMAN-SPECTROSCOPY | BIOCHEMISTRY & MOLECULAR BIOLOGY | MYCOBACTERIUM-TUBERCULOSIS DOSS | ESCHERICHIA-COLI | SENSOR DIGUANYLATE CYCLASE | LIGAND-BINDING DYNAMICS | COLI EC DOS | Protein Kinases - metabolism | Phosphorylation | Protein Kinases - genetics | Bacterial Proteins - chemistry | Protein Kinases - chemistry | Globins - metabolism | Carbon Monoxide - metabolism | Oxygen - metabolism | Heme - chemistry | Adenosine Triphosphate - metabolism | Cations, Divalent - chemistry | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Myxococcales - genetics | Mutagenesis, Site-Directed | Oxidation-Reduction | Signal Transduction | Iron - chemistry | Bacterial Proteins - genetics | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Histidine Kinase | Myxococcales - enzymology | Bacterial Proteins - metabolism | Enzyme Activation | Kinetics | Hydrogen-Ion Concentration | Oxidation-reduction reaction | Iron compounds | Research | Chemical properties | Catalysis | Life Sciences | Chemical Physics | Biochemistry, Molecular Biology | Physics
Journal Article
ACS Chemical Biology, ISSN 1554-8929, 09/2018, Volume 13, Issue 9, pp. 2699 - 2707
Polyketide synthases (PKS) are a rich source of natural products of varied chemical composition and biological significance. Here, we report the...
ELUCIDATION | DOMAIN | FABZ | CARRIER PROTEIN DEHYDRATASE | PSEUDOMONAS-AERUGINOSA | BIOCHEMISTRY & MOLECULAR BIOLOGY | ISOMERASE | BIOSYNTHETIC-PATHWAY | BETA-HYDROXYDECANOYLTHIOESTER DEHYDRASE | STEREOSPECIFICITY | DOUBLE-BOND FORMATION | Catalytic Domain | Models, Molecular | Substrate Specificity | Biosynthetic Pathways | Myxococcales - metabolism | Myxococcales - chemistry | Alkenes - chemistry | Polyketide Synthases - chemistry | Polyketide Synthases - metabolism | Fatty Acids, Monounsaturated - metabolism | Isomerases - chemistry | Myxococcales - enzymology | Protein Domains | Fatty Acids, Monounsaturated - chemistry | Hydro-Lyases - metabolism | Hydro-Lyases - chemistry | Isomerases - metabolism | Alkenes - metabolism | Index Medicus
ELUCIDATION | DOMAIN | FABZ | CARRIER PROTEIN DEHYDRATASE | PSEUDOMONAS-AERUGINOSA | BIOCHEMISTRY & MOLECULAR BIOLOGY | ISOMERASE | BIOSYNTHETIC-PATHWAY | BETA-HYDROXYDECANOYLTHIOESTER DEHYDRASE | STEREOSPECIFICITY | DOUBLE-BOND FORMATION | Catalytic Domain | Models, Molecular | Substrate Specificity | Biosynthetic Pathways | Myxococcales - metabolism | Myxococcales - chemistry | Alkenes - chemistry | Polyketide Synthases - chemistry | Polyketide Synthases - metabolism | Fatty Acids, Monounsaturated - metabolism | Isomerases - chemistry | Myxococcales - enzymology | Protein Domains | Fatty Acids, Monounsaturated - chemistry | Hydro-Lyases - metabolism | Hydro-Lyases - chemistry | Isomerases - metabolism | Alkenes - metabolism | Index Medicus
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 12/2014, Volume 53, Issue 52, pp. 14605 - 14609
The development of new antibiotics faces a severe crisis inter alia owing to a lack of innovative chemical scaffolds with activities against Gram‐negative and...
natural products | NRPS | topoisomerase inhibitors | antibiotics | myxobacteria | Topoisomerase inhibitors | Myxobacteria | Antibiotics | Natural products | QUINOLONE RESISTANCE | ESCHERICHIA-COLI | CHEMISTRY, MULTIDISCIPLINARY | DISCOVERY | IMPACT | BAD BUGS | DRUGS | DNA GYRASE | Asparagine - pharmacology | Bacterial Proteins - antagonists & inhibitors | DNA Topoisomerases, Type I - metabolism | Gram-Positive Bacteria - drug effects | DNA Topoisomerases, Type I - chemistry | Nitro Compounds - chemistry | Nitro Compounds - chemical synthesis | Peptide Synthases - metabolism | Microbial Sensitivity Tests | Topoisomerase Inhibitors - pharmacology | Asparagine - chemical synthesis | Gram-Negative Bacteria - drug effects | Topoisomerase Inhibitors - metabolism | Asparagine - analogs & derivatives | Anti-Bacterial Agents - chemistry | Myxococcales - enzymology | Nitro Compounds - pharmacology | Bacterial Proteins - metabolism | Anti-Bacterial Agents - biosynthesis | Anti-Bacterial Agents - pharmacology | Topoisomerase Inhibitors - chemistry | Asparagine - chemistry | Exhibitions | Antibacterial agents | Analysis | DNA topoisomerase I | Pathogens | Inhibitors | Congeners | Bacteria | Derivatives | Antibacterial materials | Scaffolds | Antiinfectives and antibacterials
natural products | NRPS | topoisomerase inhibitors | antibiotics | myxobacteria | Topoisomerase inhibitors | Myxobacteria | Antibiotics | Natural products | QUINOLONE RESISTANCE | ESCHERICHIA-COLI | CHEMISTRY, MULTIDISCIPLINARY | DISCOVERY | IMPACT | BAD BUGS | DRUGS | DNA GYRASE | Asparagine - pharmacology | Bacterial Proteins - antagonists & inhibitors | DNA Topoisomerases, Type I - metabolism | Gram-Positive Bacteria - drug effects | DNA Topoisomerases, Type I - chemistry | Nitro Compounds - chemistry | Nitro Compounds - chemical synthesis | Peptide Synthases - metabolism | Microbial Sensitivity Tests | Topoisomerase Inhibitors - pharmacology | Asparagine - chemical synthesis | Gram-Negative Bacteria - drug effects | Topoisomerase Inhibitors - metabolism | Asparagine - analogs & derivatives | Anti-Bacterial Agents - chemistry | Myxococcales - enzymology | Nitro Compounds - pharmacology | Bacterial Proteins - metabolism | Anti-Bacterial Agents - biosynthesis | Anti-Bacterial Agents - pharmacology | Topoisomerase Inhibitors - chemistry | Asparagine - chemistry | Exhibitions | Antibacterial agents | Analysis | DNA topoisomerase I | Pathogens | Inhibitors | Congeners | Bacteria | Derivatives | Antibacterial materials | Scaffolds | Antiinfectives and antibacterials
Journal Article
Natural product reports, ISSN 0265-0568, 02/2017, Volume 34, Issue 2, pp. 135 - 160
Covering: 2011-July 2016Myxobacteria are a rich source for structurally diverse secondary metabolites with intriguing biological activities. Here we report on...
Myxococcales - chemistry | Biological Products - chemistry | Biological Products - pharmacology | Molecular Structure | Biological Products - isolation & purification
Myxococcales - chemistry | Biological Products - chemistry | Biological Products - pharmacology | Molecular Structure | Biological Products - isolation & purification
Journal Article
Chemistry – A European Journal, ISSN 0947-6539, 11/2017, Volume 23, Issue 63, pp. 15917 - 15921
The first stereoselective total synthesis of the natural product pyrronazol B, which contains a chlorinated pyrrole–oxazole–pyrone framework, has been...
deprotection | pyrronazol | biosynthetic gene cluster | total synthesis | DOMAIN | NATURAL-PRODUCTS | POLYKETIDE SYNTHASES | CHEMISTRY, MULTIDISCIPLINARY | STRUCTURE ELUCIDATION | Pyrroles - metabolism | Multigene Family | Myxococcales - genetics | Oxazoles - metabolism | Models, Molecular | Myxococcales - metabolism | Oxazoles - chemistry | Myxococcales - chemistry | Biological Products - chemical synthesis | Biological Products - chemistry | Oxazoles - chemical synthesis | Pyrones - chemistry | Biosynthetic Pathways - genetics | Pyrroles - chemical synthesis | Biological Products - metabolism | Pyrroles - chemistry | Pyrones - metabolism | Pyrones - chemical synthesis | Synthesis | Metabolites | Oxazoles | Genomics | Physiological aspects | Proline | Biosynthesis | Organic compounds | Serine | Stable isotopes | Oxazole | Methionine | L-Serine | Genomes | Isotopes | L-Proline | Gene sequencing
deprotection | pyrronazol | biosynthetic gene cluster | total synthesis | DOMAIN | NATURAL-PRODUCTS | POLYKETIDE SYNTHASES | CHEMISTRY, MULTIDISCIPLINARY | STRUCTURE ELUCIDATION | Pyrroles - metabolism | Multigene Family | Myxococcales - genetics | Oxazoles - metabolism | Models, Molecular | Myxococcales - metabolism | Oxazoles - chemistry | Myxococcales - chemistry | Biological Products - chemical synthesis | Biological Products - chemistry | Oxazoles - chemical synthesis | Pyrones - chemistry | Biosynthetic Pathways - genetics | Pyrroles - chemical synthesis | Biological Products - metabolism | Pyrroles - chemistry | Pyrones - metabolism | Pyrones - chemical synthesis | Synthesis | Metabolites | Oxazoles | Genomics | Physiological aspects | Proline | Biosynthesis | Organic compounds | Serine | Stable isotopes | Oxazole | Methionine | L-Serine | Genomes | Isotopes | L-Proline | Gene sequencing
Journal Article
Scientific Reports, ISSN 2045-2322, 10/2015, Volume 5, Issue 1, p. 14881
Since their discovery in the soil bacterium Sorangium cellulosum, epothilones have emerged as a valuable substance class with promising anti-tumor activity....
MICROTUBULE-STABILIZING AGENTS | BIOSYNTHETIC GENE-CLUSTER | ELECTRON-TRANSFER | ADRENODOXIN REDUCTASE | SORANGIUM-CELLULOSUM | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | CHLAMYDOMONAS-REINHARDTII FERREDOXIN | HETEROLOGOUS EXPRESSION | CE56 | CYTOTOXIC ACTIVITY | Electron Transport | Ferredoxins - genetics | Epothilones - chemistry | Bacterial Proteins - chemistry | Ferredoxins - chemistry | Cytochrome P-450 Enzyme System - metabolism | Phylogeny | Antineoplastic Agents - metabolism | Cloning, Molecular | Escherichia coli - metabolism | Protein Engineering | Recombinant Proteins - metabolism | Gene Expression | Biocatalysis | Epothilones - biosynthesis | Oxidation-Reduction | Ferredoxins - metabolism | Bacterial Proteins - genetics | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Antineoplastic Agents - chemistry | Myxococcales - chemistry | Cytochrome P-450 Enzyme System - chemistry | Escherichia coli - genetics | Myxococcales - enzymology | Ketones - chemistry | Cytochrome P-450 Enzyme System - genetics | Bacterial Proteins - metabolism | Ketones - metabolism | Electrons | Protein engineering | Antitumor agents | Soil microorganisms | Neurodegenerative diseases | Ketones | Cytochrome P450 | Epoxidation | Drug development | Cancer | Life Sciences
MICROTUBULE-STABILIZING AGENTS | BIOSYNTHETIC GENE-CLUSTER | ELECTRON-TRANSFER | ADRENODOXIN REDUCTASE | SORANGIUM-CELLULOSUM | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | CHLAMYDOMONAS-REINHARDTII FERREDOXIN | HETEROLOGOUS EXPRESSION | CE56 | CYTOTOXIC ACTIVITY | Electron Transport | Ferredoxins - genetics | Epothilones - chemistry | Bacterial Proteins - chemistry | Ferredoxins - chemistry | Cytochrome P-450 Enzyme System - metabolism | Phylogeny | Antineoplastic Agents - metabolism | Cloning, Molecular | Escherichia coli - metabolism | Protein Engineering | Recombinant Proteins - metabolism | Gene Expression | Biocatalysis | Epothilones - biosynthesis | Oxidation-Reduction | Ferredoxins - metabolism | Bacterial Proteins - genetics | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Antineoplastic Agents - chemistry | Myxococcales - chemistry | Cytochrome P-450 Enzyme System - chemistry | Escherichia coli - genetics | Myxococcales - enzymology | Ketones - chemistry | Cytochrome P-450 Enzyme System - genetics | Bacterial Proteins - metabolism | Ketones - metabolism | Electrons | Protein engineering | Antitumor agents | Soil microorganisms | Neurodegenerative diseases | Ketones | Cytochrome P450 | Epoxidation | Drug development | Cancer | Life Sciences
Journal Article
Organic Letters, ISSN 1523-7060, 04/2012, Volume 14, Issue 7, pp. 1880 - 1883
A concise, enantioselective synthesis of (+)-crocacin C is described, featuring a highly diastereoselective mismatched double asymmetric...
Myxococcales - chemistry | Alkenes - chemistry | Tin - chemistry | Amides - chemical synthesis | Stereoisomerism | Amides - chemistry | Organometallic Compounds - chemistry | Molecular Structure | Alkenes - chemical synthesis | Aldehydes - chemistry
Myxococcales - chemistry | Alkenes - chemistry | Tin - chemistry | Amides - chemical synthesis | Stereoisomerism | Amides - chemistry | Organometallic Compounds - chemistry | Molecular Structure | Alkenes - chemical synthesis | Aldehydes - chemistry
Journal Article
Organic & biomolecular chemistry, ISSN 1477-0520, 06/2015, Volume 13, Issue 21, pp. 6010 - 6020
The Ugi reaction is found to be a very powerful tool for the synthesis of (pre)tubulysin derivatives, allowing the introduction of various functionalized side...
Myxococcales - chemistry | Ethers - chemical synthesis | Oligopeptides - chemical synthesis | Alkynes - chemical synthesis | Cyclization | Click Chemistry | Ethers - chemistry | Alkynes - chemistry | Oligopeptides - chemistry
Myxococcales - chemistry | Ethers - chemical synthesis | Oligopeptides - chemical synthesis | Alkynes - chemical synthesis | Cyclization | Click Chemistry | Ethers - chemistry | Alkynes - chemistry | Oligopeptides - chemistry
Journal Article
Journal of Natural Products, ISSN 0163-3864, 09/2016, Volume 79, Issue 9, pp. 2223 - 2228
Two new potent anti-Gram negative compounds, coralmycins A (1) and B (2), were isolated from cultures of the myxobacteria Corallococcus coralloides M23,...
AMERICA | IMPACT | CHEMISTRY, MEDICINAL | NO ESKAPE | PHARMACOLOGY & PHARMACY | UPDATE | BACILLI | INFECTIOUS-DISEASES SOCIETY | PLANT SCIENCES | Klebsiella pneumoniae - drug effects | Escherichia coli - drug effects | Humans | Nitro Compounds - chemistry | Depsipeptides - isolation & purification | Depsipeptides - pharmacology | Structure-Activity Relationship | Anti-Bacterial Agents - isolation & purification | Pseudomonas aeruginosa - drug effects | Hep G2 Cells | Microbial Sensitivity Tests | Myxococcales - chemistry | Asparagine - analogs & derivatives | Anti-Bacterial Agents - chemistry | Nuclear Magnetic Resonance, Biomolecular | Anti-Bacterial Agents - pharmacology | Molecular Structure | Aspartic Acid - analogs & derivatives | Aspartic Acid - chemistry | Depsipeptides - chemistry | Asparagine - chemistry
AMERICA | IMPACT | CHEMISTRY, MEDICINAL | NO ESKAPE | PHARMACOLOGY & PHARMACY | UPDATE | BACILLI | INFECTIOUS-DISEASES SOCIETY | PLANT SCIENCES | Klebsiella pneumoniae - drug effects | Escherichia coli - drug effects | Humans | Nitro Compounds - chemistry | Depsipeptides - isolation & purification | Depsipeptides - pharmacology | Structure-Activity Relationship | Anti-Bacterial Agents - isolation & purification | Pseudomonas aeruginosa - drug effects | Hep G2 Cells | Microbial Sensitivity Tests | Myxococcales - chemistry | Asparagine - analogs & derivatives | Anti-Bacterial Agents - chemistry | Nuclear Magnetic Resonance, Biomolecular | Anti-Bacterial Agents - pharmacology | Molecular Structure | Aspartic Acid - analogs & derivatives | Aspartic Acid - chemistry | Depsipeptides - chemistry | Asparagine - chemistry
Journal Article