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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, ISSN 0002-7863, 08/2008, Volume 130, Issue 33, pp. 11005 - 11012
Ruthenium-catalyzed oxidative cyanation of tertiary amines with molecular oxygen in the presence of sodium cyanide and acetic acid gives the corresponding... 
ORGANIC-SYNTHESIS | ANODIC CYANATION | ELECTRON-TRANSFER | LOW-VALENT RUTHENIUM | NITROGEN ATOM | ISOTOPE EFFECT PROFILES | AEROBIC OXIDATION | N-DEMETHYLATION | SECONDARY-AMINES | COORDINATED PALLADIUM | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
ANESTHESIOLOGY, ISSN 0003-3022, 11/2015, Volume 123, Issue 5, pp. 1142 - 1153
Background: Interindividual variability in methadone disposition remains unexplained, and methadone accidental overdose in pain therapy is a significant public... 
UNITED-STATES | MAINTENANCE TREATMENT | GENETIC POLYMORPHISMS | PLASMA-LEVELS | STEREOSELECTIVE METABOLISM | OPIATE ADDICTS | ANESTHESIOLOGY | HUMAN LIVER-MICROSOMES | N-DEMETHYLATION | CYTOCHROME P4503A CYP3A | CHRONIC NONCANCER PAIN
Journal Article
Chemical Communications, ISSN 1359-7345, 2017, Volume 53, Issue 77, pp. 10734 - 10737
We report a simple protocol that affords oxidative demethylation of N-6-methyl groups in N-6-methyl adenines (m(6)A). The biologically compatible photocatalyst... 
NUCLEOTIDES | REPAIR | RNA | TERTIARY-AMINES | DNA | PHOTOCATALYSIS | ELECTRON-TRANSFER ACTIVATION | PHOTOCHEMICAL N-DEMETHYLATION | HYDROPEROXIDES | CHEMISTRY, MULTIDISCIPLINARY | PHOTOOXIDATION
Journal Article
Journal of Hazardous Materials, ISSN 0304-3894, 05/2008, Volume 153, Issue 1-2, pp. 877 - 884
A series of Cu-loaded BiVO (Cu-BiVO ) catalysts were prepared by impregnation method and characterized by X-ray diffraction (XRD), scanning electron microscope... 
Characterization | Photocatalytic | Cu-BiVO | Methylene blue | UV-IRRADIATION | METHYLENE-BLUE | SOLAR SIMULATOR | DISPERSIONS | DYES | photocatalytic | N-DEMETHYLATION | methylene blue | ENVIRONMENTAL SCIENCES | ENGINEERING, ENVIRONMENTAL | O-2 | DEGRADATION | Cu-BiVO4 | characterization | VISIBLE-LIGHT IRRADIATION | WATER
Journal Article
The Journal of Physical Chemistry C, ISSN 1932-7447, 05/2008, Volume 112, Issue 19, pp. 7363 - 7370
A simple and facile template-free method has been developed for the fabrication of CdS hollow nanospheres via hydrothermal treatment of aqueous solutions of... 
METHYLENE-BLUE | ROUTE | NANOSIZED CDS | MICROSPHERES | SPHERES | MATERIALS SCIENCE, MULTIDISCIPLINARY | NANOCRYSTALS | SEMICONDUCTOR CDS | CHEMISTRY, PHYSICAL | NANOSCIENCE & NANOTECHNOLOGY | N-DEMETHYLATION | AQUEOUS TIO2 | LOW-TEMPERATURE
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 06/2013, Volume 135, Issue 25, pp. 9475 - 9479
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, p. 4007
Since the metabolism of (R, S)-ketamine to (2R, 6R)-hydroxynorketamine (HNK) is reported to be essential for ketamine's antidepressant effects, there is an... 
LC-MS/MS | NMDA RECEPTORS | BIPOLAR DEPRESSION | R-KETAMINE | MULTIDISCIPLINARY SCIENCES | KETAMINE METABOLITE | SUSTAINED ANTIDEPRESSANT | MECHANISMS | D-ASPARTATE ANTAGONIST | N-DEMETHYLATION | RAPID-ONSET
Journal Article
European Journal of Pharmaceutical Sciences, ISSN 0928-0987, 07/2018, Volume 120, pp. 172 - 180
Metamizole is an old analgesic used frequently in some countries. Active metabolites of metamizole are the non-enzymatically generated... 
Myeloperoxidase | N-demethylation | Metamizole | N-methyl-4-aminoantipyrine | Cytochrome P450 (CYP) | Peroxidase | Hydrogen peroxide | Metabolites | Liver | Cytochrome P-450
Journal Article
RSC Advances, ISSN 2046-2069, 2014, Volume 4, Issue 18, pp. 9139 - 9147
The AgBr/Ag2CO3 composite was synthesized by an ion-exchange reaction. The physical and chemical properties of the catalysts were characterized by X-ray... 
METHYLENE-BLUE | IRRADIATION | NANOCOMPOSITES | REACTION-MECHANISM | ORGANIC-COMPOUNDS | SIZE | PHOTODEGRADATION | DEGRADATION | N-DEMETHYLATION | CHEMISTRY, MULTIDISCIPLINARY | WATER
Journal Article
ACS Catalysis, ISSN 2155-5435, 12/2012, Volume 2, Issue 12, pp. 2810 - 2815
Tertiary amines were readily converted into secondary amines through a photoredox-catalyzed N-demethylation, a bioinspired procedure that resembles nature’s... 
oxidation | N-demethylation | visible light | cross dehydrogenative coupling | organic dye | oxygen | DEHYDROGENATIVE COUPLING REACTIONS | ATOM ECONOMY | TERTIARY-AMINES | LIGHT | CHEMISTRY, PHYSICAL | COORDINATION-COMPOUNDS | ELECTRON-TRANSFER | BASE CATALYSIS | C-C | SECONDARY-AMINES
Journal Article
Nature Reviews Drug Discovery, ISSN 1474-1776, 10/2005, Volume 4, Issue 10, pp. 825 - 833
Journal Article
Current Drug Metabolism, ISSN 1389-2002, 2001, Volume 2, Issue 1, pp. 17 - 36
The most common drug-drug interactions may be understood in terms of alterations of metabolism, associated primarily with changes in the activity of cytochrome... 
IN-VITRO | ALPHA-NAPHTHOFLAVONE | METABOLISM | ACTIVE-SITE | 3A4 | BIOCHEMISTRY & MOLECULAR BIOLOGY | CO BINDING-KINETICS | PHARMACOLOGY & PHARMACY | COOPERATIVITY | N-DEMETHYLATION | QUINIDINE | CYP3A4 | Algorithms | Animals | Cytochrome P-450 Enzyme Inhibitors | Humans | Cytochrome P-450 Enzyme System - metabolism | Kinetics | Enzyme Activation - physiology
Journal Article
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 01/2019, Volume 105, Issue 1, pp. 142 - 152
Bupropion hydroxylation is a bioactivation and metabolic pathway, and the standard clinical CYP2B6 probe. This investigation determined the influence of CYP2B6... 
IN-VITRO | GENETIC POLYMORPHISMS | HUMAN PLASMA | METABOLISM | CYTOCHROME-P450 2B6 ACTIVITY | HYDROXYLATION | CYP2B6-ASTERISK-6 ALLELE | PHARMACOLOGY & PHARMACY | N-DEMETHYLATION | P4502B6 CYP2B6 | HYDROXYBUPROPION
Journal Article
CHEMISTRY-A EUROPEAN JOURNAL, ISSN 0947-6539, 07/2016, Volume 22, Issue 30, pp. 10393 - 10398
14-Hydroxymorphinone is converted to noroxymorphone, the immediate precursor of important opioid antagonists, such as naltrexone and naloxone, in a three-step... 
naltrexone | MORPHINE | TERTIARY-AMINES | N-demethylation | aerobic oxidation | CHEMISTRY, MULTIDISCIPLINARY | DEPENDENCE | OXYMORPHONE | naloxone | CATALYZED N-DEMETHYLATION/ACYLATION | ACETATE | CYCLIZATION | flow chemistry | MOLECULAR-OXYGEN | TOOL
Journal Article
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, ISSN 0271-0749, 09/2019, Volume 39, Issue 5, pp. 485 - 488
Background Tobacco smoking rates in depressive patients are higher compared with the general population. Smoking was demonstrated to accelerate the metabolism... 
CLOZAPINE | DRUG-INTERACTIONS | PSYCHIATRY | CITALOPRAM | SEX | RISPERIDONE | N-DEMETHYLATION | P-GLYCOPROTEIN | VENLAFAXINE | tobacco smoking | IN-VITRO | pharmacokinetics | escitalopram | PHARMACOLOGY & PHARMACY | AGE
Journal Article
Journal of Colloid And Interface Science, ISSN 0021-9797, 01/2018, Volume 510, pp. 207 - 220
In this research, MnO nanosheets on montmorillonite (MnO nanosheets@MMt) was synthesized by one-pot hydrothermal method and characterized by X-ray diffraction,... 
MnO2 | Degradation | Nanocomposites | MMt | MnO | DISPERSIONS | DYE REMOVAL | ONE-POT SYNTHESIS | CHEMISTRY, PHYSICAL | COMPOSITES | N-DEMETHYLATION | AQUEOUS-SOLUTION | CATALYTIC-OXIDATION | FABRICATION | PHOTOCATALYSTS | NANOWIRES
Journal Article