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European Journal of Medicinal Chemistry, ISSN 0223-5234, 10/2014, Volume 85, pp. 418 - 437
The 2′-deoxynucleoside 5′-phosphate -hydrolase 1 (DNPH1) has been proposed as a new molecular target for cancer treatment. Here, we describe the synthesis of a... 
Inhibitor | Cross-coupling reaction | DNPH1 | Nucleoside analogues | Crystal structure | Cancer | 5'-MONOPHOSPHATE N-GLYCOSIDASE | CHEMISTRY, MEDICINAL | CYTOSTATIC 6-ARYLPURINE NUCLEOSIDES | C-MYC | HL-60 CELLS | LEAVING GROUPS | 2'-DEOXYRIBONUCLEOSIDE 5'-MONOPHOSPHATE | ANTICANCER ACTIVITY | CROSS-COUPLING REACTIONS | PROTEIN-LIGAND COMPLEXES | HYDROLASE RCL | Purine Nucleotides - pharmacology | Antineoplastic Agents - chemical synthesis | Humans | Proto-Oncogene Proteins - chemistry | Structure-Activity Relationship | Enzyme Inhibitors - chemical synthesis | Molecular Targeted Therapy | Purine Nucleotides - chemistry | N-Glycosyl Hydrolases - chemistry | Purine Nucleotides - metabolism | Antineoplastic Agents - metabolism | Enzyme Inhibitors - chemistry | Drug Design | Antineoplastic Agents - pharmacology | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Chemistry Techniques, Synthetic | Enzyme Inhibitors - metabolism | N-Glycosyl Hydrolases - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Rats | Nuclear Proteins - metabolism | Purine Nucleotides - chemical synthesis | Antineoplastic Agents - chemistry | Nuclear Proteins - chemistry | N-Glycosyl Hydrolases - metabolism | Animals | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Protein Conformation | Molecular Docking Simulation | Drug Screening Assays, Antitumor | Enzymes | Colon cancer | Leukemia | Crystals | Hydrolases | Nucleotides | Structure | Nuclear Proteins/chemistry | Purine Nucleotides/metabolism | Proto-Oncogene Proteins/antagonists & inhibitors | Enzyme Inhibitors/metabolism | Enzyme Inhibitors/pharmacology | Life Sciences | Antineoplastic Agents/pharmacology | N-Glycosyl Hydrolases/antagonists & inhibitors | Nuclear Proteins/antagonists & inhibitors | N-Glycosyl Hydrolases/metabolism | Nuclear Proteins/metabolism | Purine Nucleotides/chemistry | Enzyme Inhibitors/chemistry | Purine Nucleotides/chemical synthesis | Enzyme Inhibitors/chemical synthesis | Antineoplastic Agents/metabolism | N-Glycosyl Hydrolases/chemistry | Proto-Oncogene Proteins/chemistry | Biochemistry, Molecular Biology | Proto-Oncogene Proteins/metabolism | Purine Nucleotides/pharmacology | Antineoplastic Agents/chemistry | Antineoplastic Agents/chemical synthesis
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 04/2009, Volume 5, Issue 4, pp. 251 - 257
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 10/2012, Volume 56, pp. 301 - 307
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2004, Volume 279, Issue 52, pp. 54687 - 54694
Journal Article