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1. Full Text Administration of Excitatory Amino Acid Antagonists via Microdialysis Attenuates the Increase in Glucose Utilization Seen Following Concussive Brain Injury
by Kawamata, Tatsuro and Katayama, Yoichi and Hovda, David A and Yoshino, Atsuo and Becker, Donald P
Journal of Cerebral Blood Flow & Metabolism, ISSN 0271-678X, 01/1992, Volume 12, Issue 1, pp. 12 - 24
Ionic flux | Glucose utilization | N-methyl-D-aspartate | Hypermetabolism | Concussion | Excitatory amino acid antagonist | Endocrinology & Metabolism | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Hematology | Science & Technology | Neurology | Biological and medical sciences | Medical sciences | Nervous system involvement in other diseases. Miscellaneous | 6-Cyano-7-nitroquinoxaline-2,3-dione | Brain Concussion - physiopathology | 2-Amino-5-phosphonovalerate - pharmacology | Rats | Ions | Male | Rats, Inbred Strains | N-Methylaspartate - antagonists & inhibitors | Brain - metabolism | Glutamic Acid | Quinoxalines - pharmacology | Animals | Glucose - metabolism | Dialysis | Kynurenic Acid - pharmacology | Excitatory Amino Acid Antagonists | Brain Concussion - metabolism | Energy Metabolism - drug effects | Index Medicus
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2. Identification and characterization of novel NMDA receptor antagonists selective for NR2A- over NR2B-containing receptors
by Bettini, Ezio and Sava, Anna and Griffante, Cristiana and Carignani, Corrado and Buson, Alberto and Capelli, Anna Maria and Negri, Michele and Andreetta, Filippo and Senar-Sancho, Sergio A and Guiral, Lorena and Cardullo, Francesca
The Journal of pharmacology and experimental therapeutics, ISSN 0022-3565, 12/2010, Volume 335, Issue 3, pp. 636 - 644
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Excitatory Amino Acid Antagonists - metabolism | Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Humans | Receptors, N-Methyl-D-Aspartate - metabolism | Fluorometry - methods | Male | Neurons - cytology | Cerebral Cortex - cytology | Excitatory Postsynaptic Potentials - drug effects | N-Methylaspartate - pharmacology | Receptors, N-Methyl-D-Aspartate - genetics | Transfection | HEK293 Cells | Cell Membrane - metabolism | Molecular Structure | Neurons - metabolism | Excitatory Amino Acid Antagonists - chemistry | Neurons - drug effects | Binding, Competitive | Drug Evaluation, Preclinical - methods | Glutamic Acid - pharmacology | Rats | Excitatory Amino Acid Antagonists - pharmacology | Rats, Sprague-Dawley | Patch-Clamp Techniques | Animals | Glycine - pharmacology | Calcium Signaling - drug effects | Cell Line, Tumor
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3. Full Text N-methyl-D-aspartate (NMDA) Antagonists - S(+)-ketamine, dextrorphan, and dextromethorphan - Act as calcium antagonists on bovine cerebral arteries
by Kamel, Ihab R and Wendling, Woodrow W and Chen, Dong and Wendling, Karen S and Harakal, Concetta and Carlsson, Christer
Journal of neurosurgical anesthesiology, ISSN 0898-4921, 10/2008, Volume 20, Issue 4, pp. 241 - 248
Nimodipine | Cattle | Dextromethorphan | Vascular smooth muscle | L-type calcium channel | S( + )-ketamine | Dextrorphan | Clinical Neurology | Anesthesiology | Neurosciences & Neurology | Life Sciences & Biomedicine | Surgery | Science & Technology | Vasoconstrictor Agents - pharmacology | Dextromethorphan - pharmacology | Electric Stimulation | Calcium - metabolism | Isometric Contraction - drug effects | Middle Cerebral Artery - drug effects | Excitatory Amino Acid Agonists - pharmacology | Muscle Tonus - drug effects | Nimodipine - pharmacology | Calcium Channel Blockers - pharmacology | N-Methylaspartate - antagonists & inhibitors | Dextrorphan - pharmacology | Dose-Response Relationship, Drug | Animals | Calcium Radioisotopes | Middle Cerebral Artery - metabolism | Vascular Resistance - drug effects | In Vitro Techniques | Ketamine - pharmacology | Middle Cerebral Artery - cytology | Muscle, Smooth, Vascular - drug effects | Index Medicus | calcium channel | vascular smooth muscle | Medical and Health Sciences | Medicin och hälsovetenskap | nimodipine | dextrorphan | cattle | Klinisk medicin | dextromethorphan | Clinical Medicine | S(+)-ketamine | Anestesi och intensivvård | Anesthesiology and Intensive Care | L-type
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4. Full Text Ligands for Glutamate Receptors:  Design and Therapeutic Prospects
by Bräuner-Osborne, Hans and Egebjerg, Jan and Nielsen, Elsebet Ø and Madsen, Ulf and Krogsgaard-Larsen, Povl
Journal of medicinal chemistry, ISSN 0022-2623, 07/2000, Volume 43, Issue 14, pp. 2609 - 2645
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Biological and medical sciences | Glutamatergic system (aspartate and other excitatory aminoacids) | Medical sciences | Neuropharmacology | Neurotransmitters. Neurotransmission. Receptors | Pharmacology. Drug treatments | Excitatory Amino Acid Antagonists - metabolism | Receptors, Glutamate - metabolism | Excitatory Amino Acid Antagonists - therapeutic use | Excitatory Amino Acid Agonists - therapeutic use | Receptors, Kainic Acid - chemistry | Humans | Receptors, AMPA - chemistry | Receptors, Kainic Acid - antagonists & inhibitors | Receptors, Metabotropic Glutamate - metabolism | Receptors, Kainic Acid - agonists | Receptors, Glutamate - drug effects | N-Methylaspartate - antagonists & inhibitors | Synapses - metabolism | Drug Design | N-Methylaspartate - agonists | Excitatory Amino Acid Antagonists - chemistry | Receptors, Metabotropic Glutamate - chemistry | Receptors, AMPA - metabolism | Excitatory Amino Acid Agonists - metabolism | N-Methylaspartate - metabolism | Excitatory Amino Acid Agonists - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Receptors, Glutamate - chemistry | Receptors, Kainic Acid - metabolism | Animals | Receptors, AMPA - agonists | Ligands | N-Methylaspartate - chemistry | Receptors, Metabotropic Glutamate - agonists | Excitatory Amino Acid Agonists - chemistry | Receptors, Metabotropic Glutamate - antagonists & inhibitors | Receptors, AMPA - antagonists & inhibitors | Index Medicus
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5. Full Text NMDA antagonist memantine improves levodopa‐induced dyskinesias and “On‐off” phenomena in Parkinson's disease
by Varanese, Sara and Howard, Jonathan and Di Rocco, Alessandro
Movement disorders, ISSN 0885-3185, 03/2010, Volume 25, Issue 4, pp. 508 - 510
Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Memantine - pharmacology | Levodopa - therapeutic use | Humans | Male | Parkinson Disease - drug therapy | Dopamine Agents - therapeutic use | Antiparkinson Agents - adverse effects | N-Methylaspartate - antagonists & inhibitors | Incidence | Antiparkinson Agents - therapeutic use | Dopamine Agents - pharmacology | Dyskinesia, Drug-Induced - drug therapy | Levodopa - adverse effects | Female | Aged | Memantine - therapeutic use
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6. Full Text Rapid decrease in depressive symptoms with an N-methyl- d-aspartate antagonist in ECT-resistant major depression
by Ibrahim, Lobna and Diazgranados, Nancy and Luckenbaugh, David A and Machado-Vieira, Rodrigo and Baumann, Jacqueline and Mallinger, Alan G and Zarate, Carlos A
Progress in neuro-psychopharmacology & biological psychiatry, ISSN 0278-5846, 2011, Volume 35, Issue 4, pp. 1155 - 1159
Treatment-resistant | NMDA | Depression | Electroconvulsive therapy | Glutamate | Neurosciences | Clinical Neurology | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Neurosciences & Neurology | Psychiatry | Science & Technology | Psychology. Psychoanalysis. Psychiatry | Adult and adolescent clinical studies | Pharmacology. Drug treatments | Psychopathology. Psychiatry | Mood disorders | Biological and medical sciences | Medical sciences | Neuropharmacology | Treatments | Excitatory Amino Acid Antagonists - therapeutic use | Injections, Intravenous | Humans | Middle Aged | Excitatory Amino Acid Antagonists - administration & dosage | Linear Models | Male | N-Methylaspartate - antagonists & inhibitors | Ketamine - administration & dosage | Socioeconomic Factors | Young Adult | Psychiatric Status Rating Scales | Sample Size | Treatment Failure | Adolescent | Adult | Female | Aged | Ketamine - therapeutic use | Electroconvulsive Therapy | Depressive Disorder, Major - drug therapy | Index Medicus | electroconvulsive therapy | depression | treatment-resistant | glutamate
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7. Full Text Rapid resolution of suicidal ideation after a single infusion of an N-methyl-D-aspartate antagonist in patients with treatment-resistant major depressive disorder
by DiazGranados, Nancy and Ibrahim, Lobna A and Brutsche, Nancy E and Ameli, Rezvan and Henter, Ioline D and Luckenbaugh, David A and Machado-Vieira, Rodrigo and Zarate Jr, Carlos A
The journal of clinical psychiatry, ISSN 0160-6689, 12/2010, Volume 71, Issue 12, pp. 1605 - 1611
Psychology, Clinical | Social Sciences | Life Sciences & Biomedicine | Psychiatry | Psychology | Science & Technology | Psychology. Psychoanalysis. Psychiatry | Adult and adolescent clinical studies | Psychopathology. Psychiatry | Mood disorders | Biological and medical sciences | Depression | Medical sciences | Suicide | Diagnostic and Statistical Manual of Mental Disorders | Excitatory Amino Acid Antagonists - therapeutic use | Humans | Middle Aged | Male | Suicidal Ideation | Treatment Outcome | N-Methylaspartate - antagonists & inhibitors | Antidepressive Agents - therapeutic use | Depressive Disorder, Major - psychology | Depression - drug therapy | Psychiatric Status Rating Scales | Time Factors | Adult | Female | Ketamine - therapeutic use | Depressive Disorder, Major - diagnosis | Infusions, Intravenous | Depressive Disorder, Major - drug therapy | Index Medicus
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8. Full Text Novel AMPA and kainate receptor antagonists containing the pyrazolo[1,5- c]quinazoline ring system: Synthesis and structure–activity relationships
by Varano, Flavia and Catarzi, Daniela and Colotta, Vittoria and Lenzi, Ombretta and Filacchioni, Guido and Galli, Alessandro and Costagli, Chiara
Bioorganic & medicinal chemistry, ISSN 0968-0896, 2008, Volume 16, Issue 5, pp. 2617 - 2626
KA receptor antagonists | Ionotropic glutamate receptors | Pyrazolo[1,5- c]quinazolines | AMPA receptor antagonists | Pyrazolo[1,5-c]quinazolines | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Chemistry, Organic | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Science & Technology | Biological and medical sciences | Glutamatergic system (aspartate and other excitatory aminoacids) | Medical sciences | Neuropharmacology | Neurotransmitters. Neurotransmission. Receptors | Pharmacology. Drug treatments | Quinazolines - chemical synthesis | alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - chemical synthesis | Receptors, Kainic Acid - metabolism | Pyrazoles - chemistry | alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - chemistry | alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - pharmacology | Molecular Structure | Receptors, Kainic Acid - antagonists & inhibitors | Structure-Activity Relationship | N-Methylaspartate - chemistry | Quinazolines - pharmacology | Quinazolines - chemistry | Glutamate | Index Medicus
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9. The rise and fall of NMDA antagonists for ischemic stroke
by Hoyte, L and Barber, P.A and Buchan, A.M and Hill, Michael
Current molecular medicine, ISSN 1566-5240, 03/2004, Volume 4, Issue 2, pp. 131 - 136
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Neurons - pathology | Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Cell Survival | Humans | Guanidines - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Stroke - drug therapy | N-Methylaspartate - antagonists & inhibitors | Pipecolic Acids - pharmacology | Animals | Brain Ischemia - drug therapy | Indoles - pharmacology | Ischemia - pathology | Disease Models, Animal
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10. Full Text Blockade of NMDA receptors in the prefrontal cortex increases dopamine and acetylcholine release in the nucleus accumbens and motor activity
by Del Arco, Alberto and Segovia, Gregorio and Mora, Francisco
Psychopharmacology, ISSN 0033-3158, 12/2008, Volume 201, Issue 3, pp. 325 - 338
Nucleus accumbens | Neurosciences | Biomedicine | Dopamine | Rat | Motor activity | Schizophrenia | Acetylcholine | Prefrontal cortex | Pharmacology/Toxicology | NMDA receptor | Psychiatry | Pharmacology & Pharmacy | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Psychology. Psychoanalysis. Psychiatry | Psychoses | Adult and adolescent clinical studies | Psychopathology. Psychiatry | Biological and medical sciences | Medical sciences | Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Nicotinic Antagonists - administration & dosage |