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Chemistry Letters, ISSN 0366-7022, 1/2017, Volume 46, Issue 1, pp. 68 - 70
Direct synthesis of trimethylamine through N-methylation of NH3 or its surrogate (NH4HCO3) with both CO2 and H2 has been achieved by employing Pt and MoOx... 
Trimethylamine synthesis | Carbon dioxide (CO | N-Methylation
Journal Article
Nature Chemistry, ISSN 1755-4330, 11/2016, Volume 8, Issue 12, pp. 1085 - 1086
Journal Article
Organic Letters, ISSN 1523-7060, 10/2017, Volume 19, Issue 19, pp. 5228 - 5231
A highly efficient Co-based catalytic system, composed of a commercially available Co salt, a tetradentate phosphine ligand P­(CH2CH2PPh2)3(PP3), and a base... 
C-1 SOURCE | KETONES | IRIDIUM | CO2 | CHEMISTRY, ORGANIC | ALLENES | C-H ACTIVATION | N-METHYLATION
Journal Article
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, ISSN 0002-7863, 08/2013, Volume 135, Issue 31, pp. 11521 - 11524
The direct, asymmetric alpha-amination of aldehydes has been accomplished via a combination of photoredox and organocatalysis. Photon-generated N-centered... 
CENTERED RADICALS | AMINATION | RECEPTOR SELECTIVITY | AMIDYL RADICALS | ORGANOCATALYSIS | REACTIVITY | GENERATION | TRANSFER HYDROAMINATION | MULTIPLE N-METHYLATION | CHEMISTRY, MULTIDISCIPLINARY | CYCLIZATION
Journal Article
Advanced Synthesis & Catalysis, ISSN 1615-4150, 11/2019, Volume 361, Issue 22, pp. 5069 - 5069
The front cover picture, provided by Ji‐Bao Xia and his co‐workers, illustrates an efficient iron‐catalyzed selective N‐methylation and N‐formylation of amines... 
Mono-phosphine | N-methylation | Carbon dioxide | Iron | N-formylation
Journal Article
Chemical Science, ISSN 2041-6520, 2015, Volume 6, Issue 1, pp. 30 - 49
A noticeable increase in molecular complexity of drug targets has created an unmet need in the therapeutic agents that are larger than traditional small... 
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 07/2017, Volume 139, Issue 26, pp. 8812 - 8815
This study represents the first example of a manganese-catalyzed environmentally benign, practical three-component aminomethylation of activated aromatic... 
ALCOHOLS | KETONES | DEHYDROGENATION | HYDROGENATION | AMINES | ESTERS | ALPHA-ALKYLATION | BOND FORMATION | LIGAND | N-METHYLATION | CHEMISTRY, MULTIDISCIPLINARY | Chemical bonds | Chemical properties | Aromatic compounds | Analysis | Methanol
Journal Article
Organic Letters, ISSN 1523-7060, 10/2017, Volume 19, Issue 20, pp. 5673 - 5676
An efficient strategy toward 4-arylquinolines and 4-arylpyrimidines from readily available precursors is described. Oxidative annulation promoted by K2S2O8... 
KETONES | ACTIVATION | LIMITATIONS | ONE-POT SYNTHESIS | QUINAZOLINE | CHEMISTRY, ORGANIC | DIMETHYL-SULFOXIDE | N-METHYLATION | DERIVATIVES | CYCLIZATION | SUBSTITUTED QUINOLINES
Journal Article
Chemical Science, ISSN 2041-6520, 12/2014, Volume 6, Issue 1, pp. 3 - 49
A noticeable increase in molecular complexity of drug targets has created an unmet need in the therapeutic agents that are larger than traditional small... 
ASYMMETRIC CATALYSIS | PASSIVE MEMBRANE-PERMEABILITY | CYCLOSPORINE-A | PROTEIN | HELICAL PEPTIDES | STRUCTURAL-CHARACTERIZATION | LINEAR PEPTIDES | SCAFFOLDS | N-METHYLATION | CHEMISTRY, MULTIDISCIPLINARY | CYCLIC-PEPTIDES | Drugs | Cellular | Macrocyclic compounds | Peptides | Historic | Permeability | Bioavailability | Cyclic compounds | Readers | Chemistry
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 03/2015, Volume 25, Issue 5, pp. 1053 - 1056
Pimavanserin is a selective serotonin 2A receptor (5-HT R) inverse agonist that has shown promise for treatment of psychotic symptoms in patients with... 
N-methylation | 5-HT2A receptor | Pimavanserin | Carbon-11 | PET
Journal Article
Chemistry Letters, ISSN 0366-7022, 8/2017, Volume 46, Issue 8, pp. 1243 - 1246
CeO2-supported Cu (Cu/CeO2) acted as an effective heterogeneous catalyst for N-methylation of aniline with CO2 and H2, showing higher selectivity to... 
N-Methylation of amines | Copper sub-nanoparticle | Carbon dioxide
Journal Article
Advanced Synthesis & Catalysis, ISSN 1615-4150, 11/2019, Volume 361, Issue 22, pp. 5098 - 5104
We herein describe an efficient iron‐catalyzed selective N‐methylation and N‐formylation of amines with CO2 and silane using mono‐phosphine as ligand. With... 
Mono-phosphine | N-methylation | Iron | N-formylation | Carbon dioxide | Ligands | Amines | Methylation
Journal Article
Biophysical Journal, ISSN 0006-3495, 02/2019, Volume 116, Issue 3, pp. 433 - 444
Cyclic peptides (CPs) are a promising class of molecules for drug development, particularly as inhibitors of protein-protein interactions. Predicting... 
TURNS | DESIGN | PEPTIDES | BIOPHYSICS | PENTAPEPTIDES | SEQUENCE | SHIFTS | N-METHYLATION | EFFICIENT | ENTROPY
Journal Article
Organic Letters, ISSN 1523-7060, 09/2017, Volume 19, Issue 17, pp. 4420 - 4423
Gymnopeptides A and B are unprecedented highly N-methylated cyclic β-hairpin octadecapeptides with striking antiproliferative activities isolated from the... 
PEPTIDES | CYCLOSPORIN-A | ACIDS | CHEMISTRY, ORGANIC | EX PERS RIFAI | ANTAGONISTS | N-METHYLATION | COIBAMIDE
Journal Article
ACS Catalysis, ISSN 2155-5435, 07/2017, Volume 7, Issue 7, pp. 4462 - 4466
Deoxygenation of alcohols is an important tool in the repertoire of defunctionalization methods in modern synthetic chemistry. We report the... 
deoxygenation | manganese complex | alcohols | homogeneous catalysis | pincer complexes | HYDROGENATION | HYDROGENOLYSIS | C BOND FORMATION | REDUCTIVE DEOXYGENATION | SECONDARY | CHEMISTRY, PHYSICAL | METAL-LIGAND COOPERATION | AROMATIZATION-DEAROMATIZATION | N-METHYLATION | DEHYDROGENATION | AMINES
Journal Article
ACS Catalysis, ISSN 2155-5435, 07/2018, Volume 8, Issue 7, pp. 6440 - 6445
A general iron-catalyzed methylation has been developed using methanol as a C1 building block. This borrowing hydrogen approach employs a Knölker-type... 
borrowing hydrogen | methanol | mechanistic studies | iron catalysis | methylation | ORGANIC-SYNTHESIS | ENANTIOSELECTIVE FORMATION | ATOM ECONOMY | CHEMISTRY, PHYSICAL | BOND FORMATION | C-H FUNCTIONALIZATION | N-METHYLATION | AROMATIC-AMINES | ALPHA-ALKYLATION | BUILDING-BLOCK
Journal Article
Angewandte Chemie - International Edition, ISSN 1433-7851, 01/2019, Volume 58, Issue 3, pp. 775 - 779
A metal-catalyzed methylation process has been developed. By employing an air- and moisture-stable manganese catalyst together with isotopically labeled... 
alkylation | transition-metal catalysis | trideuteromethylation | manganese | methylation | ENANTIOSELECTIVE FORMATION | BORROWING HYDROGEN | IRON | C-H FUNCTIONALIZATION | N-METHYLATION | CHEMISTRY, MULTIDISCIPLINARY | PRIMARY ALCOHOLS | MILD | KETONES | AMINES | ALPHA-ALKYLATION
Journal Article
CHEMICAL COMMUNICATIONS, ISSN 1359-7345, 11/2019, Volume 55, Issue 89, pp. 13362 - 13365
Rule-of-five parameters and membrane permeabilities have been routinely used to guide development of orally bioavailabile drugs. Here we compare enantiomeric... 
ESTIMATE SOLUBILITY | DESIGN | POTENT | PEPTIDES | D-AMINO-ACID | PERMEABILITY | DRUG DISCOVERY | N-METHYLATION | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
Bioorganic and Medicinal Chemistry Letters, ISSN 0960-894X, 03/2015, Volume 25, Issue 5, pp. 1053 - 1056
Pimavanserin is a selective serotonin 2A receptor (5-HT 2A R) inverse agonist that has shown promise for treatment of psychotic symptoms in patients with... 
N-methylation | 5-HT 2A receptor | Carbon-11 | Pimavanserin | PET
Journal Article
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