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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, ISSN 0002-7863, 12/2013, Volume 135, Issue 48, pp. 18012 - 18015
Both chronic and neuropathic pain conditions are associated with increased expression of certain voltage-gated sodium ion channel (Na-V) isoforms in peripheral... 
PAIN | TRACER | BIOLOGICAL EVALUATION | N-SUCCINIMIDYL | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
ORGANIC & BIOMOLECULAR CHEMISTRY, ISSN 1477-0520, 2014, Volume 12, Issue 40, pp. 8094 - 8099
A novel, efficient, time-saving and reliable radiolabeling procedure via nucleophilic substitution with [F-18] fluoride is described. Different radiolabeled... 
RADIOFLUORINATION | RADIOSYNTHESIS | CHEMISTRY, ORGANIC | N-SUCCINIMIDYL | PROTEINS | F-18 | PET | PEPTIDE | FLUORIDE
Journal Article
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, ISSN 0002-7863, 09/2013, Volume 135, Issue 37, pp. 13612 - 13615
The excesses of reagents used in protein chemistry are often incompatible with the reduced or even inverse stoichiometries used for efficient radiolabeling.... 
CYCLOADDITION | BORONIC ACID | POSITRON-EMISSION-TOMOGRAPHY | PROTEIN | PEPTIDES | PROSTHETIC GROUP | N-SUCCINIMIDYL | CANCER | CHEMISTRY, MULTIDISCIPLINARY | PET | CARRIER
Journal Article
by Kim, HJ and Park, JY and Lee, TS and Song, IH and Cho, YL and Chae, JR and Kang, H and Lim, JH and Lee, JH and Kang, WJ
PLOS ONE, ISSN 1932-6203, 01/2019, Volume 14, Issue 1
Background/Purpose Aptamers are oligonucleotide or peptide molecules that bind to a target molecule with high affinity and specificity. The present study aimed... 
BREAST-CANCER | DNA APTAMERS | SYSTEMATIC EVOLUTION | BIND | MULTIDISCIPLINARY SCIENCES | RNA MOLECULES | N-SUCCINIMIDYL | SELECTION | CELL | DISCOVERY | TENASCIN-C
Journal Article
CLINICAL CANCER RESEARCH, ISSN 1078-0432, 11/2017, Volume 23, Issue 21, pp. 6616 - 6628
Purpose: Camelid single-domain antibody-fragments (sdAb) have beneficial pharmacokinetic properties, and those targeted to HER2 can be used for imaging of... 
HUMAN-BREAST-CANCER | ONCOLOGY | NANOBODIES | HER2-TARGETED THERAPIES | TARGETED RADIONUCLIDE THERAPY | RESISTANCE | RECEPTOR | N-SUCCINIMIDYL | HER-2 NEU ONCOGENE | CELL-LINES | TRASTUZUMAB EMTANSINE
Journal Article
JOURNAL OF NUCLEAR MEDICINE, ISSN 0161-5505, 08/2015, Volume 56, Issue 8, pp. 1265 - 1271
Tumor-associated macrophages constitute a major component of the stroma of solid tumors, encompassing distinct subpopulations with different characteristics... 
ACTIVATION | camelid single-domain antibody fragment (sdAb) | SUBSETS | N-SUCCINIMIDYL | BIODISTRIBUTION | CANCER | F-18 | macrophage mannose receptor (MMR) | POSITRON-EMISSION-TOMOGRAPHY | NANOBODIES | tumor microenvironment | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | PET | MICROENVIRONMENTS | PROGRESSION
Journal Article
Journal of Drug Targeting, ISSN 1061-186X, 07/2019, Volume 27, Issue 5-6, pp. 670 - 680
The major issues in messenger (m)RNA delivery are rapid mRNA degradation in the extracellular and intracellular spaces, which decreases the efficiency and... 
amidine group | Messenger RNA | polyplex micelle | dimethyl 3,3'-dithiobispropionimidate (DTBP) | disulphide crosslinking | N-succinimidyl 3-(2-pyridyldithio)propionate (SPDP) | nuclease tolerability
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2010, Volume 53, Issue 4, pp. 1732 - 1740
The labeling of biomolecules for positron emission tomography (PET) with no-carrier-added fluorine-18 is almost exclusively accomplished using prosthetic... 
CHEMISTRY, MEDICINAL | POSITRON-EMISSION-TOMOGRAPHY | RADIOPHARMACEUTICALS | RGD PEPTIDES | IN-VIVO | CHEMISTRY | TUMOR | RECEPTOR | N-SUCCINIMIDYL | PET | NUCLEOPHILIC AROMATIC-SUBSTITUTION
Journal Article
MOLECULES, ISSN 1420-3049, 12/2014, Volume 19, Issue 12, pp. 20536 - 20556
Radiolabeled peptides have been the subject of intense research efforts for targeted diagnostic imaging and radiotherapy over the last 20 years. Peptides offer... 
SOLID-PHASE SYNTHESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CLICK-CHEMISTRY REACTIONS | peptides | N-SUCCINIMIDYL | SOMATOSTATIN RECEPTORS | CHEMISTRY, MULTIDISCIPLINARY | 3+2 CYCLOADDITION | fluorine-18 | automation | POSITRON-EMISSION-TOMOGRAPHY | RAPID RADIOFLUORINATION | labeling chemistry | COPPER-FREE | microfluidic | PRECLINICAL EVALUATION | PET | DRUGGABLE GENOME
Journal Article
CHEMISTRY-A EUROPEAN JOURNAL, ISSN 0947-6539, 11/2017, Volume 23, Issue 62, pp. 15553 - 15577
Journal Article
JOURNAL OF NUCLEAR MEDICINE, ISSN 0161-5505, 12/2016, Volume 57, Issue 12, pp. 1978 - 1984
Prostate-specific membrane antigen (PSMA) is a membrane protein highly expressed on prostate cancer cells and a potential imaging target for diagnosis.... 
RADIATION-DOSIMETRY | DIAGNOSIS | F-18-SFB | ACID | BIODISTRIBUTION | F-18-labeled asymmetric urea compound | NAALADASE | prostate cancer | PSMA | GLUTAMATE CARBOXYPEPTIDASE-II | AGENT N-SUCCINIMIDYL | LIGAND | UREA-BASED INHIBITORS | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | PET
Journal Article
JOURNAL OF NUCLEAR MEDICINE, ISSN 0161-5505, 06/2016, Volume 57, Issue 6, pp. 967 - 973
The human growth factor receptor type 2 (HER2) is overexpressed in breast as well as other types of cancer. Immuno-PET, a noninvasive imaging procedure that... 
Nanobody | TARGETED RADIONUCLIDE THERAPY | AFFIBODY MOLECULE | N-SUCCINIMIDYL | BIODISTRIBUTION | F-18 | ANTIBODY FRAGMENTS | POSITRON-EMISSION-TOMOGRAPHY | PEPTIDES | RECOMMENDATIONS | residualizing label | METASTATIC BREAST-CANCER | HER2 | immuno-PET | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Journal Article
SEMINARS IN NUCLEAR MEDICINE, ISSN 0001-2998, 09/2017, Volume 47, Issue 5, pp. 474 - 492
Prosthetic group (PG) applications in F-18-radiochemistry play a pivotal-role-among-current (18)-Flabeling techniques for the development and availability of... 
LATE-STAGE | LABELING PROTEINS | CLICK-CHEMISTRY REACTIONS | ONE-STEP RADIOSYNTHESIS | N-SUCCINIMIDYL | COPPER-FREE | AUTOMATED RADIOSYNTHESIS | PET RADIOTRACER | PRECLINICAL EVALUATION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | EFFICIENT METHOD
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 09/2018, Volume 28, Issue 17, pp. 2875 - 2878
In this report, we describe the radiosynthesis of a new thiol-targeting prosthetic group for efficient radioactive iodine labeling of biomolecules.... 
Radiolabeling | Site-specific reaction | Radiopharmaceutical | Radioactive iodine | Biodistribution | CHEMISTRY, MEDICINAL | HUMAN SERUM-ALBUMIN | VOLUME | CHEMISTRY, ORGANIC | IODOBENZOATE | N-SUCCINIMIDYL | EFFICIENT METHOD | PROBES | AGENT | RADIOIODINATION | NANOPARTICLES | THERAPY | Index Medicus
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 10/2008, Volume 51, Issue 19, pp. 5901 - 5904
Numerous radiolabeled peptides have been utilized for in vivo imaging of a variety of cell surface receptors. For applications in PET using [F-18]fluorine,... 
CONJUGATION | F-18-LABELED RGD | METHODOLOGY | CHEMISTRY, MEDICINAL | SOLID-PHASE SYNTHESIS | CLICK CHEMISTRY | 1,3-DIPOLAR CYCLOADDITION | INTEGRIN-ALPHA(V)BETA | N-SUCCINIMIDYL | BIODISTRIBUTION | ALPHA-V-BETA-6 INTEGRIN
Journal Article
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, ISSN 1619-7070, 02/2019, Volume 46, Issue 2, pp. 489 - 500
PurposeMetabolic imaging using [F-18]FDG is the current standard for clinical PET; however, some malignancies (e.g., indolent lymphomas) show low avidity for... 
ImmunoPET | LABELING PROTEINS | N-SUCCINIMIDYL | TUMOR-CELLS | Same-day imaging | FDG PET/CT | F-18 | POSITRON-EMISSION-TOMOGRAPHY | PEPTIDES | TRACER | Anti-CD20 cys-diabody | B cell lymphoma | RENAL UPTAKE | Antibody fragments | PRECLINICAL EVALUATION | EXPRESSION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Journal Article
MOLECULAR PHARMACEUTICS, ISSN 1543-8384, 03/2019, Volume 16, Issue 3, pp. 1025 - 1035
Monoclonal antibodies (mAbs) are currently used as therapeutic agents in different types of cancer. However, mAbs and antibody fragments developed so far show... 
trimerbody | MEDICINE, RESEARCH & EXPERIMENTAL | DOMAIN | carcinoembryonic antigen | STABILITY | MONOCLONAL-ANTIBODY | N-SUCCINIMIDYL | radiolabeling | single-chain variable fragment | TRIMERIZATION | TUMOR XENOGRAFTS | ORIENTATION | IN-VIVO | FRAGMENT | PHARMACOLOGY & PHARMACY | GENERATION | positron emission tomography | PET
Journal Article
by Cai, WB and Zhang, XZ and Wu, Y and Chen, X
JOURNAL OF NUCLEAR MEDICINE, ISSN 0161-5505, 07/2006, Volume 47, Issue 7, pp. 1172 - 1180
The cell adhesion molecule integrin alpha v beta(3) plays a key role in tumor angiogenesis and metastasis. A series of F-18-labeled RGD peptides have been... 
BRAIN-TUMOR ANGIOGENESIS | microPET | F-18-FBEM | F-18 labeling | N-SUCCINIMIDYL | CANCER ALPHA(V)-INTEGRIN EXPRESSION | BREAST-CANCER | CONJUGATION | METHODOLOGY | POSITRON-EMISSION-TOMOGRAPHY | integrin alpha(v)beta | ALPHA-V-BETA-3 | thiol-reactive synthon | PROTEINS | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Journal Article
Physical Chemistry Chemical Physics, ISSN 1463-9076, 2009, Volume 11, Issue 22, pp. 4498 - 4508
The absorption and fluorescence properties in a class of oligothiophene push-pull biomarkers are investigated with a long-range-corrected (LC) density... 
LOCAL-DENSITY | N-SUCCINIMIDYL ESTERS | EXCITATIONS | APPROXIMATION | TRANSFER EXCITED-STATES | PHYSICS, ATOMIC, MOLECULAR & CHEMICAL | CHEMISTRY, PHYSICAL | SYSTEMS | CHARGE-TRANSFER | EXCHANGE | ENERGIES | HYBRID | Quantum Theory | Time Factors | Fluorescence | Models, Molecular | Molecular Structure | Thiophenes - chemistry | Biomarkers - chemistry | Index Medicus
Journal Article
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