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PloS one, ISSN 1932-6203, 2017, Volume 12, Issue 12, pp. e0189238 - e0189238
[This corrects the article DOI: 10.1371/journal.pone.0186347.]. 
Amyloid | N-Terminus
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 01/2011, Volume 705, pp. 15 - 30
The preparation of sufficient amounts of high-quality protein samples is the major bottleneck for structural proteomics. The use of recombinant proteins has... 
N-Terminus
Journal Article
Biochemical Engineering Journal, ISSN 1369-703X, 05/2019, Volume 145, pp. 42 - 52
Mutation in the enzyme engineering is a powerful tool that could alter enzyme properties, providing evidence for enzymology. Acylpeptide hydrolase (APH) is... 
N-terminus | Linker region | Promiscuous catalysis | Acylpeptide hydrolase | Aldol addition
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 1 - 13
The interaction of hC5a with C5aR, previously hypothesized to involve a “two-site” binding, (i) recognition of the bulk of hC5a by the N-terminus (NT) of C5aR... 
C-Terminus | Free energy | N-Terminus | PharmacoPhores
Journal Article
IMMUNITY, ISSN 1074-7613, 06/2017, Volume 46, Issue 6, pp. 1005 - 1005
CCR5 is the primary chemokine receptor utilized by HIV to infect leukocytes, whereas CCR5 ligands inhibit infection by blocking CCR5 engagement with HIV gp120.... 
AMINO-TERMINAL DOMAIN | CORECEPTOR | ENTRY | RANTES | CRYSTAL-STRUCTURE | IMMUNODEFICIENCY-VIRUS TYPE-1 | HIGH-AFFINITY BINDING | N-TERMINUS | GP120 | IMMUNOLOGY | MEMBRANE-PROTEINS
Journal Article
SCIENCE, ISSN 0036-8075, 11/2011, Volume 334, Issue 6058, pp. 977 - 982
Gene silencing is essential for regulating cell fate in eukaryotes. Altered chromatin architectures contribute to maintaining the silenced state in a variety... 
YEAST | PROTEIN INTERACTIONS | GENETIC-ANALYSIS | CHROMATIN | HISTONE H3 | MULTIDISCIPLINARY SCIENCES | TELOMERIC HETEROCHROMATIN | MATING LOCI | N-TERMINUS | SACCHAROMYCES-CEREVISIAE | CORE PARTICLE
Journal Article
Protein Engineering Design and Selection, ISSN 1741-0126, 02/2013, Volume 26, Issue 2, pp. 165 - 170
Addition of an extra methionine at the N-terminus by recombinant expression of alpha -lactalbumin in Escherichia coli significantly destabilizes the protein,... 
Methionine | N-Terminus | Crystal structure
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 1 - 11
Radionuclide molecular imaging of HER2 expression in disseminated cancer enables stratification of patients for HER2-targeted therapies. DARPin G3, a small (14... 
Histidine | Liver | N-Terminus | Xenografts | C-Terminus | Bone imaging | ErbB-2 protein | Metastases
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 1 - 19
The histamine H1-receptor (H1R) is an important mediator of allergy and inflammation. H1R antagonists have particular clinical utility in allergic rhinitis and... 
Histamine | Bioluminescence | Urticaria | Hypersensitivity | Allergic rhinitis | N-Terminus | Ligands | Fluorescent indicators | Kinetics | Drug discovery | PharmacoPhores | Index Medicus
Journal Article
Cellular Signalling, ISSN 0898-6568, 10/2018, Volume 50, pp. 121 - 130
A pathological hallmark of Alzheimer's disease (AD) is the aggregation of amyloid-β peptides (Aβ) into fibrils, leading to deposits in cerebral parenchyma and... 
N-terminus | Cerebral amyloid angiopathy | Amyloid-β | Platelets | Alzheimer's disease | Clusterin
Journal Article
ACS Chemical Neuroscience, ISSN 1948-7193, 03/2017, Volume 8, Issue 3, pp. 432 - 434
Journal Article
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 02/2018, Volume 141, Issue 2, pp. AB282 - AB282
Removing the first 3 amino acids (del3-CCL28) led to marked increase in potency, with significantly increased sRaw (p=0.001 versus unfolded del3-CCL28; n>=4)... 
ALLERGY | IMMUNOLOGY | Respiratory tract | Amino acids | Chemokines | Viral infections | N-Terminus | Asthma
Journal Article
Oncogene, ISSN 0950-9232, 2019, Volume 38, Issue 23, pp. 4620 - 4636
FBXW7 is a driver gene in T-cell lymphoblastic neoplasia acting through proteasome degradation of key proto-oncogenes. FBXW7 encodes three isoforms, α, β and... 
Cell proliferation | N-Terminus | MiRNA | Cell lines | c-Myc protein | Isoforms | Lymphocytes T | Myc protein | Lymphoma | Cdc4 protein | Tumors | Proto-oncogenes
Journal Article
Journal of Investigative Dermatology, ISSN 0022-202X, 08/2019, Volume 139, Issue 8, pp. 1658 - 1671.e8
Keratinocyte skin cancer, comprising cutaneous squamous (cSCC) and basal cell carcinoma, is the most common malignancy in the United Kingdom. P53 is frequently... 
EPITHELIAL-MESENCHYMAL TRANSITION | FAMILY-MEMBERS | ISOFORM | N-TERMINUS | P63 | UP-REGULATION | EXPRESSION | CANCER | APOPTOSIS-STIMULATING PROTEIN | P53 | DERMATOLOGY
Journal Article
Biophysical Journal, ISSN 0006-3495, 05/2019, Volume 116, Issue 9, pp. 1598 - 1608
Although the critical role of allostery in controlling enzymatic processes is well appreciated, there is a current dearth in our understanding of its... 
PHOSPHOFRUCTOKINASE | MUTAGENESIS | CONTRIBUTE | BIOPHYSICS | NETWORK REPRESENTATION | SECONDARY | COOPERATIVITY | CONFORMATIONAL DYNAMICS | COMMUNICATION PATHWAYS | N-TERMINUS | CENTRALITY | Enzymes | Liver
Journal Article
International Dairy Journal, ISSN 0958-6946, 08/2012, Volume 25, Issue 2, pp. 97 - 102
Dipeptidyl peptidase (DPP)-IV inhibitors are promising new therapies for type 2 diabetes. Currently, these inhibitors are only available as synthetic drugs.... 
DIGESTION | BIOACTIVE PEPTIDES | ENZYME | GLUCAGON-LIKE PEPTIDE-1 | SUBSTRATE | FOOD SCIENCE & TECHNOLOGY | MILK PROTEIN | N-TERMINUS | BETA-LACTOGLOBULIN | Type 2 diabetes | Peptides | Proteases | Protein hydrolysates
Journal Article
Coordination Chemistry Reviews, ISSN 0010-8545, 10/2012, Volume 256, Issue 19-20, pp. 2175 - 2187
► Cu(II) binding to Aβ is dynamic and involves several equilibria. ► The first two amino-acid residues (in blue) of human Aβ have a predominant role in Cu(II)... 
Truncations | EPR/HYSCORE/NMR | Mutations | Amyloid | Copper/bioinorganic chemistry | NEURODEGENERATIVE DISORDERS | COMPLEXES | PYROGLUTAMATE | PHYSIOLOGICAL PH | N-TERMINUS | CHEMISTRY, INORGANIC & NUCLEAR | ANIMAL-MODELS | COPPER(II) IONS | ENGLISH H6R | BRAIN | TOTTORI D7N
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 02/2015, Volume 6
The Clp protease complex degrades a multitude of substrates, which are engaged by a AAA+ chaperone such as ClpX and subsequently digested by the dynamic,... 
COMPLEX-FORMATION | ANTIBIOTICS | VIRULENCE FACTORS | MULTIDISCIPLINARY SCIENCES | ATP-DEPENDENT PROTEASE | ESCHERICHIA-COLI | CIPP PROTEASE | BETA-LACTONES | HUMAN MITOCHONDRIAL CLPP | STAPHYLOCOCCUS-AUREUS | N-TERMINUS
Journal Article