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European Journal of Organic Chemistry, ISSN 1434-193X, 08/2019, Volume 2019, Issue 30, pp. 4832 - 4843
In the present study, a palladium‐catalyzed direct oxidative acylation through cross‐dehydrogenative coupling has been investigated, utilizing readily... 
N‐Butylphthalide | Catalysis | Primary alcohols | Ketones | Oxidative coupling | ANNULATION | CHEMISTRY, ORGANIC | CARBONYLATIVE CYCLIZATION REACTIONS | ALKYNES | C-H ACTIVATION | BROMIDES | ALKENES | CARBOANNULATION | 2,3-DIARYLINDENONES | ACYLATION REACTIONS | AZOBENZENES | N-Butylphthalide | Fenofibrate | Palladium | Alcohols | Acylation
Journal Article
by Gong, Y and Liu, WG and Huang, X and Hao, L and Li, YM and Sun, SJ
FRONTIERS IN MICROBIOLOGY, ISSN 1664-302X, 07/2019, Volume 10, p. 1461
Candida albicans is a common opportunistic fungal pathogen that may cause nosocomial fungal infections. The resistance of Candida albicans to traditional... 
Candida albicans | AZOLES | APOPTOSIS | potential mechanism | n-butylphthalide | MICROBIOLOGY | CELL-CYCLE ARREST | antifungal activity | INFECTION MODEL | fluconazole | IN-VITRO | EFFLUX | SODIUM HOUTTUYFONATE | SYNERGY | RESISTANCE | TIME-KILL | Fluconazole | Mycoses
Journal Article
Journal Article
Natural Product Research, ISSN 1478-6419, 12/2016, Volume 30, Issue 23, pp. 2716 - 2719
New analogues of n-butylphthalide (NBP) bearing various lengths of alkyl and different substitution at the two-position of phthalide were designed and... 
water solubility | anti-platelet aggregation | n-Butylphthalide analogues | STROKE | CHEMISTRY, MEDICINAL | 3-N-BUTYLPHTHALIDE | CHEMISTRY, APPLIED
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 03/2014, Volume 55, Issue 11, pp. 1956 - 1958
We report a highly efficient method for the synthesis of (Z)-3-ylidenephthalides via intramolecular cyclization of readily available 2-acyl-benzoic acids... 
(Z)-3-Ylidenephthalides | Intramolecular cyclization | 2-Acyl-benzoic acid | Enol | n-Butylphthalide | 3-YLIDENEPHTHALIDES | PATHWAY | CHEMISTRY, ORGANIC | AGENTS | DERIVATIVES | CYCLIZATION | CELL-DEATH | Benzoic acid | Drugs | Tetrahedrons | Synthesis (chemistry)
Journal Article
Neurochemical Research, ISSN 0364-3190, 10/2017, Volume 42, Issue 10, pp. 2968 - 2981
l-3-n-Butylphthalide (l-NBP) exerts neuroprotective effects in animal models of cerebral ischemia, but its potential benefits in repeated cerebral... 
Neurochemistry | Biochemistry, general | Repeated cerebral ischemia–reperfusion | Learning | Neurology | Neurosciences | Biomedicine | Memory | l -3- n -Butylphthalide | Autophagy | Cell Biology | Apoptosis | l-3-n-Butylphthalide | ISCHEMIA/REPERFUSION INJURY | BIOCHEMISTRY & MOLECULAR BIOLOGY | RATS | NEUROSCIENCES | CELL-DEATH | HIPPOCAMPUS | DL-3-N-BUTYLPHTHALIDE | UNFOLDED PROTEIN RESPONSE | VASCULAR DEMENTIA | L-3-n-Butylphthalide | PATHWAY | Repeated cerebral ischemia-reperfusion | BRAIN | PARKINSONS-DISEASE | Cognitive Dysfunction - drug therapy | TOR Serine-Threonine Kinases - metabolism | Apoptosis - drug effects | Cognitive Dysfunction - metabolism | Mice, Inbred C57BL | Benzofurans - pharmacology | Male | Cognition Disorders - drug therapy | Autophagy - drug effects | Animals | Memory Disorders - drug therapy | Neuroprotective Agents - pharmacology | Reperfusion | Brain Ischemia - pathology | Proto-Oncogene Proteins c-akt - metabolism | TOR Serine-Threonine Kinases - drug effects | Disease Models, Animal | Proto-Oncogene Proteins c-akt - drug effects | Proteins | Cerebral ischemia | RNA | Neurons | Analysis | Mice | TOR protein | Occlusion | Neuroprotection | Animal models | Bax protein | Bcl-2 protein | Cognitive ability | Impairment | AKT protein | Activation | mRNA | Ischemia | Cerebral blood flow | Rodents | Surgery | Carotid artery | Lesions | Oral administration | Maze learning | Hippocampus | Phagocytosis
Journal Article
Frontiers in Pharmacology, ISSN 1663-9812, 10/2016, Volume 7, p. 394
Journal Article
Journal of Cellular and Molecular Medicine, ISSN 1582-1838, 11/2017, Volume 21, Issue 11, pp. 3010 - 3022
In this study, we examined the neuroprotective effects and anti‐inflammatory properties of Dl‐3‐n‐butylphthalide (NBP) in Sprague‐Dawley (SD) rats following... 
spinal cord injury | Dl‐3‐n‐butylphthalide (NBP) | microglia | inflammatory | Dl-3-n-butylphthalide (NBP) | Microglia - metabolism | Spinal Cord - drug effects | Spinal Cord - metabolism | Spinal Cord Injuries - drug therapy | Coculture Techniques | NF-kappa B - immunology | Benzofurans - pharmacology | Spinal Cord Injuries - genetics | Lipopolysaccharides - antagonists & inhibitors | PC12 Cells | Spinal Cord Injuries - pathology | Neuroprotective Agents - pharmacology | Spinal Cord - pathology | Female | Toll-Like Receptor 4 - antagonists & inhibitors | Microglia - cytology | Cell Line | NF-kappa B - antagonists & inhibitors | Microglia - drug effects | Signal Transduction | Anti-Inflammatory Agents - pharmacology | Gene Expression Regulation | Rats | Toll-Like Receptor 4 - genetics | Toll-Like Receptor 4 - immunology | Rats, Sprague-Dawley | Spinal Cord - immunology | Animals | NF-kappa B - genetics | Lipopolysaccharides - pharmacology | Spinal Cord Injuries - immunology | Neuroprotection | Cell culture | Spinal cord | Toxicity | Cytotoxicity | Inflammatory response | Activation | Spinal cord injury | Lipopolysaccharides | Rodents | Toll-like receptors | Biocompatibility | Inhibition | Injuries | NF-κB protein | Antiinflammatory agents | Inflammation | TLR4 protein | Microglia | Signaling | Lymphocytes B | Pheochromocytoma cells | Spinal cord injuries | Apoptosis | Original
Journal Article