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CLINICAL GENETICS, ISSN 0009-9163, 06/2017, Volume 91, Issue 6, pp. 859 - 867
Hyperkalemic periodic paralysis (HyperPP) is a dominantly inherited muscle disease caused by mutations in SCN4A gene encoding skeletal muscle voltage gated... 
ACTIVATION | novel borderline mutation | IMPAIRED SLOW INACTIVATION | MECHANISM | founder effect | GENOTYPE | hyperkalemic periodic paralysis | GATED SODIUM-CHANNELS | MUSCLE | PHENOTYPE | Na(v)1 | NA+ CHANNEL | EXCITABILITY | FUNCTIONAL EXPRESSION | GENETICS & HEREDITY
Journal Article
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, ISSN 0175-7571, 07/2017, Volume 46, Issue 5, pp. 485 - 494
The mechanism of inactivation of mammalian voltage-gated Na+ channels involves transient interactions between intracellular domains resulting in direct pore... 
C-type | DOMAIN | Na(v)1.4 | SODIUM-CHANNELS | BETA-1-SUBUNIT | BLOCK | Loss of function | MECHANISMS | Inactivation | Allosteric | IFM | BIOPHYSICS | Sodium | FUNCTIONAL EXPRESSION | Mutant | PORE | Oocyte | BETA SUBUNIT | MODULATION
Journal Article
by Han, PG and Wang, K and Dai, XD and Cao, Y and Liu, SY and Jiang, H and Fan, CX and Wu, WJ and Chen, JS
MARINE DRUGS, ISSN 1660-3397, 11/2016, Volume 14, Issue 11
mu-Conotoxin GIIIA, a peptide toxin isolated from Conus geographus, preferentially blocks the skeletal muscle sodium channel Na(V)1.4. GIIIA folds compactly to... 
THERAPEUTICS | PIIIA | CHEMISTRY, MEDICINAL | SUBTYPES | Na(V)1.4 | mu-conotoxin | MOLECULAR DETERMINANTS | PEPTIDE | ALPHA-CONOTOXINS | disulfide bond | electrophysiology | GIIIA | PORE | ANALGESICS | MUSCLE SODIUM-CHANNELS | BLOCKER
Journal Article
JOURNAL OF PHARMACOLOGICAL SCIENCES, ISSN 1347-8613, 10/2013, Volume 123, Issue 2, pp. 203 - 206
Journal Article
by Luo, J and Zhang, YY and Gong, MT and Lu, SS and Ma, YF and Zeng, XZ and Liang, SP
TOXINS, ISSN 2072-6651, 07/2014, Volume 6, Issue 7, pp. 2177 - 2193
Voltage-gated sodium channels (VGSCs; Na(V)1.1-Na(V)1.9) have been proven to be critical in controlling the function of excitable cells, and human genetic... 
NERVOUS-SYSTEM | LOCALIZATION | spider toxin | ACTIVATION | ISOFORMS | RAT | Na(V)1.4 | TOXINS | NEURONS | TOXICOLOGY | voltage gated sodium channels | SPIDER-VENOM PEPTIDES | EXPRESSION | MODULATION | JZTX-V
Journal Article
CHANNELS, ISSN 1933-6950, 03/2011, Volume 5, Issue 2, pp. 161 - 172
The antianginal drug ranolazine exerts voltage- and use-dependent block (UDB) of several Na+ channel isoforms, including Na(v)1.4. We hypothesized that... 
DEPENDENT BLOCK | PERSISTENT CURRENT | angina | BIOCHEMISTRY & MOLECULAR BIOLOGY | NA+ CHANNELS | Na channels | Markov model | HYPERKALEMIC PERIODIC PARALYSIS | action potential | HUMAN SKELETAL-MUSCLE | paramyotonia congenita | INACTIVATION | excitability | MEXILETINE | LIDOCAINE | SCN4A | NONDYSTROPHIC MYOTONIAS | MUTATIONS | skeletal muscle
Journal Article
Cell, ISSN 0092-8674, 07/2017, Volume 170, Issue 3, pp. 470 - 482.e11
Voltage-gated sodium (Na ) channels initiate and propagate action potentials. Here, we present the cryo-EM structure of EeNa 1.4, the Na channel from electric... 
Nav1.4 | electromechanical coupling | Nav channels | structural biology | the beta-1 subunit | voltage-gated sodium channels | cryo-EM | fast inactivation | Na(v) channels | Na | Na(v)1.4 | channels | Cryo-EM | 1.4 | The beta-1 subunit | Fast inactivation | Electromechanical coupling | Structural biology | Voltage-gated sodium channels
Journal Article
NEUROTOXICOLOGY, ISSN 0161-813X, 06/2005, Volume 26, Issue 3, pp. 397 - 406
Insecticidal pyrazolines inhibit voltage-sensitive sodium channels of both insect and mammalian neurons ill a voltage-dependent manner: Studies on the effects... 
Na(v)1.4 | ROOT GANGLION NEURONS | OXADIAZINE INSECTICIDE | insecticide | N-DECARBOMETHOXYLATED METABOLITE | MOLECULAR DETERMINANTS | NEUROSCIENCES | LOCAL-ANESTHETIC RECEPTOR | DIHYDROPYRAZOLE INSECTICIDES | RESISTANT | DCJW | oocyte | PHARMACOLOGY & PHARMACY | TOXICOLOGY | indoxacarb | RH 3421 | GATED NA+ CHANNELS | BRAIN
Journal Article
Journal of Biomolecular Structure and Dynamics, ISSN 0739-1102, 02/2019, Volume 37, Issue 3, pp. 702 - 713
Voltage-gated sodium (Na-v) channels play a pivotal role for the changes in membrane potential and belong to large membrane proteins that compose four voltage... 
1.5 | 1.7 | sodium channel inhibitor | VSD4 | molecular dynamics simulation | 1.4 | Na(v)1.4 | BIOPHYSICS | EFFICACY | BIOCHEMISTRY & MOLECULAR BIOLOGY | SCN9A | VOLTAGE SENSOR | Na(v)1.5 | Na(v)1.7 | ACCURACY
Journal Article
Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 05/2019, Volume 130, pp. 88 - 95
variants can be associated with overlapping phenotypes such as Brugada syndrome (BrS), sinus node dysfunction and supraventricular tachyarrhythmias. Our... 
Sinus node dysfunction | SCN5A | Brugada syndrome | Sodium currents | Supraventricular tachyarrhythmias | Closed-state inactivation | MOLECULAR-MECHANISM | CARDIAC & CARDIOVASCULAR SYSTEMS | MUTATION | NA(V)1.4 | CELL BIOLOGY | Tachycardia | Analysis
Journal Article
Brain, ISSN 0006-8950, 2016, Volume 139, Issue 3, pp. 674 - 691
Journal Article
CHANNELS, ISSN 1933-6950, 01/2019, Volume 13, Issue 1, pp. 331 - 343
The segment 4 (S4) voltage sensor in voltage-gated sodium channels (Na(v)s) have domain-specific functions, and the S4 segment in domain DIV (DIVS4) plays a... 
MOLECULAR-MECHANISM | PERIODIC PARALYSIS | sodium channelopathies | voltage sensor | BIOCHEMISTRY & MOLECULAR BIOLOGY | SCN5A MUTATIONS | CAUSES PARAMYOTONIA | voltage-gated sodium channel | CONGENITA | NA(V)1.4 | Closed-state inactivation | fast inactivation | BRUGADA-SYNDROME | GATING PORE CURRENTS | CHANNEL MUTATIONS | SPECTRUM
Journal Article
Journal Article
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