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animals (752) 752
calcium - metabolism (490) 490
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na+-ca2+ exchanger (151) 151
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contraction (79) 79
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sodium-calcium exchanger - genetics (79) 79
calcium - physiology (78) 78
intracellular calcium (78) 78
mice (78) 78
myocytes (77) 77
electrophysiology (76) 76
release (75) 75
na+/ca2+ exchange (70) 70
sarcoplasmic reticulum (70) 70
heart - physiology (68) 68
membrane potentials - drug effects (68) 68
heart failure (67) 67
muscle (65) 65
sodium-calcium exchanger - antagonists & inhibitors (65) 65
myocytes, cardiac - metabolism (60) 60
time factors (60) 60
transport (60) 60
biophysics (59) 59
peripheral vascular disease (59) 59
sarcolemma - metabolism (59) 59
excitation-contraction coupling (57) 57
rats, wistar (57) 57
sodium - pharmacology (57) 57
heart - drug effects (56) 56
ouabain - pharmacology (56) 56
calcium channel blockers - pharmacology (55) 55
heart-failure (55) 55
expression (54) 54
na +/ca 2+ exchanger (54) 54
na +/ca 2+ exchange (53) 53
membrane potentials - physiology (51) 51
ouabain (51) 51
physiological aspects (51) 51
pig ventricular myocytes (51) 51
molecular sequence data (49) 49
functional expression (48) 48
heart ventricles - metabolism (48) 48
sodium-calcium exchanger - chemistry (48) 48
cattle (47) 47
caffeine - pharmacology (46) 46
rats, sprague-dawley (46) 46
dose-response relationship, drug (45) 45
rat (45) 45
action potentials (44) 44
calcium - pharmacology (44) 44
rat ventricular myocytes (44) 44
ion exchange (43) 43
molecular-cloning (43) 43
potassium - metabolism (43) 43
action potentials - drug effects (42) 42
calcium-transporting atpases - metabolism (42) 42
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1. Full Text Sodium/Calcium Exchange: Its Physiological Implications
by Blaustein, Mordecai P and Lederer, W. Jonathan
Physiological Reviews, ISSN 0031-9333, 07/1999, Volume 79, Issue 3, pp. 763 - 854
Departments of Physiology and Medicine and the Center for Vascular Biology and Hypertension, University of Maryland School of Medicine, and Department of... 
DIALYZED SQUID AXONS | NA-CA-EXCHANGE | ROD OUTER SEGMENTS | PHYSIOLOGY | PIG VENTRICULAR MYOCYTES | CULTURED RAT ASTROCYTES | CARDIAC SARCOLEMMAL VESICLES | ADRENAL CHROMAFFIN CELLS | TRANSIENT INWARD CURRENT | SMOOTH-MUSCLE CELLS | PLASMA-MEMBRANE VESICLES | Base Sequence - genetics | Animals | Humans | Molecular Sequence Data | Sodium-Calcium Exchanger - genetics | Structure-Activity Relationship | Amino Acid Sequence - genetics | Kinetics | Sodium-Calcium Exchanger - physiology | Biological transport | Calcium metabolism | Physiological aspects | Ion channels | Research | Ion exchange | Sodium metabolism
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2. Full Text Structural Insight into the Ion-Exchange Mechanism of the Sodium/Calcium Exchanger
by Jun Liao and Hua Li and Weizhong Zeng and David B. Sauer and Ricardo Belmares and Youxing Jiang and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Science, ISSN 0036-8075, 2/2012, Volume 335, Issue 6069, pp. 686 - 690
Sodium/calcium (Na⁺/Ca²⁺) exchangers (NCX) are membrane transporters that play an essential role in maintaining the homeostasis of cytosolic Ca²⁺ for cell... 
Proteins | Colors | Passageways | RESEARCH ARTICLES | Crystals | Crystallization | Ligands | Liposomes | Detergents | Binding sites | Crystal structure | SARCOLEMMAL NA+-CA2+ EXCHANGER | CELLS | NEUROTRANSMITTER TRANSPORTERS | CRYSTAL-STRUCTURE | FUNCTIONAL EXPRESSION | BACTERIAL HOMOLOG | MULTIDISCIPLINARY SCIENCES | SODIUM-CALCIUM EXCHANGE | CARDIAC NA+/CA2+ EXCHANGER | NA-CA EXCHANGE | PROTEINS | Archaeal Proteins - metabolism | Amino Acid Sequence | Protein Structure, Secondary | Calcium - metabolism | Sodium-Calcium Exchanger - chemistry | Archaeal Proteins - chemistry | Models, Molecular | Molecular Sequence Data | Crystallography, X-Ray | Sodium - metabolism | Methanococcales - metabolism | Sodium-Calcium Exchanger - metabolism | Protein Conformation | Ion Transport | Methanococcales - chemistry | Binding Sites | Ion exchange | Research | Signal transduction | Membranes | Sodium | Calcium | Molecular biology | HOMEOSTASIS | ION EXCHANGE | SYMMETRY | ORIENTATION | MEMBRANES | CRYSTAL STRUCTURE | MATERIALS SCIENCE
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3. Full Text Sodium-calcium exchange: A molecular perspective
by Philipson, K.D and Nicoll, D.A
Annual Review of Physiology, ISSN 0066-4278, 2000, Volume 62, Issue 1, pp. 111 - 133
Plasma membrane Na+-Ca2+ exchange is an essential component of Ca2+ signaling pathways in several tissues. Activity is especially high in the heart where the... 
Calcium signaling | Sodium transport | Calcium transport | Antiporter | Excitation-contraction coupling | CARDIAC NA+-CA2+ EXCHANGER | PROTEIN-KINASE-C | PHYSIOLOGY | PIG VENTRICULAR MYOCYTES | INDUCED HEART-FAILURE | calcium signaling | sodium transport | NA-CA EXCHANGE | SARCOPLASMIC-RETICULUM | antiporter | DEPENDENT REGULATION | NA+/CA2+ EXCHANGER | FUNCTIONAL EXPRESSION | excitation-contraction coupling | calcium transport | ALTERNATIVELY SPLICED ISOFORMS | Amino Acid Sequence | Animals | Biological Transport, Active - physiology | Calcium - metabolism | Sodium-Calcium Exchanger - metabolism | Heart - physiology | Humans | Molecular Sequence Data | Cell Membrane - metabolism | Sodium-Calcium Exchanger - genetics | Sodium - metabolism | Phosphorylation | Sodium | Calcium | Transportation | Biological transport, Active | Physiological aspects | Regulation | Research | Cardiology
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4. Full Text The Na+/Ca2+ exchange molecule: An overview
by Philipson, Kenneth D and Nicoll, Debora A and Ottolia, Michela and Quednau, Beate D and Reuter, Hannes and John, Scott and Qiu, Zhiyong
Annals of the New York Academy of Sciences, ISSN 0077-8923, 2002, Volume 976, Issue 1, pp. 1 - 10
An overview of the molecular physiology of the Na+/Ca2+ exchanger is presented. This includes information on the variety of exchangers that have been described... 
NCKX family | NCX family | CHX exchangers | exchange | α repeat regions | Ca | DYNAMIC PROPERTIES | CARDIAC NA+-CA2+ EXCHANGER | MULTIDISCIPLINARY SCIENCES | alpha repeat regions | Na+/Ca2+ exchange | VENTRICULAR MYOCYTES | CA2+-BINDING DOMAIN | DROSOPHILA | NA/CA EXCHANGER | CA2 | XIP REGION | SODIUM-CALCIUM EXCHANGE | STEADY-STATE | Kidney - physiology | Animals | Alternative Splicing | Heart - physiology | Sodium-Calcium Exchanger - chemistry | Models, Molecular | Protein Conformation | Sodium-Calcium Exchanger - genetics | Sodium-Calcium Exchanger - physiology | Organ Specificity | Brain - physiology
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5. Full Text Cardiac Na+-Ca2+ Exchange: Molecular and Pharmacological Aspects
by Shigekawa, Munekazu and Iwamoto, Takahiro
Circulation Research: Journal of the American Heart Association, ISSN 0009-7330, 05/2001, Volume 88, Issue 9, pp. 864 - 876
ABSTRACT—The Na-Ca exchanger (NCX) is one of the essential regulators of Ca homeostasis in cardiomyocytes and thus an important modulator of the cardiac... 
PROTEIN-KINASE-C | CARDIAC & CARDIOVASCULAR SYSTEMS | ATP-DEPENDENT REGULATION | PIG VENTRICULAR MYOCYTES | TISSUE-SPECIFIC EXPRESSION | NA-CA EXCHANGE | SARCOPLASMIC-RETICULUM | HEART-CELLS | NA+/CA2+ EXCHANGER | Na+-Ca2+ exchange | PERIPHERAL VASCULAR DISEASE | SODIUM-CALCIUM EXCHANGE | STEADY-STATE | HEMATOLOGY | cardiac muscle | excitation-contraction coupling | Ca2+ transport
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6. Full Text Modeling Na+-Ca2+ exchange in the heart: Allosteric activation, spatial localization, sparks and excitation-contraction coupling
by Chu, Lulu and Greenstein, Joseph L and Winslow, Raimond L
Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 10/2016, Volume 99, pp. 174 - 187
The cardiac sodium (Na )/calcium (Ca ) exchanger (NCX1) is an electrogenic membrane transporter that regulates Ca homeostasis in cardiomyocytes, serving mainly... 
Sodium-calcium exchanger | Spark rate | Spark fidelity | Calcium micro-domains | Cardiac myocyte | Computational model | Calcium sparks | DYNAMIC PROPERTIES | CARDIAC & CARDIOVASCULAR SYSTEMS | NA-CA EXCHANGE | SARCOPLASMIC-RETICULUM | CA2+-BINDING DOMAIN | MUTATIONAL ANALYSIS | CELL BIOLOGY | TRANSVERSE TUBULES | RYANODINE RECEPTORS | SODIUM-CALCIUM EXCHANGE | CARDIAC NA+/CA2+ EXCHANGER | RAT VENTRICULAR MYOCYTES | spark fidelity | sodium-calcium exchanger | calcium micro-domains | spark rate | computational model | calcium sparks | cardiac myocyte
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7. Full Text Stoichiometry of NA+−CA2+ exchange is 3:1 in guinea-pig ventricular myocytes
by Masamitsu Hinata and Hisao Yamamura and Libing Li and Yasuhide Watanabe and Tomokazu Watano and Yuji Imaizumi and Junko Kimura
The Journal of Physiology, ISSN 0022-3751, 12/2002, Volume 545, Issue 2, pp. 453 - 461
In single guinea-pig ventricular myocytes, we examined the stoichiometry of Na + -Ca 2+ exchange (NCX) by measuring the reversal potential ( E NCX ) of NCX... 
SYSTEM | CELLS | TRANSPORT | PHYSIOLOGY | MECHANISM | CARDIAC MYOCYTES | SODIUM-CALCIUM EXCHANGE | NA-CA EXCHANGE | Heart Ventricles - cytology | Guinea Pigs | Sodium - chemistry | Calcium - metabolism | Electrophysiology | Male | Calibration | Sodium - metabolism | Sodium-Calcium Exchanger - physiology | Membrane Potentials - physiology | Calcium - chemistry | Myocardium - cytology | Microscopy, Confocal | Patch-Clamp Techniques | Animals | Myocardium - metabolism | Sodium-Calcium Exchanger - antagonists & inhibitors | Heart Ventricles - metabolism | Indoles | Kinetics | In Vitro Techniques | Nickel - pharmacology | Fluorescent Dyes | Myocardium - ultrastructure | Original
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8. Full Text Altered platelet calsequestrin abundance, Na+/Ca2+ exchange and Ca2+ signaling responses with the progression of diabetes mellitus
by Zheng, Yuanyuan and Wang, Limin and Zhu, Zhixiang and Yan, Xinxin and Zhang, Lane and Xu, Pingxiang and Luo, Dali
Thrombosis Research, ISSN 0049-3848, 09/2014, Volume 134, Issue 3, pp. 674 - 681
Downregulation of calsequestrin (CSQ), a major Ca storage protein, may contribute significantly to the hyperactivity of internal Ca ([Ca ] ) in diabetic... 
Platelet aggregation | Calsequestrin-1 | Diabetes | Na+/Ca2 + exchange | Ca2 + signaling | exchange | signaling | Ca | Ca(2+) signaling | Na(+)/Ca(2+) exchange | PATHWAYS | HOMEOSTASIS | ACTIVATION | ENTRY | Ca2+ signaling | HYPERACTIVITY | Na+/Ca2+ exchange | RELEASE CHANNEL | INFLUX | CA2+-ATPASE | CALCIUM | PERIPHERAL VASCULAR DISEASE | SKELETAL | HEMATOLOGY | Streptozocin | Down-Regulation | Male | Sodium-Calcium Exchanger - blood | Rats, Sprague-Dawley | Disease Progression | Adenosine Diphosphate - pharmacology | Diabetes Mellitus, Experimental - blood | Platelet Aggregation | Animals | Time Factors | Blood Platelets - metabolism | Calcium Signaling - drug effects | Diabetes Mellitus, Type 1 - blood | Diabetes Mellitus, Type 1 - chemically induced | Diabetes Mellitus, Experimental - chemically induced | Blood Platelets - drug effects | Calcium-Binding Proteins - blood
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9. Full Text Na+-Ca2+exchange in the regulation of cardiac excitation-contraction coupling
by Reuter, Hannes and Pott, Christian and Goldhaber, Joshua I and Henderson, Scott A and Philipson, Kenneth D and Schwinger, Robert H.G
Cardiovascular Research, ISSN 0008-6363, 08/2005, Volume 67, Issue 2, pp. 198 - 207
Cardiac sarcolemmal Na -Ca exchange is a central component of Ca signaling essential for Ca extrusion and contributing to a variable degree to the development... 
Heart failure | e-c coupling | Ca-channel | Na/Ca-exchanger | Membrane current | heart failure | CARDIAC & CARDIOVASCULAR SYSTEMS | NONFAILING HUMAN MYOCARDIUM | TERMINAL HEART-FAILURE | membrane current | NA-CA EXCHANGE | DILATED CARDIOMYOPATHY | FAILING HUMAN MYOCARDIUM | INTRACELLULAR NA+ | NA+/CA2+ EXCHANGER | SARCOPLASMIC-RETICULUM CA2+-ATPASE | SODIUM-CALCIUM EXCHANGE | RAT VENTRICULAR MYOCYTES | Calcium - metabolism | Humans | Hypertrophy, Left Ventricular - metabolism | Myocardial Contraction - physiology | Cardiomegaly - physiopathology | Electrophysiology | Action Potentials | Animals | Sodium-Calcium Exchanger - metabolism | Myocytes, Cardiac - metabolism | Sarcoplasmic Reticulum - metabolism | Hypertrophy, Left Ventricular - physiopathology | Calcium Signaling | Cardiomegaly - metabolism
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10. Full Text Pharmacological Inhibition of Na/Ca Exchange Results in Increased Cellular Ca2 Load Attributable to the Predominance of Forward Mode Block
by Ozdemir, Semir and Bito, Virginie and Holemans, Patricia and Vinet, Laurent and Mercadier, Jean-Jacques and Varro, Andras and Sipido, Karin R
Circulation Research, ISSN 0009-7330, 06/2008, Volume 102, Issue 11, pp. 1398 - 1405
Block of Na/Ca exchange (NCX) has potential therapeutic applications, in particular, if a mode-selective block could be achieved, but also carries serious... 
Heart failure | Calcium overload | Na/Ca exchange | Sarcoplasmic reticulum | Cardiac myocytes | MYOCARDIUM | heart failure | CARDIAC & CARDIOVASCULAR SYSTEMS | NA+/CA2+ EXCHANGE | SODIUM-CALCIUM EXCHANGER | HEART-FAILURE | MOUSE | NA+-CA2+ EXCHANGER | VENTRICULAR MYOCYTES | sarcoplasmic reticulum | cardiac myocytes | CONTRACTION | CANINE HEART | PERIPHERAL VASCULAR DISEASE | calcium overload | HEMATOLOGY | SEA0400 | Aniline Compounds - pharmacology | Calcium - metabolism | Sarcoplasmic Reticulum - drug effects | Cells, Cultured | Myocardial Contraction - drug effects | Male | Heart Failure - metabolism | Cardiotonic Agents - pharmacology | Calcium Channel Blockers - pharmacology | Phenyl Ethers - pharmacology | Mice, Knockout | Patch-Clamp Techniques | Animals | Myocytes, Cardiac - drug effects | Sodium-Calcium Exchanger - metabolism | Swine | Myocytes, Cardiac - metabolism | Female | Sodium-Calcium Exchanger - antagonists & inhibitors | Mice | Sarcoplasmic Reticulum - metabolism | Electric Stimulation - methods | Disease Models, Animal
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11. Full Text Role of Na/Ca exchange and the plasma membrane Ca2+-ATPase in cell function. Conference on Na/Ca exchange
by Noble, Denis and Herchuelz, Andre
EMBO Reports, ISSN 1469-221X, 03/2007, Volume 8, Issue 3, pp. 228 - 232
Ca-ATPase | NCX | calcium | ENTRY | Na/Ca exchange | BIOCHEMISTRY & MOLECULAR BIOLOGY | MUSCLE | ISCHEMIA | NCX1 | KNOCKOUT MICE | PUMP | CELL BIOLOGY | CONTRACTION | NA+/CA2+ EXCHANGER | DISEASE | SODIUM-CALCIUM EXCHANGE | PMCA | Animals | Sodium-Calcium Exchanger - metabolism | Sodium-Calcium Exchanger - chemistry | Models, Molecular | Calcium-Transporting ATPases - metabolism | Signal Transduction - physiology | Cell Membrane - metabolism | Mice | Structure-Activity Relationship | Apoptosis - physiology | Ca exchange | Review
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12. Full Text Alternative strategies in arrhythmia therapy: Evaluation of Na/Ca exchange as an anti-arrhythmic target
by Antoons, Gudrun and Willems, Rik and Sipido, Karin R
Pharmacology and Therapeutics, ISSN 0163-7258, 04/2012, Volume 134, Issue 1, pp. 26 - 42
The search for alternative anti-arrhythmic strategies is fueled by an unmet medical need as well as by the opportunities arising from identification of novel... 
Ventricular arrhythmias | Heart failure | Pharmacology | Na/Ca exchange | Atrial fibrillation | Ryanodine receptor | POLYMORPHIC VENTRICULAR-TACHYCARDIA | TORSADES-DE-POINTES | LONG-QT SYNDROME | FAILING HUMAN MYOCARDIUM | OUABAIN-INDUCED ARRHYTHMIAS | IMPLANTABLE CARDIOVERTER-DEFIBRILLATOR | PHARMACOLOGY & PHARMACY | SODIUM-CALCIUM EXCHANGE | CARDIAC NA+/CA2+ EXCHANGER | CONGESTIVE-HEART-FAILURE | PROTEIN-KINASE-II | Arrhythmias, Cardiac - metabolism | Arrhythmias, Cardiac - drug therapy | Animals | Sodium-Calcium Exchanger - metabolism | Anti-Arrhythmia Agents - pharmacology | Humans | Anti-Arrhythmia Agents - therapeutic use | Arrhythmia | Analysis | Anti-arrhythmia drugs | Cardiovascular agents
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