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Journal Article
PLoS ONE, ISSN 1932-6203, 04/2016, Volume 11, Issue 4, pp. e0153181 - e0153181
The KEAP1-NRF2 pathway regulates cellular redox homeostasis by transcriptional induction of genes associated with antioxidant synthesis and detoxification in... 
METASTATIC MELANOMA | PHASE-II TRIAL | UVEAL MELANOMA | NRF2 | CISPLATIN | MULTIDISCIPLINARY SCIENCES | 17-ALLYLAMINO-17-DEMETHOXYGELDANAMYCIN | DRUG-RESISTANCE | SKIN | COMBINATION | CANCER | Carcinoma, Non-Small-Cell Lung - pathology | Melanocytes - enzymology | Humans | Gene Expression Regulation | Melanoma - enzymology | Lung Neoplasms - pathology | Cisplatin - pharmacology | Melanoma - pathology | NAD(P)H Dehydrogenase (Quinone) - genetics | Lactams, Macrocyclic - pharmacology | Benzoquinones - pharmacology | Drug Synergism | HSP90 Heat-Shock Proteins - antagonists & inhibitors | Cell Line, Tumor | NAD(P)H Dehydrogenase (Quinone) - metabolism | Transcription, Genetic | Mutation | Intracellular Signaling Peptides and Proteins - genetics | Kelch-Like ECH-Associated Protein 1 | Biotechnology | Oxidative stress | Hsp90 protein | Quinone oxidoreductase | Reactive oxygen species | Transcription factors | Transcription | Toxicity | Oxidoreductase | Lung | Science | Homeostasis | Cytotoxicity | Melanocytes | Biology | Activation | Cancer therapies | Skin cancer | Antioxidants | Dacarbazine | Fibroblasts | Biocompatibility | NRF2 protein | Deoxyribonucleic acid--DNA | Small cell lung carcinoma | Dermatology | Quinone | Melanoma | Detoxification | Heat shock proteins | Non-small cell lung carcinoma | Lung carcinoma | Tumor cell lines | Cisplatin | NAD(P)H:quinone oxidoreductase | NAD | Inhibitors | Antibiotics | Cell lines | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Journal of Neural Transmission, ISSN 0300-9564, 6/2015, Volume 122, Issue 6, pp. 757 - 772
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2018, Volume 61, Issue 24, pp. 11280 - 11297
The elevation of oxidative stress preferentially in cancer cells by efficient NQO1 substrates, which promote ROS generation through redox cycling, has emerged... 
ANTITUMOR AGENTS | NAD(P)H-QUINONE OXIDOREDUCTASE-1 | DESIGN | POTENT | CHEMISTRY, MEDICINAL | SMALL-MOLECULE | ANALOGS | INHIBITORS | STRESS | MODULATION | STRUCTURE-METABOLISM
Journal Article
Organic and Biomolecular Chemistry, ISSN 1477-0520, 2019, Volume 17, Issue 21, pp. 5269 - 5278
Mutasynthetic supplementation of the AHBA blocked mutant strain of S. hygroscopicus, the geldanamycin producer, with 21 aromatic and heteroaromatic amino acids... 
SYNTHASE | NAD(P)H-QUINONE OXIDOREDUCTASE-1 | BENZOQUINONE ANSAMYCINS | NATURAL-PRODUCTS | BIOSYNTHESIS | CHEMISTRY, ORGANIC | GENERATION | INHIBITORS | HYDROQUINONE | STRUCTURAL DIVERSITY
Journal Article
JOURNAL OF ORGANIC CHEMISTRY, ISSN 0022-3263, 09/2010, Volume 75, Issue 17, pp. 6023 - 6026
A Cu(II)-mediated synthesis of indolequinones from the corresponding bromoquinones and enamines is reported. The key oxidative cyclization proceeds in good... 
NQO1 | IN-VITRO | ACTIVATION | NAD(P)H-QUINONE-OXIDOREDUCTASE-1 | QUINONES | REDUCTION | OXIDOREDUCTASE-1 | CHEMISTRY, ORGANIC | MECHANISM-BASED INHIBITORS | CYTOTOXICITY | ANNULATION REACTION
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 07/2019, Volume 29, Issue 13, pp. 1572 - 1575
Journal Article
AQUATIC TOXICOLOGY, ISSN 0166-445X, 08/2019, Volume 213
Nrf2 is a crucial transcription factor that regulates the expression of cytoprotective enzymes and controls cellular redox homeostasis. Both arsenic and... 
Oxidative stress | NAD(P)H-QUINONE OXIDOREDUCTASE-1 | SODIUM-FLUORIDE | Co-exposure | WEST-BENGAL | DNA-DAMAGE | Zebrafish | Antagonism | Nrf2 | MANGANESE SUPEROXIDE-DISMUTASE | MARINE & FRESHWATER BIOLOGY | MICE | TOXICOLOGY | ABSORPTION | DRINKING-WATER | Xenobiotic metabolizing enzymes | EXPOSURE
Journal Article
Experimental Biology and Medicine, ISSN 1535-3702, 2/2019, Volume 244, Issue 2, pp. 171 - 182
Individuals with sickle cell disease have severe anemia due to the production of abnormal hemoglobin S, chronic red blood cell hemolysis, and increased... 
KEAP1 | fetal hemoglobin | NRF2 | Sickle cell disease | oxidative stress | MEDICINE, RESEARCH & EXPERIMENTAL | NAD(P)H-QUINONE OXIDOREDUCTASE-1 | INTRAVASCULAR HEMOLYSIS | 2,2-DIMETHYLBUTYRATE HQK-1001 | NRF2-REGULATED GENES | PHASE-II | KEAP1-NRF2 PATHWAY | L-GLUTAMINE | ELEMENT SIGNALING PATHWAY | TRANSCRIPTION FACTOR NRF2 | GLOBIN INDUCER
Journal Article
Journal of Immunology, ISSN 0022-1767, 03/2018, Volume 200, Issue 5, pp. 1555 - 1559
Irritant contact dermatitis (ICD) is associated with local release of inflammatory mediators such as reactive oxygen species and regulated by various... 
APOPTOSIS | NAD(P)H-QUINONE OXIDOREDUCTASE-1 | ACTIVATION | CARCINOGENESIS | GENE | RECEPTOR | SKIN | IMMUNOLOGY | P53 | Oxidative stress | Reactive oxygen species | Hypersensitivity | Detoxification | Acetylcysteine | Lymphocytes T | Inflammation | Dermatitis | Antioxidants | Contact dermatitis | Lymphocytes | Cell death | Rodents | Ear | Skin | Mice | Infiltration | Index Medicus | Abridged Index Medicus
Journal Article
International Journal of Neuroscience, ISSN 0020-7454, 08/2019, Volume 129, Issue 8, pp. 801 - 807
Background: Treatment of blast-induced traumatic brain injury (bTBI) has been hindered. Previous studies have demonstrated that oxidative stress may contribute... 
heme oxygenase-1 | shock tube | nuclear factor erythroid 2-related factor 2 | NAD(P)H: quinone oxidoreductase-1 | Blast induced traumatic brain injury | INFLAMMATION | VETERANS | MODEL | NEUROSCIENCES | PROVIDES NEUROPROTECTION
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 01/2007, Volume 6, Issue 1, pp. 154 - 162
Journal Article
FRONTIERS IN PHYSIOLOGY, ISSN 1664-042X, 08/2017, Volume 8
Journal Article
WORLD JOURNAL OF GASTROENTEROLOGY, ISSN 1007-9327, 05/2010, Volume 16, Issue 19, pp. 2362 - 2370
AIM: To investigate whether dicoumarol, a potent inhibitor of NAD(P)H quinone oxidoreductase-1 (NQO1), potentiates gemcitabine to induce cytotoxicity in... 
Oxidative stress | QUINONE OXIDOREDUCTASE-1 | APOPTOSIS | NAD(P)H-QUINONE OXIDOREDUCTASE-1 | ACTIVATION | MECHANISM | Dicoumarol | PANCREATIC-CANCER | P53 | Chemotherapy | GLUTATHIONE | GASTROENTEROLOGY & HEPATOLOGY | UP-REGULATION | NAD(P)H quinone oxidoreductase-1 | Cholangiocarcinoma
Journal Article