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Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 11/2018, Volume 124, pp. 45 - 57
Adriamycin (ADR) is a powerful chemotherapeutic agent extensively used to treat various human neoplasms. However, its clinical utility is hampered due to... 
NQO1 | Dunnione | NAD+/NADH ratio | Cardiomyopathy | Adriamycin | NAD | NADH ratio | DOXORUBICIN-INDUCED CARDIOTOXICITY | OXIDATIVE STRESS | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | ACETYLATION | HEART-FAILURE | MECHANISMS | ANTITUMOR-ACTIVITY | CELL BIOLOGY | NAD(+)/NADH ratio | INHIBITION | METABOLISM | ANTHRACYCLINES
Journal Article
NATURE GENETICS, ISSN 1061-4036, 07/2008, Volume 40, Issue 7, pp. 844 - 853
NQO1 guards against oxidative stress and carcinogenesis and stabilizes p53. We find that a homozygous common missense variant (NQO1*2, rs1800566(T),... 
NQO1 | CELLS | APOPTOSIS | P53 PROTEASOMAL DEGRADATION | SUSCEPTIBILITY | GENETICS & HEREDITY | ALPHA | KAPPA-B | POLYMORPHISM | NAD(P)H QUINONE OXIDOREDUCTASE | ASSOCIATION
Journal Article
MOLECULAR CARCINOGENESIS, ISSN 0899-1987, 07/2017, Volume 56, Issue 7, pp. 1825 - 1834
NAD(P) H: Quinone oxidoreductase (NQO1) functions as an important part of cellular antioxidant defense by detoxifying quinones, thus preventing the formation... 
OXIDATIVE STRESS | ANTITUMOR QUINONES | NAD(P) H: quinone oxidoreductase | antioxidants | BIOCHEMISTRY & MOLECULAR BIOLOGY | streptonigrin | INTRAEPITHELIAL NEOPLASIA | CELL-LINES | PROGNOSTIC INDICATORS | pancreatic cancer | METABOLISM | ONCOLOGY | DT-DIAPHORASE | ISOLATED HEPATOCYTES | DNA
Journal Article
The FEBS Journal, ISSN 1742-464X, 04/2017, Volume 284, Issue 8, pp. 1233 - 1245
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2014, Volume 9, Issue 6, pp. e98551 - e98551
Journal Article
Sensors & Actuators: B. Chemical, ISSN 0925-4005, 09/2015, Volume 216, pp. 343 - 348
Journal Article
Bioscience Reports, ISSN 0144-8463, 01/2019, Volume 39, Issue 1, p. BSR20180459
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2018, Volume 61, Issue 24, pp. 11280 - 11297
The elevation of oxidative stress preferentially in cancer cells by efficient NQO1 substrates, which promote ROS generation through redox cycling, has emerged... 
ANTITUMOR AGENTS | NAD(P)H-QUINONE OXIDOREDUCTASE-1 | DESIGN | POTENT | CHEMISTRY, MEDICINAL | SMALL-MOLECULE | ANALOGS | INHIBITORS | STRESS | MODULATION | STRUCTURE-METABOLISM
Journal Article
Chemical Research in Toxicology, ISSN 0893-228X, 12/2011, Volume 24, Issue 12, pp. 2153 - 2166
Journal Article
Journal Article