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protein binding (15) 15
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amino acid sequence (14) 14
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enzyme inhibitors - chemistry (14) 14
histone deacetylases (14) 14
structure-activity relationship (14) 14
cell-survival (13) 13
chemistry, organic (13) 13
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substrate specificity (11) 11
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histone deacetylase inhibitors (10) 10
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nad-dependent deacetylation (10) 10
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Journal Article
Current Opinion in Chemical Biology, ISSN 1367-5931, 2005, Volume 9, Issue 5, pp. 431 - 440
The importance of NAD -dependent deacetylases (Sir2 family or sirtuins) in cell survival, ageing and apoptosis has ignited a flurry of both chemical and... 
LIFE-SPAN | NAD(+)-DEPENDENT DEACETYLASES | SIR2-LIKE PROTEINS | BIOPHYSICS | HISTONE/PROTEIN DEACETYLASES | STRUCTURAL BASIS | SMALL-MOLECULE INHIBITORS | NAD(+) SALVAGE PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | YEAST SIR2 | SACCHAROMYCES-CEREVISIAE | ACETYL-ADP-RIBOSE | Niacinamide | Ribose | Cell research
Journal Article
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2012, Volume 287, Issue 4, pp. 2468 - 2476
Journal Article
Biochemistry and Cell Biology, ISSN 0829-8211, 04/2012, Volume 90, Issue 2, pp. 179 - 187
Silent information regulators are NAD + -dependent enzymes that display differential specificity toward acetylated substrates. This report provides first... 
NAD | CobB1 | désacétylation dépendante du NAD | AcetylCoA synthetaseA | acétyl-CoA synthase (acsA) | Streptomyces coeliocolor | sirtuin | Streptomyces coelicolor | dependent deacetylation activity CobB1 | Sirtuin | NAD(+)dependent deacetylation activity CobB1 | COMPLEX | MECHANISM | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | HOMOLOG | IDENTIFICATION | CELL BIOLOGY | COENZYME-A SYNTHETASE | ADP-RIBOSYLATED PROTEINS | A3 | ACETYL-COA SYNTHETASE | SIR2 FAMILY | Acetate-CoA Ligase - chemistry | Bacterial Proteins - chemistry | Molecular Sequence Data | Recombinant Proteins - biosynthesis | Streptomyces coelicolor - metabolism | Sirtuins - chemistry | Acetate-CoA Ligase - genetics | Enzyme Inhibitors - chemistry | Conserved Sequence | Transcription, Genetic | Acetylation | Amino Acid Sequence | Catalytic Domain | Recombinant Proteins - antagonists & inhibitors | Recombinant Proteins - chemistry | Acetate-CoA Ligase - biosynthesis | Sirtuins - biosynthesis | Sequence Alignment | Streptomyces coelicolor - enzymology | Bacterial Proteins - biosynthesis | Protein Processing, Post-Translational | Streptomyces coelicolor - growth & development | Anthraquinones - chemistry | Gene Expression Regulation, Bacterial | Sirtuins - antagonists & inhibitors | Bacterial Proteins - isolation & purification | Streptomyces | Physiological aspects | Health aspects | Bovine serum albumin | Enzymes | stationary phase | Deacetylation | nicotinamide | Antibodies | Acetic acid
Journal Article
MEDICINAL RESEARCH REVIEWS, ISSN 0198-6325, 01/2012, Volume 32, Issue 1, pp. 1 - 165
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2005, Volume 48, Issue 24, pp. 7789 - 7795
Journal Article
BBA - Proteins and Proteomics, ISSN 1570-9639, 2010, Volume 1804, Issue 8, pp. 1604 - 1616
Journal Article