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1. Full Text Combined NOX1/4 inhibition with GKT137831 in mice provides dose-dependent reno- and atheroprotection even in established micro- and macrovascular disease
by Gray, Stephen P and Jha, Jay C and Kennedy, Kit and van Bommel, Erik and Chew, Phyllis and Szynalewiez, Ceic and Touyz, Rhian M and Schmidt, Harald H. H. W and Cooper, Mark E and Jandeleit-Dahm, Karin A. M
Diabetologia, ISSN 0012-186X, 05/2017, Volume 60, Issue 5, pp. 927 - 937
Oxidative stress | ACCELERATED ATHEROSCLEROSIS | RENOPROTECTION | KNOCKOUT MICE | BLOOD-PRESSURE | Nephropathy | NADPH oxidase | Atherosclerosis | MOUSE MODEL | KEY ROLE | DIABETES-ASSOCIATED ATHEROSCLEROSIS | Diabetes | PHARMACOLOGICAL INHIBITION | Medicine & Public Health | Human Physiology | Metabolic Diseases | Internal Medicine | Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Diabetes Mellitus, Experimental - drug therapy | Pyrazoles - therapeutic use | Diabetes Mellitus, Experimental - genetics | NADPH Oxidases - metabolism | NADPH Oxidases - deficiency | NADH, NADPH Oxidoreductases - deficiency | NADPH Oxidases - genetics | Diabetes Mellitus, Experimental - metabolism | NADH, NADPH Oxidoreductases - metabolism | Diabetic Nephropathies - prevention & control | Diabetes Complications - prevention & control | Pyridines - therapeutic use | NADH, NADPH Oxidoreductases - genetics | Diabetes Complications - metabolism | Diabetic Nephropathies - metabolism | NADPH Oxidases - antagonists & inhibitors | NADPH Oxidase 4 | Atherosclerosis - metabolism | NADPH Oxidase 1 | Mice, Knockout | Animals | Mice | NADH, NADPH Oxidoreductases - antagonists & inhibitors | Oxidative Stress - drug effects | Atherosclerosis - prevention & control | Oxidases | Apolipoproteins | Analysis | Diabetic nephropathies | Index Medicus
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2. Full Text Structure, Activity and Stereoselectivity of NADPH‐Dependent Oxidoreductases Catalysing the S‐Selective Reduction of the Imine Substrate 2‐Methylpyrroline
by Man, Henry and Wells, Elizabeth and Hussain, Shahed and Leipold, Friedemann and Hart, Sam and Turkenburg, Johan P and Turner, Nicholas J and Grogan, Gideon
Chembiochem : a European journal of chemical biology, ISSN 1439-4227, 05/2015, Volume 16, Issue 7, pp. 1052 - 1059
IREDs | NADPH | amines | oxidoreductases | imines | asymmetric catalysis | Pharmacology & Pharmacy | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Catalytic Domain | Biocatalysis | Oxidation-Reduction | Imines - metabolism | Models, Molecular | Substrate Specificity | Gram-Positive Bacteria - enzymology | Pyrrolidines - chemistry | Sequence Homology, Amino Acid | Imines - chemistry | Pyrrolidines - metabolism | NADH, NADPH Oxidoreductases - chemistry | NADH, NADPH Oxidoreductases - metabolism | Oxidases | Schiff bases | Aspartate | Catalysis | Analysis | Enzymes | Index Medicus
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3. Full Text Mechanisms of vascular smooth muscle NADPH oxidase 1 (Nox1) contribution to injury-induced neointimal formation
by Lee, Moo Yeol and Martin, Alejandra San and Mehta, Puja K and Dikalova, Anna E and Garrido, Abel Martin and Datla, S. Raju and Lyons, Erin and Krause, Karl-Heinz and Banfi, Botond and Lambeth, J. David and Lassègue, Bernard and Griendling, Kathy K
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1079-5642, 04/2009, Volume 29, Issue 4, pp. 480 - 487
Reactive oxygen species | Neointima | Vascular smooth muscle | NADPH oxidase 1 | Migration | Peripheral Vascular Disease | Life Sciences & Biomedicine | Hematology | Cardiovascular System & Cardiology | Science & Technology | Fundamental and applied biological sciences. Psychology | Cardiology. Vascular system | Blood vessels and receptors | Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous | Atherosclerosis (general aspects, experimental research) | Biological and medical sciences | Medical sciences | Vertebrates: cardiovascular system | Blood and lymphatic vessels | Phosphorylation | Cell Proliferation | Hyperplasia | Femoral Artery - enzymology | Femoral Artery - injuries | Transfection | Time Factors | NADH, NADPH Oxidoreductases - deficiency | NADH, NADPH Oxidoreductases - metabolism | Disease Models, Animal | NADH, NADPH Oxidoreductases - genetics | Collagen Type I - metabolism | Mice, Inbred C57BL | Cells, Cultured | Tunica Intima - enzymology | p21-Activated Kinases - metabolism | Fibronectins - metabolism | NADPH Oxidase 1 | Tunica Intima - injuries | Mice, Knockout | Cofilin 2 - metabolism | Muscle, Smooth, Vascular - injuries | Muscle, Smooth, Vascular - pathology | Animals | Carrier Proteins - metabolism | Tunica Intima - pathology | Mice | Muscle, Smooth, Vascular - enzymology | Apoptosis | Cell Movement | Index Medicus
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4. Full Text Neurotoxic Activation of Microglia Is Promoted by a Nox1-Dependent NADPH Oxidase
by Cheret, Cyril and Gervais, Annie and Lelli, Aurelia and Colin, Catherine and Amar, Lahouari and Ravassard, Philippe and Mallet, Jacques and Cumano, Ana and Krause, Karl-Heinz and Mallat, Michel
The Journal of neuroscience, ISSN 0270-6474, 11/2008, Volume 28, Issue 46, pp. 12039 - 12051
Interleukin-1 | NADPH oxidase | Nitric oxide | Nox | Neuroinflammation | LPS | Microglia | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Reactive Oxygen Species - metabolism | Oxidative Stress - physiology | NADPH Oxidases - metabolism | Nitrites - metabolism | rac GTP-Binding Proteins - metabolism | Male | Gliosis - enzymology | Gliosis - physiopathology | Cytochrome b Group - metabolism | Zymosan - metabolism | Encephalitis - physiopathology | Inflammation Mediators - pharmacology | rac GTP-Binding Proteins - genetics | NADPH Oxidases - genetics | Female | Neuropeptides - genetics | NADH, NADPH Oxidoreductases - metabolism | Corpus Striatum - enzymology | NADH, NADPH Oxidoreductases - genetics | Encephalitis - enzymology | Corpus Striatum - physiopathology | Microglia - drug effects | Mice, Inbred C57BL | Microglia - enzymology | Neuropeptides - metabolism | Cytochrome b Group - genetics | NADPH Oxidase 2 | NADPH Oxidase 1 | Membrane Glycoproteins - genetics | Mice, Knockout | Neurotoxins - pharmacology | Proteins - genetics | Animals | Proteins - metabolism | Lipopolysaccharides - pharmacology | Corpus Striatum - drug effects | Mice | Oxidative Stress - drug effects | rac1 GTP-Binding Protein | Index Medicus | Reactive Oxygen Species | Oxidative Stress | Nitrites | Neuropeptides | Lipopolysaccharides | Proteins | Life Sciences | Immunology | NADH, NADPH Oxidoreductases | Membrane Glycoproteins | Zymosan | rac GTP-Binding Proteins | Encephalitis | Neurotoxins | Inflammation Mediators | Cytochrome b Group | Gliosis | Corpus Striatum | NADPH Oxidase | nitric oxide | interleukin-1 | neuroinflammation | microglia
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5. Full Text NADPH oxidases are essential for macrophage differentiation
by Xu, Qing and Choksi, Swati and Qu, Jianhui and Jang, Jonathan and Choe, Moran and Banfi, Botond and Engelhardt, John F and Liu, Zheng-Gang
The Journal of biological chemistry, ISSN 0021-9258, 09/2016, Volume 291, Issue 38, pp. 20030 - 20041
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Reactive Oxygen Species - metabolism | Membrane Glycoproteins - metabolism | NADPH Oxidases - metabolism | NADPH Oxidases - immunology | Monocytes - immunology | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | MAP Kinase Signaling System - immunology | Extracellular Signal-Regulated MAP Kinases - immunology | Cell Differentiation - genetics | MAP Kinase Signaling System - genetics | Reactive Oxygen Species - immunology | NADPH Oxidases - genetics | Membrane Glycoproteins - immunology | NADH, NADPH Oxidoreductases - metabolism | Macrophages - immunology | Chemokines - immunology | NADH, NADPH Oxidoreductases - genetics | Chemokines - genetics | NADPH Oxidase 2 | NADPH Oxidase 1 | Macrophages - enzymology | Membrane Glycoproteins - genetics | Mice, Knockout | Cell Differentiation - immunology | Monocytes - enzymology | Animals | NADH, NADPH Oxidoreductases - immunology | Mice | Index Medicus | macrophage | cell differentiation | reactive oxygen species (ROS) | NADPH oxidase | Cell Biology
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6. Full Text A genetically encoded tool for manipulation of NADP+/NADPH in living cells
by Cracan, Valentin and Titov, Denis V and Shen, Hongying and Grabarek, Zenon and Mootha, Vamsi K
Nature chemical biology, ISSN 1552-4450, 10/2017, Volume 13, Issue 10, pp. 1088 - 1095
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | NADH, NADPH Oxidoreductases - genetics | Oxidation-Reduction | Humans | Protein Engineering | NADH, NADPH Oxidoreductases - chemistry | HeLa Cells | NADP - metabolism | NADH, NADPH Oxidoreductases - metabolism | NADP - chemistry | Enzymes | Energy metabolism | Coenzymes | Detoxification | Oxidase | Biosynthesis | Metabolism | NADH oxidase | Cells | NAD | Genetic code | Mitochondria | NADH | Pathways | Cells (biology) | Nicotinamide adenine dinucleotide | Genetics | NADP | Index Medicus
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7. Full Text Nox4 Is a Protective Reactive Oxygen Species Generating Vascular NADPH Oxidase
by Schröder, Katrin and Zhang, Min and Benkhoff, Sebastian and Mieth, Anja and Pliquett, Rainer and Kosowski, Judith and Kruse, Christoph and Luedike, Peter and Michaelis, U Ruth and Weissmann, Norbert and Dimmeler, Stefanie and Shah, Ajay M and Brandes, Ralf P
Circulation research, ISSN 0009-7330, 04/2012, Volume 110, Issue 9, pp. 1217 - 1225
Hypertension | Angiogenesis | Carbon monoxide | Nitric oxide | Redox regulation | Cardiac & Cardiovascular Systems | Peripheral Vascular Disease | Life Sciences & Biomedicine | Hematology | Cardiovascular System & Cardiology | Science & Technology | Fundamental and applied biological sciences. Psychology | Cardiology. Vascular system | Arterial hypertension. Arterial hypotension | Biological and medical sciences | Medical sciences | Vertebrates: cardiovascular system | Blood and lymphatic vessels | Catalase - pharmacology | Heme Oxygenase-1 - metabolism | Humans | NADPH Oxidases - metabolism | Male | Ischemia - genetics | Carbonates - pharmacology | RNA, Messenger - metabolism | NADPH Oxidases - deficiency | Time Factors | NADPH Oxidases - genetics | Carbonates - metabolism | Hemin - pharmacology | Hypertension - enzymology | Hypertension - genetics | Ischemia - pathology | Cytoprotection | Disease Models, Animal | Muscle, Skeletal - blood supply | NADH, NADPH Oxidoreductases - genetics | Hypertension - pathology | Hydrogen Peroxide - metabolism | Mice, Knockout | Human Umbilical Vein Endothelial Cells - enzymology | Organometallic Compounds - metabolism | Mice | Oxidative Stress - drug effects | Endothelial Cells - pathology | Endothelial Cells - enzymology | Hypertrophy | Ischemia - enzymology | Boranes - metabolism | Transfection | NADH, NADPH Oxidoreductases - deficiency | Hypertension - chemically induced | NF-E2-Related Factor 2 - genetics | Membrane Proteins - metabolism | Nitric Oxide Synthase Type III - metabolism | Angiotensin II | Polyethylene Glycols - pharmacology | Carbon Dioxide - metabolism | Mice, Inbred C57BL | Cells, Cultured | Boranes - pharmacology | Antioxidants - pharmacology | Ischemia - physiopathology | NADPH Oxidase 4 | Hypertension - physiopathology | NADPH Oxidase 1 | Animals | Lung - blood supply | Neovascularization, Physiologic | Organometallic Compounds - pharmacology | Apoptosis | Endothelial Cells - drug effects | Index Medicus
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8. Full Text Serotonin Signaling Through the 5-HT 1B Receptor and NADPH Oxidase 1 in Pulmonary Arterial Hypertension
by Hood, Katie Y and Mair, Kirsty M and Harvey, Adam P and Montezano, Augusto C and Touyz, Rhian M and MacLean, Margaret R
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1079-5642, 07/2017, Volume 37, Issue 7, pp. 1361 - 1370
receptor, serotonin, 5-HT | hypertension, pulmonary | models, animal | serotonin | NADPH oxidase | Antihypertensive Agents - pharmacology | Cell Proliferation | Reactive Oxygen Species - metabolism | Oxidative Stress | Receptor, Serotonin, 5-HT1B - drug effects | Humans | Middle Aged | NADPH Oxidases - metabolism | Extracellular Matrix - metabolism | Hypertension, Pulmonary - physiopathology | Time Factors | Receptor, Serotonin, 5-HT1B - metabolism | Hypertension, Pulmonary - enzymology | Disease Models, Animal | NADH, NADPH Oxidoreductases - genetics | Genetic Predisposition to Disease | Signal Transduction | NADPH Oxidases - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Mice, Transgenic | Hypoxia - complications | Pulmonary Artery - physiopathology | Pulmonary Artery - drug effects | Pulmonary Artery - enzymology | Mice, Knockout | Phenotype | NF-E2-Related Factor 2 - metabolism | NADH, NADPH Oxidoreductases - antagonists & inhibitors | Protein Carbonylation | Vascular Remodeling | Serotonin 5-HT1 Receptor Antagonists - pharmacology | Peroxiredoxins - metabolism | Case-Control Studies | Hypertension, Pulmonary - prevention & control | Serotonin Plasma Membrane Transport Proteins - genetics | NADH, NADPH Oxidoreductases - deficiency | Arterial Pressure - drug effects | src-Family Kinases - metabolism | Adult | Female | NADH, NADPH Oxidoreductases - metabolism | Mice, Inbred C57BL | src-Family Kinases - antagonists & inhibitors | Cells, Cultured | NADPH Oxidase 1 | Serotonin Plasma Membrane Transport Proteins - metabolism | Animals | Serotonin - metabolism | Aged | Hypertension, Pulmonary - pathology | Pulmonary Artery - pathology
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9. Full Text Unchanged NADPH Oxidase Activity in Nox1-Nox2-Nox4 Triple Knockout Mice: What Do NADPH-Stimulated Chemiluminescence Assays Really Detect?
by Rezende, Flávia and Löwe, Oliver and Helfinger, Valeska and Prior, Kim-Kristin and Walter, Maria and Zukunft, Sven and Fleming, Ingrid and Weissmann, Norbert and Brandes, Ralf P and Schröder, Katrin
Antioxidants & redox signaling, ISSN 1523-0864, 03/2016, Volume 24, Issue 7, pp. 392 - 399
News & Views | Biochemistry & Molecular Biology | Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Reactive Oxygen Species | Membrane Glycoproteins - metabolism | NADPH Oxidases - metabolism | Cytochrome P-450 Enzyme System - metabolism | NADPH Oxidases - deficiency | Kidney - metabolism | NADH, NADPH Oxidoreductases - deficiency | Myocardium - metabolism | NADPH Oxidases - genetics | Cell Membrane - metabolism | NADP - metabolism | Nitric Oxide Synthase Type III - metabolism | NADH, NADPH Oxidoreductases - metabolism | NADH, NADPH Oxidoreductases - genetics | Angiotensin II - metabolism | Oxidation-Reduction | Signal Transduction | NADPH Oxidase 4 | NADPH Oxidase 2 | NADPH Oxidase 1 | Membrane Glycoproteins - genetics | Mice, Knockout | Phenotype | Animals | Mice | Enzyme Activation | Membrane Glycoproteins - deficiency | Reactive oxygen species | Chemiluminescence | Cell membranes | Analysis | NADP (Coenzyme) | Cellular manufacture | Cytochrome | Enzymes | Membranes | Kidneys | Cytochrome P450 | Assaying | NAD(P)H oxidase | Nitric-oxide synthase | Organic chemistry | NOX4 protein | Clonal deletion | Nitric oxide | CYBB protein | Angiotensin | Aorta | Pretreatment | Angiotensin II | Cytochromes P450 | Index Medicus
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10. Full Text Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets
by Griendling, Kathy K and Sobey, Christopher G and Selemidis, Stavros and Drummond, Grant R
Nature reviews. Drug discovery, ISSN 1474-1776, 06/2011, Volume 10, Issue 6, pp. 453 - 471
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Reactive Oxygen Species - metabolism | Membrane Glycoproteins - metabolism | Humans | NADPH Oxidases - antagonists & inhibitors | Oxidative Stress - physiology | NADPH Oxidases - metabolism | Vascular Diseases - enzymology | NADPH Oxidase 2 | NADPH Oxidase 1 | Animals | Membrane Glycoproteins - antagonists & inhibitors | Antioxidants - administration & dosage | NADH, NADPH Oxidoreductases - antagonists & inhibitors | Oxidative Stress - drug effects | NADH, NADPH Oxidoreductases - metabolism | Drug Delivery Systems - methods | Vascular Diseases - drug therapy | Index Medicus
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