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Journal of the American Society of Nephrology, ISSN 1533-3450, 06/2014, Volume 25, Issue 6, pp. 1237 - 1254
Journal Article
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1524-4636, 05/2016, Volume 36, Issue 5, pp. 846 - 854
OBJECTIVE—Reactive oxygen species (ROS) are known to regulate platelet activation; however, the mechanisms of ROS production during platelet activation remain... 
blood platelets | thrombosis | NADPH oxidase | platelet activation | reactive oxygen species | Peripheral Vascular Disease | Life Sciences & Biomedicine | Hematology | Cardiovascular System & Cardiology | Science & Technology | Phospholipase C gamma - blood | Phosphorylation | Male | Blood Platelets - enzymology | Receptors, G-Protein-Coupled - agonists | NADPH Oxidases - deficiency | CD11b Antigen - blood | Time Factors | Hemostasis | NADH, NADPH Oxidoreductases - deficiency | Platelet Membrane Glycoproteins - metabolism | NADPH Oxidases - genetics | Platelet Membrane Glycoproteins - agonists | Thrombosis - blood | Blood Platelets - drug effects | Calcium Signaling | Disease Models, Animal | NADH, NADPH Oxidoreductases - genetics | Genetic Predisposition to Disease | Reactive Oxygen Species - blood | Receptors, G-Protein-Coupled - blood | Mice, Inbred C57BL | Thrombosis - enzymology | Membrane Glycoproteins - blood | NADPH Oxidases - blood | NADPH Oxidase 2 | NADPH Oxidase 1 | Membrane Glycoproteins - genetics | Mice, Knockout | Platelet Aggregation | Phenotype | Animals | Thrombosis - genetics | NADH, NADPH Oxidoreductases - blood | Platelet Activation - drug effects | Enzyme Activation | Syk Kinase - blood | Thrombin - metabolism | Membrane Glycoproteins - deficiency | Mitogen-Activated Protein Kinases - metabolism | Index Medicus
Journal Article
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1079-5642, 02/2016, Volume 36, Issue 2, pp. 295 - 307
OBJECTIVE—Oxidative stress is considered a hallmark of atherosclerosis. In particular, the superoxide-generating type 1 NADPH oxidase (NOX1) has been shown to... 
atherosclerosis | endothelial cells | diabetes mellitus | NADPH oxidase | reactive oxygen species | Peripheral Vascular Disease | Life Sciences & Biomedicine | Hematology | Cardiovascular System & Cardiology | Science & Technology | Inflammation - pathology | Vascular Remodeling | Apolipoproteins E - deficiency | Membrane Glycoproteins - metabolism | Oxidative Stress | Atherosclerosis - genetics | Humans | NADPH Oxidases - metabolism | Male | Case-Control Studies | NADPH Oxidases - deficiency | Atherosclerosis - enzymology | Transfection | RNA Interference | Time Factors | Inflammation Mediators - metabolism | Superoxides - metabolism | Aortic Diseases - prevention & control | NADPH Oxidases - genetics | Aortic Diseases - enzymology | NADH, NADPH Oxidoreductases - metabolism | Aorta - enzymology | Aortic Diseases - pathology | Disease Models, Animal | Fibrillar Collagens - metabolism | Atherosclerosis - pathology | Cytokines - metabolism | Signal Transduction | Cells, Cultured | NADPH Oxidase 4 | Plaque, Atherosclerotic | NADPH Oxidase 2 | NADPH Oxidase 1 | Hydrogen Peroxide - metabolism | Mice, Knockout | Aorta - pathology | Aortic Diseases - genetics | Animals | Apolipoproteins E - genetics | Inflammation - genetics | Inflammation - prevention & control | Endothelial Cells - pathology | Endothelial Cells - enzymology | Inflammation - enzymology | Atherosclerosis - prevention & control | Index Medicus
Journal Article
The Journal of neuroscience, ISSN 1529-2401, 11/2008, Volume 28, Issue 46, pp. 12039 - 12051
Reactive oxygen species (ROS) modulate intracellular signaling but are also responsible for neuronal damage in pathological states. Microglia, the resident CNS... 
Interleukin-1 | NADPH oxidase | Nitric oxide | Nox | Neuroinflammation | LPS | Microglia | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Reactive Oxygen Species - metabolism | Oxidative Stress - physiology | NADPH Oxidases - metabolism | Nitrites - metabolism | rac GTP-Binding Proteins - metabolism | Male | Gliosis - enzymology | Gliosis - physiopathology | Cytochrome b Group - metabolism | Zymosan - metabolism | Encephalitis - physiopathology | Inflammation Mediators - pharmacology | rac GTP-Binding Proteins - genetics | NADPH Oxidases - genetics | Female | Neuropeptides - genetics | NADH, NADPH Oxidoreductases - metabolism | Corpus Striatum - enzymology | NADH, NADPH Oxidoreductases - genetics | Encephalitis - enzymology | Corpus Striatum - physiopathology | Microglia - drug effects | Mice, Inbred C57BL | Microglia - enzymology | Neuropeptides - metabolism | Cytochrome b Group - genetics | NADPH Oxidase 2 | NADPH Oxidase 1 | Membrane Glycoproteins - genetics | Mice, Knockout | Neurotoxins - pharmacology | Proteins - genetics | Animals | Proteins - metabolism | Lipopolysaccharides - pharmacology | Corpus Striatum - drug effects | Mice | Oxidative Stress - drug effects | rac1 GTP-Binding Protein | Index Medicus | Reactive Oxygen Species | Oxidative Stress | Nitrites | Neuropeptides | Lipopolysaccharides | Proteins | Life Sciences | Immunology | NADH, NADPH Oxidoreductases | Membrane Glycoproteins | Zymosan | rac GTP-Binding Proteins | Encephalitis | Neurotoxins | Inflammation Mediators | Cytochrome b Group | Gliosis | Corpus Striatum | NADPH Oxidase | nitric oxide | interleukin-1 | neuroinflammation | microglia
Journal Article
Free radical biology & medicine, ISSN 0891-5849, 08/2016, Volume 97, pp. 95 - 108
Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease characterized by progressive loss of motor neurons, gliosis, neuroinflammation... 
SOD1G93A mice | Thioridazine | NADPH oxidase | NOX | Amyotrophic lateral sclerosis | Perphenazine | Microglia | Phenothiazine | DUOX dual oxidase | List of abbreviations ALS amyotrophic lateral sclerosis | WST-1 2-(4-Iodophenyl)-3-(4-nitrophenyl)-5-(2,4-disulfophenyl)-2H-tetrazolium, monosodium salt | PBS phosphate buffered saline | HOCl hypochlorous acid | BBB blood brain barrier | WT wild typ | 2-chloroethidium | 2-Cl-E | NOXO1 NADPH oxidase organiser type 1 | CNS central nervous system | DPI diphenyleneiodonium | ethidium | NOX NADPH oxidase | HE hydroethidine | qPCR quantitative polymerase chain reaction | MPO myeloperoxidase | LC/MS/MS Liquid chromatography-tandem mass spectrometry | GM-CSF granulocyte-macrophage colony-stimulating factor | PMA phorbol myristate acetate | TDP 43 TAR DNA binding protein 43 | DMEM Dulbecco's modified Eagle Medium | hydrogen peroxide | DNA deoxyribonucleic acid | ROS reactive oxygen species | superoxide radical anion | SOD superoxide dismutase | HBSS Hank's buffered salt solution | half maximal efficient concentration | 2-hydroxyethidium | NADPH nicotinamide adenine dinucleotide phosphate | NC non-carrier | FBS fetal bovine serum | 2-OH-E | FUS/TLS Fused in Sarcoma/Translocated in Sarcoma | DMSO Dimethylsulfoxide | Biochemistry & Molecular Biology | Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Spinal Cord - drug effects | Amyotrophic Lateral Sclerosis - genetics | Humans | Middle Aged | Male | NADPH Oxidase 1 - genetics | Thioridazine - administration & dosage | Amyotrophic Lateral Sclerosis - drug therapy | Motor Neurons - pathology | Gene Expression Regulation - drug effects | Motor Neurons - metabolism | Amyotrophic Lateral Sclerosis - pathology | Animals | NADPH Oxidase 2 - metabolism | Spinal Cord - pathology | Superoxide Dismutase-1 - genetics | Adult | Female | Aged | Mice | Perphenazine - administration & dosage | NADPH Oxidase 2 - genetics | Superoxide Dismutase-1 - antagonists & inhibitors | Disease Models, Animal | Oxidases | Nervous system diseases | Analysis | Oncology, Experimental | Superoxide | Research | Cancer | Index Medicus
Journal Article
Hepatology (Baltimore, Md.), ISSN 0270-9139, 12/2012, Volume 56, Issue 6, pp. 2316 - 2327
Journal Article
Diabetologia, ISSN 1432-0428, 02/2017, Volume 60, Issue 5, pp. 927 - 937
Oxidative stress is a promising target in diabetes-associated vasculopathies, with inhibitors of NADPH oxidases (NOX), in particular isoforms 1 and 4, shown to... 
Oxidative stress | ACCELERATED ATHEROSCLEROSIS | RENOPROTECTION | KNOCKOUT MICE | BLOOD-PRESSURE | Nephropathy | NADPH oxidase | Atherosclerosis | MOUSE MODEL | KEY ROLE | DIABETES-ASSOCIATED ATHEROSCLEROSIS | Diabetes | PHARMACOLOGICAL INHIBITION | Medicine & Public Health | Human Physiology | Metabolic Diseases | Internal Medicine | Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Diabetes Mellitus, Experimental - drug therapy | Pyrazoles - therapeutic use | Diabetes Mellitus, Experimental - genetics | NADPH Oxidases - metabolism | NADPH Oxidases - deficiency | NADH, NADPH Oxidoreductases - deficiency | NADPH Oxidases - genetics | Diabetes Mellitus, Experimental - metabolism | NADH, NADPH Oxidoreductases - metabolism | Diabetic Nephropathies - prevention & control | Diabetes Complications - prevention & control | Pyridines - therapeutic use | NADH, NADPH Oxidoreductases - genetics | Diabetes Complications - metabolism | Diabetic Nephropathies - metabolism | NADPH Oxidases - antagonists & inhibitors | NADPH Oxidase 4 | Atherosclerosis - metabolism | NADPH Oxidase 1 | Mice, Knockout | Animals | Mice | NADH, NADPH Oxidoreductases - antagonists & inhibitors | Oxidative Stress - drug effects | Atherosclerosis - prevention & control | Oxidases | Apolipoproteins | Analysis | Diabetic nephropathies | Index Medicus
Journal Article
Clinical science (1979), ISSN 0143-5221, 08/2016, Volume 130, Issue 15, pp. 1363 - 1374
Oxidative stress and inflammation are central mediators of atherosclerosis particularly in the context of diabetes. The potential interactions between the... 
atherosclerosis | inflammation | diabetes | NADPH oxidase | oxidative stress | Oxidative stress | Inflammation | Diabetes | Atherosclerosis | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Chemotaxis, Leukocyte | Aortitis - immunology | Reactive Oxygen Species - metabolism | Apolipoproteins E - deficiency | Oxidative Stress | Diabetes Mellitus, Experimental - enzymology | Atherosclerosis - genetics | Diabetes Mellitus, Experimental - genetics | NADPH Oxidases - metabolism | Aortitis - enzymology | CD4-Positive T-Lymphocytes - enzymology | CD4-Positive T-Lymphocytes - immunology | NADPH Oxidases - deficiency | Atherosclerosis - enzymology | NADH, NADPH Oxidoreductases - deficiency | Inflammation Mediators - metabolism | NADPH Oxidases - genetics | Sinus of Valsalva - pathology | Aortitis - pathology | NADH, NADPH Oxidoreductases - metabolism | Macrophages - immunology | Cytokines - immunology | Inflammation Mediators - immunology | NADH, NADPH Oxidoreductases - genetics | Atherosclerosis - pathology | Genetic Predisposition to Disease | Atherosclerosis - immunology | Cytokines - metabolism | Signal Transduction | Aortitis - genetics | NADPH Oxidase 4 | Plaque, Atherosclerotic | NADPH Oxidase 1 | Macrophages - enzymology | Mice, Knockout | Sinus of Valsalva - enzymology | Diabetes Mellitus, Experimental - immunology | Phenotype | Animals | Apolipoproteins E - genetics | Diabetes Mellitus, Experimental - pathology | Sinus of Valsalva - immunology | Immunity, Cellular | Index Medicus
Journal Article