X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
animals (3140) 3140
index medicus (3017) 3017
nadph oxidase (2218) 2218
humans (2029) 2029
oxidative stress (1999) 1999
nadph oxidases - metabolism (1863) 1863
male (1588) 1588
reactive oxygen species - metabolism (1573) 1573
rats (1321) 1321
mice (1219) 1219
nadph oxidases - antagonists & inhibitors (1199) 1199
reactive oxygen species (921) 921
biochemistry & molecular biology (911) 911
activation (866) 866
nadh oxidase (849) 849
cells, cultured (831) 831
cell biology (827) 827
oxidases (823) 823
enzyme inhibitors - pharmacology (813) 813
superoxides - metabolism (673) 673
oxidative stress - drug effects (665) 665
superoxide (639) 639
physiology (638) 638
expression (634) 634
inflammation (619) 619
nadph oxidases - genetics (615) 615
signal transduction (584) 584
apoptosis (572) 572
rats, sprague-dawley (563) 563
pharmacology & pharmacy (551) 551
mice, inbred c57bl (511) 511
female (475) 475
hypertension (470) 470
nitric oxide (457) 457
neurosciences (452) 452
phosphorylation (446) 446
research (436) 436
physiological aspects (419) 419
disease models, animal (417) 417
nitric-oxide (416) 416
peripheral vascular disease (407) 407
angiotensin-ii (399) 399
proteins (394) 394
immunology (390) 390
rodents (390) 390
signal transduction - drug effects (386) 386
cell line (383) 383
nadph oxidase 2 (383) 383
antioxidants - pharmacology (372) 372
nitric-oxide synthase (362) 362
dose-response relationship, drug (358) 358
cells (342) 342
endocrinology & metabolism (342) 342
inhibition (339) 339
antioxidants (337) 337
mice, knockout (334) 334
cardiovascular system (331) 331
nadph oxidase 4 (320) 320
analysis (314) 314
cardiac & cardiovascular systems (313) 313
acetophenones - pharmacology (312) 312
research article (308) 308
gene expression (303) 303
nadph oxidases (301) 301
smooth-muscle-cells (295) 295
nitric oxide - metabolism (294) 294
oxidation-reduction (294) 294
endothelium (293) 293
rats, wistar (289) 289
apoptosis - drug effects (285) 285
hydrogen-peroxide (279) 279
membrane glycoproteins - metabolism (277) 277
nf-kappa-b (275) 275
medicine (272) 272
atherosclerosis (270) 270
health aspects (268) 268
enzymes (262) 262
kinases (255) 255
nadh, nadph oxidoreductases - metabolism (254) 254
gene-expression (249) 249
onium compounds - pharmacology (248) 248
multidisciplinary sciences (247) 247
time factors (247) 247
angiotensin (243) 243
neutrophils - drug effects (241) 241
hydrogen peroxide - metabolism (239) 239
nadh, nadph oxidoreductases - antagonists & inhibitors (237) 237
enzyme activation (235) 235
up-regulation (234) 234
nadph-oxidase (231) 231
blotting, western (229) 229
diabetes (229) 229
angiotensin ii (224) 224
biology (222) 222
calcium - metabolism (220) 220
endothelial-cells (218) 218
mitochondria (218) 218
reactive oxygen (215) 215
endothelial dysfunction (214) 214
medicine, research & experimental (213) 213
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


British Journal of Pharmacology, ISSN 0007-1188, 06/2017, Volume 174, Issue 12, pp. 1647 - 1669
The NADPH oxidase (NOX) family of enzymes produces ROS as their sole function and is becoming recognized as key modulators of signal transduction pathways with a physiological role under acute stress and a pathological role... 
OXIDATIVE-STRESS | NOX ENZYMES | CONCISE GUIDE | INCREASED EXPRESSION | CHRONIC GRANULOMATOUS-DISEASE | ADENINE-DINUCLEOTIDE PHOSPHATE | CHRONIC HYPERTENSION | PHARMACOLOGY & PHARMACY | SMOOTH-MUSCLE-CELLS | ANGIOTENSIN-II | PHARMACOLOGICAL INHIBITION | Fibrosis - drug therapy | NADPH Oxidase 1 - antagonists & inhibitors | Anti-Inflammatory Agents - pharmacology | Pyridines - chemistry | Humans | Enzyme Inhibitors - pharmacology | Fibrosis - metabolism | Inflammation - metabolism | Pyrazoles - chemistry | Animals | Anti-Inflammatory Agents - chemistry | Inflammation - drug therapy | NADPH Oxidase 2 - metabolism | Enzyme Inhibitors - chemistry | NADPH Oxidase 1 - metabolism | Pyridines - pharmacology | Pyridones - chemistry | NADPH Oxidase 2 - antagonists & inhibitors | Pyridones - pharmacology | Pyrazoles - pharmacology | Oxidases | Physiological aspects | Cellular signal transduction | Health aspects | Analysis | Medical research | Oxidative stress | Reactive oxygen species | Disease | Oxidase | Organs | Clinical trials | Gene deletion | Modulators | NAD(P)H oxidase | Diseases | Signal transduction | Inhibitors | Pathways | CYBB protein | Isoforms | Fibrosis | Transduction | In vivo methods and tests | Inhibition | Localization | Themed Section | Review
Journal Article
Trends in Endocrinology & Metabolism, ISSN 1043-2760, 2014, Volume 25, Issue 9, pp. 452 - 463
Highlights • Endothelial cells express four NADPH oxidase isoforms: NOX1, 2, 4, and 5. • NOX1, 2, and 5 make superoxide and cause endothelial dysfunction and vascular disease... 
Endocrinology & Metabolism | hyperlipidemia | NADPH oxidases | vascular disease | selective NOX1/2 inhibitors | inflammation | reactive oxygen species | hypertension | diabetes | endothelial dysfunction | Hypertension | Vascular disease | Selective NOX1/2 inhibitors | Reactive oxygen species | Hyperlipidemia | Endothelial dysfunction | Inflammation | Diabetes | OXYGEN SPECIES PRODUCTION | OXIDATIVE STRESS | SPONTANEOUSLY HYPERTENSIVE-RATS | NITRIC-OXIDE SYNTHASE | LOW-DENSITY-LIPOPROTEIN | ANGIOTENSIN-II | REDOX SIGNALING PLATFORMS | INDUCED UP-REGULATION | ENDOCRINOLOGY & METABOLISM | HYDROGEN-PEROXIDE PRODUCTION | CORONARY-ARTERY-DISEASE | NADPH Oxidases - chemistry | Membrane Glycoproteins - metabolism | Humans | NADPH Oxidases - metabolism | Endothelium, Vascular - drug effects | Endothelium, Vascular - enzymology | Molecular Targeted Therapy | Membrane Glycoproteins - antagonists & inhibitors | NADPH Oxidases - genetics | Membrane Proteins - metabolism | Vascular Diseases - drug therapy | Membrane Proteins - genetics | NADPH Oxidases - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Mice, Transgenic | NADPH Oxidase 5 | NADPH Oxidase 4 | Vascular Diseases - enzymology | Enzyme Inhibitors - therapeutic use | NADPH Oxidase 2 | NADPH Oxidase 1 | Cardiovascular Agents - pharmacology | Membrane Glycoproteins - genetics | Mice, Knockout | Cardiovascular Agents - therapeutic use | Animals | Membrane Proteins - antagonists & inhibitors | Models, Biological | Oxidases | Blood circulation disorders | Superoxide | Peroxides | Endothelium
Journal Article
BBA - Molecular Basis of Disease, ISSN 0925-4439, 06/2019, Volume 1865, Issue 6, pp. 1332 - 1340
...) antagonist, ki16425, protected against DN in diabetic db/db mice. Here, we investigated the effects of a specific pharmacological inhibitor of LPA receptor 1 (LPA1... 
Diabetic nephropathy | Reactive oxidative stress | Inflammatory cytokines | Lysophosphatidic acid | Lysophosphatidic acid receptor 1 | AM095 | OXIDATIVE STRESS | ACTIVATION | TGF-BETA | CHEMOKINES | BIOCHEMISTRY & MOLECULAR BIOLOGY | KAPPA-B | PATHOGENESIS | GROWTH-FACTOR-BETA | BIOPHYSICS | MESANGIAL CELLS | SECRETION | EXPRESSION | Receptors, Lysophosphatidic Acid - metabolism | Lysophospholipids - metabolism | RNA, Small Interfering - genetics | Diabetes Mellitus, Experimental - drug therapy | Reactive Oxygen Species - metabolism | Transcription Factor RelA - antagonists & inhibitors | Streptozocin | Diabetes Mellitus, Experimental - genetics | NADPH Oxidases - metabolism | Diabetic Nephropathies - drug therapy | JNK Mitogen-Activated Protein Kinases - metabolism | Male | Receptors, Lysophosphatidic Acid - genetics | Transcription Factor RelA - genetics | Kidney Glomerulus - metabolism | NADPH Oxidases - genetics | Albuminuria - metabolism | Diabetes Mellitus, Experimental - chemically induced | JNK Mitogen-Activated Protein Kinases - genetics | Receptors, Lysophosphatidic Acid - antagonists & inhibitors | Toll-Like Receptor 4 - antagonists & inhibitors | Diabetes Mellitus, Experimental - metabolism | JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors | Lysophospholipids - antagonists & inhibitors | Signal Transduction | Diabetic Nephropathies - metabolism | Kidney Glomerulus - drug effects | Mice, Inbred C57BL | NADPH Oxidases - antagonists & inhibitors | Diabetic Nephropathies - chemically induced | Gene Expression Regulation | Toll-Like Receptor 4 - genetics | Diabetic Nephropathies - genetics | Antioxidants - pharmacology | Kidney Glomerulus - pathology | Toll-Like Receptor 4 - metabolism | Hypoglycemic Agents - pharmacology | Albuminuria - genetics | Reactive Oxygen Species - antagonists & inhibitors | Animals | Transcription Factor RelA - metabolism | Albuminuria - drug therapy | Albuminuria - chemically induced | Mice | Oxidative Stress - drug effects | Phenylacetates - pharmacology | RNA, Small Interfering - metabolism
Journal Article
Diabetologia, ISSN 1432-0428, 2017, Volume 60, Issue 5, pp. 927 - 937
Journal Article
Journal Article
Journal Article
Free radical biology & medicine, ISSN 0891-5849, 2012, Volume 53, Issue 2, pp. 289 - 296
.... Homologs of NADPH oxidases (NOXs) are major sources of ROS, but the exact role of the individual homologs in liver disease is unknown... 
NADPH oxidase 4 | Liver fibrosis | Stellate cell activation | Hepatocyte apoptosis | NADPH OXIDASE | ACTIVATION | TGF-BETA | ISOFORMS | BIOCHEMISTRY & MOLECULAR BIOLOGY | INJURY | FIBROGENESIS | MECHANISMS | HEPATIC STELLATE CELLS | ENDOCRINOLOGY & METABOLISM | NAD(P)H OXIDASES | STRESS | Liver - pathology | Pyrazoles - therapeutic use | Liver - enzymology | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Bile Ducts - metabolism | Humans | NADPH Oxidases - metabolism | Hepatitis, Autoimmune - drug therapy | Hepatocytes - pathology | Smad3 Protein - metabolism | Liver Cirrhosis - enzymology | Hepatic Stellate Cells - cytology | Hepatitis, Autoimmune - pathology | Fas Ligand Protein - pharmacology | Ligation | Liver - drug effects | Gene Deletion | NADPH Oxidases - genetics | NADH, NADPH Oxidoreductases - metabolism | Hepatocytes - drug effects | Hepatic Stellate Cells - drug effects | Pyrazoles - pharmacology | Pyridines - therapeutic use | Liver Cirrhosis - drug therapy | NADH, NADPH Oxidoreductases - genetics | Bile Ducts - drug effects | NADPH Oxidases - antagonists & inhibitors | Rats | Bile Ducts - surgery | NADPH Oxidase 4 | NADPH Oxidase 1 | Reactive Oxygen Species - antagonists & inhibitors | Animals | Signal Transduction - drug effects | Liver Cirrhosis - pathology | Mice | NADH, NADPH Oxidoreductases - antagonists & inhibitors | Pyridines - pharmacology | Dactinomycin - pharmacology | Transforming Growth Factor beta - metabolism | Hepatitis, Autoimmune - enzymology | Hepatocytes - enzymology | Oxidases | Phosphates | Niacinamide | Purines | Liver diseases | Analysis | Liver | Fibrosis | Bone morphogenetic proteins | Transforming growth factors | Muscle proteins | Apoptosis | stellate cell activation | liver fibrosis | hepatocyte apoptosis | nicotinamide adenine dinucleotide phosphate reduced oxidase 4
Journal Article
Journal Article
Journal of the American Society of Nephrology, ISSN 1533-3450, 2014, Volume 25, Issue 6, pp. 1237 - 1254
Journal Article
PLoS biology, ISSN 1544-9173, 09/2010, Volume 8, Issue 9, p. e1000479
Journal Article
Journal Article